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Pyronine G 와 계면활성제 사이의 상호작용에 관한 연구
송기동,김성현,최칠남,이범규,최형기 ( Ki Dong Song,Sung Hyun Kim,Chil Nam Choi,Beom Gyu Lee,Hyeong Ki Choi ) 한국공업화학회 1997 공업화학 Vol.8 No.2
Pyronine G(PG)와 계면활성제 사이의 상호작용을 흡수 및 형광 분광학적으로 조사하였다. PG-AOT계 내에서 γ-band의 최적 조건은 S/D(계면활성제의 농도)/PG의 농도)의 80 부근에서 가장 좋았으며, 그 이상에서는 stacking 형태가 점차 파괴되는 해리현상이 일어남을 알 수 있었다. 그리고 양이온 및 비이온 계면활성제계들이 첨가되면 PG 단위체의 흡수세기가 증가하였다. 한편, PG-AOT계 내에서 NaCl 농도가 증가함에 따라 S/D < 10까지는 γ-band의 흡수세기가 감소하였다. 그러나 S/D>20에서는 흡수세기가 큰 차이를 보이면서 증가하였다. NaCl를 첨가한 PG-AOT계는 NaCl를 첨가하지 않은 계보다 더 큰 해리현상이 일어남을 알 수 있었다. The interaction between pyronine G(PG) and surfactants has been examined by the absorption and fluorescence spectroscopy. The optimum condition for γ-band in PG-AOT system was found when S/D(concentration of surfactant / concentration of PG) was in the vicinity of 80. The disassociation of stacking conformation occured gradually at S/D>80. In PG-cationic and nonionic surfactant systems the absorptivity of monomeric PG increased. With the increment of the concentration of NaCl in PG-AOT system, the absorptivity of γ-band decreased at S/D < 10 but, increased remarkably at S/D>20. PG-AOT system with the addition of NaCl showed greater dissociation than that without the addition of NaCl.
GnRH의 맥동성 투여에 의한 남성 성선기능저하증의 치료
박기현,지용석,이병석,이보연,조동제,송찬호,이무상,최형기,이현철,허갑범,Park, Ki-Hyun,Jee, Yong-Seok,Lee, Byung-Seok,Lee, Bo-Yun,Cho, Dong-Jae,Song, Chan-Ho,Lee, Moo-Sang,Choi, Hyung-Ki,Lee, Hyun-Chul,Heo, Kab-Beom 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1
The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination of surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of $10{\mu}g$ every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone. Testicular volumes increased. Spermatogenesis was induced in 8 patients. Pulsatile GnRH therapy is an effective treatment for idiopathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of surgery and irradiation for pituitary or hypothalamic tumor.