Correlation between skeletal and dental changes after mandibular setback surgery-first orthodontic treatment

Chang-Hoon Rhee,Youn-Kyung Choi,Yong-Il Kim,Seong-Sik Kim,Soo-Byung Park,Woo-Sung Son 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.2

Objective: To investigate skeletal and dental changes after application of a mandibular setback surgery-first orthodontic treatment approach in cases of skeletal Class III malocclusion. Methods: A retrospective study of 34 patients (23 men, 11 women; mean age, 26.2 ± 6.6 years) with skeletal Class III deformities, who underwent surgery-first orthodontic treatment, was conducted. Skeletal landmarks in the maxilla and mandible at three time points, pre-treatment (T0), immediate-postoperative (T1), and post-treatment (T2), were analyzed using cone-beam computed tomography (CBCT)-generated half-cephalograms. Results: The significant T0 to T1 mandibular changes occurred ?9.24 ± 3.97 mm horizontally. From T1 to T2, the mandible tended to move forward 1.22 ± 2.02 mm, while the condylar position (Cd to Po-perpendicular plane) shifted backward, and the coronoid process (Cp to FH plane) moved vertically. Between T1 and T2, the vertical dimension changed significantly (p < 0.05). Changes in the vertical dimension were significantly correlated to T1 to T2 changes in the Cd to Po-perpendicular plane (r = ?0.671, p = 0.034), and in the Cp to FH plane (r = 0.733, p = 0.016), as well as to T0 to T1 changes in the Cp to Poperpendicular plane (r = 0.758, p = 0.011). Conclusions: Greater alterations in the vertical dimension caused larger post-treatment (T2) stage skeletal changes. Studying the mandibular position in relation to the post-surgical vertical dimension emphasized the integral importance of vertical dimension control and proximal segment management to the success of surgery-first orthodontic treatment.

GIS기법과 기후변화시나리오를 이용한 극한 강우에 따른 재해 영향성 평가

함창학(Hahm, Chang Hahk),김병식(Kim, Byung-Sik) 한국측량학회 2012 한국측량학회 학술대회자료집 Vol.2012 No.4

There has been growing the damage in an urban area on account of recent climate change. As the complicated type of damages such as domestic flooding, landslide overflow of rivers etc., has been emerged, great attention has been shown to the question of extreme precipitation, local downpour. Under confined spaces and limited resources, we should selectively take appropriate counterplan on flood disaster in accordance with the climate change. For decision making, we should consider the estimation of disaster according to extreme precipitation affected by climate change. Simulating the daily rainfall in the future (2001-2100) by using SRES A2 scenarios and high-resolution RCM model, we estimated EVI(Extreme Volatility Index), HRI(Human Risk Index), and DII(Disaster Impact Index). Then, we finally evaluated the effect of occurrence of extreme precipitation in future climate change through comparison and analysis on spatio-temporal distribution of the Korean Peninsula. The conclusion which can be drawn from study are these: 1) Extreme Volatility Index loomed large in Gyeongsang-do and Jeolla-do, 2) Human Risk Index has largely revealed 7 metropolitan city and national capital region, and 3) Area located on the border of the whole area on the West Coast , Gyeongsang-do and Jeolla-do have large Disaster Impact Index. In short, these areas will be influenced by flood disaster in accordance with the future climate change.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

상전 및 하전을 동반한 안구후퇴증후군에서 외직근의 후전 및 Y형 분리술(Y-Splitting)의 효과

민병무,김창식 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

The upshoot and downshoot are occurred when the eye is rotated into the adducted position in Duane's retraction Syndrome. These phenonemons are believed to be related to a taut or leash effect ("Bridle effect") from the lateral rectus muscle. Seven patients with Duane's retraction syndrome demonstrated above findings and underwent Y-sptting and recesion of the lateral rectus muscle. All 7 patients demonstrated a marked decrease in the up-or downshoot and retraction of the eye ball, and became better primary position of the eye ball after the operation.

위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

상처치유시 Antisense TGF-β1 Oligodeoxynucleotides가 Inducible Nitric Oxide Synthase발현 조절에 미치는 영향

최병민,곽현정,전창덕,임정식,박석돈,정헌택 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4

Wound healing in the skin may be complicated by both microbial invasion and inflammation. Following injury, platelet degranulation releases a number of chemotactic factors including transforming growth factor (TGF-fl) and platelet derived growth factor (PDGF). TGF-19 is a cytokines that modulates many cellular function and gene expression. However, it is not known whether TGF-P could regulate inducible nitric oxide synthase (iNOS) gene expression during wound healing. Here we report that down regulation of TGF-Q gene expression by antisense oligodeoxynucleotides increase iNOS during wound healing. Our reverse transcription- polymerase chain reaction (RT-PCR) result has shown that antisense TGF-fil oligodeoxynucleotides (ODN) targeting the TGF-J11 translation initiation region markedly reduced TGF-(il mRNA levels in wounded skin. Also, marked reduction in TGF-fl1 mRNA after antisense treatment invited that the increment of iNOS mRNA in wounded skin. Therefore, our irnmunohistochemical studies revealed a "pattern of iNOS product in wounded skin treated antisense TGF-fl1 ODN that was similar to the pattern of RNA synthesis detected by RT-PCR. In conclusion, our results indicated that the regulatory actions of TGF fl1 on iNOS. might be involved in the initiation and faciliates the resolution of inflammation following wounding.

위암에 의한 간 전이의 CT 진단에 있어 조영제의 급속 정맥주사방법을 이용한 문맥기 역동적 CT의 유용성 : Usefulness of Bolus Dynamic CT During Portal Phase

조준식,송창준,김종철,이병철 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

Purpose : We evaluated the usefulness of dynamic CT during portal phase with faster injection rate of contrast material in detecting hepatic metastases from gastric cancers. Subjects and Methods : We retrospectively analyzed two-phase dynamic CT findings (portal phase and equilibrium phase) in 17 patients with pathologically proven gastric cancers and hepatic metastases. In 13 patients, a total of 150ml of nonionic contrast material was administered with a power injector at a flow rate of 5ml/sec for 30 sec, and two-phase images were obtained at 45-70 sec (portal phase) and 2-4 min (equilibrium phase) after the start of bolus injection. In four patients, two-phase dynamic CT with spiral technique was performed with the same method. Results : In cases of metastases less than 1 cm in diameter, 65 lesions were detected in the portal phase that showed clearly defined hypodense lesions in highly enhanced hepatic parenchyma. Whereas, only nine (14%) lesions were detected in the equilibrium phase and the remaining 56(86%) lesions showed isoattenuation. In cases of metastases more than 1 cm in diameter, 37 lesions were detected in the portal phase that showed clearly defined hypoattenuations. whereas, the images of equilibrium phase showed isoattenuation in five (14%), mixed attenuation in three (8%), and hypoattenuation in 29 (78%). The lesions detected in the equilibrium phase showed poorly defined hypodense lesions and tended to decrease in size due to peripheral enhancement of lesions. Conclusion : Dynamic CT during portal phase with faster injection rate of IV contrast material is an useful technique in detecting hepatic metastases from gastric cancers, particularly small lesions less than 1 cm in diameter.

초자체흡인술이 폐쇄우각 녹내장의 전방깊이에 미치는 영향

안병헌,김창식,김용백 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

From an eye with chronic angle-closure glaucoma, 0.4 ml of vitreous was aspirated at the same time of trabeculectomy. The ultrasonographic measurement revealed decrease in the length of the vitreous cavity and increase in the depth of the anterior chamber by 0.3 mm at 2 months following the vitreous tap when compared with the preoperative measurement. The other 4 eyes which had undergone argon laser iridectomy or trabeculectomy alone did not show change in the intraocular intersegmental distances. In certain cases with chronic angle-closure glaucoma, it seemed that the vitreous tap procedure might deepen the anterior chamber following a filtration surgery and give a beneficial effect to prevent a further postoperative synechial closure of the chamber angle.

후복막섬유증 5례의 임상적 고찰

정충식,김수현,안병수,심대성,박도영,김철성,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Retroperitoneal fibrosis is a fibrotic process of the retroperitoneum that frequently produces ureteral obstruction. It can occur as an idiopathic disease or in association with various non-malignant and malignant condition. In the early phase of the retroperitoneal fibrosis ; symptoms originate from the disease process itself, while in the late state the clinical features represent the effect of obstructive uropathy and renal failure. Treatment consist of steroid therapy, urinary diversion and ureterolysis with jntraperitonealization or lateralization or wrapping with omentum. Herein we present 5 cases of retroperitoneal fibrosis.