Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

워터드라이브 내부 유동 특성 파악을 위한 수치해석 연구

곽민희(Minhee Kwak),허남건(NahmKeon Hur),장춘수(Choon-Soo Chang),강남원(Nam-Won Kang) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11

Water drive is one of the hydraulic coupling used for torque transmitting. This paper performs numerical analysis to investigate flow characteristics in water drive with different operating condition. Rotating speed of the primary wheel is fixed but that of the secondary wheel is changed. Also water volume fraction are changed. The realizable k-ε turbulence model and VOF method are used to simulate air-water two-phase flow inside the water drive. The simulation are conducted using the sliding grid. The results are presented in the form of flow patterns, torque values and circulation mass flow rate between the primary wheel and secondary wheel.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

국내 Epstein-Barr 바이러스 일차감염의 임상적 특성

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2007 감염과 화학요법 Vol.39 No.6

In this study, the clinical features of 264 patients of primary Epstein-Barr virus (EBV) infection between the years of 2002-2006 were evaluated retrospectively. The median age of the patients was 6 years old (0-69), and the hospitalization rate was 78.0%. Fever (83.3%) and sore throat (50.4%) were the most common symptoms. Cervical lymphadenopathy (71.2%), tonsillitis (51.1%), splenomegaly (26.1 %), hepatomegaly (25.8%), rash (10.2%) and jaundice (1.5%) were observed. Cervical lymphadenopathy was less frequent in older age groups. The annual number of primary EBV infections according to the age group during the study period did not change significantly in this study.

쯔쯔가무시병에서 가피의 위치와 복장과의 관계

김백남,곽이경,문치숙,김의석,박상원,이창섭 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 쯔쯔가무시병의 예방을 위하여 위험지역에서 긴소매 윗옷을 입고 바지 끝을 양말 속에 넣는 것이 권장되고 있다. 이러한 예방조치의 효용성을 알아보기 위하여 우리는 쯔쯔가무시병에서 가피의 위치와 신발과 복장과의 관계를 살펴보았다. 재료 및 방법 : 2005년 10-12월 사이 6개 병원에서 전형적인 임상양상, 가피의 존재, 혈청검사 결과로 쯔쯔가무시병이 의심되거나 확진된 159명의 성인을 대상으로 가피의 위치, 추정 감염일, 야외활동, 당시 착용한 신발과 복장 등 을 조사하였다. 결과 : 혈청검사는 5명에서 시행되지 않았고 99명이 양성이었으며, 가피는 142명에서 발견되었다. 몸의 두 군데에서 발견된 6명을 제외한 136명 중 82명(60.3%)에서 가피는 하반신(아랫배, 엉덩이, 서혜부, 생식기, 넓적다리, 종아리)에 있었다. 감염일이 추정가능하고 가피가 1개만 있는 44명을 대상으로 하였을 때, 가피가 하반신에서 발견된 17명에서 슬리퍼를 신거나 맨발인 경우는 5명이었으나 상반신에 있는 27명 중에는 아무도 없었다(P=0.006). 바지아랫단을 양말 속에 집어 넣은 4명 중 1명은 하반신에서 3명은 상반신에서 가피가 발견되었다. 42명이 긴 소매 윗옷을 입었는데, 이중 16명은 하반신에서 26명은 상반신에서 가피가 발견되었다(P=1.00). 결론 : 쯔쯔가무시병 환자에서 신발을 신지 않거나 발이 잘 보호되지 않았을 때 가피는 하반신에 더 잘 생겼다. 바지 아랫단의 처리방법이나 긴 소매 윗옷의 착용은 가피의 위치와 통계적으로 유의한 연관관계는 발견되지는 않았다. 그러나 표본수가 적고 유충의 침범경로에 영향을 줄수 있는 다른 요인이 있기 때문에 가피의 위치와 연관관계가 없다고 이 연구에서 단정할 수는 없다. 따라서 쯔쯔가무시병의 예방을 위한 실용적인 권고를 위해서는 더 많은 연구가 필요하다. Background:Wearing a long-sleeved shirt and tucking the pants legs into the socks is recommended to prevent scrub typhus. This study investigated associations between the location of eschar and the type of clothes and shoes to evaluate the efficacy of these protective measures. Materials and Methods:One-hundred and fifty nine patients in whom scrub typhus was confirmed or suspected based on the typical clinical manifestations, presence of eschar, or positive results of serologic tests at 6 Korean hospitals from October to December 2005 were included in this study. We collected the information on the location of eschar, presumed exposure date to chiggers, and the clothes and shoes which they had worn. Results:Serologic tests were positive in 99 patients. Eschars were observed in 142 patients and 6 of them exhibited more than 2 eschars. Eighty-two (60.3%) of 136 patients with a single eschar had an eschar on the lower half of the body. Of the 44 patients whose exposure date could be estimated, and who had only a single eschar, 5 of the 17 patients with eschars in the lower half of their bodies, and none of the 27 patients with eschars in the upper half of their bodies went barefoot or wore open footware (P=0.006). Only 4 patients tucked the pants into their socks, and an eschar was found in the lower half in one patient, and in the upper half of the body in the other 3 patients. Of 42 patients who wore long-sleeved shirts, eschars were found in their lower bodies in 16, and on their upper bodies in 26 (P=1.00). Conclusion:When the feet were not protected properly with shoes, eschars were found more frequently on the lower half of the body than on the upper half. Wearing a long-sleeved shirt or tucking the pants legs into the socks was not found to be significantly correlated to the location of eschars. Further studies involving larger samples are necessary for the development of practical guidelines of protective measures to prevent scrub typhus.

휘안광의 부선특성에 관하여

박경호,오재현,곽창섭,심원석 연세대학교 산업기술연구소 1980 논문집 Vol.12 No.2

The authors investigated thoroughly the flotation characteristics of stibnite. The flotation behavior of this mineral was carried out by using modified hallimond tube with various xanthates as a collector and modifying agents such as copper sulphate, lead acetate, sodium sulfide, zinc sulphate, sodium cyanide, sodium sulfite and potassium dichromate. The main results obtained in this experiments are summarized as follows; (1) Stibnite shows that it has maximum floatability in pH range 4.0 to 8.0. (2) Stibnite is activated by copper sulphate and lead acetate. (3) Potassium dichromate is an effective depressing agents in stibnite-xanthate system in pH range 4.0 to 6.0. (4) In the pH range in which the zinc sulphate is preciptated by hydroxide, stibnite is depressed effectively (5) Stibnite is depressed by sodium sulfide in alkaline solution.

단안 카메라 기반 3차원 물체 인식 기법 및 6축 머니퓰레이터 경로계획을 이용한 탁구 로봇의 구현

윤재성(Jae-Seong Yoon),곽창희(Chang-Hee Kwak),김영현(Young-Hyeon Kim),김원호(Won-Ho Kim),옥승호(Seung-Ho Ok) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.8

In this paper, we propose a path planning method of a 6-axis manipulator and a monocular camera-based detecting method of a ball coordinate in 3D space for a table tennis robot. In the path planning, we plan the path by using kinematic analysis and searching minimal joint change. One of two monocular cameras detects the coordinate of the ball and the other estimates hit point by tracking the ball speed and trajectory. In order to measure hit rate of the proposed table tennis robot, we compared the existing model without ball position coordinate calibration system to the proposed model. As a result of the performance evaluation, hit rate of the table tennis robot with the proposed ball position coordinate calibration system is increased to 50% hit rate from the 10% hit rate of the existing model.

Comparison of DEM and FDM for Analysis of Road Embankment in Karst Region

Chang Won Kwak,Inn Joon Park 한국지반공학회 2010 international journal of geo-engineering Vol.2 No.1

Humidity-Independent Oxide Semiconductor Chemiresistors Using Terbium-Doped SnO₂ Yolk-Shell Spheres for Real-Time Breath Analysis

Kwak, Chang-Hoon,Kim, Tae-Hyung,Jeong, Seong-Yong,Yoon, Ji-Won,Kim, Jun-Sik,Lee, Jong-Heun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.22

<P>The chemiresistive sensing characteristics of metal oxide gas sensors depend closely on ambient humidity. Herein, we report that gas sensors using Tb-doped SnO<SUB>2</SUB> yolk-shell spheres can be used for reliable acetone detection, regardless of the variations in humidity. Pure SnO<SUB>2</SUB> and Tb-doped SnO<SUB>2</SUB> yolk-shell spheres were prepared via ultrasonic spray pyrolysis and their chemiresistive sensing characteristics were studied. The sensor resistance and gas response of the pure SnO<SUB>2</SUB> yolk-shell spheres significantly changed and deteriorated upon exposure to moisture. In stark contrast, the Tb-doped SnO<SUB>2</SUB> yolk-shell spheres exhibited similar gas responses and sensor resistances in both dry and humid [relative humidity (RH) 80%] atmospheres. In addition, the Tb-doped SnO<SUB>2</SUB> yolk-shell sensors showed a high gas response (resistance ratio) of 1.21 to the sub-ppm-levels (50 ppb) of acetone with low responses to the other interference gases. The effects of Tb oxide and the chemical interactions among the Tb oxide, SnO<SUB>2</SUB>, and water vapor on this humidity-independent gas sensing behavior of the Tb-doped SnO<SUB>2</SUB> yolk-shell sensors were investigated. This strategy can provide a new road to achieve highly sensitive, selective, and humidity-independent sensing of acetone, which will facilitate miniaturized and real-time exhaled breath analysis for diagnosing diabetes.</P> [FIG OMISSION]</BR>

Feeding Value of Whole Crop Cereal Silage for Pigs

Chang-Hee Lee, Won Yun, Ji-Hwan Lee, Woo-Gi Kwak, Seo-Young Oh, Shu-Dong Liu,Seong-Jeong Park, and Jin-Ho Cho 忠北大學校 農業科學硏究所 2016 農業科學硏究 Vol.32 No.2

Feed cost is one of the most important parts of the pig production industry. Whole crop cereal is cheaper price than corn which is contained in a lot of formula feed. In order to increase the nutritional value, whole crop cereals are usually made into silage. The silage method can have an effect of lengthening the storage period, and reduce the difficult to digest dietary fiber through lactic acid fermentation. Fermented whole crop cereal could have an advantage of productivity and healthy in pigs. As results, fermented whole crop cereal could potentially replace as a part of concentrated feed for pigs.