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          조상헌 가톨릭대학교 산업의학센터 2001 韓國의 産業醫學 Vol.40 No.1

          Occupational asthma is the most common form of occupational lung disease in the developed world. The population attributable risk of asthma due to occupational exposures is considerable. In this review, the epidemiology, the current status in Korea, pathogenesis/mechanisms, clinical presentations, longterm prognosis, and prvention of occupational asthma are discussed. More than 300 hundred occupational allergens have been reported. In Korea, most important allergens are isocyanate, reactive dyes and spider mites. Current understanding of the mechanisms by which many agents cause occupational asthma is limited. High molecular weight (eg, graindust, flour) and some low molecular weight sensitizers (eg, acid anhydrides) have been shown to induce occupational asthma through an immunoglobulin E (IgE)-dependent mechanism while cell-dependent immunologic mechanisms are likely to be more relevant for occupational asthma induced by other low molecular weight sensitizers (eg, toluene diisocyanate and western red cedar). The pathology of the airway mucosa of occupational asthma is remarkably similar to the pathology of nonoccupational asthma. The diagnosis of occupational asthma is generally established on the basis of a suggestive history of a temporal association between exposure and the onset of symptoms and objective evidence that these symptoms are related to airflow limitation, such as PEFR moniroring or allergen provocation test. The prognosis of occupational asthma is determined by many factors. Occupational asthma may have complete resolution or may persist for years following its initial presentation Early diagnosis and elimination of exposure to the responsible agent, may play important roles in the prevention of long-term persistence of asthma.

        • KCI등재

          방사선 조사된 참깨에서 hydrocarbon류 검지를 위한 초임계 유체 추출 공정의 이용

          조성길,서상철,이보경,홍주헌,최용희 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

          초임계 유체 추출 공정을 이용하여 참깨에서 hydrocarbon류를 검출하여 참깨의 방사선 조사 여부 검지 전처리 기술에 활용하고자 하였다. 참깨를 2 kGy의 감마선을 조사하여 hexane으로 지방을 추출한 용매 추출과 초임계 유체 추출을 이용하여 추출한 지방을 Florisil coulumn으로 분리한 후 hydrocarbon 류를 GC-MS로 분석하였다. 용매 추출에서와 같이 초임계 유체 추출 공정을 이용하여 검출된 hydrocarbon 류은 동일하게 검지되었으며 그 marker 로써 활용 가능한 hydrocarbon 류인 13:3, 17:2, 16:2, 17:1은 비조사 참깨에서는 검출되지 않아TEk. 보조 용매르 사용한 초임계 추출 공정에서 각 보조용매에서 추출된 지방량은 용매 추출보다 많았으며 보조용매를 사용하여 검출된 hydrocarbon 류의 검출량은 methanol을 제외하고 전반적으로 많이 검출되었다. 특히 acetone의 경우 marker로 사용가능한 hydrocarbon류는 용매 추출에서보다 3~4배 정도, CO₂만을 사용함 초임계 유체 추출 공정에서 보다 거의 2배의 검출 특성을 보여주었다. 이러한 결과는 초임계 유체 추출 공정이 방사선 조사 여부 검지 기술에 있어서 기존의 용매 추출에 비해 지방 추출시 용매 소모량의 감소, hydrocarbon 류의 검출량 증가 등의 이유로 hydrocarbon 류의 검지 기술에 있어 전처리 기술로 활용 가능하리라 사료된다. Radiation-induced hydrocarbons from the irradiated sesame were investigated in this study to compare the chemical properties of irradiated and non-irradiated foodstuff. The detective volatile hydrocarbons for the irradiated sesame were (C14:0), 1-tetradence (C14:1), n-pentadecane (C15:0), n-hexadecane (C16:0), 1-hexadecane (C16:1), n-heptadecane (C17:0), 8-heptadecene (C17:0), 1,7-hexadecadiene (C16:2) 1,7,10-hexadecadiene (C16:3) 6,9-heptadecadiene (C17:2). The characteristic of extracts was also investigated at the change of pressure and temperature. And then it was found that the increase of the pressure and the decrease of the temperature in supercritical fluid extraction have made possible much more rapid extraction of volatile hydrocarbons. The amounts of volatile hydrocabons for irradiated and non-irradiated foodstuff were definitely differentiate. It could be concluded that the supercritical fluid extraction was possible for detective extraction method irradiated foods.

        • 급성 담낭염에 대한 내과적 치료의 역할

          강성원,조한래,한설해,박현주,정인성,홍선미,김성걸,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

          In 58 patients who were admitted to department of internal medicine, ChungNam national university hospital from January 1989 to March, 1993. We evaluated for medical treatments and the following results were obtained. 1) The ratio of male and female was 1 : 1 and mean age of the patients was 57.4 years. 2) At arrival on hospital, the most common clinical symptom was pain in right upper quadrant and epigastrium(93.1%), the remainders were fever and chill(79.3%), nausea(51.7%) and vomiting(36.2 %) in order of frequency. 3) The most common physical findings was tenderness on the right upper quadrant and epaigastrium(98%), the remainders were jaundice(50%) and palpable gall bladder(13.8%) in order of freguency. 4) In laboratory examination, elevated levels of ESR(82.8%), leukocytosis(67.2%), elevated levels of AST(62.0%), ALT(50.0%), serum total bilirubin(51.7%) and alkaline phosphatase (43.1%) were noted. 5) The mean period of NPO was 3.9 days and the mean hospital period was 13.5 days. 6) The rates of combined complications in patients with acute cholecystitis were 17.2%; these are gall bladder empyema(5.2%), hydrops(5.2%), perforation(3.4%), sepsis(3.4%) and intestinal obstruction (1.7%). 7) In 96.6 percent of 58 cases, the symptoms of acute cholecystitis were improved by conservative management. 8) The mean follow-up period was 25.5 months and the recurrence rate was 10% during this period.

        • KCI등재후보

          자녀의 기도과민성에 대한 부모의 유전적 소인

          김상훈,홍성철,김선신,장윤석,반준우,김윤근,조상헌,민경업,김유영 대한알레르기학회 2002 천식 및 알레르기 Vol.22 No.4

          Background : Atopy and bronchial hyperresponsiveness (BHR) which are characteristics of asthma, are strongly correlated but independently inherited traits. The relative contribution of maternal and paternal condition to the risk of offspring's condition is not certain. Objective : The aim of this study was to evaluate maternal or paternal contribution to childhood atopy and BHR in a population-based sample of 140 Korean nuclear families. Subjects and Methods : A total of 486 subjects (133 mothers, 132 fathers and 221 offsprings) participated in this study. All subjects provided questionnaire data and 483 subjects underwent allergy skin prick test with 13 inhalant allergens. Total serum IgE levels were determined in 444 subjects and methacholine bronchial provocation test were performed in 483 subjects. Results : Serum total IgE level in the offspring was correlated with both maternal and paternal total IgE (mother : R=0.273, p<0.01 : father : R=0.200, p<0.01). Bronchial hyperresponsiveness was associated with parental atopy index (mother: R=0.175, p<0.01: father : R=0.205, p<0.01) and maternal BHR (R=0.201, p<0.01). The development of wheezing in the offspring was significantly associated with maternal BHR, but not paternal. Conclusion : These results suggest that maternal BHR does confer more risk than paternal BHR to risk of offspring's BHR. (J Asthma Allergy Clin Immunol 22: 695-702, 2002)

        • KCI등재

          주암호의 계절별 수온 구조와 열수지 변화

          선연종,조철,김병춘,허인애,윤준헌,장남익,차성식,조양기 한국육수학회 2003 생태와 환경 Vol.36 No.3

          주암호의 수직 수평적 수온 구조의 계절변화를 이해하기 위하여, 2000년 3월부터, 2001년 5월까지 수온을 관측하였다. 관측된 수온자료와 기상자료를 이용하여, 수온 변화에 직접적인 영향을 미치는 열수지를 정량적으로 계산하였다. 겨울에는 호수가 대기로 열을 빼앗겼는데, 12월에 최대 109.45W/㎡의 열을 잃었다. 표층수의 냉각으로 대류가 일어나, 수직적으로 균일한 수온을 보였다. 수평적으로는 수온의 차이를 보여, 호수로 물이 유입되는 상류 쪽은 수온 3℃, 댐 부근에서는 약 5℃의 물이 존재했다. 봄이 되면서 주로 표층을 통해 얻는 열로 인해 표층 수온이 상승하여, 수직적인 온도 차이를 보였다. 여름에는 표층을 통해 유입되는 열의 양이 증가하여, 7월에 최매 101.95W/㎡였다. 표층 가열과 함께, 상류로부터 크게 증가한 유량으로 인해 주암호 내부의 열이 증가하여 8월에는 표층 수온이 최대 29℃ 이상이 되었다. 그러나 저층수는 약 7℃였다. 가을이 되면서 표층을 통해 열을 잃게 되어 표층수의 수온이 낮아졌고, 표면혼합층은 두꺼워졌다. 기온이 더 낮아지는 겨울에는 표층을 통한 열 손실이 더 증가하여 2월에 수온이 가장 낮아졌고, 수직적으로 균일한 수온 특성을 보였다. 이러한 수온구조는 3월까지 지속되었다. Temperature profiles were observed to understand seasonal variation of thermal structures in the Juam reservoir from March 2000 to May 2001. Heat flux which affects thermal structures was calculated by observed water temperature and meteorological data. temperature became homogeneous vertically by convection due to the surface cooling in winter. Maximum heat loss through the surface (109.45 W/m²) occurred in December. There was a horizontal gradient of water temperature in winter. The temperature was 3℃ at upstream and 5℃ near the dam. The surface temperature increased by the increase of solar radiation in spring and summer. Maximum heat gained through the surface was 101.95W/m² in July. Maximum surface temperature was 29℃ in August, whereas the bottom water was 7℃. Surface mixed layer became thicker and its temperature decreased by surface heat loss in fall and winter.

        • 최대 등척성 수축시 표면근전도에서 근 수축 개시점 결정을 위한 기법들의 신뢰도

          정이정,조상현,이정훈,이상헌 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          The purpose of this study was to compare the relative accuracy of a range of computer-based analysis with respect to EMG onset determined visually by an experienced examiner. Ten healthy students (6 male, 4 female) were recruited and three times randomly selected trials of isometric contraction of wrist flexion and extension were evaluated using four technique. These methods were compared which varied in terms of EMG processing, threshold value and the number of samples for which the mean must exceed the defined threshold, and beyond 7% of maximum amplitude. To identify determination of onset time, ICCs(Intraclass Correlation Coefficients) was used and inter-rater and intra-rater reliability ranged good in visually derived onset values. The results of this study present that in wrist flexion and extension, the reliability of the inter and intra-examiner muscle contraction onset times through visual analysis showed beyond .971 with ICCs. The reliability of the muscle contraction onset time decision through visual reading, tested with computer analysis, showed a relationship of all the selected analysis methods with ICCs .859 and .871. The objective computer-based analysis comparing with visual reading at the same time is the effective and qualitative data analysis method, considering the specificity of each study method.

        • KCI등재

          타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

          박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

          The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

        • SCISCIESCOPUS

          Batteries: Cable‐Type Flexible Lithium Ion Battery Based on Hollow Multi‐Helix Electrodes (Adv. Mater. 38/2012)

          Kwon, Yo Han,Woo, Sang,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced materials Vol.24 No.38

          <P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>

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