외상성 경막하수종 환아에서 조기 수술의 유용성

김병욱,이승명,김석원,김현성,신호 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

Background and Objectives: This study was performed to evaluate the usefulness of early operation in children with traumatic subdural hygroma. Materials and Methods: The subjects were eleven patients (Glasgow coma scale (GCS) score was below 10 and age was below 10 years old) who developed subdural hygroma after trauma between January 2000 to December 2002. Subduroperitoneal shunt was performed in one group and not performed in the other group. We analyzed the GCS score on admission and at 1 year after operation. Overall clinical results were evaluated retrospectively. Results: Patients who underwent operation exhibited higher GCS scores at 1 year after trauma compared to those in the patients who were treated by conservative therapy (p<0. 05). Conclusion: The early operation could be an effective treatment to children with subdural hygroma who showed delayed improvement of consciousness and to patients with hygroma that didn't decrease or was above moderate amount.

수학과 교육과정 실제 및 분석

김민경,노선숙,유현주,조성민,차인숙 이화여자대학교 사범대학 교과교육연구소 2001 교과교육학연구 Vol.5 No.1

21세기 지식기반사회는 자기 주도적으로 정보를 처리하고 해석하며 판단하는 능력과 지적 가치를 창조할 수 있는 능력을 길러주는 학교수학 교육을 요구하고 있다. 이에 수학교육과정에 담겨져야 할 수학적 지식의 구조․내용․범위, 지식기반 사회에 적합한 수학과 교수-학습, 평가, 교사역할 등 역시 새로운 관점에서 재조명될 필요가 있으며, 이러한 연구는 학교 현장에 대한 이해에서 출발하고 개인의 필요성과 사회의 요구를 반영한 것이어야 한다. 이에 본 연구에서는 지식기반사회에 대비하기 위한 수학과 교육과정 개발 연구의 기초 단계로 교사, 학생, 학부모를 대상으로 현장 설문 조사를 전국 규모로 실시하였다. 설문 조사는 Goodlad의 학교 교육과정 탐구의 개념적 구도를 바탕으로 한국 교육의 실정을 반영하여 설계되었다. 수학 교육과정 실체의 다양한 국면을 조사하기 위한 설문 내용은 목적 및 목표, 교과내용, 교수-학습방법, 평가, 수학적 지식의 성격, 교육정보화, 교사교육, 사교육, 교육과정일반으로 구성되었다. 본 고에서는 Goodlad의 교육과정 탐구모형과 그 모형에 기초하여 작성된 본 연구의 수학교육과정 탐구모형, 실시된 설문조사의 방법 및 절차를 소개하였고, 설문조사의 주된 결과를 토대로 수학교육과정 개발연구에의 시사점을 찾고자 하였다. This study is to provide suggestions for the development of better mathematics curriculum model of Korea based on a national survey of teachers (527), students (1314), and parents (638). It is our belief that understanding the perceptions and experiences of those involved in the process of teaching and learning of mathematics education needs to be the first priority in any effort to explore better mathematics curriculum model. For the study, Goodlad's conceptual system for curriculum inquiry has been used, but modified to take into account Korean context and the nature of mathematics curriculum. In this paper we introduce the Goodlad's curriculum inquiry model and mathematics curriculum inquiry model based on the Goodlad's conceptual system as well as the survey process. We made few recommendations from the main results of the survey for the research and development of mathematics curriculum model in Korea.

Epidermal Growth Factor가 돼지 난자의 성숙과정동안 미토콘드리아 기능 향상에 미치는 영향

양욱현, 김은지, 최향순, Qinyue Lu, Zhi Chen, 허근 충북대학교 농업과학기술연구소 2023 農業科學硏究 Vol.39 No.1

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합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.

Space Syntax를 활용한 보행네트워크 분석에 관한 기초 연구

임현식,김영욱 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The current methodology in analyzing the pedestrian environment is limited to the qualitative analysis using the checklist and the range of satisfaction surveyed after having experienced the street environment. Also, other means such as the observation of pedestrian service status and street furniture are insufficient in properly delineating the quantitative distinction that results from an evolution of structural development and in making assessments of alternate options. This research consists of the study of Space Syntax Theory that not only produces an objective and descriptive analysis of the spatial characters, but also resolves the relative interaction with other physical pedestrian Network System. This study suggest a pedestrian network model by analyzing the case study movement pattern within Insa-Dong. Hence, predicting the movement pattern of the imminent development in the study area by applying the methodology of analysis that was selected for studying the current status quo. From the research the outcome was helpful in providing the developers a greater perspective with the pedestrian Network System that is not confined to a certain parameter, but in a larger scale within the urban environment. Also, it aided in planning optimal scheme that concurs with the predictable pedestrian movement.

자궁경부 상피암에서 Human Papillomavirus(HPV) 감염에 관한 연구

강현욱,김창진,오승훈 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The uterine cervical carcinoma is the most common malignant tumor among Korean women. The pathogenic mechanisms have not been elucidated so far. Several lines of evidence suggest that sexually transmittable agents are responsible for the pathogenesis of uterine cervical carcinoma. Among them, human papillomavirus(HPV) was considered to be the most possible oncogenic agent. The HPV types 6, 11, 16, 18, 31, 33 and 35 are the most important types involved in cervical lesion among 70 HPV types so far known. The uterine cervical carcinomas containing HPV-18 gene in the nuclei are more aggressive than those comtaining other types of HPV genes. It would be helpful to type the HPV in the uterine cervical carcinoma for the prediction of prognosis. In this study, the types of HPV were determned in the uterine cervical carcinoma, comprising 30 cases of cervical intraepithelial neoplasia(CIN), 10 cases of microinvasive carcinoma and 15 cases of invasive carcinoma, by polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP). The results were as follows: 1. HPV DNA was detected in 19 cases(63.3%) of 30 if CIN. The types 16, 18, 33 and other high risk HPVs were 33.3%, 6.7% and 10% respectively. 2. In CIN Ⅱ and CIN Ⅲ, HPV-16, 18 were 54.4%, 28.6% and 9.1%, 21.4% respectively. 3. In microinvasive carcinomas, HPV-16 and 18 were 50% and 20% respectively. 4. In invasive carcinomas, HPV-16 and 18 were 26.7% and 33.3% respectively. Above results suggest that HPV infections have positive relationship with uterine cervical carcinoma. And as the HPV-18 type DNA has some role for the progression of the carcinoma, it would be feasible to type HPV in uterine cervical carcinoma for the prediction of the prognosis.

위암에서 p53 유전자의 변이에 대한 연구

강현욱,김창진,정문석 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The pathogenic mechanisms of gastric carcinoma, which is the most common malignant tumor in Korea, have not been completely elucidated. Recently the carcinogenic mechanisms have been explored in depth of genetic mutations. Several lines of evidence showed that oncogenes and anti-oncogenes played some roles in the pathogenesis of human malignant tumors. Among several anti-oncogenes, p53 is the most commonly mutated in varoius human malignat tumors. This study is conducted to see the rate of p53 gene nutation in gastric carcinoma by the loss of heterozygosity(LOH). The DNA is extracted from the cells harvested from paraffin block sections. The exon 4 of p53 is amplified by polymerase chain reaction(PCR) and the product is digested with Tha I endonuclease. Among 20 informative cases, 7 (35%) revealed loss of heterozygosity. Among 14 cases of well differentiated carcinoma and 6 cases of poorly differentiated carcinoma, LOH was observed in 5 cases (36%)and 2 cases (33%) respectively. The above results revealed that p53 mutation plays some roles in the pathogenesis of gastric carcinoma. But to elucidate the roles genetic mutaton in the pathogenesis of gastric carcinoma, more numbers of different exons should be searched.

대장암에서 Adenomatous Polyposis Coli(APC) 유전자의 변이에 대한 연구

강현욱,김창진,이봉재 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The colorectal carcinoma was once considered a dominant malignancy in the westerized country. But as Korean life and food consumption styles follow those of western country,colorectal carcinoma in Korea has been increased. Among the several mechanisms of colorectal carcinogenesis, the molecular genetic alterations are best understood of any other common human cancers. Colorectal carcinomas demonstrate extensive molecular genetic alterations throughout the genome. Among several dominant acting oncogenes, a kind of tumor suppressor gene, APC(adenomatous polyposis coli) gene mutation has been commonly observed in colorectal carcinoma, and the deletion of APC gene appears to be an early event in the tumorigenesis. This study is conducted to see the APC gene mutation in 10 cases of adenomas, 20 cases of adenocarcinomas and 3 cases of familial polyposis by observing LOH(loss of heterozygosity) in APC gene exon 11. The DNA was extracted from paraffin block tissue sections and APC gene exon 11 was amplified by polymerase chain reaction(PCR). The PCR product was digested by Rsa I endonuclease and LOH was observed by gel electrophoresis. In the study, only informative cases are included. The resuslts were as follows; 1. Among 10 cases of adenoma, 7 cases (70%) revealed LOH, while among 20 cases of carcinomas, 10 cases(50%) showed LOH. All the 3 cases of familial polyposis revealed LOH. 2. There is no relatoinship between clinical stages and LOH of APC gene. Above results showed that APC exon 11 gene mutation contribute to early stage of colorectal carcinogenesis and it has no effect on tumor progression. But to elucidate precise mechanism of carcinogenesis, more studies in the molecular level should be conducted.

도시 맥락적 관점에서 본 문화공간의 의미 : 예술의 전당을 중심으로 focused on the Seoul Arts Center

송정화,김영욱,이현수 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

The purpose of this study was to examine the accessibility and spatial configuration of a cultural and art center in an urban setting using space syntax, this research analyzed the Seoul Arts Center and Its surrounding area, elaborated the built environment and its layouts, and delineated the significance and Implications of the built form In the situated context The research found that the Seoul Arts Center, as a cultural venue, didn't run the full gamut and was not accessible It was noted that the location of the studied building reduced the accessibility, and the core area of the City would be an appropriate alternative location Also, the results indicated that the spatial cognition of the Seoul Arts Center was high and conspicuous, while the interaction with surroundings was weak This qualitative research suggested that the cultural and art center be located in an area that is more accessible and emphasizes the functional integration

방선균 분리주가 생산하는 Phospholipase C 저해물질인 MT2617-2B의 분리 및 특성

고학룡,이현선,오원근,안순철,김보연,강대욱,민태익,안종석 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

방선균 분리주 MT2617-2의 배양액으로 부터 phospholipase C (PLC) 저해물질인 MT2617-2B를 n-butanol 추출 및 column chromatography 법을 이용하여 분리하였다. MT2617-2B는 IR ^13C- 및 ^1H-NMR 그리고 ESI-MS에 의한 구조분석 결과, 한 개의 hemiketal ring, polyhydroxyl 및polymethyl groups으로 구성되었으며 side chain으로 한 개씩의 malonate 및 guanidine group을 가지는 분자량 1057의 macrolide 화합물이었다. 따라서, MT2617-2B를 기존의 macrolide 항생제인 copiamycin 및 niphithricin A로 동정하였다. 한편, MT2617-2B는 methanol 용액에서 실온에서 방치하였을 때 도일한 분자량을 가진 두 개의 이성질체를 생성하였다. PLC γ1과 -β1에 대해 각각 25 및 50㎍/㎖의 IC_50 값을 가지며, Staphylococcus aureus 와 Candida albicans에 대해서는 항균활성을 나타내지만 Escherichia coli에는 나타내지 않았다. A phospholipase C (PLC) inhibitor (MT2617-2B) was isolated from the culture broth of actionmycetes isolate MT2617-2 by the extraction with n-butanol and column chromatographic techniques. The molecular weight of the inhibitor was 1057, by the spectroscopic analyses of IR ^13C- and ^1H-NMR and ESI-MS. The chemical structure of MT2617-2B was found to be a macrolide compound consisted of a hemiketal ring, polyhydroxyl and polymethyl groups, which had a malonate and guanidine group as its side chain. MT2617-2B produced its two isomers having the same molecular weight by standing in methanol solution at room temperature. Therefore, MT2617-2B was identified as copiamycin and niphithricin A, macrolide antibiotics. The values of IC_50 against PLC γ1 and PLC-β1 were 25 and 50㎍/㎖, respectively. MT2617-2B had antimicrobial activities against Staphylococcus aureus and Candida albicans, but not against Escherichia coli.