필기체 숫자인식의 최적 신경망 구조 설계를 위한 개선된 유전자 알고리즘

박찬란,김향태,정재영,위승정,최봉한,최호진,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

본 논문에서는 필기체 숫자인식의 최적 신경망 구조 설계를 위하여 유전자 알고리즘과 역전파 알고리즘을 병합하는 방법을 이용하였으며, 유전자 알고리즘은 유전인자의 역할에 따라 독립적으로 적응하는 개선된 선택, 교배, 돌연변이 연산자를 제안하였다. 실험결과는 유전인자의 역할에 적응하는 개선된 연산자들의 실행으로 최적의 신경망 구조를 설계하였고, 설계된 신경망 구조에서의 학습이 가장 좋은 성능을 나타내었다. In this study, the method of using both genetic algorithm and back propagation is proposed to design the structure of optimal neural network recognizing handwritten digits. Improved selection, crossover and mutation operator which can control the genetic algorithm independently according to the role of gene are used in the proposed method. Simulation result shows that the neural network of this method can search effectively the optimal hidden node numbers, connection weight, learning rate and the momentum because of above proposed operators.

자동화요구분석 시스템의 설계에 관한 연구 : 요구명세서 오류검증을 중심으로 Centered on Verifying Errors in Requirement Specification

박찬란,이성주 조선대학교 기초과학연구소 1989 自然科學硏究 Vol.12 No.1

The quality of softwares depends upon the validity how exactly they perform in accordance to their purpose and how maintainable they are. If there is an error in requirement specification describing user requirement or if it is not correct, the result that the software developed by this requirement specification produce is different from user requirement, and it is not to be trusted. Therefore, the analysis stage for producing a correct requirement specification is of more importance in the software life cycle. Many kinds of requirement analysis tools have been developed in order to improve the above defects and Structured Analysis Methodology is typical of them. The Structured Analysis Methodology is useful for users to understand easily because it describes the items of user requirement as a graphic model and a way of partition, but it has such defects that it lacks in the ability of system modeling of the user's requirement contents which are fragmentary and descriptive as a formalized form and it is impossible for it to verify errors automatically. In this thesis, I have studied of the Requirement Analysis System, and have designed the system to verify automatically errors of requirement specification in order to improve theses defects.

유방암 환자의 림프부종에 대한 한의학적 치료: 체계적 문헌 고찰

박찬란,이가영,손창규,조정효,이남헌 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.3

Objectives: Traditional oriental medicine is used in treating breast cancer-related lymphedema to alleviate symptoms. Upper limb lymphedema is a symptom that is frequently observed in patients with breast cancer, and it impairs their quality of life. This systematic review aimed to summarize the current available evidence to evaluate the effect of traditional oriental medicine on upper limb lymphedema in breast cancer patients. Methods: The review evaluated randomized controlled trials (RCTs) measuring the effect of herbal medicine, acupuncture, and moxibustion on upper limb lymphedema in breast cancer patients within four electronic databases . The Cochrane risk of bias (ROB) tool was used to assess the quality of the RCTs. Results: In total, 23 RCTs met the inclusion criteria. Among them, 22 studies reported that the rate of severity of lymphedema improved after treatment in the traditional treatment group using herbal medicine, acupuncture, or moxibustion better than in the conventional medicine group. The methodological quality of the RCTs was insufficient with an unclear and high ROB. Conclusions: Traditional oriental medicine may have a potential to improve lymphedema in patients with breast cancer. To confirm the clinical recommendation, further research with a rigorous study design is required to support the effects of traditional oriental medicine.

유전자 알고리즘을 이용한 윤곽선 추출

박찬란,이웅기 한국컴퓨터정보학회 1998 韓國컴퓨터情報學會論文誌 Vol.3 No.2

한방치료 후 NK세포 활성도의 호전을 보인 암환자 증례보고 3례

박찬란,김은지,손창규,조정효,이남헌,Park, Chan-ran,Kim, Eun-ji,Son, Chang-gue,Cho, Jung-hyo,Lee, Nam-hun 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.3

Objectives: High natural killer cell activity (NKA) is associated with a clinically favorable status in patients with cancer. This study explores whether traditional Korean medicine (TKM) improves NKA in patients with cancer. Methods: We report three clinical cases involving patients with cancer who underwent NKA tests while they received TKM treatment, including acupuncture, moxibustion, wild ginseng pharmacopuncture, and Korean herbal medicines. We analyzed the treatment process and NKA test results of each patient. Results: The NKA of all three patients presented with an increasing tendency during the treatment process. Patient 1, who had been diagnosed with breast cancer, received inpatient treatment 3 times between September 16, 2017 and February 27, 2019. The NKA increased from 7.2 pg/mL to 571.7 pg/mL. Patient 2, who had thyroid cancer, was hospitalized 4 times between July 23, 2019 and August 27, 2020. The NKA improved from 317.4 pg/mL to 2000 pg/mL. Patient 3, who had liver cancer, received inpatient treatment 4 times between May 27, 2016 and January 10, 2017. The NKA increased from 22.2 pg/mL to 459.5 pg/mL. The chief complaints of these patients also were alleviated. Conclusions: TKM may be an effective treatment for accelerating NKA. Further research is needed to establish evidence that TKM stimulates NKA.

구연 : 라미부딘 내성 만성 B형간염 환자에서 라미부딘 아데포비어 병합과 아데포비어 단독의 치료 효과 비교

박우영,장병국,황재석,신정우,박능화,이병석,이준혁,정은욱,이연재,유찬란,배시현,이현석,탁원영,이준성,이천균,백순구,신제형,이태희 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3(S)

항암 치료 후 발생한 수족증후군에 대한 한의학적 치료의 효과에 대한 고찰

김은지,박찬란,손창규,조정효,이남헌,Kim, Eun-ji,Park, Chan-ran,Son, Chang-gue,Cho, Jung-hyo,Lee, Nam-hun 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.3

Objectives: Hand-foot syndrome (HFS) is a common adverse effect of chemotherapy in cancer patients. This review synthesizes research results to assess the effect of traditional Korean medicine (TKM) on HFS in cancer patients. Methods: Four databases (PubMed, The Cochrane Central Register of Controlled Trials, Research Information Sharing Service, China National Knowledge Infrastructure) were searched for randomized controlled trials (RCTs) to assess the effects of TKM on HFS. The effects and quality of RCTs were assessed with the Cochrane risk of bias (ROB) tool. Results: Six RCTs met our study criteria. In all six, TKM showed improvement in HFS symptoms as well as quality of life scores when compared to the control group. However, the methodological quality of RCTs was relatively low due to the unclear or high ROB. Conclusions: TKM would be helpful to patients with HFS after chemotherapy. To clarify the clinical efficacy of TKM, well-designed studies are required in the future.

유전자 알고리즘을 이용한 타원 검출

김향태,박찬란,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

본 논문은 농도화상에서 타원을 검출할 수 있는 알고리즘을 새롭게 제안한다. 알고리즘은 먼저 초기 화상에서 윤곽선을 검출한 후 윤곽선에서 타원을 만들 수 있는 가능한 후보를 선별해 낸다. 제안된 알고리즘에서 타원이란 세 점을 이용해서 윤곽선을 정의한다. 뿐만 아니라 유전자 알고리즘을 이용해서 화상에 가장 적합도가 높은 세 점의 윤곽선을 찾는 알고리즘을 제안한다. 또한 초기 화상을 사용해서 제안된 알고리즘의 성능을 평가한다. We present a new algorithm to detect ellipses in an intensity image. The algorithm first extracts line support regions from the original image. Next, candidates for elliptic arcs are selected from these line support regions. In the proposed algorithm, each ellipse is defined by triplet of line support regions, And, using a genetic algorithm, the proposed algorithm searches for triplets of line support regions that have highest fitness to the image. By experiments using original images, we estimate the performance of the proposed algorithm.

담도 스텐트 시술 후 장천공 증례보고 및 장천공에 대한 고찰

이가영,박찬란,조정효,손창규,이남헌 대한한의학회 2022 대한한의학회지 Vol.43 No.3

Objectives: This study aimed to emphasize the importance of accurate and timely diagnosis of acute abdominal pain with simple radiography by reporting a case of gastrointestinal perforation. Methods: We closely observed the diagnosis and progress of acute abdominal pain after biliary stent and reviewed the outline of gastrointestinal perforation. Results: Patient diagnosed with urethral cancer metastasis to lung and peritoneum was treated with complex Korean medicinal treatments to deal with anorexia, abdominal pain, jaundice and oliguria. During hospitalization, the patient's acute abdominal pain after biliary stent was diagnosed with gastrointestinal perforation by using plain chest and abdominal radiography. Conclusion: Using simple radiography to find out the emergency diseases such as perforation in acute abdominal pain is important clinically.

청간플러스의 간기능 개선 효과 : 후향적 증례보고 8례

이가영,박찬란,조정효,손창규,이남헌 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.3

Objectives: The purpose of this study was to retrospectively assess the effectiveness of Chunggan plus extract (CGX) in improving liver function in a Korean medical clinic. Methods: We collected the data of inpatients who received CGX to improve abnormal liver function test (LFT) results from March 2016 to February 2020. We analyzed the changes in LFT and adverse events based on subjective symptom changes and creatinine results. Results: The data of eight patients, three male and five female, were selected by inclusion criteria (patients who did LFT before and after the prescription of CGX and who prescribed CGX more than 6 days) and exclusion criteria (patients who administered other herbal medicine for improving liver function except CGX and who are diagnosed with terminal stage of hepatobiliary cancer). As a cause of abnormal LFT, one case was diagnosed with alcoholic liver disease, two cases with non-alcoholic fatty hepatitis, and one case with cholecystitis. Three of the other four were suspected to have drug-induced hepatitis, and one case was determined to have an unknown cause. Most patients showed a decrease in LFT results (Aspartate transaminase 87.5%, Alanine transaminase 87.5%, and Alkaline Phosphatase 100%) without any critical adverse events. Conclusions: CGX may be an efficient and convenient herbal medicine for improving liver function regardless of the chief impression. Further study should be conducted to evaluate the effectiveness of CGX.