Interleukin-2와 결핵균 30 kDa 항원이 구개편도 및 말초혈액 T 세포 증식에 미치는 상승효과

박정규,박찬권,조은경,김화중,백태현,고필준,김병국,남부현,나기상,박찬일 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Widespread use of BCG has not controlled tuberculosis, and more effective vaccines are clearly needed. Although chemotherapy will remain the mainstay of antituberculosis treatment, the use of adjunctive immunotherapeutic modalitites is attractive, particularly in persons with drug-resistant tuberculosis. Administration of IL-2 or IFN-γto tuberculosis patients enhance bacillary elimination. Cell-mediated immunity is the critical protective immune response in tuberculosis. Mycobacterial antigens are recognized by T cells and that elicit production of protective cytokines are potentially important vaccine antigens. The 30 kDa antigen is secreted in large quantities by growing mycobacteria. That antigen elicits greater proliferation in lymphocytes from healthy tuberculin reactors than healthy tuberculin nonreactors. In this study, the T lymphocyte proliferative responses to 30 kDa antigen from Mycobactrium tuberculosis H37Rv were examined by using tonsilar and peripheral blood lymphocytes from PPD(+) and PPD(-) tonsilectomized persons. When cultured with 30 kD antigen, tonsilar mononuclear leukocytes and T cells of PPD(+) demonstrated more ^3H-thymidine incorporation than PPD(-) persons (stimulation index was 2.5 and 1.9, 0.8 and 1.0, repectively). Peripheral blood mononuclear cells (PBMC) and peripheral blood T lymphocytes were shown the similar responses to this antigen. The combination of IL-2 and 30 kDa antigen elicited a significant proliferative responsiveness in tonsilar mononuclear leukocytes and T cells of PPD(+) persons (SI was 20 and 14.1). PBMC and peripheral blood T cells of PPD(+) persons were also shown a significant responsiveness, but PPD(-) persons did not show. These results demonstrate that the 30 kDa antigen and IL-2 have a synergistic stimulatory property in mycobacteria sensitizing lymphocytes.

협동학습에서 팀 구성원의 자기 및 동료평가를 위한 평가문항 개발

부성미,박찬정 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.4

제7차 교육과정이 시작되면서 수업의 형태가 다양화되어지고 있다. 이 중에 팀별로 문제를 해결하는 협동학습이 학교에서 진행되고 있는데 협동학습 시 평가를 위한 연구는 많이 진행되고 있지않다. 한편, 웹기반교육인 경우 매체의 특성 때문에 협동학습이 더욱 잘 활용될 수 있다. 향 후, 웹기반 협동학습을 위한 선행연구로서 전통적 협동학습에서 결과 중심의 평가방법을 지양하면서 팀별로 문제해결을 위한 과정을 종합적으로 평가하며 팀 구성원을 개별적으로 평가할 수 있는 새로운 학습자 평가문항이 요구된다. 본 논문에서는 ABET EC 2000에서 개발한 프로그램 결과물과 평가에 관한 속성들 중에서 관련되는 속성을 추출하고 Bloom의 인지적 영역을 혼합하여 평가문항을 마련한다. 또한, 본 논문에서는 제안한 평가방법에 의해 반은 점수와 제안한 평가문항으로 설문을 실시한 후의 점수를 이용하여 본 논문의 결과물에 대한 응용 사례를 제시한다. There are various kinds of instructional models in the 7th national curriculum. Among them, cooperative learning is given to students in some schools. In cooperative learning, the items for assessing the team members are required in order to evaluate the individual activities for problem solving, and to know the way of objective thinking each student does. Web-based environment is good for cooperative learning. In this paper, as a previous research work of web-based cooperative learning, we propose new assessment items which are based on the outcome D belongs to the set of 11 student teaming outcomes design attributed framework developed by ABET EC-2000 and the cognitive categories defined by Bloom’s taxonomy. These assessment items consist of self and peer assessment. The self assessment items include the evidence of the students’ thought and their own assessment. On the other hand, the peer assessment can give the students the opportunities to participate in their activities enthusiastically, to offer interactive individual feedbacks, and to develop potential through various experiences.

正常家兎의 聽性腦幹誘發反應

朴贊日,尹成基,南富鉉 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Auditory brain stem response measurements were performed in normal rabbits, anesthetized with intraperitoneal urethane. Auditory brain stem responses in rabbits showed stable patterns of 5 waves, similar in man, within 4.0 msec after sound stimulation. And the wave latencies were decreased with increasing of the intensity of stimulation. As conclusion, the rabbit offers attractive features in auditory brain stem response and it can be used in animal experiments for electrophysiologic study on 8th nerve and auditory brain stem pathway.

소아 삼출성중이염에서 중이환기관삽입의 임상적 고찰

박찬일,원시영,남부현 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A clinical course following tympanostomy tube on 50 ears in 26 children with secretory otitis media, who were examined every one or two months for at least 24 months postoperatively, was observed. The mean duration of functioning tube was 8.9 months after initial procedure and repeated procedures were required in 32%. And postoperative otorrhea was noted in 15.5%. Atrophy of the ear drum was observed in 30%, tympanosclerosis in 24%, and adhesive otitis media in 6%. At postoperative 24th month, there was no abnormality on the ear drum in 38% and normal hearing in 66%.

후외상성 진주종 2례

남부현,김병국,고필준,심장한,박찬일 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

Post-traumatic cholesteatoma can be originated in the middle ear or mastoid cavity after head trauma such as temporal bone fracture, penetrating injury of the temporal bone or blast injury of the tympanic membrane. It usually takes a long time to develope cholesteatoma after injury, and physicians may overlook its association with previous, trauma. Post-traumatic cholesteatoma can be suspected in patients with head trauma history and atypical cholesteatoma findings. We experienced two cases of cholesteatoma which found behind the intact tympanic membrane in 7 and 13 years old boys with history of head trauma, and we are reporting this with a discussion and literatural review.

경유양동상미로접근법에 의한 안면신경감압술 16례

남부현,이민한,장재웅,전우진,박찬일 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

With increase of traffic accidents, the otologic problems including facial palsy with skull fracture are more concerned. This paper is report our experiences with 16 cases of traumatic facial nerve palsy which have been employed transmastoid supralabyrinthine facial nerve decompression during last four years. The results are as follows: 1. Of the 16 patients, 13 patients(81.3%) were men and 3 patients (18.8%) were women. And sex ratio was 1.4:1 (male predominent). 2. In fracture type, longitudinal fracture was 10 cases (62.5%), transverse fracture was 1 case(6.3%) and mixed fracture was 2 cases(12.5%). 3. Cerebral contusion was combined in 8 cases(50%) and facial bone fracture was combined in 6 cases(37.55). Because of these combined lesions, otologic diagnoses and treatment was delayed. 4. The most common physical finding on clinical examination were a bloody otorrhea(75%) and hearing impairment(75%). 5. In frequency of lesion in facial nerve, tympanic segment(35.7%) was the most common site, followed by geniculate ganglion(14.3%). Suggested mechanisms in facial palsy were nerve compression(57.1%), granulation tissue and congestion. 6. There were improvment of House-Brackmann grades in 13 cases after decompression. 7. Incudostapedial separation was found in 4 cases and incus fracture was found in 2 cases. Hearing improvement was found in 3 cases being ossiculoplasty.

기니픽에서 절단된 외반규관의 골유합에 관한 형태학적 연구

남부현,송영복,박찬일 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

There has been a little hiistopathologic study concerning the bony healing of injured labyrinth. Authors obserbed a seriease of morphologic change of guinea pig temporal bone after transection of the lateral semicircular canal(LSCC). In the 1st. postoperative week there was a proliferation of perilymphatic connective tissue meshwork along with aggregation of fibroblast around the necrotic material occluding transected bony canal lumen. In the 2nd, postoperative week there was a fibroblastic ingrowth with callous bone formation over the surgical defect of LSCC. In the 4th. postoperative week the fibrous tissue over the surgical defect completed callus formation, and the necrotic material in the canal lumen showed on going new bone formation. These findings suggested that the periosteal layer conduct early calus formation, and the endosteal layer paly a role in forming enchondral bone in late stage.

女子中ㆍ高等學生의 服飾行動과 服裝規範에 대한 硏究 : 學校에서의 服裝規定을 中心으로 Focusing on Clothing Regulations in the School

유덕화,박찬부 한국 가정과 교육 학회 1991 한국가정과교육학회지 Vol.3 No.-

The purpose of this study was to investigate the following contents ; 1. Relationship between clothing behavior (modesty, conformity, importance) and clothing regulations of school girls. 2. The differences between middle school girls and high school girls in clothing behavior and in attitude toward clothing regulations. 3. The differences between stuendts gerself norms and subjective norms (the students thoughts which would be parents opinions and teachers opinins) in attitude toward clothing regulations. Questionnaires were designed and administered to 300 middle school girls and 302 high school girls in Inchon. The obtained data were statistically analyzed by Pearson's correlation coefficients, t-test, F-test, and Duncan test. The results of the study were summarized as follows; 1. As tho the differences in responses between school levels, the high school girls showed higher interest in conformity. But there is on differances in Modesty and Importance by school levels. 2. As tho the differences in responses between school levels, there were on differences in attitued toward clothing regulations. But according by types of clothing regulations, high school girls showed higher desired in shoes and sack. 3. In correlation coefficients between the variables on clothing behaviors and the attitudes toward clothing regulations of school girls, modesty is the most related toward clothing reguations of school girls and conformaity, importance the next. The higher the school girls are in modesty, the more follow the clothing reguations. And the higer the school girls are in conformity and importance, the lower follow the clothing reguations. 4. The differences between students herself norms and subjective norms (the studenst thoughts which would be parents opinions and teachers opinions), students and parents showed lower scores than teachers. That is tho say, theachers put more restrictions on students clothing than parents do.

韓國産 紅花子와 中國産 紅花子가 鎭痛 , 消炎 및 關節炎에 미치는 效果

서부일,이은숙,박지하,김상찬,변부형,최호영 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1

This experimental study was done to compare the efficacy of Korean and Chinese Carthami Semen on analgesic effect and remedy of inflammation and arthritis. The results were as follows; 1. In analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid, Korean and Chinese Carthami Semen extract group showed significant decrease in comparison with control group. And in analgesic action on the writhing syndrome in mice induced by Acetylcholine HC1, Korean and chinese Carthami Semen extract group showed significant decrease in comparison with control group. 2. In Anti-inflammatory effects, Chinese Carthami Semen extract group showed significant decrease at 150 and 180 minutes after inducing paw-edema in comparison with control group. 3. In the method of adjuvant arthritis, orally administered for 21 days, Korean Carthami Semen extract group showed significant inhibition of the hind paw edema after 1 day and 21 days. Whereas Chinese Carthami Semen extract group showed some reduction, but the results didn's show significant decrease. 4. In the level of leucocytes count, Korean and Chinese Carthami Semen extract group showed significant decrease in comparison with control group. And in the level of total protein. CRP and glucose, Korean and Chinese Carthami Semen extract group didn't showed significant change in comparison with control group.

췌장의 가성낭종 파열에 의한 하부 위장관 출혈 1예

장성종,김병수,부귀범,김동규,박찬국,김만우,김정용,박상헌 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Pancreatic pseudocysts usually develop as a complication of acute pancreatitis or repeated attacks of chronic pancreatitis. Pseudocysts may also develop as a result of traumatic injuries or neoplasms. An uncommon complication is massive hemorrhage inside the pancreatic pseudocyst. The exact mechanism of hemorrhage is unknown. Enzymatic digestion, pressure erosion from the cyst mass or a combination of these processes may play an important role. Gastrointestinal hemorrhage associated with a pancreatic pseudocyst can occur in 10 percent of cases. When hemorrhage occurs because of erosion into a blood vessel involved in the pseudocyst, surgery is indicated since the episodes of hemorrhage are often severe and may even be fatal. When there is colonic involvement, various complications may occur. The most dangerous one is spontaneous rupture into the colon, which requires immediate surgical treatment because of high incidence of fulminating sepsis or massive hemorrhage. We examined a sixty eight-year-old man complaining of hematochezia and dizziness, and reported that it was a case of massive lower gastrointestinal hemorrhage caused by pseudocyst of the pancreas ruptured into the colon associated with chronic pancreatitis. On operative findings, the peripancreatic fatty tissue had severe adhesions to transverse colon and tail portion of pancreas, where the pseudocyst had formed. A distal pancreatectomy, splenectomy and resection of transverse colon were performed. By microscopic examination, hemorrhagic necrosis and inflammatory change were observed in the pancreas specimen. The tail portion of pancreas had a 6×6 cm sized cystic mass and was proven to be a pseudocyst with no epithelial lining.