영아기 호흡기 질환의 이환요인에 관한 연구

신상원,김은영,노영일,양은석,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Purpose: Respiratory tract infections are common in the first year of life. Severity of respiratory tract infection in infants is associated with early-life environmental factors, In recent, genetic studies suggest a role of heredity in susceptibility to severe respiratory tract infection(RTI) in infants. We designed a case control study to further investigate relative importance of familial influence in risk of respiratory tract infection in infants compared to environmental factors. Methods: We selected 126 children(44 cases; 82 controls) that admitted or visited to Chosun University Hospital. Cases were infants under age 1 year admitted to hospital with severe respiratory tract infection. Familial history and other factors were recorded in cases and controls by questionnaire. Results: Out of 126 infants, Patients admitted with severe respiratory tract infection are 44 cases. Diagnosis of patients with RTI are acute bronchitis 15 cases(34.1%), pneumonia 12 cases (27.3%), acute nasopharyngitis 7 cases (15.9%), acute bronchiolitis 5 cases (11.4%), infantile asthma 3 cases (6.8%), and croup 2 cases (4.5%). The crude odd ratio of repiratory tract infection of parental smoking is 3.35 and cow mik feeding 3.13, Prematurity & low birth weight 2.39, maternal allergic disease 2.13, and child allergy 1.92. Conclusion: Maternal allergic disease, parental smoking, Prematurity and low birth weight, and Allergic diseases increased the risk of respiratory tract infection in infants. Breast milk feeding decreased that. These results support the possibility that genetic factors play an important role in susceptibility to recurrent and severe respiratory infections in early life.

정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

게르마늄 내성효모의 성분분석

김경신,김덕숙,이명환,김종현,박원봉 서울여자대학교 자연과학연구소 1995 자연과학연구논문집 Vol.6 No.-

1. 게르마늄 내성효모는 64.0%의 높은 단백질을 함유하고 있었으며 일반효모보다 단백질의 함량이 증가하였으며, 지질, 총당, 환원당, 조다당의 함량도 감소, 또는 증가하는 등 차이가 있는 것으로 나타났다. 2. 게르마늄 내성효모의 총 지방산의 함량은 0.31㎍/g으로 일반효모보다 감소한 것을 알 수 있었으며 특히 포화 지방산의 함량은 현저히 감소하였다. 3. 내성효모균은 asparagine, glutamin acid, leucine의 함량 등의 아미노산 함량이 일반효모보다 증가하였으며, 일반효모균에 있던 cystein이 포함되지 않는 반면, 일반효모균에는 없었던 tyrosine이 포함되어 있는 것으로 나타났다. 4. 내성효모균 단백질의 Sephdex G-75 column과 DEAE-cellulose ion exchange column에 의한 분리 pattern을 일반효모균 단백질과 비교하여 보면, 큰 차이가 있는 것으로 나타났다. 이와같이 게르마늄 함유배지에 적응시킨 내성효모의 성분이 일반효모균의 성분과 차이가 있는 것은 게르마늄이 효모세포내에 흡착되어 유기 게르마늄을 생합성하는 과정에서 효모세포내의 다른 성분들의 생합성과정에 영향을 미치는 것으로 추측된다. A germanium-tolerant yeast was derived by a series of subcultures in the media containing increasing Ge0_2 concentrations and incubated in the medium containing GeO_2(80ppm). The proximate compositions, polysaccharides, fatty acids and amino acids of germanium-tolerant yeast were analyzed and compared with those of wild-type yeast. The protein of germanium-tolerant yeast was also fractionated by Sephadex G-75 column chromatography and DEAE-cellose ion exchange chromatography and compared with those of wild-type yeast.

게르마늄 내성효모에 의한 게르마늄의 세포내 축적

김경신,함희숙,김종현,박원봉 서울여자대학교 자연과학연구소 1995 자연과학연구논문집 Vol.6 No.-

게르마늄 내성 효모를 개발하여, 유기게르마늄을 생합성할 수 있는 최적의 조건을 알아보고, 게르마늄의 효모균체내에서의 생합성을 확인하였다. 1. 게르마늄 내성효모의 성장정도가 일반효모보다 약간 높은 것으로 나타났으며, 내성효모 배양액의 pH는 시간이 경과함에 따라 일반효모의 배양액보다 pH의 상승정도가 큰 것으로 나타났다. 2. 내성효모의 성장정도는 GeO2 의 농도가 90ppm까지는 점차 상승하다가 그 이상에서는 성장정도가 점차 감소하는 추세를 보였으나 일반효모보다는 감소하는 정도가 적은 것으로 나타났다. 3. 배지의 GeO2 농도를 80ppm으로 하고 pH를 8.0으로 조절한 후 30℃ 24시간동안 배양한 효모 중의 게르마늄의 농도가 0.818g/mg으로 가장 높게 나타났다. 4. 효모세포내의 게르마늄의 분포상태를 측정한 결과, 대부분의 게르마늄이 효모세포벽을 구성하는 고분자 다당체나 단백질에 결합된 것으로 추측된다. 또한 게르마늄의 일부는 수용성 단백질과 결합되어 있는 것을 확인할 수 있었다. A mutant of Saccharomyces cerevisiae ACTC 4105 was derived by a series of subcultures in the media containing increasing GeO_2 concentrations. The growth of tolerant yeast cells and the yield of organic germanium was studied as a function of GeO_2 concentrations, temperature and pH of media. The distribution of organic germanium in the tolerant yeast cells incubated in the media containing GeO_2 was also studied.

혈액투석중인 말기신부전 환자에서 Fludrocortisone acetate (FCA) 투여 후 혈청 칼륨 저하 효과

류봉관,강대웅,정지용,윤나라,신병철,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background: Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (fludrocortisono acetate) on serum potassium level in the serum of hyperkalemic end-stage renal disease patients. Methods: Fourteen patients on hemodialysis receiving fludrocortisone acetate (FCA) 0.1 mg/day were observed for 2 months periods. Consecutive monthly biochemical profiles were compared for the druration of the pre-and post-treatment of FCA. Result: Fourteen patients with mean age (±SE) of 51.5 years (4 males and 10 females) and mean hemodialysis period of 51.9 months were studied. Mean serum potassium levels significantly fell (p<0.05) during the post-FCA period (5.2±0.66 mEq/L) compared with potassium levels during the pre-FCA (5.8±0.43 mEq/L) period. Pre-and post-FCA values were not different for sodium, chloride, protein, albumin, AST/ALT, glucose, blood nitrogen, creatinine, phosphate and calcium. Conclusions: FCA appears to decrease serum potassium value in patients with end-stage renal disease. These results suggested that FCA could be effective to treat hyperkalemia without any adverse effect in patients undergoing hemodialysis.

뇌수술 시 과호흡과 만니톨의 투여가 뇌혈류와 뇌산소대사에 미치는 영향

김지헌,김경식,문봉기,조경기,신용삼,이영주,김진수 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: There are therapies to lower intracranial pressure (ICP) including head elevation, hyperventilation, diuretics injection, intravenous mannitol, hypothermia, cerebrospinal fluid drainage, and cerebral resection in neurosurgical patients. However in recent reports, hyperventilation followed by mannitol administration may lead to cerebral ischemia. Therefore, we investigated the effect of 0.5-1.0 g/kg mannitol administration on jugular venous oxygen saturation (SjVO_2) and cerebral arterial-jugular venous oxygen content difference (AVDO_2) at PaCO_2 25-30 mmHg and 35-40 mmHg in patients undergoing neurosurgery. Methods: we studied 17 patients undergoing neurosurgery in the Ajou University Hospital. Anesthesia was induced with fentanyl, midazolam, thiopental, and vecuronium, and maintained with )_2-Air-Isoflorane, a continuous infusion of fentanyl, and vecuronium. Patients were divided into two groups. Group 1 (n = 10) which is PaCO_2 25-30 mmHg and Group 2 (n = 7) which is PaCO_2 35-40 mmHg by controlling ventilator. Measurements of SjVO_2 and AVDO_2 in following time intervals: Ⅰ = preinjection of mannitol, Ⅱ = postinjection 20 minutes of mannitol, Ⅲ = postinjection 40 minutes of mannitol were obtainde for each group. 0.5-1.0 g/kg mannitol was administered intravenously just at duramater opening. Results: Hemodynamics and hematologics were not significantly different among the two groups. SjVO_2 of each group are as follows; Group 1; Ⅰ (70.3 ± 8.1%), Ⅱ (66.3 ± 6.9%), Ⅲ (69.1 ± 7.9%) and Group 2; Ⅰ (78.6 ± 7.4%), Ⅱ (75.1 ± 8.1%), Ⅲ (76.0 ± 11.2%), Hyperventilation significantly decreased SjVO_2- AVDO_2 was not significantly different but SjVO_2 in Ⅱ was significantly decreased compared with Ⅰ and Ⅲ in Group 1 (20% patients). Conclusions: Mannitol produced a change of SjVO_2 during hyterventilation. Therefore, intravenous mannitol during hyperventilation should be given cautiously according to the patients status because it may cause cerebral ischemia in critical patients. (Korean J Anesthediol 2002; 43: 462~467)

사람 YB-1 유전자의 프로모터에 결합하는 핵인자에 관한 연구

김유리,한상원,류필열,김경근,안봉환,신부안 全南大醫大 2001 전남의대학술지 Vol.37 No.1

Si Bulk Micromachining을 위한 Wafer Rolling Etching 및 그 특성

김건년,이보나,박효덕,신상모,공경준,장동근,김병철,권혁채,이봉희 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

A wafer rolling etching system for the silicon bulk micromachining has been designed and fabricated. The silicon diaphragms were anisotropically etched in a 24.5 weight percent KOH solution. Compared to the conventional KOH etching systems, pyramidal hillocks, and wave-shaped structures on the etched surfaces were greatly reduced by using this system. After etching for time of 438 minutes, the average etched depth and the etch-rate were measured to be 537μm and 1.22μm/min, respectively. The average etching uniformity of etching depth was 0.87% in 5-inch wafer. Our results showed that the wafer rolling method enhanced etch uniformity and etch rate.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

Establishing EU Norms as a Global Actor: Application of New Concepts in FTAs

Bong-Chul Kim(Bong-Chul Kim),Eui-Chan Shin(Eui-Chan Shin),Kyung-Eun Park(Kyung-Eun Park) The International Academy of Global Business and T 2023 The International Academy of Global Business and T Vol.19 No.1

Purpose - This study conducts an analysis on the strengthening of the EU’s capacity as a normative power, and the direction of global standardization of these norms. Specifically, this study examines how trade and sustainable development provisions are applied in FTAs with Asian countries. Design/Methodology/Approach - To analyze the relationship between the EU as normative power and its expansion to global standardization as a new concept in the field of trade, this study first focuses on the concept of the EU’s normative power. Based on the concept, the study conducts a comparative analysis of the Korea-EU FTA, EU-Singapore FTA, and EU-Vietnam FTA, which are known as representative FTAs of the EU with Asian countries. Findings - The EU is trying to develop its norms into global standards as a normative power by applying the concept of trade and sustainable development when signing trade agreements with other countries amid changes in multilateral trade norms. This is evidently revealed in the FTAs of the EU with Korea, Singapore, and Vietnam. Research Implications - When discussing the revision of the Korea-EU FTA in the future, it is necessary to recognize and respond to these changes, and Korea, as a middle power, also needs to consider the ripple effect of the EU’s formation and spread of its norms as a normative power.