뇌 아밀로이드 혈관병과 고혈압성 뇌출혈의 감별에 있어서 Apolipoprotein Eε4와 점상 출혈 분포의 유용성

김용범,이광호,이수주,나덕렬,조수진,정진상,이원용 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

네이티브 광고의 브랜드 및 제품 노출이 수용자의 광고 인지와 태도, 공유 의도에 미치는 영향

이수범(Lee, Soo?Bum),송민호(Song, Min?Ho),문원기(Moon, Won?Ki),신명희(Shin, Myoung?Hee) 한국광고홍보학회 2016 광고연구 Vol.0 No.111

본 연구는 60명을 대상으로 아이트래킹과 실험연구를 병행하여 네이티브 광고의 효과를 파악하기 위해 네이티브 광고에 대한 인지, 수용자 태도, 공유 의도를 검증하였다. 구체적으로 네이티브 광고를 콘텐츠와 브랜드 및 제품의 노출 형태(직접 노출/간접 노출)를 고려하여 두 유형의 네이티브 광고에 대한 시각적 주의가 피험자들의 광고 인지에 미치는 영향을 비교하였다. 또한 두 유형의 네이티브 광고에 대한 태도(콘텐츠 태도, 브랜드 태도, 공유 의도)를 측정하여 각 유형에 따른 차이를 비교하였다. 분석결과, 직접 노출 형태의 네이티브 광고의 구성 요소 중 콘텐츠 본문에 브랜드 관련 문구를 포함하였을 때 피험자들의 광고 인지에 긍정적인 영향을 미치는 것으로 나타났다. 또한 각 노출 유형별 콘텐츠 태도의 차이는 유의미하지 않았으나, 직접 노출일 때 브랜드 태도가 더 호의적인 것으로 나타났다. 마지막으로 직접 노출일 때 네이티브 광고의 공유 의도는 상대적으로 높게 나타났다. 이러한 결과를 종합하여 네이티브 광고 제작을 위한 실무적 제언을 담았다. This study explored the effects of native advertising on readers’ recognition, attitude, and sharing intention. This study used both quasiᐨexperiment and eyeᐨtracking for 60 participants to analyze advertising effectiveness (Attitudes toward contents/brands, and sharing intention) of two types native advertisements such as brand exposure (direct/indirect). According to the result of this study, direct exposure type ads had a high advertisement recognition that included brand wording in ad contents. In addition, there was no significant difference of attitudes toward contents among each ad types but direct exposure type ads had more favorable brand attitude than indirect type ads. Finally, this study also showed that the sharing intention of direct exposure type ads were higher than indirect type ads. Based on the findings, this study provided a practical implication for the production of native advertising.

수근관 증후군에서의 무증상성 척골신경병증

문준식,이성수,이지용,한범기,권준범,양현덕,이성익 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

당뇨병 환자에서 혈장 Thrombin-Antithrombin Ⅲ 및 Plasmin-α_2-Plasmin Inhibitor 복합체의 임상적 의의

김경욱,김은숙,정상수,윤수지,박우일,이준희,남수연,안철우,문병수,김경래,차봉수,송영득,임승길,이현철,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:당뇨병 환자에서 혈액응고 및 섬유소용해 체계의 이상경향이 있어 그 결과로 여러 혈관합병증의 발생위험이 높다는 사실은 널리 알려져 있다. 그 기전은 아직 확실히 밝혀지지 않았으나, 고혈당으로 인한 혈장 단백질들의 비효소성 당화작용이나 산화성 스트레스로 인한 유리 라티칼 작용으로 응고항진이나 섬유소용해 활성의 저하를 유발하는 것으로 생각되고 있다. 최근 응고 및 용해인자와 그 억제자의 복합체들의 증가가 이 상태를 비교적 예민하게 반영한다고 알려져 있다. 방법:본 연구에서는 당뇨병 환자 101명과 정상 대조군 20명에서 혈장내 thrombin­antithrombin complex(TAT)와 plasmin­α₂­plasmin inhibitor complex(PIC)를 측정하여 비교하고, 당뇨병 환자에서 미세혈관 합병증과 대혈관합병증의 유무에 따른 차이와, 이미 혈관 질환의 위험인자로 알려져 있는 인자들간의 상관성을 알아보고자 하였다. 결과:1. 환자의 분포를 살펴보면 혈관합병증이 있는 군은 85명, 혈관합병증이 없는 군은 16명이었고, 평균연령은 각각 57.9±14.1세, 49.9±16.6세로 혈관 합병증이 있는 군에서 더 나이가 많았고, 체질량지수는 23.2±3.4㎏/㎡, 24.1±3.4㎏/㎡로 두 군간 유의한 차이는 없었다. 또 두 군간의 혈압 및 HbA1c, 공복혈당 및 인슐린과 C­peptide, 총 콜레스테롤, 중성지방, HDL­콜레스테롤, Lp⒜는 유의한 차이가 없었고, 미세혈관합병증이 있는 군에서 당뇨병의 유병기간이 길었다. 2. TAT 및 PIC의 농도는 정상 대조군에서는 2.8±1.2 ng/mL, 240.4±69.7 ng/mL이었고, 당뇨병 환자군에서는 9.5±22.6 ng/mL, 472.2±258.7 ng/mL이었다. TAT와 PIC 모두 당뇨병 환자군에서 정상 대조군에 비해 유의하게 증가되어 있었고(p<0.001), TAT/PIC ratio는 두 군간 차이가 없었다. 3. 당뇨병 환자의 혈관합병증에 따른 TAT 및 PIC, fibrinogen 농도는 합병증이 없는 군은 각각 4.1±2.4ng/mL, 362.2±272.0ng/mL, 322.7±102.4mg/mL으로 PIC와 fibrinogen의 증가를 보였으나, 연령을 보정한 후에는 통계학적 유의성은 없었다. 또 대혈관 합병증군에서는 각각 6.0±4.9 ng/mL, 507.4±321.6 ng/mL, 427.1±194.7 mg/dL이었으며 미세·대혈관 합병증군에서는 10.4±6.4 ng/mL, 484.8±269.7 ng/mL, 388.4±132.4 mg/dL으로 TAT의 증가를 보였으나 역시 연령을 보정한 후에는 통계학적 유의성은 없었다. 4. 미세혈관합병증군에서 HbA1c(>8%)가 높은 군의 PIC 농도가 유의하게 높았고(p=0.049), 대혈관합병증군에서 HbA1c(>8%)가 높은 군의 총 콜레스테롤 농도가 유의하게 높았다(p=0.042). 5. 총 당뇨병 환자군에서 PIC는 fibrinogen과 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며(r=0.47, 0.31,-0.25), 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다(r=0.67). 결론:이상의 결과에서 혈장 TAT 및 PIC 농도는 당뇨병 환자에서 정상 대조군에 비해 의미있게 증가되어 있었고, 당뇨병 환자군에서는 연령의 증가와 유병기간이 혈액응고항진 및 용해의 장애에 큰 역할을 함을 알 수 있었으며, 총 당뇨병 환자군에 PIC와 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다. 따라서 당뇨병 환자에서 혈액응고 및 용해의 장애가 동반되어 있다고 볼 수 있으며, 혈장 TAT 및 PIC는 혈관합병증으로의 진행을 예측하는 지표로서 유용하리라 생각된다. 또 혈당조절정도와 상관성이 있으므로 혈당조절후에 추적검사를 시행하여 합병증의 예방이 가능한지 추후 연구가 필요하리라 생각된다. Background : Abnormality of coagulation and fibrinolystic system is known as a predisposing factor of vascular complication in diabetes. Although the pathogenesis is not well known, non-enzymatic glycation reaction and the increase in production of free radicals due to an increased oxidative stress may be linked to the hypercoagulibility and hypofibrinolytic activity. As indices of abnormality in coagulation and firinolysis in peripheral blood, plasma thrombin-antithrombin Ⅲ complex (TAT) and plasmin-α_2-plasmin inhibitor complex (PIC) were measured. The purpose of this study was to clarify whether hypercoagulability exists in diabetic patients with or without vascular complication. Methods : In our study, we measured plasma thrombin-antithrombin Ⅲ compelx (TAT) and plasmin-α_2-plasmin inhibit or complex (PIC) in 101 diabetic subjects and 20 controls. Comparing TAT and PIC levels in diabetic microvascular complication group, diabetic macrovascular complication group and controls, we examined correlation between risk factors associated with diabetic vascular complication. Results : 1. The group with diabetic vascular complication was older than group without complication. There was no significant difference in BMI, blood pressure, HbA_ic, blood sugar level, insulin, C-peptide, serum creatinine, total cholesterol, triglyceride, HDL-cholesterol, Lp (a) between two groups. The group with diabetic microvascular complication had longer duration of diabetes. 2. Concentration of TAT and PIC were 2.8±1.2 ng/ mL, 240.4±69.7 ng/ mL in controls and 9.5±22.6 ng/ mL, 472.2±258.7 ng/ mL in diabetic patients, respectively. TAT and PIC were significantly higher in diabetic patients than in control (p<0.001). But TAT/PIC ratio was no significant difference between two groups. 3. In diabetic patients, concentration of TAT and PIC and fibrinogen were respectively 4.1±2.4 ng/ mL, 362.2±272.0 ng/ mL, 322.7±102.4 mg/ dL in group without vascular complication and 5.3±4.1 ng/ mL, 529.5±258.7 ng/ mL, 374.9±106.2 mg/ dL in group with microvascular complication, which group had increase in PIC and Fibrinogen but no significance after correction of age. Concentration of TAT and PIC and Fibrinogen were 60.±4.9 ng/ mL, 507.4±321.6 ng/ mL, 427.1±194.7 mg/ dL in macrovascular complication, and 10.4±6.7 mg/ mL, 484.8±269.7 ng/ mL, 388.4±132.4 mg/ dL in combined vascular complication which group showed increase of TAT but also had no significant increase after correction of age. 4. In diabetic microvascular complication patients, group of high HbA_1c (>8%) (p=0.049) had significant high PIC concentration. In diabetic macrovascular complication patients, group of high HbA_1c (>8%) (p=0.042) had significant high total cholesterol concentration. 5. In all diabetic patients, PIC was positively correlated with fibrinogen and HbA_1c and negatively correlated BMI (r=0.47, 0.31, -0.25). Only in daibetic patients without angiopathy, TAT was positively correlated with HbA_1c (r=0.67). Conclusion : In this study, plasma TAT and PIC concentration significantly increased in diabetic patients compared with controls, and PIC was increased in group with microvascular complication, TAT were increased in group with combined micro macrovascular complication. However, there was no significance relationship existed when correctinf for age. PIC was correlated with HbA_1c. TAT was correlated with HbA_1c only in the group without angiopathy. Abnormality of coagulation and fibrinolysis were combined in diabetes, plasma TAT and PIC can be used as an index of vascular complication. Also we found the correlation with the degree of the blood glucose control. Therefore we need follow up study for the possibility of prevention of vascular complication after controlling the blood glucose to age-matched patients (J Kor Diaabetes Asso 25:354~363, 2001).

정지가동상태에서 자동차에 의한 오염물질 배출에 관한 연구

이범진,이성수,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

This study was conducted to evaluate the levels of exhaust emission of vehicles from Yesan Gun area. During 1995 through 1996, 360 vehicles were sampled randomly and analyzed by vehicle owner's characteristics, owner's vehicle manufacturing companies, owner's vehicle purchase types(new or used), owner's vehicle residence, owner's vehicle types, vehicle fuels used, vehicle mileages, and vehicle model years, also vehicle exhaust emissions on idling condition were measured. To evaluate the exhaust emissions of the diesel engine vehicles(n=140) by particulate, those of the gasoline engine vehicles (n=220) were examined by CO and HC. The results were as follows; 1. The frequency of vehicle owner's gender was 287 persons in male and 18 persons in female, whereas that of vehicle purchase types(new or used) was 306 persons in new vehicles and 53 person in used vehicles. The frequency of owner's vehicle residence was 214 persons in town area and 144 persons in rural area, whereas that of owner's vehicle manufacturing companies was 141 persons in A company vehicles, 141 person in B company, 42 persons in C company, and 35 persons in D company. 2. The mean value of vehicle model years was 3.2±2.9 years in gasoline engine vehicles and 3.1±1.8 years in diesel engine vehicles, whereas that of vehicle mileage was 5.6±4.3(10,000Km) in gasoline engine vehicles and 6.1±6.5(10,000Km) in diesel engine vehicles. But no significant difference in vehicle model years and vehicle mileages between the diesel engine vehicles and the gasoline engine vehicles was observed The mean value of vehicle exhaust emission of CO or HC was 0.70 ± 1.75 ppm (CO) and 93.29 ± 127.96 ppm (HC) in gasoline engine vehicles, respectively, whereas that of vehicle exhaust emission of particulate was 34.31 ± 12.02 in diesel engine vehicles. 3. In pearson's correlation analysis of gasoline engine vehicles, HC was correlated with CO(r=0.64, p=0.0001), vehicle mileage(r=0.25, p=0.0002), vehicle model year(r=0.23, p=0.0006), and remnant period of regular exhaust emission examination(r=0.09, p=0.1925). In pearson's correlation analysis of diesel engine vehicles, particulate was correlated with remnant period of regular exhaust emission examination(r=0.16, p=0.0599), vehicle model year(r=0.09, p=0.2745), and vehicle mileage(r=0.01, p=0.8297). 4. Multiple linear regression analysis using CO as dependent variable and selected variables(owner's gender, owner's age, vehicle manufacturing company, vehicle purchase type, remnant period of regular exhaust emission examination, vehicle mileage, and vehicle model year) as independent variables, revealed that none of them was significant to the dependent variable. Multiple linear regression analysis using HC as dependent variable and selected variables as independent variables, revealed that owner's gender was significant(p=0.012) to the dependent variable, and vehicle model year was marginally significant(p=0.063). Multiple linear regression analysis using particulate as dependent variable and selected variables as independent variables, revealed that vehicle model year was significant(p=0.015) to the dependent variable, and vehicle mileage was marginally significant(p=0.096). 5. Logistic analysis of the excess of exhaust emission criteria of CO with selected independent variables(owner's gender, owner's age, vehicle manufacturing company, vehicle purchase type, remnant period of regular exhaust emission examination, vehicle mileage, and vehicle model year) indicated that only vehicle model year was significant to the dependent variable(odds ration=1.233, 95% confidence interval : 1.094- 1.389). Logistic analysis of the excess of exhaust emission criteria of HC or particulate with selected independent variables indicated that none was significant to the dependent variable, respectively.

수중 기계식 폭기기의 현장조건에서 산소전달율 평가

이국희,김종수,이범구 선문대학교·중소기업기술지원연구소 1998 선문공대 연구/기술 논문집 Vol.3 No.1

공황장애에서 Paroxetine 단기약물치교가 심리적 상태에 미치는 영향

이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

공황장애에서 Paroxetine 단기약물치료가 심리적 상태에 미치는 영향

이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

Objectives : This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological Pre-dictors of treatment response. Methods : Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by Pa-roxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sen&itivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. Results : Panic patients showed significant improvement in seventy of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective seventy was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). Conclusion : This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without ago-raphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on Catastro-phic thoughts may play an important role in symptom improvement in panic disorder.

The Study on the Speed of the Biased Random Walk on Galton-Watson Trees

이범수 世明大學校 1998 世明論叢 Vol.7 No.-

끝없이 이어지는 Galton-Watson 분지 과정을 표현하는 트리상에서 뿌리로 향하는 성질을 가지는 임의 걸음에 대하여 생각해 보았다. 걸음이 출발점으로 돌아오지 않는다면 속도의 하계를 구하므로써 속도가 양이라는 사실은 알려져 있다. 본 논문에서는 몇 가지 상계를 구하거 정확한 속도를 구했다.

1. 06㎛ Nd : YAG Laser를 이용한 요추간판탈출증의 경피적 수핵감압술

이흥선,변박장,최순관,신원한,권귀향,이인수,이경석,김범태 순천향대학교 1994 논문집 Vol.17 No.4

The 1.06㎛ Neodymium-YAG Laser(800 micron hemisherical) is revealed a useful tool for percutaneous laser disc decompression(PLDD). Especially PLDD would be applied to the management of lumbar disc herniation with minimal intervention. Total irradiated energy to one level of disc space was bout 1000 to 2000 joules. We performed this method at 10 levels, in 7 cases of patients, consisting of 4 males and 3 females with an average age of 37.7 years. Five cases showed excellent and good results, were observed. In two cases, open surgery was required because of unsatisfactory results. The best results were obtained in the protrusion type of disc herniation. We have summarized some advantages of PLDD: a) safe and simple procedure in an outpatient setting, b) avoiding general anesthesia, late spinal instability, c) possibility of repetitive use.