Micronucleus Test of $Scutellariae$ $Radix$ Aqueous Extract in Bone Marrow Cells of Male ICR Mice

정인권,전우현,강수진,구세광,이영준,Chung, In-Kwon,Cheon, Woo-Hyun,Kang, Su-Jin,Ku, Sae-Kwang,Lee, Young-Joon Society of Preventive Korean Medicine 2012 대한예방한의학회지 Vol.16 No.1

Objectives : In this research, the genotoxic effect of $Scutellariae$ $Radix$(SR), the dried roots of $Scutellaria$ $baicalensis$ Georgi has been traditionally used as antipyretic agent, was evaluated using the mouse micronucleus test. Methods : SR aqueous extract(yield = 27.2%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide(CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus(MN) in polychromatic erythrocyte(PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Results and Conclusions : Although significant(p<0.01) increase of the number of PCE with one or more nuclei(MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of SR extracts treated mice with over 0.33 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that SR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels - the limit dosage in rodents.

原著 : 근로자들의 심박변이도 검사를 통한 피로도 분석

장우석 ( Woo Seok Jang ),백경민 ( Kyung Min Baek ),전우현 ( Woo Hyun Cheon ),정인권 ( In Kwon Chung ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.2

Objective: This study was designed to analyze the fatigability of workers in the automobile company by Heart Rate Variability (HRV), Method: The subjects consisted of 32,049 workers who had answered about questionnaires of a job position, age, the state of drinking, smoking, exercise and sex, The fatigability was examined by SA3000P, We analyzed the differences of fatigability according to job positions, ages, the state of smoking, drinking, exercise and sex by T-test or ANOVA with SPSS ver17.0, Results Regarding the differences of fatigability among job classes, the fatigability was highest in engineers, lowest in others. Among ages, the fatigability was highest in 20s, lowest in 50s. In smoking, the fatigability was higher in smoking group. In drinking, the fatigability was higher in drinking group. In exercise, the fatigability was higher in non-exercising group. In sex, there was no significant difference. Conclusion: According to these results, we should establish the methods of controlling fatigue from the perspective of Korean traditional medicine.

굴 효소 가수분해물의 제조 및 기능특성

정인권(In-Kwon Chung),김혜숙(Hye-Suk Kim),강경태(Kyung Tae Kang),최영준(Yeung Joon Choi),최종덕(Jong-Duck Choi),김진수(Jin-Soo Kim),허민수(Min Soo Heu) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.7

양식 굴을 효율적으로 이용할 목적으로 6가지의 상업적효소(Alcalase, Flavourzyme, Neutrase, Protamex, pepsin, trypsin)를 이용하여 굴 효소 가수분해물을 제조하고, 그 특성에 대하여 살펴보았다. 상업적 효소 굴 가수분해물의 항산화능 및 ACE 저해능은 모두 Protamex로 1시간동안 가수분해시킨 것이 가장 우수하였고, 이 때 이들의 IC??값은 각각 1.16 mg/mL 및 1.49 mg/mL이었다. 하지만 항균성은 모든 효소 가수분해물에서 인정되지 않았다. 또한, ACE 저해능 및 항산화능은 가수분해 시간에 따른 의존성이 인정되지 않았다. Protamex로 1시간동안 처리한 굴 가수분해물의 경우가수분해 처리하지 않은 대조구에 비하여 29~66 kDa 획분과 6.5 kDa 부근의 획분이 모두 감소하여 저분자화 하는 경향을 나타내었다. The study was carried out to prepare oyster hydrolysates by using Alcalase, Flavourzyme, Neutrase, Protamex, pepsin and trypsin, and to investigate its functional properties. The ACE inhibitory activity and antioxidant activity of enzymatic oyster hydrolysates did not increase with hydrolysis time. Among enzymatic oyster hydrolysates, oyster hydrolysates incubated with Protamex for 1 hr (OHP) showed the most excellen ACE inhibitory activity and antioxidant activity, and their IC?? values were 1.16 mg/mL and 1.49 mg/mL, respectively. However, all enzymatic oyster hydrolysates were not detected in antimicrobial activity.

All IP 환경에서 상용화 IP Phones 과 IMS 서버 제품 군에 대한 문제점 분석 및 해결 방안연구

정인권 ( In-kwon Chung ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.1

국내의 초고속 통신망 인프라를 기반으로 고속, 고품질의 ALL IP 통신망이 더하여 짐으로 가정 및 기업용 Phones 들이 PSTN 망에서 번호 이동을 통한 IP 망으로 전환되고 있는 시점이다. ALL IP 환경의 상용 IP Phones 과 IMS 서버 제품들에 문제점이 발생되면 쉬게 접근하기 어려우며 해결이 어렵다. 따라서, 이와 같은 문제점이 발생 되기 전에 문제점을 분석하고 문제점을 해결하기 위한 방안에 대해 논하려 한다. 본 논문의 구성은 먼저 IMS 망을 이용하는 IP 단말들에 대한 간략한 설명과 문제점 대해 살펴보고, 본문에서 IP 폰들에 발생하고 있는 문제점들의 특징과 현황을 언급하고 마지막으로 IP 단말의 문제점 원인을 분석하고 해결할 수 있는 방법을 소개한 후, 향후 발생할 수 있는 잠재적인 문제점 해결방법을 제시하고 결론을 맺도록 한다. (Based on superspeed nation-wide communication infrastructure, high speed and high quality ALL IP communication network is created. It is a point in time where such infrastructure allows residential and commercial phones to be ported from PSTN to IP network. The problem experienced on IP phones in ALL IP environment and IMS server products are not easily approachable and dealt with. Therefore, this paper discusses approaches used in analyzing and resolving problems before they actually occur. This paper first discusses briefly the IP phones used in IMS network and their related problems. Then next topic deals with characteristics of these problems and current status. Last but not least, the causes of the problems are analyzed and solutions to these problems are introduced. Also discussed are solutions to possible future issues followed by conclusion.)

2단 가수분해에 의한 굴 가수분해물의 기능성 개선

정인권 ( In Kwon Chung ),김진수 ( Jin Soo Kim ),허민수 ( Min Soo Heu ) 한국수산과학회 2006 한국수산과학회지 Vol.39 No.3

차세대 이동 통신 시스템 설계 및 응용 : IMS기반의 멀티미디어 링 백톤 서비스 시스템의 설계 및 구현

정인권 ( In Kwon Chung ),한만호 ( Man Ho Han ),오시영 ( C Young Oh ) 대한산업공학회 2005 대한산업공학회 추계학술대회논문집 Vol.2005 No.-

굴 효소 가수분해물 첨가 요구르트의 제조 및 특성

정인권(In-Kwon Chung),김혜숙(Hye-Suk Kim),강경태(Kyung Tae Kang),최종덕(Jong-Duck Choi),허민수(Min Soo Heu),김진수(Jin-Soo Kim) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.7

양식산 굴에 대하여 Protamex(1단 가수분해)와 Neutrase(2단 가수분해)로 가수분해하고, 한외여과장치(MWCO, 3kDa)로 분획한 획분을 동결건조한 다음, 이의 효율적 이용을 위하여 굴 효소가수분해물(OHP) 첨가 기능성 강화 요구르트의 제조를 시도하였고, 아울러 그 특성에 대하여도 살펴보았다. pH, 적정산도, 점도, 생균수 및 관능평가를 통해 OHP 첨가 요구르트의 최적 starter는 Lactobacillus bulgaricus와 bulgaricus와 Streptococcus thermophilus의 1:1의 비율로 혼합한 균주로 선정되었다. OHP의 첨가량별 최적 발효시간은 무첨가 제품 8시간, OHP 0.5 제품이 6.5시간, OHP 1.0 제품은 5.5시간, OHP 1.5 제품은 5.0시간, OHP 2.0 제품의 경우 4.5시간이었다. ACE 저해능 및 항산화능은 OHP 무첨가 대조군 및 시판 요구르트에 비해 우수하였고, 관능검사 결과 OHP를 1.0 g 첨가한 제품이 가장 적합하였다. OHP 1.0 제품의 일반성분, pH 4.31, 적정산도(1.07%) 및 생균수(4.9×10? CFU/mL)는 시판 요구르트에 비하여 조단백질의 함량만이 다소 높은 반면, pH, 적정산도 및 생균수는 차이가 없었다. 저온저장 중 시제 요구르트의 pH, 적정산도 및 생균수의 변화 결과로 미루어 보아 OHP 첨가 요구르트는 5℃에서 15일간 유통 가능할 것으로 판단되었다. The base for preparing oyster hydrolysate-added yogurt was consisted of whole milk (1,000 mL), skim milk (44.05 to 42.05 g), enzymatic oyster hydrolysates powder (OHP, 0 to 2.0 g) and pectin. The yogurt base was fermented with 7 kinds of starter cultures (3% based on yogurt volume), such as Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus pentosus, Streptcoccus thermophilus and the mixed starters (L. bulgaricus and S. thermophilus) at optimal temperature. Processing condition and quality characteristics of the yogurt were evaluated by analyzing pH, titratable acidity, viscosity, viable cell count, functional properties and sensory evaluation. The results suggested that the optimal conditions for preparing the good quality yogurt revealed the mixed starters (L. bulgaricus and S. thermophilus) for starter culture, 1.0 g of 3 kDa hydrolysate for amount, and 5.5 hrs for fermentation time. The good quality yogurt showed 4.31 for pH, 1.07% for titratable acidity, 469 cps for viscosity and 4.9×10? CFU/mL for viable cell count. The hydrolysate-added yogurt was 2 times higher in ACE inhibitory and antioxidant activities than commercial yogurt, and kept good quality during storage of 15 days at 5℃.

2011년도 대구한의대학교 학생 건강검진 결과 보고

백영두 ( Young Doo Back ),정인권 ( Chung In Kwon ),최성훈 ( Seong Hun Choi ) 대구한의대학교 제한동의학술원 2011 東西醫學 Vol.36 No.4

Objectives : The aim of this paper is to report the results of medical examinations in Daegu Haany University 2011. Methods: 1. Subjects : AU students who wanted to enter the dormitory, or who were interested in health care. 2. Period : 8(tuesday)~(thursday), November 2011. 3. All students could choose one of the following medical examinations: Type II : chest x-ray(pulmonary tuberculosis), hepatitis B surface Antigen (HBsAg) & hepatitis B surface Antibody(Anti-HBs). Type II : chest x-ray(puhmnary tuberculosis), HBsAg & Anti-HBs, liver function test(SGOT, SGPT), complete blood count(CBC), urine test. Results : 408 students took part in medical examination. Among them, 77 students were males, 331 students were females. Results of chest x-ray for all students were within normal limits. In HBsAg & Anti-HBs tests, 3(0.74%) of students found to be HBsAg-positive, 282(69.1%) of students found to be Anti-HBs-negative and 126(30.8%) of students found to be Anti-HBs-positive or the trace of Anti-HBs. 69 students applied for type II examination. Among them, 30(43.4%) of students are estimated to be mild anemic patients. Conclusions : Results of screening for pulmonary tuberculosis and hepatitis B are in good, but there is need to strengthen the nutritional educations to anemic students.

제균요법 전과 후에 시행한 stool antigen의 진단적 가치

권기태 ( Ki Tae Kwon ),이동석 ( Dong Seok Lee ),정인권 ( In Kwon Chung ),박민재 ( Min Jae Park ),박창근 ( Chang Keun Park ),조창민 ( Chang Min Cho ),탁원영 ( Won Young Tak ),권영오 ( Young Oh Kweon ),김성국 ( Sung Kook Kim ),최용 대한소화기학회 2004 대한소화기학회지 Vol.44 No.4

Background/Aims: The efficacy of a new enzyme immunoassay designed to detect H. pylori antigens in stool (HpSA) was evaluated before and after the eradication therapy. Methods: HpSA test was performed in 75 patients whose H. pylori status was defined on t

맥파전도속도(PWV)를 이용한 체질별 죽상동맥경화 위험인자에 대한 상관관계 연구

임은영,이제원,장우석,백경민,전우현,정인권,Im, Eun-Young,Lee, Je-Won,Chang, Woo-Seok,Baek, Kyung-Min,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Object : The purpose of this study was to investigate the correlation of atherosclerosis risk factors and pulse wave velocity (PWV) of carotid-femoral artery with Sasang constitution. This study also aimed to investigate the relationship between PWV and risk factors of atherosclerosis, including serum cholesterol and homosisteine, hs-CRP. Methods : We enrolled 160 patients without experience strokes who visited our hospital for a medical examination from January 1, 2008 to April 30, 2010 except patients whose body constitutions were undetermined according to QSCCII. We investigated the correlation between serum cholesterol values, blood pressure, body mass index(BMI), homosistein, hs-CRP and PWV. Pearson's correlation and partial correlation analysis were applied to examine the relationship between PWV and risk factors of atherosclerosis. Result : Among the 160 subjects, 54 were Taeumin, 54 were Soyangin, and 52 were Soeumin. The prevalences of high BMI (P-value <0.01), high hs-CRP(P-value <0.05), and high PWV(P-value <0.05) of Taeumin were higher than those of the other constitutions. PWV of carotid-femoral artery was significantly different among the three constitutional groups(Taeumin: $8.12{\pm}1.64m/sec$, Soyangin: $7.48{\pm}1.16m/sec$, Soeumin: $7.49{\pm}1.12m/sec$)(P-value <0.05). This research has show a statistical significance between the average amount of carotid-femoral artery PWV that is higher in Taeumin. Age factor of Taeumin was the effective determinant of the increase of mean PWV of carotid-femoral arteries. Conclusions : There were significant differences in the prevalence of atherosclerosis according to Sasang constitution. This study showed that atherosclerosis was more prevalent in Taeumin. Therefore, according to our results, risk of atherosclerosis was higher in Taeumin than among other constitutions.