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이세영,지연태,김익영 한국유전학회 1984 Genes & Genomics Vol.6 No.3
Klebsiella pneumoniae lacks tryptophanase and, therefore, is better host of the amplified trp operon for the production of tryptophan. For the purpose of host development, tryptophan repressor deficient mutation, tryptophan aminotransferase-deficient mutation and L-serine deaminase-deficient mutation were introduced into the K. pneumoniae host cell and their effects on the expression of amplified recombinant E. coli trp operon (R_6K: :Mu-trpL (Δatt) trpE^(FBR)) were examined. The trpR^- mutation derepressed the expression of the recombinant E. coli trp operon and both tat^- and ssd^- mutation also increased the activities of anthranilate synthetase and tryptophan synthetase as well as the production of tryptophan in K. pneumoniae.
두경부암에서 Human Papillomavirus의 검출 방법
이세영 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.1
Ever since human papillomavirus (HPV) has known to be associated with head and neck cancer, there have been many studies investigating the role of HPV as its causative factor. The most important thing among studies for HPV is to obtain HPV from cancer tissue and find out whether the obtained HPV is related to the development of cancer. However, until now, there has been no standardized method in diagnosing HPV infection. The various detecting methods for HPV and difference in sensitivity among experimental methods are one of the reasons for the controversy over the role of HPV. In this review, we present the advantages and disadvantages of HPV detection methods those are currently used and suggest standardized methods that may be used to detect HPV in head and neck cancer in the future.
이세영,김승회,이윤영,구양모,Se Young Lee,Seung Hoi Kim,Youn Young Lee,Yang Mo Goo 대한화학회 1992 대한화학회지 Vol.36 No.2
3-알킬리덴-2,4-펜탄디온(1)과 아릴히드라진을 메탄올에서 반응시키면 4-아세틸(2), 4-(1-메톡시알킬)-(3) 또는 4-비닐피라졸 유도체(4)가 얻어진다. 3-(2,2,2-트리클로로에틸리덴)-2,4-펜탄디온(9)과 아릴히드라진과의 반응에서는 4-아세틸-1-아릴-3-메틸피라졸(11)이 생성된다. 이 반응들의 가능한 메카니즘을 제시하였다. Reaction of 3-alkylidene-2,4-pentanediones(1) with arylhydrazines in methanol afforded 4-acetyl-(2), 4-(1-methoxyalkyl)-(3), or 4-vinylpyrazole derivatives(4). 3-(2,2,2-Trichloroethylidene)-2,4-pentanedione(9) reacted with arylhydrazines to give 4-acetyl-1-aryl-3-methylpyrazoles(11). Possible mechanisms for these reactions were proposed.