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최연수 ( Yeon Soo Choi ),오승일 ( Seung Il Oh ),이장환 ( Jang Whan Lee ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),유대현 ( Dae Hyun Yoo ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Objective: New nonsteroidal anti-inflammatory drugs (NSAIDs) with highly selective cyclooxygenase-2 (COX-2) inhibition afford protection against gastropathy, but their acute and long-term effects on the central nervous system are unclear. Our aim was to investigate the influence of COX-2 specific inhibitor (celecoxib) on cognitive function. Methods: Within the context of a randomized controlled parallel trial of NSAIDs for osteoarthitis (OA), we performed a battery of neuropsychological tests in consecutive 10 osteoarthritis patients with celecoxib (200 mg/day) and 13 osteoarthritis patients with diclofenac (100 mg/day) before and after 4 weeks by clinical psychologists who were not involoved in the study and unaware of study protocols and treatment allocation. The tests were performed randomly in sequence in order to minimize learning effect. The examed cognitive domains included memory, reasoning/problem solving, simple and complex attention, visual-spatial processing, and psychomotor speed. Results: Demographic characteristcs (age, sex, disease duration, functional status measured by patient`s and physician`s global assessment and KWOMAC, CES depression score, education level) were not significantly different between both treatment groups. In all cognitive domains, we did not find out significant cognitive decline before and after treatments either with celecoxib or diclofenac. There was no difference in the change of cognitive function between both treatment groups. Conclusion: The short-term use of COX-2 specific inhibitor as well as conventional NSAID may not impair cognitive function. The long-term follow up study using large number of patients is in progress.
이종선(Jong Sun Lee),이성욱(Seang Wock Lee),최정황(Jung Hwang Choi),백두성(Doo Sung Baik),최연수(Yeon Soo Choi) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
Urea-SCR system has been known so far to one of effective aftertreatment for the reduction of NOx. In order to achieve an better performance in SCR system, optimal geometric conditions for a urea injection system should be achieved. This research focused to evaluate characteristics of urea spray injected SCR system of a heavy duty diesel engine by applying visualization techniques. The experiment was conducted by varying injection pressure and flow rates of urea and its flow visualization was made by photographing techniques of CCD camera. This investigation may provide with fundamental data in future.
정상인에서 도플러 초음파술을 이용하여 측정한 니트로글리세린 투여후 두개내 혈류속도의 변화
박일(Il Park),장경식(Kyoung Sig Chang),안기완(Gi Wan An),최연수(Yeon Soo Choi),국기용(Ki Yong Kook),홍순표(Soon Pyo Hong) 대한내과학회 1995 대한내과학회지 Vol.48 No.4
N/A Objectives: With advances in transcranial ultrasound technology, transcranial color-code Doppler ultrasonography provides the anatomical location of basal transcranial vessel and their blood flow. To study of changes of cerebral blood flow, we measured continuously the blood flow velocity of middle cerebral artery by transcranial Doppler(2.5MHz) before and after sublingual administration of 0.6mg. nitroglycerin in twenty healthy young persons. Methods: Pulse rate and systolic and diastolic blood pressure and velocity of percussion(P), tidal (T) and dicrotic(Dc) wave, and diastole(Ds), velocity time integral(VTI), mean velocity(V), pulsatility index(PI) were measured. Results: Heart rate was increased, and systolic blood pressure was decreased significantly two minutes after administration of nitroglycerin. Diameter of outer margin of color Doppler spectrum was increased, and P, T, Ds, VTI and V were decreased significantly after two minutes. PI was increased significantly after two minutes, but returned to baseline level soon. Conclusion: We concluded that dilatation and decreased blood flow velocity of middle cerebral artery were resulted by nitroglycerin.
조립식 경량 캠 샤프트 내구성 및 신뢰성 향상에 관한 연구
나완용(Wan Yong Na),이문석(Mun Seok Lee),최현규(Hyeon Gyu Choi),최연수(Yeon Soo Choi) 한국자동차공학회 2007 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The aim of this study is to evaluate durability and reliance on lightweight assembled camshaft. The reliance valuation was performed by analyzing the cause of failure from field data and making improved tools through process Improvement. Durability and endurance test were implemented during the evaluation process. Solidity test, texture test by rubbing. cutting strength test. torque wrench test were all performed for test items and a valuation basis. The endurance test was performed in order to find out the volume of abrasion. The improvement items through the durability valuation guarantee more durability and decrease the rate of defects. This study is accomplished by the Ministry of Commerce Industry and Energy for the improvement of Reliance on Small Business.
최연수,박일,죄희충,김원식,양태영,허경,안기완,정춘해 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2
Histiocytic medullary reticulosis (HMR) is a malignant noeplastic process, with tumor cells belonging to the histiomonocytic line, and originally described by Scott and Robb-Smith in 1939 characterized by its acute onset, progression to death within a few months and its clinical features are fever, lymphadenopathy, hepatosplenomegaly, jaundice, and purpura common laboratory findings are characterized by severe anemia, leukopenia, thrombocytopenia and histologically by systemic progressive invasion of morphologically atypical histiocytes or of their precursor. 61 and 37-year-old males were admitted with camplaints of high fever and chilling sensation and were treated by cyclophosphamide, vincristine, prednison and antiobiotics, but patients all died 17 and 14 days after admission due to probably sepsis and respiratory failure.
두개강내 출혈을 동반한 불응성 특발성 혈소판감소성 자반증의 CYCLOPHOSPHAMIDE 치험 1예
서정철,양태영,최연수,박유환,김완중,허경,정원영,정춘해 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Idiopathic thrombocytopenic purpura(ITP) is an autoimmune bleeding disorder characterized by the development of antibodies to one's own platelets, which are then destroyed by phagocytosis in the spleen and liver. Its clinical manifestations are characterized by bleeding and the most serious complication is hemorrhage into the central nervous system, but which is rarely seen below 1%. In treating IPT, the therapy of first chice is administration of adrenocorticosteroid and r-globuline. If satisfactory results are not obtained, then splenectomy is recommended. If this also proves inadequate, then administration of immunosuppressants is carried out. 16-year-old male was admitted with complaints of left hemiplegia and nasal bleeding. This case may be developed spontaneous intracerebral hemorrhage causing thrombocytopenia and was treated by steroid, r-globuline and splenectomy, but satisfactory results are not obtained. After all, the paient was successfully treated with cyclophosphamide.
용혈성 빈혈과 흑수열을 동반한 Chloroquine저항성 수입 열대열 말라리아 1예
조희충,국기용,박일,최연수,이승일 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1
저자들은 최근 아프리카를 여행하는 도중 말라리아의 예방약제인 chloroquine을 복용하였음에도 불구하고 용혈성 빈혈과 흑수열을 동반한 chloroquine 저항성 수입 열대열 말라리아를 Fansidar를 투여하여 치료가 된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. This previously healthy 26 year-old student was admitted to Cho Sun university hospital due to paroxysmal high fever, dizziness of 2 weeks duration and he also noted passage of dark brownish colored urine of 3 days duration. He had made journey to Africa for 2 months before admission. He had taken chloroquine 1 week before his jurney and continued this weekly throughout his stay. On admission, there was fever of 38.5℃ and numerous parasitemia of ring form of P. falciparum in the peripheral blood smear. On physical examination, he had jaundice and splenomgaly. On laboratory examination, he had jaundice and splenomegaly. On laboratory examination hemoglobin was 5.Og / dl, reticulocytecount was 11%, plasma hemoglobin was 7.5mg /dl and urine hemoglobin was 2.5mg /dl. He received Fansidar on 2nd day of admission. Five days later, his blood was completely clear of parasite and 7th day after admission, all symptoms were almost improved and then he was discharged.
이용엽,손준광,이용국,신홍주,박옥영,최연수,이승,길광채,홍순표 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1
An aneurysm of the pulmonary artery is a rare entity and a current knowledge is mainly derived from autopsy findings, Pulmonary artery ancurysms arc associated with congenital heart disease : patient ductus arteriosus, ventricular septal detect, atrial septal defect and etc. In the remaining cases, such aneurysms are associated mainly with secondary acquired lesions, such as Behcet's disease, bacterial endocarditis, syphilis, tuberculosis, atherosclerosis, vasculitis, hypertension and trauma. We experienced a case of primary pulmonary artery ancurysm with pericardial effusion detected on a echocardiography in a 79 year-old female. A computed tomographic scan and pulmonary angiography showed dilatation of the main and proximal pulmonary arteries, accompanying by pericardial effusion. We report this case with a brief review of literature. 폐동맥류는 그 빈도가 매우 드물며 저자들은 호흡곤란을 호소하는 폐동맥류 1례를 경험하였기에 보고하는 바이다.