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열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
이석호,옥치석,최보경,김영옥,최리나,박상애,최명신,김길수,이강춘 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
아크리놀은 살균,소독에 쓰이는 약물로서 연로제 및 지사제용도의 경구투여제제등게 이용되고 있다. 공정서에 수재된 아크리놀의 분석법은 적정법이고 제제에서늬 분석법은 확립되지 않았고 원료의 적정법을 제제에 적용시 다른 주성분이나 부형제 또는 안정제 드으이 영향으로 분석오차가 생길 우려가 있다. 따라서 아크리놀을 보다 신속·정확하게 확인 및 정량분씬을 할 수 있고 강도와 분리능이 우수한 HPLC를 이용하여 아크리놀을 분석하고자 하였다. MPLC 분석조건은 이동상 :아세료니트릴 · 1% 인산일수소나트륨혼합액(40:60)(p템 5.2), 칼랏 :옥타데실실릴화한 실리카칼럼,검출기 :자외부흡광광도계(측정파장 : 254nm)을 사용하여 양호한 결과를 얻었다. 틴PLC법의 분석 결과, 검량선의 상관계수는 0.9999, 재현성(aSD(%))은 0.5234. 정균회수율은 100.28%(RSD=0.89%)로 정량성 및 재현성이 높온 분석 결과를·얻었다. 또한 시판품에 대하여 려PLC분석법과 공정서에 수재된 적정법의 시칩결과를 비교하였을 때 핀Plf법인 더욱 정확한 결과를 얻을 수 있었으므로, 조작이 간편하고 재현성이 높은 딘PLC분석법을 약전차정의 기초자료로 활용하고자 한다. We describe a method for the determination of acrino1 and its preparations by HPLC. The optimum analrtical coriditions were as follows;column : u-Bondapak C_(18) mobile phase : acetonitrile 1% Na_(2)HPO_(4), buffer (40:60)(pH 5.2), detector : 254nm, flow rate 1.OmL/min, injection volumn : 5uL, The calibration curve at 254nm was linear within the range of 10 ~ 140㎍/mL. This HPLC method has been validated to be precise, accurate and linear. This method has also been found to be applicable to other formulations containing acrinol.
Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice
PARK, Shin Ae,JEONG, Seong Mok,YI, Na Young,KIM, Min Su,JEONG, Man Bok,SUH, Jun Gyo,OH, Yang Seok,WON, Moo Ho,NAM, Tchi Chou,PARK, Jae Hak,SEO, Kang Moon Japanese Association for Laboratory Animal Science 2006 Experimental animals Vol.55 No.2
<P>In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.</P>
백양사 사찰림 비자나무 임분의 테르펜류 잔존량과 성분특성
김애란 ( Ae-ran Kim ),양천은 ( Cheon-eun Yang ),허예나 ( Ye-na Heo ),김강산 ( Kang-san Kim ),박종석 ( Jong-suk Park ),김은일 ( Eun-il Km ),안기완 ( Ki-wan An ),김민희 ( Min-hee Kim ) 한국산림경제학회 2018 산림경제연구 Vol.25 No.1
본 연구는 비자나무 임분내의 NVOCs 잔존량을 규명하고 비자나무에서 방출되는 NVOCs의 성분을 규명하고자 수행하였다. 실험은 2017년 4월부터 10월까지, 총 7회에 걸쳐 장성군에 위치한 내장산국립공원 백양지구 내 비자나무 임분에서 이루어졌다. NVOCs의 포집은 가지에 테틀러백을 씌우고 순수공기를 주입시켜 11시부터 12시까지 포집하는 테틀러백 법과 임분 내에서 직접 포집하는 미니펌프법으로 실시하였다. 테틀러백을 이용한 비자나무의 월별 NVOCs 잔존량은 각각 146,156 pptv/4월, 176,786 pptv/5월, 132,466 pptv/6월, 22,908pptv/7월, 73,782pptv/8월, 38,736pptv/9월, 41,233pptv/10월로 측정되었으며, 비자나무 임분 내에서 측정한 월별 NVOCs는 5,169 pptv/4월, 11,940 pptv/5월, 7,657 pptv/6월, 6,864pptv/7월, 13,912pptv/8월, 2,640pptv/9월, 1,828pptv/10월로 나타났다. NVOCs의 15종에 대한 성분을 7회 평균값을 산출한 결과, limonene이 약 43∼52%로 가장 많은 함량을 차지하고 있었으며 α-pinene 은 약 35∼39%의 비율인 것으로 분석되었다. 비자나무를 대상으로 포집방법의 차이에 따른 NVOCs 잔존량은 최소 15배에서 28배까지 차이를 보였으며, NVOCs 성분의 대부분이 limonene과 α-pinene으로 나타났다. 임분내 NVOCs에 대한 기초자료로서 활용될 수 있을 것으로 사료된다. This study aims to identify the NVOCs(Natural Volatile Organic Compound) retention volume of Torreya nucifera stand and the characteristic of chemical compositions of the NVOCs emitted from it. This experiment was performed seven times in total from April to October, 2017 at Torreya nucifera temple forest of Naejangsan National Park Baekyangsa in Jangseong-gun. Two methods were used as the sampling methods of NVOCs. The first one was to use tedlar bags. After placing a tedlarbag over a branch and leafs, we injected pure air into it and captured NVOCs for 2 hours from 11 a.m. to 12 p.m. The second one was to capture NVOCs directly in a stand of Torreya nucifera used mini pump. When tedlarbags were used, the monthly NVOCs retention volumes of Torreya nucifera were 146,156pptv/April, 176,786pptv/May and 132,466pptv/June, 22,908pptv/July, 73,782pptv /August, 38,736pptv/September, 41,233pptv/October respectively. In addition, when measured using minipump in the stand, the monthly NVOCs retention volumes were 5,169 pptv/April, 11,940pptv /May, and 7,657pptv/June, 6,864pptv/July, 13,912pptv/August, 2,640pptv/September, 1,828pptv/October respectively. In order to identify the characteristic of compositions, 15 kinds of terpenes were analyzed, and their average was calculated seven times. As a result, limonene had the highest percentage of 43 to 52%, and α-pinene accounted for 35 to 39%. The NVOCs retention volume depended on the sampling method from Torreya nucifera stand. The highest NVOCs retention volume was at least 15 to 28 times higher, and most components of NVOCs were limonene and α-pinene. It is believed that NVOCs within the domain can be utilized as a baseline.
( Ha Na Kim ),( Chang Hwan Park ),( Eun Ae Cho ),( Soo Jung Rew ),( In Hyung Park ),( Sung Uk Lim ),( Chung Hwan Jun ),( Seon Young Park ),( Hyun Soo Kim ),( Sung Kyu Choi ) 대한간학회 2015 Gut and Liver Vol.9 No.4
Intraductal ultrasonography (IDUS) is one of the most useful diagnostic tools for various extrahepatic biliary diseases. However, conventional IDUS has some limitations in providing accurate cross-sectional imaging of the bile duct in patients with extensive pneumobilia. Using a balloon-sheathed catheter, the US system (balloon-sheathed IDUS) can overcome these limitations. Sixteen patients underwent balloon-sheathed IDUS during endoscopic retrograde cholangiography. The balloon-sheathed IDUS was inserted via a transpapillary route when visualization of the bile duct with conventional IDUS was distorted by extensive pneumobilia. The patient group had a mean age of 65.5 years, and 56.3% (9/16) were male. The balloon-sheathed IDUS permitted successful visualization of the bile duct in all patients, regardless of the extent of pneumobilia. Using this system, remnant common bile duct stones were detected in five patients (31.3%), and cholangiocarcinoma was detected in one patient (6.3%). The balloon-sheath IDUS aided in stone sweeping. No significant complications, including bleeding, perforation, or pancreatitis, occurred in any of the patients. The balloon-sheathed catheter US system was useful and safe for biliary IDUS in patients with extensive pneumobilia. (Gut Liver 2015;9:561-565)
In Ae Cho,Ji Kwon Park,Jong Chul Baek,A Na Ha,Min Young Kang,Jae Ik Lee,Ji Eun Park,Jeong Kyu Shin,Won Jun Choi,Soon Ae Lee,Jong Hak Lee,Won Young Paik 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.2
Distal limb deformities are congenital malformations with phenotypic variability and high genetic heterogeneity. Split hand/ foot malformation, also known as ectrodactyly, is a congenital limb malformation characterized by a defect of the central rays of the hands and/or feet. Split hand/foot malformation with long-bone deficiency (SHFLD) is a rare condition related to a 17p13.3 duplication. Recently, genomic duplications encompassing BHLHA9 have been associated with SHFLD. We report a case of SHFLD presenting with campomelia of the right femur, bilateral agenesis of fibulae, bilateral club feet, and oligosyndactyly of the hands and feet, that was associated with a 17p13.3 duplication, as determined prenatally using array comparative genomic hybridization.
Su Bin Park,Ha Na Kim,Gwang Hun Park,Ho-Jun Son,Hyun Ji Eo,Jeong Ho Song,Hun Min Song,Ji Ae Park,Jin Boo Jeong 한국자원식물학회 2018 한국자원식물학회지 Vol.31 No.3
In this study, we investigated the effect of the extracts from Vaccinium oldhamii on cell proliferation and the regulatory mechanisms of cyclin D1 protein level in human cancer cells. The branch extracts from Vaccinium oldhamii (VOB) showed higher inhibitor effect against the cell growth than leave extracts (VOL) and fruit extracts (VOF) in human colorectal cancer, breast cancer, prostate cancer, non-small lung cancer, pancreatic cancer and liver cancer cells. In addition, VOB decreased cyclin D1 level at both protein and mRNA level. MG132 treatment attenuated VOB-mediated cyclin D1 downregulation. A point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by VOB. In addition, the inhibition of nuclear export by leptomycin B (LMB) attenuated cyclin D1 degradation by VOB. But, the treatment of PD98059 (ERK1/2 inhibitor), SB203580 (p38 inhibitor), SP600125 (JNK inhibitor), LiCl (GSK3β inhibitor), LY294002 (PI3K inhibitor) or BAY 11-7082 (IκK inhibitor) did not affect VOB-induced cyclin D1 degradation. In conclusion, VOB induced cyclin D1 degradation through redistribution of cyclin D1 from the nucleus to cytoplasm via T286 phosphorylation of cyclin D1, which resulted in the inhibition of cancer cell proliferation.
근거기반실무 교육 프로그램이 임상간호사의 근거기반실무 준비도 및 근거기반 의사결정에 미치는 효과
남애리나(Nam, Ae Ri Na),이은호(Lee, Eun Ho),박정옥(Park, Jeong Ok),기은정(Ki, Eun Jung),남수민(Nam, Su Min),박미미(Park, Mi Mi) 한국간호행정학회 2017 간호행정학회지 Vol.23 No.3
Purpose: Today"s clinical nurses deal with complex problems that need accurate evidence for practice and decision making. In this study the effectiveness of an EBP education program was examined. Methods: A pre-posttest design was used for this study and participants were 46 nurses working at a tertiary hospital located in Suwon, Korea. Date collection was done before and after the education program, from July 27 to October 2, 2015. Data were analyzed using paired t-test and ANCOVA with SPSS 21.0. Results: There were significant differences in scores before and after the EBP education program for EBP readiness: belief (t=-5.65, p<.001), implementation(t=-2.89, p=.006), competence (t=-4.21, p<.001), and for evidence-based decision making (t=-16.25, p<.001) by the nurses. Conclusion: The findings indicate that the EBP education program has positive effects on EBP belief, implementation, competence and evidence-based decision making. In the future, it is necessary to reinforce the content of the program in the clinical workplace and to provide continuous education for clinical nurses.