18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

Jun-Jang Jin,Il-Gyu Ko,Sung-Eun Kim,Lakkyong Hwang,Man-Gyoon Lee,Dae-Young Kim,Sun-Young Jung 한국운동재활학회 2017 JER Vol.13 No.4

Ethylenediaminetetraacetic acid(EDTA)항응고제에 의한 Mean Corpuscular Volume(MCV)변화

홍승민,박영진,최하영,임진,정옥연,이호준,이호영,장숙진,문대수 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

It is essential that we put the anticoagulant into the blood specimen of the CBC test. However, the value of some parameters in the CBC test can be changed whenever using some anticoagulants. EDTA anticoagulant is mostly used these days. There are 3 kinds of EDTA, that is K_(2-), K_(3-), and Na_(2-) EDTA. The author studies how many effects each the EDTA gets into the true value of blood specimen for MCV of RBCs. Especially we compared the MCV effect of different concentrations of 3 EDTA anticoagulants on the bias with time and instrument. Some results are gotten. In our results, K_(3-)EDTA anticoagulant shows more satisfactory MCV value than K_(2) or Na_(2-)EDTA. On using concentration of EDTA, 1.5㎎ EDTA/㎖ of blood show more satisfactory MCV value than 7.5㎎ EDTA/㎖ of blood. However, the choice of anticoagulant may be dependant on the different instruments.

Aerobic Exercise Affects Myostatin Expression in Aged Rat Skeletal Muscles: A Possibility of Antiaging Effects of Aerobic Exercise Related With Pelvic Floor Muscle and Urethral Rhabdosphincter

Ko, Il Gyu,Jeong, Jin Woo,Kim, Young Hoon,Jee, Yong Seok,Kim, Sung Eun,Kim, Sang Hoon,Jin, Jun Jang,Kim, Chang Ju,Chung, Kyung Jin Korean Continence Society 2014 International Neurourology Journal Vol.18 No.2

<P><B>Purpose</B></P><P>Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recommended for the prevention and the treatment of these age-related frail states. We investigated the effects of treadmill exercise on muscle strength, myostatin mRNA and protein expression, and gastrocnemius myocytes proliferation in aged rats to investigate the possible antiaging effects of aerobic exercise on skeletal muscles such as pelvic floor muscles and urethral rhabdosphincter muscle.</P><P><B>Methods</B></P><P>In this study, 5-month-old male Sprague-Dawley rats were used as the young-age group (n=20) and 24-month-old rats were used as the old-age group (n=20). Each group was randomly divided into two groups (n=10 in each group): the sedentary and the treadmill exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 minutes, once a day, for 6 weeks. For this study, a weight load test, hematoxylin and eosin staining, real-time and reverse transcription polymerase chain reaction for myostatin mRNA, myostatin western blot, and 5-bromo-2'-deoxyuridine immunohistochemistry were performed in the gastrocnemius muscle.</P><P><B>Results</B></P><P>The age-induced reduction of muscle mass and strength was associated with a decrease in myocyte proliferation and an increase in myostatin mRNA and protein expression in the gastrocnemius. However, treadmill exercise improved muscle mass and strength through suppression of myostatin mRNA and protein expression, and myocyte proliferation increase in the gastrocnemius against the aging process.</P><P><B>Conclusions</B></P><P>Aerobic exercise is a useful strategy for enhancing muscle function against aging-induced loss of skeletal muscle mass and functions.</P>

Ethylenediaminetetraacetic acid (EDTA)항응고제에 의한 Mean Corpusculaar Volume(MCV)변화

홍승민,박영진,최하여,임진,정옥연,이호준,이호영,장숙진,문대수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

무인감시시스템 구현을 위한 이동체 인식 알고리즘에 관한 연구

장국렬,방만원,박진홍,박순영 木浦大學校 情報産業硏究所 1996 情報産業硏究誌 Vol.4 No.-

In this paper, an effective algorithm which can detect moving objects from the image sequences and classify an intruder from other moving objects is presented for an implementation of unmanned surveillance system. The proposed algorithm uses a stick figure model for features of the moving object since the stick figure model can be represent the characteristics of the moving objects. The stick figure model is extracted by applying the thining algorithm to the binary difference image between the reference and the image of a moving object. The computer simulation is carried out to analyze the performance of the proposed algorithm. The results show that the algorithm can discriminate a moving person and a moving animal with high degree of reliability.

하지에 발생한 피부 결손의 치료에서 전 외측 대퇴부 유리 피판술의 유용성

권영호,장수진 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : The objective of this study was to evaluate the clinical results of operative treatment on skin defect of lower extremities by free anterolateral thigh flap. Methods : Between 2005 to 2009 we followed up 10 cases who undergoing anterolateral thigh free flap because of lower extremity skin and soft tissue defect. 3 cases are heel, ankle and foot dorsum are each 2 cases, sole and knee, thigh are each 1 case. We observed that of implanted area's color, peripheral circulation at 3, 5, 7 days after operation and evaluation with operating time, amount of hemorrhage, implanted skin necrosis, additional operation, complications. Results : 9 cases of 10 showed successful localization and 1 case showed fail. Size of soft tissue defect due to trauma was 9.5 × 7.3cm (5 × 6cm∼13 × 8cm), due to trauma or infection was 18.3 × 11.8cm (13 × 6cm∼30 × 20cm). Skin color change was mainly due to congestion with hematoma, flap was not observed global congestion or necrosis except 2 cases which showed partial necrosis on margin that treated with conservative therapy. Conclusion : Anterolateral thigh free flap is useful in radical skin defect treatment and had a good results after operation functional reconstruction.

비엔나협약규정 신호체계와 우리나라 신호체계에 관한 비교연구

장건영,이정윤,김진태,장명순 東亞大學校 建設技術硏究所 2004 硏究論文集 Vol.27 No.2

20세기 말 국제사회는 정치 경제적인 교류 · 협력의 증가에 따른 국제 경제활동 빛 여가활동범위의 확대로 국가간 방문교류가 증가했다. 1968년 국제연합 (UN, United Nation)은 국제도로교통을 활성화하고 도로안전의 증진을 위하여 도로교통에 관한 국제협약인 도로교통협약(Convention on Road Traffic)과 표지 및 신호체계협약(Convention on Road Signs and Signals)을 선포하였다 2002년 10월 기준으로 표지 벚 신호체계협약에는 50개국이 가입하였고 도로교통협약에는 60개국이 가입한 상태이다. 국내에서는 도로교통에 관한 이 국제협약이 ‘비엔나협약’이라고 통칭되고 있으며 1968년에 버엔나협약 제정시 승인 서명만 했을 뿐 비엔나협약에 가입하지 않았다. 이에 본 연구에서는 비엔나협약의 신호체계와 극내 신호체계를 비교하여 (1) 그 차이점을 분석하고, (2) 비엔나협약 표지 빛 신호체계협약 가업을 가정시 유발되는 문제점에 대한 개선사항에 대해 분석하고자 하였다. 분석결과 차량 신호등의 형태 및 가변형 가변등의 형태 녹색등 황색등 적색등의 동일 색의 화살표시등으로의 교체 가능성 여부, 녹색등화 적색등화 황색등화의 의미, 적색등화 점멸의 의미, 화살표시등의 등화, 녹색등과 적색 및 황색등과의 동시 등화 운용여부 등에서 차이점이 있는 것으로 분석되었다. 또한 비엔나협약 표지 및 신호체계협약 가업을 가정시 유발되는 문제점에 대한 개선사항으로는 (1) 도로교통법의 적색신호 및 황색신호 시 우회전허용 또는 비보호 우회전 허용에 관한 내용의 검토, (2) 국내에 현재 운영중언 4색등의 사용을 금하고 직진 및 좌회전 두 개의 전용 신호등으로 구분한 신호등 재설치 및 이에 따른 국내 지역제어기 교체 검토 빛 새로운 지역제어기의 운영 소프트웨어 개발 검토, (3) 가변형 가변등의 가변차로 전환 신호기의 교체 검토, (4) 도로교통법에서의 적색신호등의 점멸에 관한 내용의 검토, (5)도로교통법에 화살표시등에 대한 법규정 신설에 관련된 내용 검토 및 현장에서 운영되고 있는 하향 황색 화살표시의 방향을 상향으로 전환에 관한 검토, (6) 도로교통법에 자전거 전용신호등에 대한 법규정 신설에 관련된 내용 검토, (7) 비엔나협약 표지 및 신호체계협약에 따라 수정되는 신호체계에 대한 기존 운전자 재교육의 필요성 검토가 필요한 것으로 분석되었다.

生體血의 保存環境과 腐敗産物에 依한 血中알콜濃度變化에 關한 硏究

張成吉,金英雲,柳在薰,吳世珍,權五星,朴世延 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-