대동맥판막하 좌심실류로 인한 급성심장사

황청수,김창현,김영주,하홍일 대한법의학회 2016 대한법의학회지 Vol.40 No.1

Subaortic left ventricular aneurysm is a rare, mostly congenital condition, and occurs as a result of a defect in the alveolar fibrosa between the mitral and aortic annuli. Clinically, most subaortic left ventricular aneurysms are asymptomatic, but some of them cause arrhythmia, chest pain, and even sudden cardiac death. We report an autopsy case of sudden cardiac death due to subaortic left ventricular aneurysm in a 38-year-old male sailor.

제올라이트 수지 및 ZnO, AgMnO3 등의 무기흡착제를 이용한 반도체 공정에서 사용되는 염산가서의 처리 및 측정에 관한 연구

황청수,박정준,임흥빈 한국분석과학회 2003 분석과학 Vol.16 No.3

Synthesis of the Water Dispersible L-Valine Capped ZnS:Mn Nanocrystal and the Crystal Structure of the Precursor Complex: [Zn(Val)2(H2O)]

황청수,Narae Lee,Young-Ah Kim,박윤봉 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.11

The L-Valinate anion coordinating zinc complex, [Zn(val)2(H2O)], was isolated and structurally characterized by single crystal X-ray crystallography. The crystal possess orthorhombic symmetry with a space group P212121, Z = 4, and a = 7.4279(2) , b = 9.4342(2) , c =20.5862(7) respectively. The compound features a penta-coordinate zinc ion in which the two valine anion molecules are directly coordinating the central zinc metal ion via their N (amine) and O (carboxylate) atoms, and an additional coordination to zinc is made by water molecule (solvent) to form a distorted square pyramidal structure. In addition, further synthesis of the valine capped ZnS:Mn nanocrystal from the reaction of [Zn(val)2(H2O)] precursor with Na2S and 1.95 weight % of Mn2+ dopant is described. Obtained valine capped nanocrystal was water dispersible and was optically characterized by UV-vis and solution PL spectroscopy. The solution PL spectrum for the valine capped ZnS:Mn nanocrystal showed an excitation peak at 280 nm and a very narrow emission peak at 558 nm respectively. The measured and calculated PL efficiency of the nanocrystal in water was 15.8%. The obtained powders were characterized by XRD, HR-TEM, and EDXS analyses. The particle size of the nanocrystal was also measured via a TEM image. The measured average particle size was 3.3 nm.

Sudden Unexpected Death Due to Myocarditis Caused by Coronavirus Disease 2019: Postmortem Histopathologic Evaluation

황청수,나주영,고영산,박영일,허진행,송호석 대한법의학회 2022 대한법의학회지 Vol.46 No.4

Coronavirus disease 2019 (COVID-19) is a manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its major symptoms include pulmonary complications, such as pneumonia. However, it also involves the cardiovascular system and the developed myocarditis can lead to sudden unexpected death. Herein, we present a case in which a patient died four days after release from isolation due to SARS-CoV-2 infection. SARS-CoV-2 was confirmed again during postmortem (PM) inspection at the scene of death. Autopsy revealed myocarditis and evidence of pulmonary involvement with SARS-CoV-2. Pathological examination revealed myocardial perivascular infiltration of lymphocytes and macrophages with multifocally injured cardiomyocytes. The pathological findings of COVID-19–induced myocarditis differ from those of other viral myocarditis, and we assume that different pathophysiological mechanisms could have been responsible for this manifestation. After a comprehensive PM examination, including gross dissection, microscopic examination, PM computed tomography, and PM laboratory tests, the cause and manner of death were determined to be myocarditis caused by COVID-19 and naturally, respectively. This case highlights the significance of autopsy and comprehensive PM examinations in both forensic and public healthcare systems.

Characterization of the ZnSe/ZnS Core Shell Quantum Dots Synthesized at Various Temperature Conditions and the Water Soluble ZnSe/ZnS Quantum Dot

황청수,조일희 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.11

ZnSe/ZnS, UV-blue luminescent core shell quantum dots, were synthesized via a thermal decomposition reaction of organometallic zinc and solvent coordinated Selenium (TOPSe) in a hot solvent mixture. The synthetic conditions of the core (ZnSe) and the shell (ZnS) were independently studied at various reaction temperature conditions. The obtained colloidal nanocrystals at corresponding temperatures were characterized for their optical properties by UV-vis, room temperature solution photoluminescence (PL) spectroscopy, and further obtained powders were characterized by XRD, TEM, and EDXS analyses. The synthetic temperature condition to obtain the best PL emission intensity for the ZnSe core was 300 ûC, and for the optimum shell capping, the temperature was 135 ûC. At this temperature, solution PL spectrum showed a narrow emission peak at 427 nm with a PL efficiency of 15%. In addition, the measured particle sizes for the ZnSe/ZnS nanocomposite via TEM were in the range of 5 to 12 nm. Furthermore, we have synthesized water-soluble ZnSe/ZnS nanoparticles by capping the ZnSe/ZnS hydrophobic surface with mercaptoacetate (MAA) molecules. For the obtained aqueous colloidal solution, the UV-vis spectrum showed an absorption peak at 250 nm, and the solution PL emission spectrum showed a peak at 425 nm, which is similar to that for hydrophobic quantum dot ZnSe/ZnS. However, the calculated PL efficiency was relatively low (0.1%) due to the luminescence quenching by water and MAA molecules. The capping ligand was also characterized by FT-IR spectroscopy, with the carbonyl stretching peak in the mercaptoacetate molecule appearing at 1575 cm1. Finally, the particle sizes of the MAA capped ZnSe/ZnS were measured by TEM, showing a range of 12 to 17 nm.

Large-Scale Synthesis of Carbon Nanotubes by an Ethanol Thermal Reduction Process

황청수 ( Hwang Cheong Su ) 한국공업화학회 2003 공업화학전망 Vol.6 No.4

Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)–Positive Breast Cancers

이소정,황청수,김영금,이현정,안상정,신나리,이정희,신동훈,최경운,박도연,이창훈,허기영,설미영,이희진,공경엽,김지연,김아롱 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2

Purpose The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been determined in breast cancers. Interferons can affect T-cell activity through direct and indirect mechanisms. Myxovirus resistance A (MxA) is an excellent marker of interferon activity. Here, we evaluated TILs and MxA expression in human epidermal growth factor receptor 2 (HER2)–positive breast cancers. Materials and Methods Ninety cases of hormone receptor (HR)+/HER2+ tumors and 78 cases of HR–/HER2+ tumors were included. The TILs level was assessed using hematoxylin and eosin–stained full face sections, and MxA expression was evaluated by immunohistochemistry with a tissue microarray. Results MxA protein expression was significantly higher in tumors with high histologic grade (p=0.023) and high levels of TILs (p=0.002). High levels of TILs were correlated with high histological grade (p=0.001), negative lymphovascular invasion (p=0.007), negative lymph node metastasis (p=0.007), absence of HR expression (p < 0.001), abundant tertiary lymphoid structures (TLSs) around ductal carcinoma in situ (p=0.018), and abundant TLSs around the invasive component (p < 0.001). High levels of TILs were also associated with improved disease-free survival, particularly in HR–/HER2+ breast cancers. However, MxA was not a prognostic factor. Conclusion High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. Additionally, a high level of TILs was a prognostic factor for breast cancer, whereas the level of MxA expression had no prognostic value.

Synthesis of a White-Light-Emitting ZnSe:Mn Nanocrystal via Thermal Decomposition Reaction of Organometallic Precursors

이상민,황청수 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.1

Biological Toxicity Changes of Mercaptoacetic Acid and Mercaptopropionic Acid Upon Coordination onto ZnS:Mn Nanocrystal

공훈영,황청수,변종회 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.2

Mercaptoacetic acid (MAA) and mercaptopropionic acid (MPA) capped ZnS:Mn nanocrystals were synthesized and their physical characteristics were examined by XRD, HR-TEM, EDXS, and FT-IR spectroscopy. The optical properties of the MPA capped ZnS:Mn nanocrystals dispersed in aqueous solution were also measured by UV/Vis and solution photoluminescence (PL) spectra, which showed a broad emission peak around 598 nm (orange light emissions) with calculated relative PL efficiency of 5.2%. Comparative toxicity evaluation of the uncoordinated ligands, MAA and MPA, with the corresponding ZnS:Mn nanocrystals revealed that the original ligands significantly suppressed the growth of wild type E. coli whereas the ligandcapped nanocrystals did not show significant toxic effects. The reduced cytotoxicity of the conjugated ZnS:Mn nanocrystals was also observed in NIH/3T3 mouse embryonic fibroblasts. These results imply that potential toxicities of the capping ligands can be neutralized on ZnS:Mn surface.

무기흡착제를 이용한 반도체 공정에서 사용되는 할로겐 가스 (BCl₃, CF₄) 의 처리 및 측정에 관한 연구

임흥빈,황청수,박정준,Lim, H.B.,Hwang, Cheong-Soo,Park, Jeong-Jun 한국분석과학회 2003 분석과학 Vol.16 No.5

반도체 공정에서는 많은 종류의 가스를 사용하는 데 그중 할로겐 가스는 독성과 환경오염 문제를 야기 시키고 있다. 본 실험은 할로겐 가스를 기존의 제거 방식이 아닌 수지를 이용한 제거 방법 및 측정을 하는 연구를 하였다. 우선 실험에 사용한 할로겐 가스로는 $BCl_3$와 $CF_4$ 가스를 제거하는 실험을 하였다. 실험 장치는 실험조건을 고려하여 직접 제작을 하였다. 그리고 수지를 이용한 흡착 제거를 하기 위해 제올라이트, $Ag^+$ 이온으로 치환된 제올라이트, $AgMnO_3$, ZnO등 여러 가지 수지를 이용하여 실험하였다. 가스의 분석을 위해서 실제 사용되어지는 적외선 분광기 (FT-IR)를 이용하여 정성 및 정량분석을 하여 각각의 수지에 대한 할로겐 가스의 제거량을 계산하여 수지의 제거 능력을 확인하였다. 제올라이트, Ag 제올라이트, $AgMnO_3$, ZnO등의 수지중에서 ZnO가 가장 좋은 제거 효율을 보였으며 $BCl_3$ 가스의 경우 수지 1g에 대해 0.094 g을 제거하는 결과를 보였다. 그러나 $CF_4$ 가스는 일반적인 고체 수지는 제거를 하지 못하고 액체인 $CHCl_3$가 약간의 제거능력을 보이는 결과를 얻었다. Halogen gases such as $BCl_3$ and $CF_4$ are among the most problematic gases used in semiconductor process. They raise serious environmental and health problems due to their extreme toxicity. This study is to develop a method to effectively remove those gases during the process by using various types of inorganic gas adsorption agents such as zeolite A, modified AgA zeolite, ZnO, and $AgMnO_3$, which have not been attempted in the conventional methods. The removal efficiencies of the gases were both qualitatively and quantitatively measured by a FT-IR spectrophotometer. The whole device for the measurement has been designed and built in our lab. The removal efficiencies of the gases were compared between those used resins. The experimental result revealed that ZnO showed the best removal efficiency for BCl3 gas that had removed 0.094 g per 1 g of the resin used. For $CF_4$ gas, none of the solid resins was able to remove the gas effectively. However, liquid $CHCl_3$ showed some removal ability of the $CF_4$ gas.