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김병국,고필준 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2
Congenital neck masses are known as a second most common cause of neck mass in children. Diagnosis could be done by physical examination and various imaging techniques, but final diagnosis could be obtained by the histopathologic findings. We evaluated the 43 cases of the congenital neck masses, which were confirmed histopathologically in Department of Otolaryngology, Chungnam National University Hospital. The results were as follows; 1. Among the 43 cases, branchial cleft anomaly was most common(44.1%), and thyroglossal ductcyst(34.8%), cystic hygroma (11.6%), epidermoid cyst(4.7%), hemangioma (4.7%) were in order. 2. There was slight difference in sex distribution (male 67.4%, female 32.6%). 3. Congenital neck masses were moslty detected under 20 years of age (60.6%). 4. Congenital neck masses were located at midline(39.5%), anterior cervical triangle(53.4%) and posterior cervial triangle(7.0%). 5. Frequency of postoperative complication and recurrence was relatively low (complication 9.3%, recurrence 4.6%).
외이도 냉자극이 백서 중이점막의 혈관투과성에 미치는 영향
박찬일,고필준,이민한 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2
The increased vascular permeability is first sign of inflammation and one of the early major sign in otitis media with effusion. The vascular permeability of the tympanic mucosa was observed after stimulation with cold water through the external auditory canal of rats and injection of Monastral blue, using whole mount preparations. Many monastral blue labelled vessels were noted in the pars flaccida and the tympanic mucosa near the office of eustachian tube but not in the pars tensa. The results suggest that cold stream stimulation through the external auditory canal could increase the vascular permeability in the middle ear mucosa of rats and that might be used an animal model to study early pathogenesis of otitis media with effusion.
남부현,김병국,고필준,심장한,박찬일 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1
Post-traumatic cholesteatoma can be originated in the middle ear or mastoid cavity after head trauma such as temporal bone fracture, penetrating injury of the temporal bone or blast injury of the tympanic membrane. It usually takes a long time to develope cholesteatoma after injury, and physicians may overlook its association with previous, trauma. Post-traumatic cholesteatoma can be suspected in patients with head trauma history and atypical cholesteatoma findings. We experienced two cases of cholesteatoma which found behind the intact tympanic membrane in 7 and 13 years old boys with history of head trauma, and we are reporting this with a discussion and literatural review.
Interleukin-2와 결핵균 30 kDa 항원이 구개편도 및 말초혈액 T 세포 증식에 미치는 상승효과
박정규,박찬권,조은경,김화중,백태현,고필준,김병국,남부현,나기상,박찬일 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1
Widespread use of BCG has not controlled tuberculosis, and more effective vaccines are clearly needed. Although chemotherapy will remain the mainstay of antituberculosis treatment, the use of adjunctive immunotherapeutic modalitites is attractive, particularly in persons with drug-resistant tuberculosis. Administration of IL-2 or IFN-γto tuberculosis patients enhance bacillary elimination. Cell-mediated immunity is the critical protective immune response in tuberculosis. Mycobacterial antigens are recognized by T cells and that elicit production of protective cytokines are potentially important vaccine antigens. The 30 kDa antigen is secreted in large quantities by growing mycobacteria. That antigen elicits greater proliferation in lymphocytes from healthy tuberculin reactors than healthy tuberculin nonreactors. In this study, the T lymphocyte proliferative responses to 30 kDa antigen from Mycobactrium tuberculosis H37Rv were examined by using tonsilar and peripheral blood lymphocytes from PPD(+) and PPD(-) tonsilectomized persons. When cultured with 30 kD antigen, tonsilar mononuclear leukocytes and T cells of PPD(+) demonstrated more ^3H-thymidine incorporation than PPD(-) persons (stimulation index was 2.5 and 1.9, 0.8 and 1.0, repectively). Peripheral blood mononuclear cells (PBMC) and peripheral blood T lymphocytes were shown the similar responses to this antigen. The combination of IL-2 and 30 kDa antigen elicited a significant proliferative responsiveness in tonsilar mononuclear leukocytes and T cells of PPD(+) persons (SI was 20 and 14.1). PBMC and peripheral blood T cells of PPD(+) persons were also shown a significant responsiveness, but PPD(-) persons did not show. These results demonstrate that the 30 kDa antigen and IL-2 have a synergistic stimulatory property in mycobacteria sensitizing lymphocytes.