강재 슬릿형 댐퍼를 부착한 철근콘크리트조 골조의 거동

신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.

토끼 수막염 모델을 이용한 다제내성 폐렴구균에 대한 Meropenem의 치료 효과

김신우,진정화,강수정,정숙인,김연숙,기현균,김춘관,이혁,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

목적 : 다제내성 폐렴구균에 의한 수막염은 기존과 단일 항생제로는 근치가 어려워 ceftriaxone과 vancomycin 혹은 rifampin의 병용요법이 권유되고 있다. 다제내성 폐렴구균에 사용할 수 있는 다른 약제 중 meropenem은 시험관내 폐렴구균에 대한 항균력이 좋고 경련 등의 중추신경계 부작용이 거의 없어 다제내성 폐렴구균에 의한 수막염의 치료에 이용할 수 있을 것으로 기대되나 이에 대한 자료가 매우 부족한 상태이다. 이에 연자 등은 meropenem과 meropenem+vancomycin의 병용요법이 다제내성 폐렴구균 수막염의 치료에 효과가 있는지를 토끼 수막염 동물 모델을 이용하여 검증하고자 하였다. 방법 : 인체에서 수막염을 일으킨 다제내성 폐렴구균 균주(penicillin MIC 2, ceftriaxone MIC 4, meropenem MIC 0.5㎍/㎖)를 토끼 척수강 내에 직접 주입하여 수막염을 유발한 후 ceftriaxone, vancomycin, rifampin, meropenem의 단일 항균요법, ceftriaxone+vancomycin, ceftriaxone+rifampin, meropenem+vancomycin의 병용요법 간에 치료 효과의 차이를 비교 하였다. 각 치료군은 6 마리의 토끼를 대상으로 하였다. 각각의 항생제는 5 시간 간격으로 2번 정주하였으며, ceftriaxone은 1회 투여하였다. 균주 주입 후 각 치료군이 토끼에서 치료 후 0, 5, 10, 24 시간에 척수액을 채취하여 균주의 수를 측정하여 24시간째의 살균 여부를 최종 치료 효과로 판정하였다. 결과 : meropenem 단독 요법은 10시간째에 모든 균주를 살균하였으나 24시간 째에 다시 균의 성장이 관찰되었으며, meropenem+vancomycin의 병용요법은 단독 약제보다 우수한 살균효과를 보였으나 상승작용은 없었다. 결론 : meropenem+vancomycin의 병용요법은 기존의 ceftriaxone+vancomycin보다 24시간째에 더 큰 균의 감소 경향을 보여(P=0.054) 임상에서 사용이 가능할 것으로 기대되며 향후 실제 수막염 환자에서의 임상효과를 증명하는 연구가 필요할 것으로 생각된다. Background : Because antimicrobial monotherapy for pneumococcal meningitis caused by penicillin-resistant strains is not satisfactory, ceftriaxone+vancomycin [C+V] or ceftriaxone+rifampin [C+R] regimens are recommended. Meropenern [M] is one of the monotherapy options for penicillin-resistant pneumococcal meningitis due to good in-vitro activity against pneumococci and rare adverse reactions in CNS. But there have been few reports in the efficacy of meropenern against pneumococcal meningitis. We evaluated therapeutic efficacy of the meropenern and meropenem+vancomycin in a rabbit model of meningitis caused by penicillin-resistant S. pneumoniae (PRSP). Methods : Meningitis was induced by intracistemal inoculation of a pneumococcal strain isolated from a patient with meningitis (MIC; penicillin 2, ceftriaxone 4, meropenem 0.5 g/㎖). Bacterial concentrations in the CSF were measured at 0, 5, 10, and 24 h after therapy was started. Therapeutic efficacy was evaluated by the final bacterial concentration in the CSF at 24 h. Results : C+V cleared the CSF at 10 h, but regrowth of bacteria was noted at 24 h. Meropenem monotherapy resulted in sterilization at 10 h but regrowth at 24 h. M+V was superior to M or V monotherapy but did not show synergism. Therapeutic efficacy of M+V was at least equal or superior to that of C+V (P = 0.054). Conclusion : Meropenem+vancomycin regimen could be one of the useful options in the treatment of PRSP meningitis. Clinical trials to evaluate the M or M +V are warranted in the future.

다제 내성 폐렴 구균에 대한 CFC-222 의 시험관내 항균력 및 살균 속도

이혁,김종성,진정화,양지원,김신우,김성민,백경란,송재훈 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

목적 : 새로이 개발된 quinolone 제제인 CFC-222와 함께 기존의 항균제들의 MIC를 비교하여 CFC-222가 항균제 내성 폐렴 구균의 치료에 사용될 수 있는 약제인지를 검증하고 아울러 in vitro time kill assay를 시행하여 CFC-222의 살균 속도를 검증하고자 하였다. 방법 : 국내 및 아시아 지역 국가에서 분리 확인된 폐렴 구균 균주 200주를 대상으로 하여 cefotaxime, CFC-222, ofloxacin, levofloxacin, sparfloxacin, ciprofloxacin, 그리고 meropenem에 대한 한천희석법을 이용하여 MIC를 결정하였다. In vitro time kill assay는 총 8균주(2 penicillin-susceptible, 2 intermediate, 4 resistant)를 대상으로 시행하였고 대상이 되는 항균제는 CFC-222, sparfloxacin, penicillin G로 하였다. 결과 : 폐렴 구균 균주 200주에 대한 한천 희석법을 이용한 MIC 결과는 페니실린 MIC가 증가함에 따라 cefotaxime과 meropenem의 MIC가 증가하는 경향을 보였다. Quinolone제제 중에서는, CFC-222와 sparfloxacin의 MIC_(90)이 페니실린 내성과 관계없이 0.5㎍/mL 이하로 가장 낮았다. time kill assay 결과 CFC-222는 MIC의 4배 농도에서 페니실린 고도내성 4균주 전체에 대해 8시간째 살균 효과를 보였다. 반면 sparfloxacin과 penicillin은 MIC의 4배 농도에서 12시간째 살균효과를 보였다. 결론 : CFC-222와 sparfloxacin이 가장 우수한 시험관내 항균 효과를 보였다. In vitro time kill assay 결과 CFC-222가 sparfloxacin에 비해 페니실린 고도 내성 균주에 대해 더 빠른 살균속도를 보였다. Background : CFC-222 is a new fluoroquinolone which possesses a broad antibacterial activity, being especially potent against gram-positive bacteria as well as gram negative bacteria. To evaluate the in vitro activity and the bactericidal killing rate of CFC-222 against Streptococcus pneumoniae, agar dilution test and lime-kill study was performed. Method : 200 clinical isolates were tested by agar dilution method to determine MICs of penicillin, cefotaxime, meropenern, ciprofloxacin, ofloxacin, levofloxacm, sparfloxacin, and CFC-222. Time-kill studies were performed with 8 pneumococcal isolates (2 peni-cillin-susceptible, 2 intermediate, and 4 resistant) to compare the bactericidal activity of penicillin, sparfloxacin, and CFC-222. Results : MICs of cefotaxime and meropenem showed increasing tendency as penicillin MIC is increased. Of the quinolones tested, CFC-222 and sparfloxacin had the lowest MIC (MIC90 = 0.5 ㎎/mL), regardless of the penicillin-susceptibility of the strains. CFC-222 yielded 99.9 % killing of all penicillin-resistant strains after 8 h at 4 MIC, while penicillin and sparfloxacin were bactericidal after 12 h at 4 MIC. Conclusion : By MIC and time-kill combined, CFC-222 and sparfloxacin were the most potent agents according to the MICs, whereas CFC-222 was more rapidly bactericidal than sparfloxacin against penicillin-resistant isolates.

조직학적 진단된 chronic necrotizing pulmonary aspergillosis 2예

김연숙,정숙인,기현균,김춘관,김신우,한정호,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

CNPA는 기존의 폐질환 및 폐절제술로 인해 국소방어기전에 저하가 있거나 비특이적 전신면역상태저하를 갖고 있는 환자들에게서 주로 발생하는 만성적인 공동성 폐질환이다. 현재까지 우리나라에서는 CNPA의 보고가 없는 상태이고, 저자들은 최근 조직학적으로 진단된 CNPA 2예를 경험하였기에 보고하는 바이다. 저자들이 경험한 CNPA 환자들은 만성알코올 중독 및 기관지확장증과 같은 기저질환과 폐절제술을 받은 병력이 있었다. Aspergillus가 폐실질을 침윤하고 있는 조직소견과 조직배양에서 Aspergillus가 검출되어 조직학적 진단이 가능하였고, amphotericin B의 정주요법 및 경구 itraconazole 투여와 폐절제술 등으로 성공적으로 치료되었다. 아직 많은 임상의들에게는 낯선 질환인 CNPA의 치료성적은 환자의 동반질환 및 CNPA 자체의 중증도, 진단과 치료 시작의 지연 등에 의해 크게 좌우되므로 만성적으로 진행하는 공동성 폐병변을 갖고 있는 환자에게서 CNPA를 감별하는 것이 중요하다. Chronic necrotizing pulmonary aspergillosis (CNPA) is a chronic cavitary form of pulmonary aspergillosis. Dozens of CNPA cases have been reported in patients with systemic immunologic dysfunction or altered local defense mechanism from preexisting pulmonary disease. Review of literatures revealed that no CNPA cases have been reported in Korea yet. We experienced two cases of CNPA proven by lung biopsy. A 53-year-old alcoholic male in poor nutritional state was admitted with generalized weakness and weight loss. Chest CT revealed a cavitary nodule surrounded with ground-glass attenuation. CT-guided fine needle aspiration and biopsy was done. The biopsy specimen demonstrated dichotomously branching septated hyphae consistent with those of Aspergillus sp. Another case was a 39-year-old man with bronchiectasis who was admitted with persistent hemoptysis. He had a past history of pulmonary tuberculosis. A parahilar lesion with intracavitary soft tissue mass was incidentally detected in high-resolution GT. Left lingular segmentectomy was done due to uncontrolled hemoptysis and CNPA was histologically diagnosed. Both patients were successfully treated with intravenous amphotericin B followed by oral itraconazole. Even though CNPA is unfamiliar to most clinicians, it should be included in differential diagnoses of chronic progressive cavitary pulmonary lesion, especially in patients with immunologic dysfunction.

센서기반 지능형 아크 용접 로봇 시스템의 동향

정지훈(Ji Hoon Joung),신현호(Hyeon-Ho Shin),송영훈(Young Hoon Song),김수종(SooJong Kim) 제어로봇시스템학회 2014 제어·로봇·시스템학회 논문지 Vol.20 No.10

In this paper, we introduce an intelligent robotic arc welding system which exploits sensors like as LVS (Laser Vision Sensor), Hall effect sensor, voltmeter and so on. The use of industrial robot is saturated because of its own limitation, and one of the major limitations is that industrial robot cannot recognize the environment. Lately, sensor-based environmental awareness research of the industrial robot is performed actively to overcome such limitation, and it can expand application field and improve productivity. We classify the sensor-based intelligent arc welding robot system by the goal and the sensing data. The goals can be categorized into detection of a welding start point, tracking of a welding line and correction of a torch deformation. The Sensing data can be categorized into welding data (i.e. current, voltage and short circuit detection) and displacement data (i.e. distance, position). This paper covers not only the explanation of the each category but also its advantage and limitation.

선천성 자궁 기형의 산과적 영향에 대한 연구

김민정 ( Min Joung Kim ),임시연 ( Si Yeon Lim ),최예훈 ( Ye Hoon Choi ),박철훈 ( Chul Hoon Park ),허수영 ( Soo Young Hur ),이귀세라 ( Gui Sera Lee ),김은중 ( Eun Joung Kim ),신종철 ( Jong Chul Shin ),김사진 ( Sa Jin Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9

Potential Methane Production on Anaerobic Co-digestion of Swine Manure and Food Waste

Joung Du Shin,Sang Won Park,Sang Hyoun Kim,Jack Duangmanee,Po Heng Lee,Shi Hwu Sung,Bong Hoon Lee 한국환경농학회 2008 한국환경농학회지 Vol.27 No.2

Potential Methane Production on Anaerobic Co-digestion of Swine Manure and Food Waste

Shin, Joung-Du,Park, Sang-Won,Kim, Sang-Hyoun,Duangmanee, Jack,Lee, Po-Heng,Sung, Shi-Hwu,Lee, Bong-Hoon The Korean Society of Environmental Agriculture 2008 한국환경농학회지 Vol.27 No.2

Anaerobic co-digestion of swine manure and food waste for biogas production was performed in serum bottles at various volatile solids(VS) contents and mixing ratios of two substrates(swine manure:food waste=$100:0{\sim}0:100$). Through kinetic mode of surface methodology, the methane production was fitted to a Gompertz equation. The ultimate methane production potential of swine manure alone was lower than that of food waste regardless of VS contents. However, it was appeared that maximum methane production potentials in 80 : 20 of the mixing rate at VS 3% was enhanced at 144.7%, compared to its only swine manure. The potential increased up to 815.71 ml/g VS fed as VS concentration and food composition increased up to 3.0% and 20%, respectively. The ultimate amount of methane produced had significantly a positive relationship with that of methane yield rate. Overall, it would be strongly recommended that feeding stocks use 20% of mixing ratio of food waste based on VS 3% contents when operating the anaerobic reactor on site at $35^{\circ}C$ if not have treatment of its anaerobic waste water.

Effect of ice-quenching on the change in hardness of a Pd-Au-Zn alloy during porcelain firing simulation

Shin, Hye-Jeong,Kim, Min-Jung,Kim, Hyung-Il,Kwon, Yong Hoon,Seol, Hyo-Joung JAPANESE SOCIETY FOR DENTAL MATERIALS AND DEVICES 2017 Dental materials journal Vol.36 No.2

<P>This study examined the effect of ice-quenching after degassing on the change in hardness of a Pd-Au-Zn alloy during porcelain firing simulations. By ice-quenching after degassing, the specimens were softened due to homogenization without the need for an additional softening heat treatment. The lowered hardness by ice-quenching after degassing was recovered greatly from the first stage of porcelain firing process by controlling the cooling rate. The increase in hardness during cooling after porcelain firing was attributed to the precipitation of the f.c.t. PdZn phase containing Au, which caused severe lattice strain in the interphase boundary between the precipitates and matrix of the f.c.c. structure. The final hardness was slightly higher in the ice-quenched specimen than in the specimen cooled at stage 0 (the most effective cooling rate for alloy hardening) after degassing. This was attributed to the more active grain interior precipitation during cooling in the ice-quenched specimen after degassing.</P>

Regulation of PLK1 through competition between hnRNPK, miR-149-3p and miR-193b-5p

Shin, Chang Hoon,Lee, Hong,Kim, Hye Ree,Choi, Kyung Hee,Joung, Je-Gun,Kim, Hyeon Ho The Author(s) 2017 CELL DEATH AND DIFFERENTIATION Vol.24 No.11

<P>Polo-like kinase 1 (PLK1) is a critical regulator of cell cycle progression and apoptosis. However, its regulation remains poorly understood. In the present study, we investigated the molecular mechanism underlying the post-transcriptional regulation of PLK1. We observed that heterogeneous nuclear ribonucleoprotein K (hnRNPK) and PLK1 were positively associated in several different cancers and high expression levels of them correlated with poor prognosis in patients with cancer. Knockdown of hnRNPK resulted in reduced expression of PLK1, whereas conversely, PLK1 expression was increased in hnRNPK-overexpressing cells. We found that hnRNPK regulated PLK1 expression through KH1- and KH2-dependent interactions with the 3'UTR of PLK1 mRNA. In addition, microRNA-149-3p (miR-149-3p) and miR-193b-5p suppressed PLK1 expression by targeting the 3'UTR of PLK1 mRNA. MicroRNA-elicited enrichment of PLK1 mRNA in Ago2 immunoprecipitation was altered by the presence or absence of hnRNPK. Furthermore, the deletion of the cytosine (C)-rich sequences of the 3'UTR of PLK1 mRNA abolished the decreased PLK1 expression observed via hnRNPK silencing and administration of miRNAs, a finding that suggests that hnRNPK shares this C-rich motif with miR-149-3p and miR-193b-5p. We also found that downregulation of PLK1 by either silencing hnRNPK or overexpression of miR-149-3p and miR-193b-5p decreased clonogenicity and induced apoptosis. Our findings from this study demonstrate that hnRNPK regulates PLK1 expression by competing with the PLK1-targeting miRNAs, miR-149-3p and miR-193b-5p.</P>