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반월상 연골판 손상의 한의학적 치료에 대한 국내외 최신 연구 동향 분석
한시훈,오태영,오민석 대한한의학회 2022 대한한의학회지 Vol.43 No.1
Objectives: The purpose of this study was review the current clinical studies about the effect of Korean traditional medicine treatment for meniscus injury. Methods: Clinical studies on Korean traditional medicine treatment of meniscus injury were searched through 11 online databases. We analyzed the authors, publication year, country, study design, subjects, treatment methods, treatment effects, evaluation tools and adverse events of the selected studies. Results: 23 studies which included 9 randomized controlled trials, 8 case reports, 4 retrospective observational studies, 2 non-randomized controlled trials were selected through the databases. A total of 9 Korean traditional medicine treatments were used, among them, acupuncture treatment was the most used. The most commonly used outcome was effective rate. Conclusions: Through this study, we could confirm that Korean traditional medicine is an effective treatment for meniscus injury. It was suggested that various clinical studies on the effects of Korean traditional medicine for meniscus injury are needed and it is necessary to establish more scientific evidence through studies with a high level of evidence.
한시훈,이기언,변다영,김영익,김민균,민부기,임한빛,정연재,오민석 한방재활의학과학회 2019 한방재활의학과학회지 Vol.29 No.3
Objectives The purpose of this research is to evaluate the effectiveness of moxibustion theraphy for frozen shoulder through systematic review and meta-analysis. Methods The effect of moxibustion for frozen shoulder was constructed as a key question to search randomized controlled trials (RCTs) in 16 databases without type of publication restriction. Results A total of 790 studies were searched and 22 RCTs were finally selected through primary and secondary selection/exclusion process. In most of the evaluation indexes used in each study, moxibustion treatment for shoulder pain was statistically significant compared with other treatments. A meta-analysis of effective rate in 10 studies comparing moxibustion with acupuncture and acupuncture showed a statistically significant effect of moxibustion treatment. And there was a significant effect on the improvement of the shoulder mobility, but the effect size of shoulder pain was no significant effect for shoulder pain reduction. In addition in the result of meta-analysis of 4 studies' effective rate comparing moxibustion with electronic acupuncture, the effect of moxibustion was significantly higher than that of electronic acupuncture in frozen shoulder. Conclusions Moxibustion therapy was effective in symptoms in patients with frozen shoulder. However because of the high risk of bias in the quality of the included studies, the applicability of this study seems to be limited. It is thought that future randomized controlled trials will need to be designed and performed by reviewing ways to minimize bias. (J Korean Med Rehabil 2019;29(3):35-49)
교통사고로 발생한 경추 골절 환자에 대한 한방복합치료 효과: 증례보고
한시훈 ( Si-hoon Han ),이기언 ( Gi-eon Lee ),조경상 ( Kyeong-sang Jo ),변다영 ( Da-young Byun ),오민석 ( Min-seok Oh ) 대한한의학회 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.2
The objective of this study is to report the effects of complex Korean Medicine treatment for 2 patients who had cervical spine fracture casued by traffic accident. We used acupuncture, pharmacopuncture, moxibustion and herbal medicine to treat patients with cervical spine fracture. We observed the changes of pain by Numeric Rating Scale(NRS), Neck Disability Index(NDI) and EuroQol-5 Dimension Index(EQ-5D Index). After complex Korean Medicine treatment, we found that neck pain was reduced and quality of life were improved by NRS, NDI and EQ-5D Index. Complex Korean Medicine could be effective for patients with cervical spine fracture caused by traffic accident. (J Korean Med Rehabil 2018;28(2):113-120)
김현수,한시훈,김효철,김현주,신석균 대한내과학회 1996 대한내과학회지 Vol.50 No.2
Gaucher's disease is an inherited metabolic disorder characterized by enzyme defect, cerebroside β-glucosidase and accumulation of glucocerebroside in reticuloendothelial system. There are three subtypes of Gaucher's disease. Type 1(non-neuronopathic) is the chronic form occurring rather frequently and shows hepatosplenomegaly, pancytopenia and bone lesion. Type 2(acute neuronopathic) is uniform in se- verity and progression, showing acute neurologic deterioration and early death. Type 3(subacute neuronopathic) is less rapidly progressive than type 1 disease, but is also a neurovisceral storage disorder. The diagnosis is confirmed by assay of glucocerebrosidase in white cells or fibroblasts. With enzyme assay, however, carrier and subtype determination is unreliable. But it is possible that studies of the gene for glucocerebrosidase and its mutation may lead to more definitive determination. The treatment is divided into two modalities, the first is symptomatic management with splenectomy, the second is enzyme replacement, allogeneic bone marrow transplantation and somatic cell gene transfer. The second modalities are currently experimental. Recently, two sisters of subacute neuronopathic Gaucher's disease who presented with pancytopenia, hepatosplenomegaly and seizure disorder, were diagnosed as type III Gaucher's disease and confirmed by the enzyme assay. Here we reported these cases with literature review.
Metabolic evaluation of children with global developmental delay
은소희,한시훈 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.4
Global developmental delay (GDD) is a relatively common early-onset chronic neurological condition,which may have prenatal, perinatal, postnatal, or undetermined causes. Family history, physical andneurological examinations, and detailed history of environmental risk factors might suggest a specificdisease. However, diagnostic laboratory tests, brain imaging, and other evidence-based evaluationsare necessary in most cases to elucidate the causes. Diagnosis of GDD has recently improved becauseof remarkable advances in genetic technology, but this is an exhaustive and expensive evaluation thatmay not lead to therapeutic benefits in the majority of GDD patients. Inborn metabolic errors are one ofthe main targets for the treatment of GDD, although only a small proportion of GDD patients have thistype of error. Nevertheless, diagnosis is often challenging because the phenotypes of many genetic ormetabolic diseases often overlap, and their clinical spectra are much broader than currently known. Appropriate and cost-effective strategies including up-to-date information for the early identification ofthe “treatable” causes of GDD are needed for the development of well-timed therapeutic applicationswith the potential to improve neurodevelopmental outcomes.
윤혜란,한시훈,안영민,신윤정,Yun, Hye-Ran,Han, Si-Hun,An, Yeong-Min,Sin, Yun-Jeong 대한유전성대사질환학회 2001 대한유전성대사질환학회지 Vol.1 No.1
아시아 및 한국에서 처음 발견된 3명의 소아 Ethylmalonic encephalopathy (EE) 환자들은 riboflavin을 이용한 치료법에 점진적인 호전을 보인 것으로 나타났다. Ethylmalonic aciduria가 3가지 효소-2-methyl-branched-chain acyl CoA dehydrogenase (2MBCAD), iso-valeryl CoA dehydrogenase (IVCAD), 그리고 short-chain acyl CoA dehydrogenase (SCAD) - 들의 부분적인 결함으로 생긴다는 가설하에 dehydrogenase (탈수효소)의 보조 효소인 riboflavin이 부분적으로 나마 치료 과정에서 어떤 역할을 수행하는지의 여부를 살펴보았다. 다음의 세 증례에서 riboflavin 혹은 coenzyme Q10을 병행하여 치료한 결과 인지 행동(cognitive behavior)과 만성 점액성 설사(chronic mucoid diarrhea)가 호전된 것으로 관찰되었다. 또한, 치료 후 운동 기능도 일부 호전되었다. EE의 질병 발생 기전이 현재까지 완전히 밝혀지지는 않았지만, 세 명의 EE 환자들의 치료경과를 관찰하여 위의 가설을 뒷받침 할 수 있었다.