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모 컴퓨터 회사 근로자 건강증진 사업 전개를 위한 수요조사
임현우,안병용,최환석,박정일,김경수,이강숙,김정아,구정완 가톨릭대학산업의학쎈타 산업의학연구소 1997 韓國의 産業醫學 Vol.36 No.4
Before conducting the health promotion program, we surveyed the health risk appraisal(HRA) of 210 workers (186 men and 24 women) in a computer company, for the need assessment, selection of target population, priority setting, and as a standard for comparision after performing the program. The smokers were 115(88.6%), and drinkers (over 1 bottle of Soju per week) were 91(44.8%) in men. Entire women and 148(78.0%) men never or irregularly exercise. Type A personality were 73(39.2%) in men, 8(33.3%) in women, and 26(14.0%) of men and 6(25.0%) of women were high stress risk group. 53(25.2%) of men and 2(8.3%) of women were obese (BMI ≥25kg/m²), and workers who consumed exess of total calory compared with recommendation were 142(76.3%) in men and 18(75%) of women. By the health risk appraisal, it was suggested that smoking cessation program, drinking counselling, exercise prescription, stress management, and weight control program should be conducted effectively for the high risk group.
최환석,정치경 가톨릭대학산업의학센타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.4
This study was performed to investigate the pattern of health behaviors and the relationship between normal and abnormal group. The analysis and interpretation were done concerning health behavior of the whole persons who visited health checkup center in Kang-Nam St. Mary's Hospital in April 1993 by questionnaire. According to the results of health examination, the subjects were classified into normal and abnormal group. The results from the study were as the follow : 1. Normal and abnormal group of the subjects were 48.4% and 51.6%, respectively. 2. Significant differences of the distribution of subjects between normal and abnormal group were observed in sex and age among personal characteristics. 3. The distribution of subjects between two groups was significantly related to smoking and alcohol drinking in group of 40-59 years of age and self-reported hypertension in group of 39 years and below. 4. Behavioral risk factors had significant relations with sex and years of education. With the above consideration in minds, behavioral risk factors were significantly related to sex, age and educational level. Study findings suggested that health education concerning behavioral risk factors be important.
흰쥐 췌장 선포에서 Cholecystokinin 에 의해 유발된 Amylase 유리에 미치는 Somatostatin 의 영향
김명석,최환석,조양혁,윤신희,한상준,심상수,이덕주,이세영 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: The inhibitory effect of somatostatin (SS) on cholecystokinin (CCK)-induced amylase release and the role of intracellular cAMP in this process were investigated. Methods: Pancreatic acini were isolated from rat pancreas and treated with solution involving collagenase and then, dispersed. Amylase release was measured. In another set of experiment, cAMP and inosito phosphate (IP) formation were measured. Results: SS-14 inhibited CCK-8-induced amylase release Octreotide, somatostatin analog, also inhibited CCK-8-induced amylase release equipotently. The inhibitory effect of octreotide on CCK-8-induced amylase release was not found in the presence o 8-bromo-cAMP. Forskolin, an adenylyl cyclase activator, potentiated K-8-induced amylase release. However, the amylase release achieved by the simultaneous administration of CCK-8 and octreotide was not altered by forskolin, while the cAMP level in response to the administration of CCK-8 and octreotide was increased significantly by forskolin. Octreotide inhibited the basal cellular cAMP leve significantly, but CCK-8 alone did not exhibit any change. CCK-8-induced IP formation was no changed by octreotide. Tyrosine phosphatase inhibitors did not affect inhibitory action of octreotide on CCK-8-induced amylase release. Conclusions: From the above results, it is concluded that SS inhibits amylase release induced by CCK in dispersed pancreatic acini of rat. A decrease in pancreatic amylase release in response to octreotide may be attributed to inhibited basal cAMP formation Further study is needed to elucidate the related process.
고지혈증 치료에서 Ciprofibrate 와 Lovastatin 의 효능과 안전성에 대한 다기관 임상 연구
박혜순,김영식,신호철,최환석,이혜리 한국지질학회 1997 韓國脂質學會誌 Vol.7 No.1
To compare the efficacy and safety of ciprofibrate and lovastatin, we conducted multicenter double-blind controlled clinical trial. We included hyperlipidemic patients who were indicated drug therapy by NCEP ATP II. Patients were divided into two groups according to a randomization, and received either ciprofibrate 100㎎ daily or lovastatin 20㎎ daily for 8 weeks. After 8weeks of drug therapy, we compared several cardiovascular risk factors and side effects between ciprofibrate and lovastatin. The total study subjects were 84 patients. Three patients were dropped out and six patients stopped drug medication by side effects. The following changes were seen under ciprofibrate(C) and lovastatin(L) ; TC (C) -11.5% vs (L) -15.7%, not significantly different, TG (C) -39.2% vs (L) -11.4%, significantly reduction in (C), HDL-C (C) 22.9% vs (L) 9.5%, significantly increase in (C), LDL-C (C) -12.4% vs (L) -19.4%, not significantly different, TC/HDL-C (C) -26.3% vs (L) -18.4%, not significantly different, Apo A1 (C) 21.1% vs (L) 8.6%, not significantly different, Apo B (C) -13.3% vs (L) -12.0%, not significantly different, Apo A1/Apo B (C) -20.1% vs (L) -14.6%, not significantly different, fibrinogen (C) -10.0% vs (L) 2.6%, significantly reduction in (C). We conclude that both drugs are efficient and safe in lowering lipid levels. Ciprofibrate showed more significant reduction of triglyceride and fibrinogen, more increase of HDL-cholesterol than lovastatin. There was no significant difference in reduction of total cholesterol and LDL-cholesterol and in the incidence of side effects between ciprofibrate and lovastatin.