Clinical and Biochemical Characteristics of Elderly Patients With Hyperglycemic Emergency State at a Single Institution

Yun Jae Shin,Dae In Kim,Dong Won Lee,Beung Kwan Jeon,Jung Geun Ji,Jung Ah Lim,Young Jung Cho,Hong Woo Nam 대한노인병학회 2016 Annals of geriatric medicine and research Vol.20 No.4

Background: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are two of the most serious acute complications of diabetes mellitus. In this study, we investigated the clinical characteristics of elderly diabetic patients in a hyperglycemic emergency state. Methods: We reviewed the medical records of elderly patients admitted with a diagnosis of DKA and HHS over the past 5 years at the National Medical Center in Korea. Patients were divided into 3 groups: those with only DKA, those with only HHS, and those with both DKA and HHS. We assessed the clinical characteristics, economic vulnerability, precipitating factors, and hospital mortality. Results: Twenty-seven patients (31 episodes) fulfilled the inclusion criteria. Nineteen episodes occurred in male patients. The mean age, blood glucose, and glycosylated hemoglobin (HbA1c) were 78.9 years, 700.7 mg/dL, and 10.6%, respectively. The mean mortality rate was 22.5%; the mortality rates of the DKA only group, the HHS only group, and the group with both DKA and HHS were 10%, 23%, and 37.5%, respectively. DKA was diagnosed in 10 patients (32%), HHS was diagnosed in 13 patients (42%), and both DKA and HHS were diagnosed in 8 patients (26%). There was no relationship between age, sex, economic vulnerability, HbA1c, insulin use, and mortality rate. However, the mortality rate was higher than that of a previous report. Self-discontinuation of diabetes medication and infections are the most common precipitating factors. Conclusion: Elderly patients with diabetes are prone to experience hyperglycemic emergency and have a high mortality rate. Therefore, more focused education and a social medical service system for those with diabetes should be instituted.

한국인 바렛식도에서 p53과 Ki-67 단백의 면역조직화학 발현

김창환 ( Chang Whan Kim ),이보인 ( Bo In Lee ),김병욱 ( Beung Wook Kim ),김진일 ( Jin Il Kim ),박수헌 ( Soo Heon Park ),김재광 ( Jae Kwang Kim ),한석원 ( Sok Won Han ),정인식 ( In Sik Jung ),선희식 ( Hee Sik Sun ),이아원 ( A Won L 대한소화기학회 2005 대한소화기학회지 Vol.46 No.3

목적: 바렛식도는 식도선암의 전구병변으로 원주상피로 치환된 식도상피의 특수장상피화생에서 이형성이 존재할 경우 식도선암의 발생과 관련이 깊다. 최근 한국에서 역류 식도질환이 증가하고 있지만 아직 바렛식도와 식도선암의 유병률은 서구에 비해 현저히 낮다. 이에 저자들은 바렛식도의 암성 변화의 예측에 유용한 p53과 Ki-67단백의 면역조직화학 발현 양상을 알아보고자 하였다. 대상 및 방법: 상부위장관 내시경검사에서 원주상피로 치환된 식도상피의 변화가 관찰되어 바렛식도의 확진을 위해 식도 조직검사를 시행한 95명을 대상으로 하였다. 특수장상피화생의 진단을 위해 모든 생검 예에서 alcian blue 염색(pH 2.5)을 시행하였고, 장형화생의 유무를 관찰하기 위해 high ion diamine 염색을 하였다. 그리고 전 예에서 p53과 Ki-67 면역조직화학 검사를 시행하였다. 결과: 내시경검사에서 바렛식도가 의심되었던 95명 중 55명(57.9%)에서 특수장상피화생이 관찰되었고 전 예에서 이형성은 없었다. 이들 55명 중 31명(56.4%)에서 sulfomucin 양성인 장형화생이 관찰되었다. 바렛식도로 조직 진단을 받은 55명 중 6명(10.9%)에서 p53 단백질의 핵내 침윤소견이 관찰되었고 이들 6명 모두에서 장형화생이 존재하였다. Ki-67 표지지수는 특수장상피화생이 있거나 p53 양성일 때 상대적으로 높게 나타났으나 유의성은 없었다. 결론: 바렛식도 환자에서 p53 단백질이 발현된 경우는 10.9%로 이들 모두에서 장형화생을 동반하고 있어 한국인에서도 바렛식도는 이형성의 발생이나 암성변화의 위험도가 높은 전암병소이며 향후 이들에 대한 추적 검사가 필요하다. Background/Aims: Barrett`s esophagus is a premalignant lesion of the esophagus in which normal squamous epithelium is replaced by intestinalized columnar epithelium. In Korea, adenocarcinoma associated with Barrett`s esophagus is rare compared with that of Western country. The purpose of this study was to investigate the immunohistochemical expression of p53 and Ki-67 in Barrett`s esophagus which had predictive value for cancer risk in Korea. Methods: Ninety five patients (43 male and 52 female, median age 44, range 21-75) who have been suspected to have Barrett`s esophagus by endoscopic assessment were enrolled in this study. Alcian blue (pH 2.5) and high ion diamine stain for the evaluation of specialized intestinal metaplasia (SIM) and immunohistochemical stain for p53 and Ki-67 were done. Results: 57.9% (55/95) of biopsies from the columnar lined esophagus showed SIM, but no dyspalsia. 56.4% (31/55) of Barrett`s esophagus showed sulfomucin positive colonic metaplasia. The p53 expression was observed in 10.9% (6/55) of the patients of Barrett`s esophagus and all of them showed colonic metaplasia. Ki-67 labeling index showed no difference significantly. Conclusions: In Korea, 10.9% of Barrett`s esophagus had p53 mutation and moreover all of them had colonic metaplasia. Consequently, we expect that these patients have high risk of developing dysplasia and adenocarcinoma and need careful follow-up. (Korean J Gastroenterol 2005;46:189-195)

Monitoring the soil chemical properties of paddy fields in Korea

( Beung Gan Jung ),( In Sang Jo ),( Jung Hui Yoon ),( Yoo Hak Kim ),( Moon Hee Park ) 한국토양비료학회 2001 한국토양비료학회 학술발표회 Vol.2001 No.-

Monitoring the soil chemical properties of paddy fields in Korea

Beung Gan Jung,In Sang Jo,Jung Hui Yoon,Yoo Hak Kim,Moon Hee, Park 한국토양비료학회 2001 한국토양비료학회 학술발표회 초록집 Vol.2001 No.5

Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice

Ahn, Beung-Chul,Pyo, Kyoung-Ho,Xin, Chun-Feng,Jung, Dongmin,Shim, Hyo Sup,Lee, Chang Young,Park, Seong Yong,Yoon, Hong In,Hong, Min Hee,Cho, Byoung Chul,Kim, Hye Ryun Springer; 1999 2019 Journal of Cancer Research and Clinical Oncology Vol.145 No.6

<P><B>Purpose</B></P><P>Immune checkpoint inhibitors (ICI) have shown marked responses in patients with non-small cell lung cancer (NSCLC) in clinical trials. However, because such trials comprise cohorts selected based on specific criteria, it is unclear if their results represent routine clinical practice.</P><P><B>Methods</B></P><P>We examined 155 patients with advanced NSCLC who were administered either nivolumab or pembrolizumab at Yonsei Cancer Center, Korea between March 2014 and January 2019. Patient characteristics, <I>EGFR</I>/<I>ALK</I> mutation status, metastatic locations, response to ICIs, and adverse events were retrospectively analyzed.</P><P><B>Results</B></P><P>The median age was 64 years and 72.9% of patients were male; former or current smokers constituted 67.1% of the subjects. Adenocarcinoma was predominant (67.7%), and 50.3% of the patients underwent ≥ 2 previous treatments. Twenty-three patients (14.8%) were <I>EGFR</I> mutation- or <I>ALK</I> rearrangement-positive. The objective response rate (ORR) was 23.9% [95% confidence interval (CI) 17.4–31.4%]; the median progression-free survival (PFS) and overall survival (OS) were 3.06 (95% CI 1.893–4.21) and 10.25 (95% CI 5.39–15.11) months, respectively. Multivariate analysis identified ECOG performance status, <I>EGFR</I> mutation/<I>ALK</I> rearrangement status, liver metastasis and PD-L1 proportion as independent predictors of OS. Furthermore, 61.9% of the patients had adverse events of any grade; 38.1% had immune-related adverse events that were associated with PFS and OS on multivariate analysis.</P><P><B>Conclusions</B></P><P>The real-world ORR, PFS, OS, and adverse event profiles were comparable to previous clinical trials despite the patients’ different baseline characteristics. Our findings can aid in establishing effective immunotherapeutic management of NSCLC in routine clinical practice.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1007/s00432-019-02899-y) contains supplementary material, which is available to authorized users.</P>

오미자(Schisandra chinensis Baillon)로 부터 추출한 리그난이 고추종자의 발아에 미치는 영향

Woo Jung Shin(신우정),You Jin Lee(이유진),Beung Gu Son(손병구),Jum Soon Kang(강점순),Yong Jae Lee(이용재),Young Hoon Park(박영훈),Young Geun Lee(이영근),Yong Cheol Kim(김용철),In Soo Choi(최인수),Sun Tae Kim(김선태),Young Whan Cho 한국생명과학회 2010 생명과학회지 Vol.20 No.3

오미자의 헥산 추출물로부터 dibenzocyclooctadiene류인 schisandrin 1143.7 ㎎, schisandrin C 317.3 ㎎, gomisin A 261.4 ㎎ 및 gomisin N 213.4 ㎎을 순수분리하여 구조를 동정하였다. 각각의 리그난은 ¹H-NMR, 13C-NMR 및 GC-MS 스펙트럼으로부터 구조를 동정하였다. 오미자로부터 분리한 schisandrin, schisandrin C, gomisin A 및 gomisin N을 10<SUP>-5</SUP> M, 10<SUP>-6</SUP> M 및 10<SUP>-7</SUP> M로 조정한 용액에 1시간 침지 후 발아율을 비교하였다. Gomisin A의 처리 시 모든 농도에서 발아율이 억제되었고, 농도가 높을수록 발아 억제효과가 높았다. Gomisin N처리 시에는 대조구에 비하여 모든 농도에서 발아율이 높았다. 리그난 처리 48시간 후 발아율은 대조구와 비교한 결과, schisandrin C와 gomisin A는 발아율을 억제하였다. 따라서 오미자로부터 추출한 리그난은 종자발아를 촉진시키는 효과가 있었고, 이차대사산물로서는 많이 함유되어 있으므로 생장조절제로서 이용가능이 있을 것으로 기대한다. In this study, the effects of dibenzocyclooctadiene on seed germination were investigated in pepper. Four C18 dibenzocyclooctadiene lignans - schisandrin (1143.7 ㎎), schisandrin C (317.3 ㎎), gomisin A (261.4 ㎎) and gomisin N (213.4 ㎎) - were isolated from hexane extracts of the fruits of Schisandra chinensis. The molecular structures of the four lignans were elucidated based on spectroscopic analyses including 1D NMR experiments, and by comparing their spectroscopic data with those of previous literatures. Seeds were immersed in 10<SUP>-5</SUP> M schisandrin, 10<SUP>-6</SUP> M schisandrin C, and 10<SUP>-7</SUP> M gomisin A and gomisin N for 1 hr and incubated at 25℃ in the dark for germination. Compared to untreated control, treatment with schisandrin C and gomisin A suppressed seed germination at 48 hrs after incubation, whereas treatment with gomisin N increased germination rate at 48 hrs after incubation. The results of the germination activity of the lignans from S. chinensis confirm their potential plant growth role, and the relative natural abundances of these metabolites suggest their potential use as natural plant growth regulators.

Quenching of Ofloxacin and Flumequine Fluorescence by Divalent Transition Metal Cations

Hyoung-Ryun Park,Chu-Ha Oh,Hyeong-Chul Lee,Jae Gyu Choi,Beung-In Jung,Ki-Min Bark* 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.12

This study examined the quenching of ofloxacin (OFL) and flumequine (FLU) fluorescence by Cu2+, Ni2+, Co2+ and Mn2+ in an aqueous solution. The change in the fluorescence intensity and lifetime was measured at various temperatures as a function of the quencher concentration. According to the Stern-Volmer plots, the fluorescence emission was quenched by both collisions (dynamic quenching) and complex formation (static quenching) with the same quencher but the effect of static quenching was larger than that of dynamic quenching. Large static and dynamic quenching constants for both OFL and FLU support significant ion-dipole and orbital-orbital interactions between fluorophore and quencher. For both molecules, the static and dynamic quenching constants by Cu2+ were the largest among all the metal quenchers examined in this study. In addition, both the static and dynamic quenching mechanisms by Cu2+ were somewhat different from the quenching caused by other metals. Between Ni2+ and FLU, a different form of chemical interaction was observed compared with the interaction by other metals. The change in the absorption spectra as a result of the addition of a quencher provided information on static quenching. With all these metals, the static quenching constant of FLU was larger than those of OFL. The fluorescence of OFL was quite insensitive to both the dynamic and static quenching compared with FLU. This property of OFL can be explained by the twisted intramolecular charge transfer in the excited state.

갈색세포종 환자 1례의 임상증례(臨床證例) 보고

김국범,한종현,한인선,김은곤,이정희,강병철,성경화,최영규,심윤섭,Kim, Guk-Bum,Han, Jong-Hyun,Han, In-Sun,Kim, Eun-Gon,Lee, Jung-Hi,Kang, Beung-Chul,Seung, Kyung-Wha,Choi, Young-Kuy,Shim, Yun-Seub 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1

Objective : Pheochromocytoma may arise within the adrenal medulla, or in other locations, where symptheic ganglia or chromaffin tissues are known to exist. Approximately 0.1 % of hypertensive patients have Pheochromocytoma, This study is to report the clinical effects of ShiHo-GuiZhiTang on pateints who have suffered from such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort. Method : ShiHo-GuiZhiTang was used for a patient who had suffered from symptoms of Pheochromocytoma which was diagnosed as Banpeubanri-jueng of soyang disease in Sanghan-Ron. Result : In treating the patient with symptoms of Pheochromocytoma with ShiHo-GuiZhiTang, results were good. Conclusion : The results of this study suggest that ShiHo-GuiZhiTang is effective for such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort.

Quenching of Ofloxacin and Flumequine Fluorescence by Divalent Transition Metal Cations

Park, Hyoung-Ryun,Oh, Chu-Ha,Lee, Hyeong-Chul,Choi, Jae-Gyu,Jung, Beung-In,Bark, Ki-Min Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.12

This study examined the quenching of ofloxacin (OFL) and flumequine (FLU) fluorescence by $Cuj^{2+}$, $Ni^{2+}$, $Co^{2+}$ and $Mn^{2+}$ in an aqueous solution. The change in the fluorescence intensity and lifetime was measured at various temperatures as a function of the quencher concentration. According to the Stern-Volmer plots, the fluorescence emission was quenched by both collisions (dynamic quenching) and complex formation (static quenching) with the same quencher but the effect of static quenching was larger than that of dynamic quenching. Large static and dynamic quenching constants for both OFL and FLU support significant ion-dipole and orbital-orbital interactions between fluorophore and quencher. For both molecules, the static and dynamic quenching constants by $Cu^{2+}$ were the largest among all the metal quenchers examined in this study. In addition, both the static and dynamic quenching mechanisms by $Cu^{2+}$ were somewhat different from the quenching caused by other metals. Between $Ni^{2+}$ and FLU, a different form of chemical interaction was observed compared with the interaction by other metals. The change in the absorption spectra as a result of the addition of a quencher provided information on static quenching. With all these metals, the static quenching constant of FLU was larger than those of OFL. The fluorescence of OFL was quite insensitive to both the dynamic and static quenching compared with FLU. This property of OFL can be explained by the twisted intramolecular charge transfer in the excited state.

합곡 침자가 뇌혈류에 미치는 영향에 대한 핵의학적 고찰

이건목,황유진,양유선,김성진,유동수,김민자,조은희,김현중,양명복,이인,이병철 대한침구학회 2001 대한침구의학회지 Vol.18 No.6

Objective : To localize and compare the cerebral regions- activated by the the stimulation of traditional and burning acupunctures in right Hap-Kok (LI4) acupoints. Methods : Thirty-four healthy normal volunteers (19 males, 15 females, age 31±11 years) were studies by rest/acupuncture Tc-99m HMPAO SPECT using same-dose sequential injection method using right Hap-Kok(LI4), traditional and burning acupunctures. All images were spatially normalized and the differences between rest and acupuncture activation state were statistically analyzed using SPM 96. Results : Statistical analysis of the effect by the stimulation using traditional acupuncture in right L14 showed regional cerebral perfusion increase in right inferior frontal lobe, right straight gyrus, left anterolateral frontal lobe, left anteroinferor temporal lobe, left posterior temporal lobe, and left cerebellum. In the stimulation using burning acupuncture in right L14, regional cerebral perfusion increased in right posterior prefrontal lobe, right precental gyrus, right postcentral gyrus, right poteroinferior temporal lobe, left precentral gyrus, left Broca's area, left anterior parietal lobe, left posterior prefrontal lobe, and left cerebellum. In right LA, diffuse perfusion increase were noted in the both inferior frontal lobe by traditional acupuncture compared to burning acupuncture. Conclusion : The results localized the cerebral areas showed the effect of the acupuncture on cerebral blood flow. The effects of traditional and burning acupunctures on cerebral blood flow were similar in right Hap-Kok (L14) acupoints. But the effects of traditional acupunctures on cerebral blood flow are stronger than those of burning acupunctures on cerebral blood flow.