Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention

Byoung-won Park,Seong Soon Kwon,Min Ho Lee,Do Hoi Kim,Min Su Hyon,Duk Won Bang 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1

Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). Methods: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. Results: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. Conclusion: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

정신장애인 치료에 중요 역할 담당자의 정신질환에 대한 태도조사

김병후,정선욱,강연화,김윤,김창엽,홍진표,한오수,조맹제,김용익 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

Objectives : Attitudes of families of mentally ill, health personnels and community leaders to the mentally ill after the development and utilization of the community mental health program and reintegration of the chronically ill patients into society. This study was designed to compare the attitudes toward the mentally ill patient of the persons who have important role in treating the mentally ill and to find the variables influencing the attitudes. Methods : We measured attitudes toward mental illness in psychotic patients' families(N=139), community leaders(N=180) and health personnels(N=324) including mental health personnels before the implementation of community mental health services in Yonchon county and Seodaemun district area. The instrument used to measure attitudes was Opinion about Mental Illness(O. M. I.) scale. Results : 1) Health personnel showed lower Authoritarianism(Factor A) and higher Benevolence(Factor B) scores on the average than community leaders and psychotic patients families. 2) Current residence affect the attitudes in psychotic patients' families, not in community leaders and health personnels. Families in urban area showed lower Authoritarianism(Factor A) and Social Restrictiveness(Factor D) and higher Benevolence(Factor B) scores than in the rural areas. 3) Many patient variables were correlated to the attitudes of families. Duration of illness, number of recurrence, number of admission, age of patient and family burden were positively correlated mainly to Social Restrictiveness(Factor D). 4) Sex and religion of respondents showed no or weak relationship with the factor scores. Conclusions : Education for community leaders and families is required to achieve successful community mental health services. Community support program should be developed for chronic, recurrent and burdensome psychiatric patients in the first place.

예비교사와 경력교사의 교육과정 문해력 수준 비교에 대한 사례 연구* - 국어교과를 중심으로 -

김병수(Kim, Byoung­su),이현명(Lee, Hyun­Myoung) 성신여자대학교 교육문제연구소 2016 교육연구 Vol.67 No.-

본 연구는 교육과정 문해력 연구 중에서 교육과정 문해력 수준 비교에 대한 사례 연구이다. 교육과정 문해력의 사례를 분석하여 문해력 단계를 구체화하고 이를 통해 교사들의 전문성 단계(예비교사와 경력교사) 또는 관점에 따른 교육과정 문해력의 양상을 확인하고자 한다. 연구 참여자는 예비교사와 경력교사로 구분된다. 예비교사는 C교육대 학교 국어교육과 4학년 9명으로 교육실습에 참여한 학생들을 대상으로 하였다. 경력교사는 교육과정 문해력 탐색을 위해 참여관찰을 했던 경력 10년 이상의 교사 5명과 참여관찰에 어려움이 있어 개별적으로 동영상을 보내준 경력 10년 이상의 교사 1명을 포함한 총 6명이다. 본 연구는 질적 사례연구로 교육과정 문해력 수준을 비교하기 위해 연구자들은 예비 교사 수업 10편과 경력교사 수업 9편을 수집하여 비교하였다. 예비교사와 경력교사 간 교육과정 문해력의 수준을 비교해 본 결과각 집단 간의 특별한 경향성을 보이지는 않았다. 단지 몇 가지의 특징을 들 수 있었는데, 예비교사는 교과서를 통한 교과서의 내용을 이해하고 있었고, 경력교사는 예비교사에 비해서 교육과정 내용의 성취 기준을 강조하고 있었다. 수업 지도안에 나타나는 교육과정 문해력은 형식적인 수업 지도안이나 수업 모형을 강조하는 측면도 있었고, 교육과정의 목표와 성격을 이해하고, 성취 기준에 있는 내용 요소와 기능 요소를 잘 반영한 수업들도 있었다. 교육과정 문해력에 대한 계속되는 연구는 교사가 수업 전문성뿐만 아니라, 개별 수업의 토대로 작용하는 교육과정에 대한 교사 전문성 신장에 목적을 둔다는 점에서 의미를 가진다고 볼 수 있다. 한 가지 이 연구 에서 시도된 교육과정 문해력 수준에 대한 구분은 연구자가 잠정적으로 구분한 것이며, 이에 대한 타당성은 계속 논의되어야 할 것이다. 그리고 교사 발달과 교육과정 문해력 수준 발달과는 꼭 일치하지는 않는 것임을 직시할 필요가 있다. The purpose of this study is to compare levels of curriculum literacy. It articulates levels of curriculum literacy by analyzing a number of cases of curriculum literacy practices. At the same time, it also has an attempt to identify certain features of curriculum literacy in terms of its perspective or levels of teacher professional development(pre-service teacher and veteran teacher) Participants in this research were divided into pre-service teachers and in-service teacher. 9 pre-service teachers were seniors at the Korean education department who were placed in practicum. 6 in-service teachers were veteran teachers who were more than 10 year teaching experiences and involved in classroom observation for exploring curriculum literacy. This study was a qualitative case study which compared levels of curriculum literacy. For this purpose, these researchers collected and analyzed 10 class videos from the pre-service teacher and 9 class videos from the veteran teacher. As a result, there was no distinctive tendency observed between these two groups in comparison of levels of curriculum literacy. However, some important characteristics were constantly unfolded. For instance, pre-service teachers understood the content of teaching through a textbook itself. Veteran teachers emphasized more on achievement standards for curriculum contents than pre-service teachers. curriculum literacy in the lesson plan was underscored a forma lesson plan or an instructional model and understood goals and characteristics of curriculum. some of teaching was throughly reflect on content and functional elements of achievement standards. A purpose of the continuous study of curriculum literacy was not only promoting the professionalization of teaching but also fostering teacher professional development regarding curriculum based on each individual class. However, levels of curriculum literacy in this study were provisionally classified and constantly discussed its trustworthiness. These researcher came to realize that the development of curriculum literacy level and teacher professional development was not necessarily matched.

토지이용패턴에 따른 하천수질과 식생분포

오영주,강병화,김병우,김성필,한민수,김진호,나영은 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

名詞의 複合表現 構造 : Lees와 Levi의 深層分析을 中心으로 Chiefly on their properties and derivation on the theories of Lees and Levi

金柄洙 단국대학교 교육대학원 1985 敎育論叢 Vol.1 No.-

This study is an attempt to gain a systematic insight into the internal structure of "complex nominals", comprising a head noun preceeded by a modifying element which is in some cases a noun, in others nonpredicating adjective. Levi's evidence of the nominal origins of nonpredicating adjectives enables 'Nonpred. Adj + N' types to be derived basically in the same way sa'N+N' types are derived. The general criteria for CNs such as phonological, morphological, and semantic ones are worth studying, but the creativity and procdctivity of CNs denies the criterion of semantic specialization, which will regard CNs as lexicalized. The criteria should reflect more basic nature of these expressions: the internal structure from which these are derived. The types of CNs reveal two major patterns: syntactic relations on the one hand, and semantic on the other. these expressions indicate roughly the differences in grammatical form embedded in themselves and patterned after their source sentences, such as 'subject-predicate', 'subjcet-object', etc.. They can also be classified according to their predicates deleted in the surface. The set of these deletable predicates can be recovered in the usual reading of them. Complex nominals are all derived from just one of two syntactic processes: the delation or nominalization of the predicates in the underlying sentence. The process includes compound adjective formation, relative pronoun formation, WH-be deletion, RDP deletion, ect.. In conclusion, such a large variety of grammatically different types of CNs should be explained in accordance with our intuitive mastery of the mechanisms they contain, the mechanisms showing 'rule-governed' and 'creative' aspect of human language.

초등학교 고학년 학생의 구강보건에 관한 인식 및 행동

김영경,문혁수,정재연,한수진,이병진,김은경,정혜련 韓國學校保健學會 2001 韓國學校保健學會誌 Vol.14 No.1

The purpose of this study was to collect basic data for the development of effective oral health education program in elementary school. The subjects in this study were 604 fourth-year, fifth-year and sixth-year students of an elementary school in Seoul. Oral health awareness and behaviors were surveyed and analyzed. The findings of this study were as follows: 1. The most common time for toothbrushing was after dinner(62.0%) and before bedtime(62.3%). By school year, the largest number who brushed their teeth after dinner were fourth and fifth graders while the greatest number who did so after breakfast were sixth graders Seventy-four percent of respondents brushed the teeth twice or more a day. By school year, the fifth-year students brushed their teeth the least while girls outperformed the boys in daily toothbrushing frequency(p<0.05). Regarding the intake of cariogenic food, 62.1% took that kind of food once or more a day. By school year, the fifth graders took the most (p<0.05), and girls took more cariogenic food than the boys(p<0.05). 2. Ninety percent of the respondents had visited a dental clinic. By grade, the sixth-year students had visited a dental clinic more frequently and girls more frequently than boys. Eighty percent of the respondents visited a dental clinic to receive treatment but just 12.3% visited a dental clinic to prevent oral diseases. Concerning the fetor of dental treatment only 14.4% expressed fear. School year made no difference, yet the percentage of girls who experienced fear was higher than that of boys(P<0.05). Regarding preventive treatment, 39.7% experienced pit and fissure sealing and 24.2% experienced the application of fluorides. All the students hadn't much experience in preventive treatment regardless of school year -- gender didn't make a difference. 3. Fourty-six percent of respondents had a preference for the fluoride mouth rinsing program; 38.4% wanted that grogram to continue. As to the reason for preference, 38.2% preferred it because of the prevention of dental caries, 43.0%, the largest percentage, didn't favor it because they found it too much trouble to do(some of the respondents gave two different answers). 4. Despite an increase in the frequency of toothbrushing at the right time, they still took cariogenic food frequently Their visit to a dental clinics also aimed at treatment more than at prevention, and they had very narrow experience of preventive treatment. Furthermore, the fluoride mouth rinsing program failed to draw their interest. Therefore, it is recommended that a successful real health education program should be developed.

모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

CD44 is the major human cell surface receptor for hyaluronate and mediate cellmatrix and cell-cell interactions involved in the mechanisms of tumor invasion and metastasis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution, In contrast, congenital melanocytic nevi have a different course and prognosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. We investigated the expression of CD44 in acquired and congenital melanocytic nevi, and malignant melanoma by immunohistochemical technique. Formalin-fixed and paraffin-embeded tissue from 5 compound nevi, 6 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanoma were immunolabeled with monoclonal antibodies directed against CD44. All acquired melanocytic nevi showed negative or weak staining for CD44. However, all congenital melanocytic nevi exhibited positive staining for CD44 with minimal irregularities according to location. In malignant melanoma, there was variable intensity of staining for CD44 in different areas of the tumor. These findings suggest that the different expression of CD44 in melanocytic nevi may contribute to different biological behavior between acquired and congenital meanocytic nevi. and CD44 seems to be related to metastasis and tumorigenesis of the malignant melanoma.

고정상태에서 경상용차용 타이어의 진동특성

김용우,최동수,김병삼 순천대학교 2000 순천대학교 자연과학논문집 Vol.19 No.1

To investigate differences between the dynamic characteristics of two kinds of light-duty truck tires, modal testings have been performed on radial tire and bias tire under constrained condition. Through the test, modal parameters, such as natural frequencies, modal decay rates and mode shapes, were obtained. The mode shapes in direction of circumference and of meridian are presented. The test results have shown that the modal frequencies of bias tire are much higher than the corresponding values of radial tire with a similar mode shape, which is in accordance with the fact that the radial rigidity of bias tire is higher than that of radial tire. Most of the modal decay rates of bias tire are larger than those of radial tire within the scope of this experiment. In the frequency domain range of test, the bias tire has extra mode which do not occur in the radial tire. This difference is based on the fact that the circumferential rigidity of the bias tire is quite low whereas that of radial tire is so high that the frequencies of the corresponding modes are out of the frequency range of test. As the inflation pressure increases, the natural frequencies are increased while most of the modal decay rates remain constant or are decreased slightly.

전주산업단지 및 주변지역 VOCs 및 악취물질 모니터링

김용문,박비오,고영삼,심재정,송병식,양고수 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

Important main odorous compounds and VOCs(volatile organic compounds) possibly emitted from the Jeon-Ju Industrial Sites were identified and measured in amount through making air sampling over Jeon-Ju Industrial Sites and analyzing them with the sate of the art analytical instrument. Sampling sites were chosen 8 points by considering the industrial characteristics for the 1,2 Industrial Sites and 2 points for the 3 Industrial. Site Sampling times were two times, the first one was March. 2002 - April. 2002, and the second was May. 2002 - July. 2002. Canister sampling units and polyester bags were used to collect 6 liters air samples during 1hour or 3minutes for VOCs and polyester bags were used to sample 10 - 50 liters of air for 3 minutes depending on analytic characteristics of odor compounds. The important main VOCs were measured as acetone, ethyl benzene, n-hexane, m,p-xylene, toluene, M.E.K.(methyl ethyl ketone), isopropanol, ethyl acetate, o-xylene, n-butyl acetate, ethanol, benzene as in order of average concentration for the Industrial Sites. The main odorous compounds were COS, H2S, CS2, MM(methyl mercaptan), form aldehyde, acetaldehyde for the 1,2 Industrial Sites and COS, H2S, form aldehyde, acetaldehyde were measured as main species for the 3 Industrial Site. NH3 was measured as below the detection limit of the instrument. The concentrations of sulfide compounds for the 1,2 Industrial Sites were relatively higher than ones for the 3 Industrial Site. Among aldehydes, form aldehyde, acetaldehyde were detected very highly as 0.1- 1ppm over all the Industrial Sites.