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급성기 뇌경색 환자의 두통에 대한 파한활혈탕(破寒滑血湯)의 임상적 효능
심윤섭,성기원,Shim, Yun-Seub,Seong, Ki-Won 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
Objectives : The purpose of this clinical study is to evaluate the clinical efficacy of Pasaekhwalhyeol-Tang on acute headache from acute cerebral infarct. Methods : Pasaekhwalhyeol-Tang was prescribed to 15 acute cerebral infarct patients for two weeks. Symptoms were checked and VAS(Visual Analog Scale) scores were kept every week. Results : After prescription of Pasaekhwalhyeol-Tang, VAS scores on headache and accompanying symptoms decreased. No significant changes were shown in laboratory findings. As for the laboratory findings, ALT showed an upward tendency within a week and increased over normal values in two cases(13%). But two weeks later, ALT decreased within normal values. And the mean serum level was within normal values and the other hepatic enzymes did not increase over normal values in either week nor week 2. Conclusions : Results suggest that Pasaekhwalhyeol-Tang is effective in reducing the severity of acute headache from acute cerebral infarct.
심윤섭,김국범,한종현,한인선,김은곤,이정희,강병철,성경화,최영규 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Objective: Pheochromocytoma may arise within the adrenal medulla, or in other locations, where symptheic ganglia or chromaffin tissues are known to exist. Approximately 0.1% of hypertensive patients have Pheochromocytoma. This study is to report the clinical effects of ShiHo-GuiZhiTang on pateints who have suffered from such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort. Method: ShiHo-GuiZhiTang was used for a patient who had suffered from symptoms of Pheochromocytoma which was diagnosed as Banpeubanri-jueng of soyang disease in Sanghan-Ron. Result: In treating the patient with symptoms of Pheochromocytoma with ShiHo-GuiZhiTang, results were good. Conclusion: The results of this study suggest that ShiHo-GuiZhiTang is effective for such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort.
심윤섭,천상훈,곽경섭,Shim, Yun-Sup,Chun, Sang-Hun,Kwak, Kyung-Sup 한국전기전자학회 1999 전기전자학회논문지 Vol.3 No.1
The existing CREG-VP, a technique to compensate the successive cell losses caused by traffic congestion using the FEC method on the Vp, has the merits of the short average encoding decoding time and the compatibility with the ATM standard cell format, but it has the restriction in the number of regenerable cells. In this thesis, we propose a scheme to efficiently regenerate the cell losses even in the burst traffic property by the expansion of the CREG-VP. The proposed scheme improves the detection capability of the lost cells by changing the CRP and the regeneration performance of the successive cells by using the interleaved parity cell. The simulation result shows that the proposed method produces much improvements compared with the existing ones in the cell loss rate reduction factor. 기존의 CREG-VP는 VP상에서 FEC기법을 사용하여 트래픽 과잉으로 인한 연속적인 셀 손실을 보상하는 기법으로써, 평균 코딩/디코딩 시간이 짧고, ATM 표준 셀 형식과 호환성을 유지할 수 있다는 장점을 지니고 있으나, 복구할 수 있는 셀의 수에는 제한이 존재한다. 본 논문에서는 CREG-VP를 확장하여 버스트 특성을 갖는 트래픽에서도 효과적으로 셀 손실을 복구하는 기법을 제안하였다. 제안된 기법은 CRP를 변경하여 셀 손실의 검출 성능을 향상시켰고, 인터리브 패리티 셀을 적용하여 연속적인 셀의 복구성능을 향상시켰다. 실험 결과 제안된 기법은 CREG-VP 방식보다 셀 손실률 감소 계수를 향상 시킴을 알 수 있었다.
심윤섭,송호섭 대한침구의학회 2014 대한침구의학회지 Vol.31 No.2
Objectives : We investigated whether snake venom toxin(SVT) from Vipera lebetina turanica sensitizes HT29 human epithelial colorectal cancer cells to tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) induced apoptosis in cancer cells. Methods : Cell viability assay was used to assess the inhibitory effect of TRAIL on cell growth of HT29 human colorectal cancer cells. And 6-diamidino-2-phenylindole(DAPI), terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay(TUNEL) staining assay were used to evaluate cell-apoptosis. Western blot analysis were conducted to observe apoptosis related proteins and death receptor. To assess whether the synergized inhibitory effect of SVT and TRAIL on reactive oxygen species(ROS) generation was reversed by strong anti-oxidative agent. Results : SVT with TRAIL inhibited HT29 cell growth different from TRAIL alone. Consistent with cell growth inhibition, the expression of TRAIL receptors; Expression of death receptor(DR)4 and DR5 was significantly increased and intrinsic pro-apoptotic cleaved caspase-3, -9 was subsequently increased together with increase of Bax/Bcl-2 ratio and extrinsic pro-apototic caspase-8 was also activated. In addition, the expression of anti-apoptotic survival proteins, a marker of TRAIL resistance(eg, cFLIP, survivin, X-linked inhibitor of apoptosis protein(XIAP) and Bcl-2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the ROS scavenger N-acetylcysteine abolished the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the intrinsic pro-apoptotic caspase-3 and-9. Conclusion : The collective results suggest that SVT facilitates TRAIL-induced apoptosis in HT29 human epithelial colorectal cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 and consecutive induction of bilateral apoptosis via regulating apoptosis related proteins.
심윤섭,변지환,황순현,전태보,Shim, Yun-Seop,Byeon, Ji-Hwan,Hwang, Soon-Hyun,Jeon, Tae-Bo 강원대학교 산업기술연구소 2011 産業技術硏究 Vol.31 No.2
Simulation plays a pivotal role in the analysis of complex systems. In this study, a job shop manufacturing system has been analyzed through DBR (Drum-buffer-rope) simulation. Specific attention has been put to examine the rate of due-date achievement. We first derived key factors affecting the system performance. We then developed ARENA simulation program based on DBR of TOC (Theory of Constraints) concepts. Based on the performance measure, factors, and experimental design, we obtained the results. We have drawn meaningful results through examination of the results. The results obtained from this study may provide a good base for practical applications.