도시하천 악취물질의 발생원조사에 대한 연구

조정구,배병훈,최금찬,임경택 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study has been carried out to investigate odor characteristics and removal methods on the water quality and sulfuric material of four urban sewage. The results from these experiments are as followings ; 1. For sediment, N contents(%) was shown 0.068mg/l at S-1, 0.109mg/l at S-2, 0.043mg/l at S-3, 1.233mg/l at S-4 and S contents(mg/g) was shown 2.192mg/l at S-1, 2.410mgA at S-2, 1.564mg/l at S-3, 15.146mg/l at S-4. The sample of S-4 was indicated the worst value to 1.233mg/l 2. NH₃, one of the representative odor materials, which was showed the highest value at S-1 in the water, showed the highest value at the S-4 in the air. It means that the cause of odor comes from the disintegration of sediment orgamisms, which has more important effect than the water pollution. 3. To control the odor materials, it is desirable to minimizes the inflow of sewage from pollutant source itself. One of the considering odor method is H₂O₂ or activated carbon input into the sewage, which has several advantages as chemical treatment of odor materials is to be desirable.

이질 환경을 위한 XML 미들웨어 시스템 연구

진병률,정지문,최성,우성구 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

최근 들어 기존에 존재하는 많은 서로 다른 형태의 데이터를 통합, 저장, 접근하고자 하는 노력들이 급속히 늘어나고 있다.또한 웹을 중심으로 한 많은 응용들이 등장하고 있다.앞으로는 웹상에서 정보 전송 및 처리에 사용되는 데이터는XML이 표준화 될 조짐을 보임을 보인다.이에 이질 환경을 위한 XML 미들웨어 시스템으로 XWEET를 웹 환경에서의 XML을 잘 처리하기 위한 시스템으로 제안하고자한다.

소아기 붕괴성 장애 1례

강병구,조수철,홍강의 대한소아ㆍ청소년정신의학회 1996 소아청소년정신의학 Vol.7 No.1

반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅱ)

배병훈,신남철,조정구,문종익,임경택 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

A combination of process modification and various additives to a lime-based spray-dryer/fabric-filter system was evaluated for its value in promoting sorbent utilization and simultaneous removal of HC1 and SO₂ from waste incineration flue gas. The variety of operating conditions were tested to evaluate important factors such as spray drying reactor(SDR) outlet temperature, retention time, molar equivalence ratio( MER ), fabric filter velocity, etc. For the sorbent activity enhancement, additives such as KmnO₄, NaOH, NaHCO₃, CaCl₂, a mixture of NaOH and CaCl₂ were added to Ca(OH)₂ at optimum operating condition. The mixture of NaOH and CaCl₂ ( 2 : 1 by weight ) was found to be the best economic additive. When that additive, 10% of Ca(OH)₂ by weight, was added, under the condition of Ca(OH)₂ of MER 1.0, HCl/SO₂ removal efficiencies at fabric filter were 98.3% and 97.1%, respectively.

朝鮮朝 儒家의 理想國家觀과 敍事文學的 形象 : 『金鰲新話』를 中心으로

문범두,김정호,조구호,문병우 진주산업대학교 2003 論文集 Vol.42 No.-

한국인 성인 남성 폐쇄성수면무호흡 환자의 측모 두부 방사선계측학적 비교

황상희,박인숙,남기영,김종배,조용원,서영성,안병훈,박신구,박효상 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

본 연구는 비만도에 따른 한국인 남성 폐쇄성수면무호흡 환자의 측모 두부 방사선계측학적 특성을 파악하기 위하여 시행되었다. 이를 위하여 계명대학교 의과대학 동산의료원 수면클리닉에 수면장애를 주소로 내원하여 수면다원검사 후 치과에서 측모 두부방사선계측사진 촬영을 한 87명의 성인 환자들을 체질량지수(BMI)와 수면무호흡지수(AHI)에 따라 비비만 단순코골이군(Non-obese, simple snorers), 비만 단순코골이군(Obese, simple snorers), 비비만 수면 무호흡군(Non-obese, OSA patients), 비만 수면무호흡군(Obese, OSA patients)의 4군으로 나누어 비교하였다. 그결과, 4군 중 비만 수면무호흡군의 수면무호흡지수가 가장 컸으며, 비만 수면무호흡군보다 비비만 수면무호흡군의 하악각이 더 크고 혀 길이는 더 작았다. 또한, 비비만 수면무호흡군보다 비만수면무호흡군의 설골이 더 전하방에 위치하였고, 수면무호흡지수에 영향을 미치는 기여 인자는 비만 수면무호흡군에서는 혀 길이, 비비만 수면무호흡군에서는 설골의 후방위치였다. 이처럼 비만 수면무호흡 환자와 비비만 수면무호흡 환자의 측모 두부방사선계측학적 특성과 기여 인자가 다르게 나타나므로, 치료방법도 따라서 다르게 선택해야 할 것이다. 비만 수면무호흡 환자들에게는 먼저 체중감량이 권고되어야 할 것이고, 비비만 수면무호흡 환자들은 폐쇄부위에 따라 구강 내 장치나 Nasal CPAP (continuous positive airway pressure), UPPP (uvulopalatopharyngoplasty) 등이 추천될 수 있을 것이다. Objective: The purpose of this study was to compare the cephalometric measurements of obese and non-obese Korean male patients with obstructive sleep apnea syndrome (OSA). Methods: Eighty-seven adults who had visited the Sleep Disorder Clinic Center in Keimyung University, Daegu, Korea were examined and evaluated with polysomnography (PSG) and lateral cephalogram. They were divided into 4 groups (non-obese simple snorers, obese simple snorers, non-obese OSA patients, obese OSA patients) according to AHI (Apnea-Hypopnea Index) and BMI (Body Mass Index). Results: The obese OSA group had the highest AHI among the 4 groups. The non-obese OSA group had a significantly steeper mandibular angle and shorter tongue length than the obese OSA group. The hyoid bone of the obese OSA group was positioned anterior and inferior as compared with the non-obese OSA group. Multiple regression analysis showed that tongue length in the obese OSA group and retroposition of hyoid bone in the non-obese OSA group were significant determinants for the severity of AHI. Conclusions: From a cephalometric point of view, the obese and non-obese pateints with OSA may be characterized by different pathogeneses. Therefore, they have to be managed by individualized treatment. For the obese OSA patients, weight control must be advised as a first choice and for the non-obese OSA patients, oral appliance, nasal CPAP, UPPP and others could be chosen according to the obstructive sites.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

Validation of Recently Proposed Consensus Criteria for Thrombotic Microangiopathy After Allogeneic Hematopoietic Stem-Cell Transplantation

Cho, Byung-Sik,Yahng, Seung-Ah,Lee, Sung-Eun,Eom, Ki-Seong,Kim, Yoo-Jin,Kim, Hee-Je,Lee, Seok,Min, Chang-Ki,Cho, Seok-Goo,Kim, Dong-Wook,Lee, Jong-Wook,Min, Woo-Sung,Park, Chong-Won Lippincott Williams Wilkins, Inc. 2010 Transplantation Vol.90 No.8

BACKGROUND.: The lack of an accepted definition of transplantation-associated thrombotic microangiopathy (TMA) has led the Blood and Marrow Transplants Clinical Trials Network (CTN) and International Working Group (IWG) to propose a definition for TMA with some differences. However, there have been few studies validating and comparing both newly proposed criteria for TMA. METHODS.: To validate recently proposed criteria for TMA by CTN and IWG, we analyzed 672 patients who underwent allogeneic stem-cell transplantation between January 2002 and December 2006. RESULTS.: The cumulative incidences of TMA by CTN and IWG were 6.1% and 2.5%, respectively. The cumulative incidence of overall TMA (O-TMA) including probable-TMA defined as meeting CTN criteria without renal or neurologic dysfunction, as well as TMA by CTN (definite-TMA), was 12.7%. Sixty-six percent of TMA by CTN did not have any degree of schistocytosis by IWG criteria (≥4%), and 18% of TMA by IWG criteria did not have renal or neurologic dysfunction. On multivariate analyses, probable-TMA as well as definite-TMA adversely affected the survival of a cohort including all patients. In patients with O-TMA, the degree of schistocytosis (≥4% or not) failed to show prognostic significance, whereas renal involvement was a significant prognostic factor associated with poor survival. CONCLUSIONS.: Both proposed consensus criteria have major pitfalls in their use as uniformly accepted diagnostic criteria for TMA. The use of O-TMA as a broad definition for TMA and the grading system by the presence of renal involvement may be a counterproposal for future trials.

<i>WT1</i> Measurable Residual Disease Assay in Patients With Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation: Optimal Time Points, Thresholds, and Candidates

Cho, Byung-Sik,Min, Gi-June,Park, Sung-Su,Shin, Seung-Hwan,Yahng, Seung-Ah,Jeon, Young-Woo,Yoon, Jae-Ho,Lee, Sung-Eun,Eom, Ki-Seong,Kim, Yoo-Jin,Lee, Seok,Min, Chang-Ki,Cho, Seok-Goo,Kim, Dong-Wook,Le Elsevier 2019 BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Vol.25 No.10

<P><B>ABSTRACT</B></P> <P>The absence of relevant guidelines for <I>Wilms tumor 1</I> (<I>WT1</I>) gene quantification as a measurable residual disease (MRD) assessment for patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) has limited the widespread use in practice. We investigated optimal time points, thresholds, and candidates for the bone marrow <I>WT1</I> MRD assay in 425 consecutive patients with AML who underwent allo-HSCT. <I>WT1</I> expression kinetics before allo-HSCT and at 1 or 3 months after allo-HSCT were determined by real-time PCR using the European LeukemiaNet (ELN) normalized method. Relapsed patients had significantly higher <I>WT1</I> levels before allo-HSCT and at 3 months after allo-HSCT. The best time point for the <I>WT1</I> MRD assay was before allo-HSCT by the receiver operating characteristic curve. Among various thresholds, 250 copies recommended from ELN researchers were mostly predictive of post-transplant relapse. In multivariate analysis, <I>WT1</I> MRD positivity independently predicted relapse, resulting in inferior survival. In subgroup analyses, pretransplant <I>WT1</I> MRD positivity was predictive of post-transplant relapse in the intermediate group, whereas <I>WT1</I> MRD positivity occurred at 3 months after allo-HSCT in favorable and adverse risk groups. Among MRD-positive patients before allo-HSCT, all patients who were MRD positive at 3 months relapsed within 6 months. The <I>WT1</I> MRD assay before allo-HSCT or 3 months after allo-HSCT is useful for predicting post-transplant relapse with a different significance in each risk group by time points, showing the benefit of multiple tests over time. Such monitoring is particularly available in patients with AML without specific molecular targets.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>WT1</I> assay is useful for predicting post-transplant relapse in acute myeloid leukemia (AML). </LI> <LI> Optimal threshold for the <I>WT1</I> assay would be 250 copies/10<SUP>4</SUP> copies of <I>ABL1</I>. </LI> <LI> <I>WT1</I> assay is particularly available in AML without specific molecular targets. </LI> <LI> <I>WT1</I> assay in each risk group by time points have different significance. </LI> </UL> </P>

How to Take Ginseng for What

Byung Goo Cho,Ae Kyung Park,Hoon Park 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-