모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향

김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

고령자 남녀와 20대 남녀에 있어서 다양한 등속수축중 최대 모멘트의 비교

金智源(Ji-Won Kim),金相佑(Sang-Woo Kim),文基旭(Ki-Wook Moon),嚴光文(Gwang-Moon Eom),李泳揆(Young-Gyu Lee),南貞淑(Jung-Sook Nam),朴寬龍(Kwan-Yong Park),金耀翰(Yo-Han Kim),洪廷和(Jeong-Hwa Hong),朴炳奎(Bung-Kyu Park) 대한전기학회 2008 전기학회논문지 Vol.57 No.10

In this paper, we investigated the maximum ankle joint plantarflexion moment (MPM) of young and elderly subjects during various modes of isokinetic contractions with special interest in the elderly females who were reported to have higher fall rate than the elderly males. Subjects include the young subjects (14 males: 22.7±2.5yrs, 13 females: 20.5±1.3yrs) and the elderly subjects (17 males: 65.8±10.5yrs, 26 females: 71.4±5.2yrs). The MPM was normalized by each subject's body weight. The MPM of elderly females was the weakest among the groups, particularly, at the eccentric contractions. The male-to-female ratio of MPM was greater in the elderly than in the young and the young-to-elderly ratio of MPM was greater in female than in male, both during the eccentric contractions. The result suggests that the decreased muscle force per body weight, especially at the eccentric contraction, may be one reason for the more frequent fall of the elderly female than the elderly male.

인체 방광암에서 p33^ING1의 발현 변화

이석영,신관희,한광희,이상철,김용태,김원재 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

천연가스 사용 난방 및 산업보일러의 NOx와 CO 배출계수 산정 연구

장영기,최상진,김관,송기봉,김호정,정봉진 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.5

This study was conducted for developing the emission factors of nitrogen oxide(NOx) and carbon monoxide (CO) from the combustion boilers burning liquefied natural gas (LNG). These emission factors were compared with those of U.S. EPA and European Environment Agency (EEA). NOx and CO concentration in the flow gas were measured using Kane-May, KM9106 and Thermo Environmental Instruments Inc., 42C-HL. Measurement were conducted at thirty industrial and commercial LNG boilers. Emission factors were calculated on the basis of fuel consumption (kg-pollutant/㎥-fuel burned). NOx concentration at industrial boiler was 14~125 ppm and it was measured as 35~125 ppm at commercial boiler. NOx emission factors of industrial boiler and commercial boiler were 1.84kg/㎥ and 2.09kg/㎥, respectively. NOx emission factor of commercial boiler was higher than that of industrial boiler. The NOx emission factors estimated in this study were lower than those of U.S. EPA and higher than those of EEA. Average CO emission factor of industrial boiler was 0.65 kg/㎥ and at commercial boiler it was 0.70kg/㎥, CO emission factor at industrial boiler was lower than that at commercial boiler.

스포츠 현장에서 사고 분쟁해결을 위한 법적 구조 및 그 효용성 분석

박형상,육조영,김우규,이재봉,유관호,이무연,박태민,이신언 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

1. The purpose of this study is to reflect reality of sports to legal structure. This author classified types of sports related accidents as match accidents, school accidents, leisure and living sports accidents. Out of such accidents common factors such as 'the provider of virtue' and 'user' could be deduced and this author reviewed what kinds of obligations must be shouldered by these people respectively. In particular this author stressed the fact that disproportionate emphasis is placed on malfeasance in disposition of dispute over the sports accidents. Malfeasance is a method for seeking relief through money after the accident. However default in an obligation enables supplementary completion when it is not performed or imperfectly performed. Thus if object which must be performed is providing safety then it is possible to secure safety prior to accident. Furthermore at such time mistake of the debtor can not become a factor. For this reason this line of thinking has the following merits: (1) In comparison with constitution of malfeasance default of an obligation has long prescription. It seems that such fact was a motivation for saving obligation for safety consideration by making it fall under the principle of faith. (2) Default of an obligation is not an obligation for ordinary attention which is cause of malfeasance but it takes up issue with obligation for attention required for performance. Game organization, sponsor and spectators etc. shares certain sense of identity and are demanded to have manners. As method for evaluation of such relationship of faith it may be possible to impose a special kind of obligation for attention and it will be close to constitution of default of an obligation. (3) Imposing obligation for provision clarifies that such responsibility belongs to game organizations promoting sports to which anyone can participates or to national or public organizations, sponsor, schools which induced such sports as a part of its educational programs, installer who made people use it as leisure facility or person in charge for its management. (4) It is also applicable to umpires, players or spectators who use field of sports. It is possible to reflect reality whereby these people specifically relate themselves to sports. In consequence it will be possible to make people feel the necessity of expanding the principals of sports from 'doers' to 'watchers.' (5) The obligation of provision is an obligation under the principle of faith therefore mutual negotiation may be expected to clarify such fact. It may be also evaluated by effectuation of users' self-determining right. 2. If the above mentioned structure is provided then, although it is limited to sports, students who are subjects of instruction, seminar attendants, and furthermore players who finished games may be obligated to bear responsibility for safety consideration under the principle of faith. Accordingly level of relief for considerable number of victims may be increased as cases of treating even borrowed materials as default of obligation being expanded. 3. As scope of responsibility becomes more clearer it will be possible to prevent disputes while securing more safety as rules and regulations become more clearly enacted or new contract is signed or existing contract is revised.

뇌동맥류의 수술중 파열

황성남,박관,김영백,민병국,석종식,최덕영 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.6

Intraoperative aneurysmal rupture can be defined as aneurysmal rupture that takes place during any procedure from the induction of anesthesia to the closing of the wound and may result in a disastrous surgical outcome if not managed properly. The author experienced 11 cases of intraoperative aneurysmal rupture among 134 cases of aneurysm surgeries over the past 7 years at Yong-San hospital. The intraoperative rupture rate was 8% and there was statistically significant higher incidence of rupture in the early operated group. Rupture occured during dissection in 5 cases and during the clipping procedure in 6. The early and late mortality was 27 %, which included one case that could also be attributed to the direct effect of subarachnoid hemorrhage.

工團廢水의 嫌氣性消化에서 SO₄²-의 조沮害에 따른 糞尿의 비混合處理 效率에 關한 硏究

이관영,박상현 大邱大學校 科學技術硏究所 1998 科學技術硏究 Vol.5 No.3

We did biological treatment experimentation of the Anaerobic digestion of the factory sludge including highly concentrated SO₄²- after we mixed 10% night-soil with that sludge. We analyzed and investigated the results and then we could have the conclusions as follows 1. In the continuous experimentation in which the digestion temperature read 25±1℃, the removal rate of COD and VS was 41% and 39% each in case of the digester with the only factory sludge. But the result was different in the event of the mixed sludge with 10% night-soil. The removal rate of COD was 44% and that of VS, 45%, And the quantity of gas generation was 1,120㎖ in the only factory sludge, but 1,430㎖ in the mixed sludge with 10% night-soil, that is, the former generated 4.1㎖ time more gas than the injection quantity, the latter, 5.2 times more. 2. In the continuous experimentation at the digestion temperature of 35±1℃, the removal rate of COD and VS was 41% and 37% each in case of the digester with the factory sludge only. But in case of the mixed sludge with 10% night-soil, the removal rate was 44% and 45% each. And the gas generation quantity was different in each case. In the single sludge digester, the quantity was diferent in each case. In the single sludge digester, the quantity was 570㎖, but in the mixed sludge digester, the quantity was 760㎖. That means that the former generated 2.1 times more gas than the injection quantity and the latter, 3.0 times more. 3. Through the experimentation of the treatment of the mixed factory sludge including highly concentrated SO₄²- with 10% night-soil, we could see not only the improvement of treatment efficiency but also the remarkable increase of the generation quantity of Methane. Accordingly we could have the conclusion that this kind of mixed treatment of the factory sludge with night-soil would be very efficient.

燒却施設의 效率的인 運營方案에 關한 硏究 : 大邱市를 中心으로

이관영,박상현,김영섭 대구대학교 과학기술연구소 1996 科學技術硏究 Vol.3 No.2

Nowadays several nations have revealed that incineration plants were producing a large volume of hazardous waste, including Taegu city in Korea, which threatens our environment and our health. So the author has completely worked out literature review relating to incineration plants producing air pollution in the world. Therefore, this paper suggested to effective incinerator's operations to improve environmental aspects and assure that they are both safe and effective.

柔軟 生産 시스템을 위한 非線形 生産計劃 問題의 定式化 및 解法

허성관,우병훈,조영구 대구대학교 산업기술연구소 1992 産業技術硏究 Vol.11 No.-

FMS is the system controlled by a computerized conveyer and the system that numerically controls the machines which manufacture the variety of parts of medium lot size. In a metal cutting industry, a FMS is designed for the purpose of obtaining the well-balanced efficiency in the process of moving the machines. The characteristics and restrictions of this system are similar to the process of ordered system. In this paper, we defines a set of five production scheduling problems which present a solution to the efficient usage of FMS. These problems are formulated by the nonlinear mixed 0-1 integer programming problems. In order to obtaining the solution procedure, we test some linearization approaches and apply to the real data set of existing FMS system. For the computational efficiency, we reduce the number of constraints of linearized integer problems. Computational results reveals that the the computational times are within the acceptable level by the use of the linearization approaches and standard MIP code. If a special-purpose MIP code is used with utilize the structures of the problem, the large scale problem can be solved also.