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전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정
김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4
다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.
有機鹽素系 化合物(γ-BHC)을 投與한 마우스의 脂肪代射에 관한 硏究
金炳洙,尹蓮淑 梨花女子大學校 韓國生活科學硏究院 1976 韓國生活科學硏究院 論叢 Vol.17 No.-
正常群, γ-BHC低用量 投與群, γ-BHC中等用量 投與群, 및 γ-BHC高用量 投與群에 對하여 Liver lipid classes의 定性分析, liver total lipid量 및 liver total cholesterol量을 測定하여 γ-BHC의 肝臟脂肪代謝에 미치는 영향을 檢討하였다. 測定方法은 Thin-layer chromatography와 吸光度測定法을 使用하였다. 그結果를 綜合하면 다음과 같다. 1) 正常群과 γ-BHC投與各群들의 liver lipid chasses는 同一하였다. 2) Liyer total lipid量은 正常群에 比해 γ-BHC 投與各群들에서 增加하였다. 3) Liyer total chalesterol量은 正常群에 比해 γ-BHC 投與各群들에서 增加하였다. The qualitative analysis of mouse liver lipid chasses was carried out by TLC. The total mouse liver lipid was determined by spectrophotometry. The total mouse liver cholesterol was determined by spectrophotometry. The above experimentes were carried out at non, low, medium and high concentration γ-BHC administrated mouses. The results were as follows: 1) The lipid classes of mouse liver were the same in normal and γ-BHC administrated mouses. 2) The total lipid of mouse liver was increased in γ-BHC administrated mouses. 3) The total cholesterol of mouse liver was increased in γ-BHC administrated mouses.
Association between allergy and cancer in Korean adults
( Byung Soo Kang ),( So Hee Lee ),( Tae Whan Kim ),( Hye Ryun Kang ),( Sae Hoon Kim ),( Heung Woo Park ),( Yoon Seok Chang ),( Sun Sin Kim ),( Kyung Up Min ),( Sang Heon Cho ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background: Neumerous epidemiological studies have evaluated the association between allergy and cancer occurrence and It has been a debate that whether allergy is a risk factor of protective factor for cancer. However, no study has been conducted among Koreans. Objective: To evaluate the association between cancer and atopy, airwary hyperresponsiveness or allergy in Korean general population. Methods: A retrospective review of subjects who visited the Seoul National University Hospital Gangnam Healthcare Center from October 2003 to May 2011 was done. Atopy was defined if a subject had a positive result on skin prick test or in vitro allergen specific IgE tests. Airway hyperresponsiveness (AHR) was defined when PC20 was less than 25 mg/dL in methacholine bronchial provocation test (MBPT). Information on cancers was obtained from medical history, endoscopic or ultrasonography-guided biopsy, and imaging studies such as computed tomography or magnetic resonance imaging. Results: Among 12479 subjects, 498 subjects had atopy, 546 had AHR, 920 (7.4%) had allergic diseases and 326 (2.6%) cases of cancer occurred. 13 atopic individuals (p=0.818 compared with non-atopics) and 19 subjects with AHR (p=0.262 compared with subjects without AHR) had cancer. Patients with allergic rhinitis had slightly more cancer compared with individuals without allergic rhinitis (p=0.044) and there is no significance in other allergic diseases. Conclusion: We observed a small increased incidence of cancer in allergic rhinitis patients. Further investigation is warranted to confirm these associations.
Kim, Young-Il,Kim, Mi-Jung,Park, Sook Ryun,Kim, Hark Kyun,Cho, Soo-Jeong,Lee, Jong Yeul,Kim, Chan Gyoo,Kim, Gwang Ha,Park, Moo In,Nam, Byung-Ho,Park, Young Iee,Choi, Il Ju The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.2
Purpose: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. Materials and Methods: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). Results: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. Conclusions: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).
최근 국내 유입 Vibrio cholerae균 및 1995년도 국내 집단 발생 콜레라의 역학적 양상
김호훈,신영학,강연호,유천권,박미선,김동술,유재연,전정훈,이복권,박기덕,김동진,정태화,이종구,박기동,김상순,이동모,김문식,조병륜 대한감염학회 1996 감염 Vol.28 No.6
목적 : 1992년 이후 국내에 유입, 확인되는 V. cholerae 균은 현격한 증가 추세를 보이고 있으며, 1995년도 국내 집단 발생 콜레라의 역학적 양상이 종래의 경우와 상이한 바 있어 최근의 콜레라균 유입상황과 국내 역학적 특성을 정리하여 향후의 방역 대책에 참고로 하기 위하여 본 연구를 시행하였다. 방법 : 국내 유입 V. cholerae 균은 세균학적 방법에 의해 1986-1995년 사이에 확인된 균주를 대상으로 분석하였고, 국내 집단발생 콜레라는 1995년도에 내국인 거주자에게서 진성 콜레라 환자로 구명된 환자를 대상으로 역학적 양상을 살펴보았다. 결과 : 국내 유입 V. cholerae균은 1992년 이후 1995년 사이에 계절과 무관하게 뚜렷한 증가 추세를 보였다. 1995년도 콜레라 국내 집단 발생의 역학적 양상은 초발 환자가 인지되면서 단기간 사이에 지역적 연고가 없는 다양한 지역에서 콜레라 환자 발생이 확인되었다. 환자 발생 지역 내에서는 비교적 소규모 환자 발생에 그쳤고 진성 콜레라 환자로 확인된 환자 중 사망자는 없었으며 남성에서 여성보다 발병율이 높았다. 결론 : V.cholerae O1균의 국내 유입이 최근 현격히 증가되었고, 1994년에는 V. cholerae O139균의 국내유입이 처음으로 확인되었다. 콜레라 환자의 국내 집단 발생 위험은 1992년 이후 증가되었으며 1995년도의 집단 환자 발생은 지역적 연고가 없는 다양한 지역에서 비교적 단기간에 사망자 없이 소규모의 환자 발생양상을 보였다. Background: Imported Vibrio cholerae strains have increasingly been found since 1992 and the pattern of recent cholera epidemic outbreak in Korea showed a little difference from that of former epidemic outbreak. Methods: We had collected suspected V. cholerae isolates from Quarantine Stations or Public Health Laboratories, which were identified as V. cholerae O1 or O139. Epide miological analysis was made on the base of field surveys. Results: During the period from 1986 through 1995, 138 V. cholerae strains were imported. Nearly 85.5% of the strains (118 strains) were imported within recent 4 years from 1992 to 1995. One hundred and twenty-eight strains were E1 Tor-Ogawa type V. cholerae O1, 6 strains were V. cholerae O139 and 4 strains were E1 Tor-Inaba type V. cholerae O1. Of 138 strains, 71 strains were isolated from the airplane toilet swab and 67 strains from the passengers who entered into Korea after international travel. From 1993 to 1995, 101 strains were imported from the Southeast Asian countries; including Thailand(65), Indonesia(17), Philippines(10), Hongkong(6) Singapore(2) and Vietnam(1). During the cholera epidemic in 1995, 68 patients with V. cholerae O1 (E1 Tor-Ogawa) were found. Oneset of the index-case occurred on August 26th and the last on September 13th. Geographically it occurred in Incheon city(25), Chungcheongnam do(25), Kangwon do(6), Kyungsangbuck do(5), Kyunggi do(4), Daejeon city(2) and Pusan city(1). Of total 68 cases, 39 were male. Cases were found in all age groups, but it was more common in elderly groups. During the epidemic, E1 Tor-Ogawa type V. cholerae O1 strains were also isolated from the coastal sea water of Kanghwa kun where the epidemic outbreak occurred. Conclusions: In Korea, the imported V. cholerae O1 and V. cholerae O139 strains have increasingly been found without seasonal variation since 1992. Cholera epidemic outbreak in 1995, occurred simultaneously at many different local areas within a short period without mortality.
Kim, Ji‐,Won,Lee, Keun‐,Wook,Kim, Kyu‐,Pyo,Lee, Ju Hyun,Hong, Yong Sang,Kim, Jeong‐,Eun,Kim, Sun Young,Park, Sook Ryun,Nam, Byung‐,Ho,Cho, Sang‐,Hee,Chung, Ikȁ AlphaMed Press 2017 The oncologist Vol.22 No.3
<P>Background. Irinotecan-based chemotherapy is a standard backbone of therapy in patients with metastatic colorectal cancer (CRC) or gastric cancer (GC). However, there is still a paucity of information concerning the efficacy and safety of irinotecanbased regimens in elderly patients. Patients and Methods. Using the patient cohort (n=1,545) from the UGT1A1 genotype study, we compared the efficacy and safety between elderly and nonelderly patients with metastatic CRC (n=934) or GC (n=611) who received first-or second-line FOLFIRI (irinotecan, leucovorin, and 5-fluorouracil) chemotherapy. Results. Despite lower relative dose intensity in elderly patients, progression-free survival and overall survival were similar between elderly (age >= 70 years) and nonelderly (<70 years) patients in the CRC cohort (hazard ratio [HR], 1.117; 95% confidence interval [CI], 0.927-1.345; p=.244, and HR, 0.989; 95% CI, 0.774-1.264; p=.931, respectively) and the GC cohort (HR, 1.093; 95% CI, 0.854-1.400; p=.479, and HR, 1.188; 95% CI, 0.891-1.585; p=.241, respectively). In both cohorts, febrile neutropenia (22.1% vs. 14.6% in CRC cohort and 35.2% vs. 22.5% in GC cohort) and asthenia (grade 3: 8.4% vs. 1.7% in CRC cohort and 5.5% vs. 2.9% in GC cohort) were more frequent in elderly patients. In the CRC cohort, mucositis and anorexia were more frequent in elderly patients. In the GC cohort, nausea and vomiting were less frequent in elderly patients. Conclusion. The efficacy of the FOLFIRI regimen was similar between elderly and nonelderly patients in both the CRC and the GC cohorts. However, special attention should be paid to elderly patients because of increased risk for febrile neutropenia and asthenia.</P>