기니픽에서 Salicylate에 의한 유발이음향방사의 변화

박찬일,장재웅,신광철,이오영 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

A Reversible hearing loss and tinnitus have been known resulting from large doses or longterm use of salicylate. The exact cause of salicylate ototoxicity is unknown. Cochlear electrophysiology and otoacoustic emission studies suggest that the drug may interfere with outer hair cell clectromotility. The changes in transiently evoked otoacoustic emission(TEOAEs) were observed in guinea pigs after the intramuscular injection of salicylate(150, 300, 450 mg/kg). TEOAEs decreased slowly after the injection salicylate in a dose-dependent manner. Absence of echo response was detected 3 hours after the injection of 300mg/kg in 2 of 5 guinea pigs, 2 hours after the injection of 450mg/kg in 3 of 6 guinea pigs, 3 hours after the injection of 450mg/ kg in 3 of 6 guinea pigs. Echo response returned to control level in 6 hours after injection of 300mg/kg, in 7 hours after infection of 450 mg/kg. Findings support that salicylate affect electromotility of outer hair cells.

컴퓨터 중재 읽기프로그램이 정신지체아의 읽기 상위인지, 작동기억 및 읽기 이해력에 미치는 영향

박찬웅 한국정신지체아교육학회 1999 지적장애연구 Vol.1 No.-

본 연구는 정신지체아에 있어서 컴퓨터 중재를 통한 읽기 자료의 제시가 읽기 이해의 성취와 읽기 상위인지 및 읽기 작동기억의 범위에 어떠한 영향을 미치는가를 알아보기 위해 수행되었다. 관련문헌 및 선행연구의 고찰을 통해 컴퓨터 중재 프로그램을 통한 읽기자료의 제시가 정신지체아의 읽기 상위인지 및 읽기 작동기억 범위, 그리고 읽기 이해력 성취에 영향을 미칠 것으로 논의되었다. 초등학교 특수학급에 재학 중인 정신지체아 40명을 선정하여 컴퓨터 화면을 통해 읽기 프로그램이 제시되는 실험집단과 인쇄교재를 통해 읽기 프로그램이 제시되는 통제집단으로 나누어 배치하였다. 연구결과 컴퓨터 중재를 통한 읽기 자료의 제시는 전통적인 교재의 제시방법에 비해 정신지체아의 읽기 이해 성취수준과 읽기 상위인지 수준향상에 효과적인 반면, 읽기 작동기억 범위 수준에는 비효과적이었다. The purpose of this study was to investigate the effects of computer mediated reading program to reading ability, Two group was trained by computerized text and the control group was trained by traditional paper text The data were analyzed to answer several questions. The questions were to compare ability of reading comprehension, reading metacognition, and working memory span between experimental and control group. The conclusions drawn from both the results and synthethical considerations are as follows: The presentation condition of CAI caused different effects on reading ability of the mentally retarded children. The reading comprehension and reading metacognition ability of experimental group children were higher than control group children. But working memory span of experi- mental group children were lower than that of control group children.

개념훈련과 전략지도가 정신지체아의 문제해결 전략 일반화에 미치는 효과

박찬웅 한국정신지체아교육학회 2002 지적장애연구 Vol.4 No.-

본 연구는 정신지체아들에게 개념훈련과 전략지도가 문제해결과제에서 전략일반화에 미치는 효과를 밝히기 위해 수행되었다. 일반화는 근일반화와 원일반의 두 유형으로 나누어 수행되었다. 연구대상으로 생활연령11~14세인 정신지체아 28명을 실험집단과 통제집단으로 배치시켰으며, 실험집단에는 개념훈련과 전략지도를 30회기씩 실시하였다. 연구 결과 근일반화 검사에서 실험집단이 통제집단보다 통계적으로 유의하게 높은 점수를 나타냈으나, 원일반화 검사에서는 두 집단 간에 통계적으로 유의한 차이는 나타나지 않았다. 따라서 연구결과를 기초로 해서 얻은 결론은 다음과 같다. 첫째, 정신지체아에 있어 개념훈련과 전략지도는 문제해결 전략의 근일반화에 효과적이다. 둘째, 정신지체아에 있어 개념훈련과 전략지도는 문제해결 전략의 원일반화에 효과적이지 않다. 이러한 점은 정신지체아들에 있어 새로운 문제에 직면하였을 때 적절한 문제탐색과 전략을 선택하여 적용하는데는 과제에서 요구되는 전략의 구성에 대한 지식과 결과의 예측, 결과의 평가 등에 관한 상위인지와 같은 고등집행기능이 필요하다는 점을 강하게 시사한다고 하겠다. Many researches emphasized the close relationship between planing and generalization, the application of a trained strategy to a new untrained task, and demonstrated that the retarded children were capable of acquisition and maintenance of a trained strategy. The purpose of this study was to experimentally assess the effectiveness of language concepts training and strategy instruction on generalized problem solving in mentally retarded children. Twenty-eight mentally retarded children were randomly assigned to one of two groups. One was experimental group and the other was control group. Each groups consisted 14 children who were identified as educable mentally retarded. Their IQ scores ranged from 50 to 70 and mean of CA was 12.1 years. Each subject was given a pretest on number pattern completion task before training and a posttest on near and far generalization test after training session. The obtained data were analyzed by t-test. The processing for data was made using SPSS/PC+ to insure precision. The conclusions drawn from both the results and synthethical considerations was follows: Firstly, language concepts training and strategy instruction has positive effects on near generalization of mentally retarded children's problem solving. Secondly, language concepts training and strategy instruction has not positive effects on far generalization of mentally retarded children's problem solving. Results of the present study, in general, shed light on the importance of teaching effective mediators, particularly language, in enhancing independent problem solving in mentally retarded children. The positive effect of training in language concepts prior to task specific strategy training provides further support for the task analytic approach to the education of the mentally retarded.

납기지연 및 조기생산 비용을 고려한 생산일정계획

박찬웅 경원전문대학 2001 論文集 Vol.23 No.-

This study presents a single machine scheduling algorithm to minimize total cost(lateness cost and earliness cost) by controlling machining speed. Generally, production scheduling uses the information of process planning and machining speed is not changed at production scheduling. Therefore, the purpose of this study is to consider the change of machining speed for efficient production scheduling. And consider the total cost as performance criteria.

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

필기체 숫자인식의 최적 신경망 구조 설계를 위한 개선된 유전자 알고리즘

박찬란,김향태,정재영,위승정,최봉한,최호진,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

본 논문에서는 필기체 숫자인식의 최적 신경망 구조 설계를 위하여 유전자 알고리즘과 역전파 알고리즘을 병합하는 방법을 이용하였으며, 유전자 알고리즘은 유전인자의 역할에 따라 독립적으로 적응하는 개선된 선택, 교배, 돌연변이 연산자를 제안하였다. 실험결과는 유전인자의 역할에 적응하는 개선된 연산자들의 실행으로 최적의 신경망 구조를 설계하였고, 설계된 신경망 구조에서의 학습이 가장 좋은 성능을 나타내었다. In this study, the method of using both genetic algorithm and back propagation is proposed to design the structure of optimal neural network recognizing handwritten digits. Improved selection, crossover and mutation operator which can control the genetic algorithm independently according to the role of gene are used in the proposed method. Simulation result shows that the neural network of this method can search effectively the optimal hidden node numbers, connection weight, learning rate and the momentum because of above proposed operators.

제 1형 고실성형술의 결과

박찬일,성열웅,변상내,이오영 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

The functional and anatomical results of a series of 122 type I tympanoplastics for drum perforation in chronic otitis media were retrospectively reviewed. Drum closure was realized in 93% at 1 year after surgery. An air-bone gap of less than 25dB was reached in 95% at 1 year after surgery. The considered influencing factors in outcomes of type I tympanoplasty, including age, size of perforation, middle ear pathology, technique of closure of perforation and status of ossicular mobility were evaluated.

골프지도자 서번트 리더십과 신뢰관계

최웅재,박찬희 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This study aims to examine the relationship beetween golf leaders' servant leadership style and trust. The study used survey research methods to analyze a sample group of students of from the department of golf teaching. Results were analyzed using the SPSS statical sftware program Generally, the main statistics employed were frequency, average and simple correlationship. To analyze the hypothesis, the overall regression F-test, ANOVA and LSD analysis were used. In this contest, the findings are as follow: The regression analysis with regard to golf leaders' leadership style showed that it was highly related to servant "sympathy(r=.262)". The lowest variable presented were sympathy related to servant. Opinion could impact golf leader and player's place or circumstances under trust. Result show that opinions could impact golf leader and player's place or circumstances under trust. Most of players select human network(72.2%), including active communication, building trust, sympathy ,and friendly exchange between alumni.

독립요소분석에서 누적분포함수를 사용한 신호분리

김웅명,박찬호,이현수 경희대학교 산학협력기술연구원 2001 산학협력기술연구논문집 Vol.7 No.-

In this paper, the aim is to solve blind source separation problem using ICA(Independent Component Analysis) in neural networks. ICA is method of joint entropy maximization from mixed signal(observed signal). However, when probability distribution function of unknown source signals are various, Infomax ICA can not separate the source signal from mixed signal because of using fixed activation function. Infomax ICA use To solve this problem, we use MWARP algorithm which can make adaptive activation function similar to the cumulative distribution function of source. Several experiments have been tested with three source signals uniform distribution noise, pure sinusoid and speech signal. The result shows that MWARP efficiently separates source signals.

에러역전파 학습을 위한 적응적 알고리즘 성능 분석

김웅명,박찬호,이현수 慶熙大學校 1996 論文集 Vol.25 No.-

에러역전파학습에서 출력오차를 줄이기 위한 연결강도의 조정은 학습률과 중간층 및 출력층의 역전파량에 관계가 있다. 본 논문에서는 적응적인 학습률을 생성하는 가우시안 학습알고리즘과 출력층의 역전파량을 변화시키는 POS 학습알고리즘에 대해 고찰한다. 실험은 알파벳인식과 4bit parity, 5bit parity문제를 대상으로 수행하였다. 실험결과, 에러역전파 알고리즘과 비교하여 학습회수는 감소되며 수렴율이 향상되었다. 또한, 가우시안 학습은 학습의 안정화상태에서 적합하였으며, POS학습은 학습시 패턴간의 oscillation현상이 발생할 경우 적합함을 알 수 있었다. In Backpropagation learning, weight updating procedure in order to reduce output error is related to learning rate and amount of error propagation from output to hidden and from hidden to input layer. In this paper, we investigate a gaussian learning algorthm which generate learning rate adaptively and a POS learning algorithm to control amount of error propagation of output layer. We performed simulations of alphabet recognition, 4-bit parity and 5-bit parity problem. As the cosequence, learning iteration decreased and convergence rate improved to compare with backpropagation algorithm. In addition to, we show that gaussian learning is suitable in stable state of learning and POS learning fit in case of pattern oscillation phenomenon.