알루미나 나노산화물이 Nitrendipine 제조 공정에 미치는 영향

채은진,엄영랑,한병선,이창규,박상언,Chae, E.J.,Uhm, Y.R.,Han, B.S.,Rhee, C.K.,Park, S.E. 한국분말야금학회 2007 한국분말재료학회지 (KPMI) Vol.14 No.2

The alumina nano powders synthesized by levitational gas condensation (LGC) method were applied to catalyst in manufacturing process of Hanzsch reaction for Nitrendipine. The L-tartaric acid on the surface is carried out with participation of carbonyl fragments, O-H, C-H bonds which affects stereo selectivity, yield on the reagents positively. From the analysis of the IR-spectroscopy, the carbonyl fragments, O-H, and C-H bond were created by the catalytic reaction. From the analysis of the rR-spectroscopy, the carbonyl fragments, O-H, and C-H bond were created by the catalytic reaction. The newly created bonds made a chiral center on the final product.

모야모야병에 동반된 두개강내 주머니모양 동맥류

채은진 대한뇌졸중학회 2003 Journal of stroke Vol.5 No.2

Department of Radiology, Neurosurgery*, Anesthesiology**, Asan Medical Center,University of Ulsan College of Medicine, Seoul, KoreaBackground: Intracranial saccular aneurysms are not uncommon findings in patients with moyamoya disease. The discovery of a saccular aneurysm in underlying moyamoya patient with SAH is a diagnostic and therapeutic challenge. The purpose of the present study was to explore the frequencies and clinical significance of intracranial saccular aneurysms in moyamoya disease. Methods: Of 206 patients with moyamoya disease registered in our institute, six patients who have intracranial saccular aneurysms were enrolled in this study. Medical and radiological records were collected from registry, retrospectively. Incidence, distribution, and size of aneurysms and clinical outcome were investigated. Results: Six patients had total eight saccular aneurysms. Locations of aneurysms were; the aneurysms located at the circle of Willis including the basilar artery (n=2), posterior communicating artery (n=1), and superior cerebellar artery (n=1), at the collateral vessels including the anterior and posterior choroidal artery (n=3), and between the persistent trigeminal artery and the basilar artery (n=1). The longest diameter of aneurysms ranged from 3 mm to 15 mm (mean, 7.6 mm). 75% of the cases whose initial Hunt and Hess grade (H&H grade) were 1, 2, or 3 showed favorable outcome. 50% of H&H grade 4 cases had an unfavorable outcome of GOS 3. There was no difference in outcome with regard to the aneurysmal location. Conclusion: Saccular aneurysms in moyamoya disease is uncommon and tend to be located in the posterior circulation. The outcome of patients depends on initial clinical status rather than the location of aneurysm.

육계의 제한급여에 따른 지방합성, 근육관련 유전자의 발현 양상 비교 분석

채은진,강혜경,박경자,김명섭,손시환,장인석,문양수 한국가금학회 2007 한국가금학회 정기총회 및 학술발표회 Vol.24 No.-

Ross mail broiler chicken were used to determined the effect of either energy restriction(ER) or quantitative diet restriction(DR) on lipogenic genes in liver and myogenic genes in muscle. Diet restriction in all experiments was accomplished by providing chicks with 70 % or 85 % energy level of control(ER70, ER85), and 70 % or 85 % diet intake of control(DR70, DR85). Diet restriction groups of chickens were restricted for 7days, starting at 8days of age. Ad libitum feeding was resumed after the restriction periods, and continued through end of the experiment at 35 days of age. A control group was fed ad libitum throughout the experiment. Hepatic expressions of fatty acid synthtase(FAS) gene from DR70 and ER70 were 2-fold lower than that of control at 14days of age whereas DR85 and ER85 groups were not much different from the control group. The FAS gene expressions in DE70 and DR85 were not completely caught up the control group at 35 days of age while its expressions of ER85 and DR70 were not different from control. The expression levels of C/EBP-α, PPAR-γ and SREBP were not different among treatments at d14. Except ER70, the mRNA expressions of myogenic genes were not much changed by diet restriction in chickens. The results of the study indicated that feeding regimen alters expression of lipogenic genes in liver and may influence lipid metabolism of broilers.

Airway Measurement for Airway Remodeling Defined by Post-Bronchodilator FEV1/FVC in Asthma: Investigation Using Inspiration-Expiration Computed Tomography

채은진,김태범,조유숙,박찬선,서준범,김남국,문희범 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.2

Purpose: Airway remodeling may be responsible for irreversible airway obstruction in asthma, and a low post-bronchodilator FEV1/FVC ratio can be used as a noninvasive marker of airway remodeling. We investigated correlations between airway wall indices on computed tomography (CT) and various clinical indices, including post-bronchodilator FEV1/FVC ratio, in patients with asthma. Methods: Volumetric CT was performed on 22 stable asthma patients who were taking inhaled corticosteroids. Airway dimensions were measured at four segmental bronchi using in-house software based on the full-width/half-maximum method. Parameters included luminal area, wall thickness (WT), wall thickness percentage (WT%), wall area percentage (WA%), bronchial-to-arterial diameter (BA) ratio on inspiration CT, airway collapsibility (AC), and air trapping index (ATI). Correlations were analyzed between CT parameters and clinical indices, including %FEV1, FEV1/FVC, FEF25–75%, and post-bronchodilator FEV1/FVC ratio. Results: Post-bronchodilator FEV1/FVC showed significant correlations with WT%, WT, BA ratio, AC, and ATI (r=–0.503, –0.576, 0.454, 0.475, and –0.610, respectively). WT showed negative correlations with FEV1/FVC and FEF25–75% (r=–0.431 and –0.581), and WT% was negatively correlated with %FEV1, FEV1/FVC, and FEF25–75% (r=–0.434, –0.431, and –0.540, respectively). WA% showed correlations with FEF25–75% and body mass index (r=–0.459 and 0.453). The BA ratio was positively correlated with %FEV1 (r=0.459) and FEF25–75% (r=0.479). AC showed strong positive correlation with FEV1/FVC (r=0.592), and ATI showed negative correlations with FEV1/FVC (r=–0.534) and FEF25–75% (r=–0.591). Conclusions: WT%, WT, BA ratio, and AC on inspiration and expiration CT are good indices for measuring airway remodeling defined by post-bronchodilator FEV1/FVC in stable asthma patients treated with inhaled corticosteroids.

카르본산계 고성능 감수제의 제조시 혼합조성의 영향

채은진,홍지숙,서정권,박진원,이정민 한국공업화학회 2005 한국공업화학회 연구논문 초록집 Vol.2005 No.-

PC(Polycarboxylate)계 고유동화제가 시멘트 수화 반응에 미치는 영향

채은진(Chae, Eun Jin),신진용(Shin, Jin Yong),서정권(Suh, Jeong Kwon),홍지숙(Hong, Ji Sook),김재영(Kim, Jae Young) 한국콘크리트학회 2006 한국콘크리트학회 학술대회 논문집 Vol.2006 No.5

PC(Polycarboxylate)계 고유동화제가 시멘트 수화 반응에 미치는 영향

채은진(Eun-Jin Chae),신진용(Jin-Yong Shin),서정권(Jeong-Kwon Suh),이정민(Jung-Min Lee),박진원(Jin-Won Park) 한국콘크리트학회 2006 콘크리트학회논문집 Vol.18 No.4

드문 간질성 폐렴인 Idiopathic Pleuroparenchymal Fibroelastosis: 증례 보고

박종천,채은진,송준선 대한영상의학회 2014 대한영상의학회지 Vol.70 No.4

Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a recently described, very rare type of fibrotic interstitial lung disease predominantly involving subpleural areas of both upper lungs. IPPFE has distinctive radiologic and pathologic features: progressive subpleural opacity with fibrotic changes, predominantly in upper lungs, and dense elastic component on histology. We experienced one case of surgically confirmed IPPFE, with progression of radiologic findings on the serial CT examinations. We herein report the characteristic radiologic features of IPPFE with pathologic and clinical manifestations. Idiopathic pleuroparenchymal fibroelastosis (이하 IPPFE)는 최근 기술되기 시작한 상부 폐의 흉막 하에 주로 발생하는, 매우 드문 특발성 간질성 폐 질환이다. IPPFE는 다른 특발성 간질성 폐 질환들과 달리 상엽, 그 중에서도 주로 흉막 하에 병변이 위치하며 병리학적으로는 탄력섬유증(fibroelastosis)을 보인다는 점이 특징적이다. 저자들은 수술적 생검을 통해 IPPFE로 확진된 환자에서 컴퓨터 단층촬영(computed tomography)을 통한 8년간의 장기적 추적관찰로 질병의 형태학적 진행을 잘 보여주는 증례를 경험하여, 이 환자의 임상적, 영상 의학적, 병리학적 소견을 보고하고자 한다.

전신경화증 관련 간질성 폐질환에서의 임상적 특징과 예후 인자 분석

여유미,채은진,김동순,송진우 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

Interstitial lung disease (ILD) is a frequent complication in patients with systemic sclerosis and is associated with significant morbidity and mortality. However, limited data exist regarding clinical characteristics and prognostic factors in Asian patients with systemic sclerosis related ILD (SSc-ILD). The aim of this study is to evaluate the clinical features, outcome and prognostic factors for SSc-ILD patients in South Korea. Clinical data were retrospectively analyzed in 85 patients with SSc-ILD (biopsy proven case, n=17). The Cox proportional hazards regression model was used for analyzing predictors for clinical outcomes. Median follow-up period was 4.6 years (interquartile range: 2.7-7.4 years). Mean age of the subjects was 53 years, 15% were male, and 21% were smokers. The overall mortality rate was 12.9% during follow-up (1-year=0%, 3-year=4.7%, 5-year=5.9%). Non-survivors showed shorter duration of dyspnea (0.9years vs. 2.1 years, p=0.006) and lower diffusing capacity of carbon monoxide (49.3±23.1 % predicted. vs. 60.5±18.7 % predicted. p=0.089) compared with survivors; however, there were no significant differences in other variables including age, sex, smoking history and exercise capacity. In univariate Cox analysis, age (hazard ratio [HR], 1.140), male gender (HR, 3.527), estimated pulmonary artery systolic pressure (HR, 1.102) and Gender-Age-Physiology (GAP) stage (HR, 6.899) were predictors for mortality.

악성흉막중피종의 병기판정에서 자기공명영상의 진단적 유용성 평가

이은솔,채은진,강선지,염유경,이현주,박종천,신소연,최윤영,최준호,도경현 대한자기공명의과학회 2013 Investigative Magnetic Resonance Imaging Vol.17 No.3

Purpose : We investigated the possible added value of magnetic resonance imaging (MR) in staging of malignant pleural mesothelioma (MPM) compared to computed tomography (CT). Materials and Methods: We retrospectively enrolled 20 patients (M;F = 14:6; mean age, 53.5 yrs) who diagnosed as MPM by histology and underwent CT and MR at initial evaluation from Jan 1997 to Dec 2012. Two radiologists performed clinical staging by using CT alone or MR alone in consensus. In patients underwent surgery (n = 13), we evaluated the diagnostic accuracy of CT and MR in terms of staging compared to surgical staging. In all patients,we compared clinical staging of CT only and CT with MR. Results: The diagnostic accuracy for T staging of CT only was 23.1% (3/13) and that of combined CT and MR was 38.5% (5/13), respectively. Among 13 patients underwent surgery, surgical stage was higher than combined CT and MR stage in 5 patients, but lower in 3 patients. CT only and combined CT and MR agreed in 85.0% (17/ 20). In cases of disagree (15.0%, 3/20), combined CT and MR showed higher stage than CT only. Conclusion: Combined CT and MR increases the diagnostic accuracy in staging of MPM compared to CT only and is important in determining the appropriate treatment in patients being considered for surgery. 목적 : 악성흉막중피종 (이하 MPM)의 임상적 병기판정에 있어 자기공명영상 (이하 MR)의 진단적 유용성을 컴퓨터단층촬영(이하 CT)과 비교하였다. 대상 및 방법 : 1997년부터 2012년까지 MPM으로 확인된 환자 중 진단 시 CT와 MR을 얻은 환자 20명 (남:여=14:6; 평균연령= 53.5세)을 대상으로 하였다. CT 혹은 MR 단독을 이용하여 두 명의 영상의학과 의사가 의견 일치 하에 병기판정을시행하였다. 수술적 병기판정을 받은 환자의 경우 이와 비교하여 CT 단독 및 CT와 MR을 함께 시행하였을 때의 진단적 정확도를 평가하였다. 또 CT 단독과 CT와 MR을 함께 시행하였을 때의 임상병기의 일치도를 비교하였다. 결과 : CT를 이용한 T stage의 정확도는 23.1% (3/13)였고 MR과 함께 시행한 경우 38.5% (5/13)였다. CT 및 MR을함께 시행한 경우 수술 후 수술적 병기에서 5명의 환자는 상위 진단을, 3명의 환자는 하위 진단을 보였다. CT 단독 및 CT와MR을 함께 시행한 병기를 서로 비교하였을 때 85.0% (17/20)의 일치도를 보였고 불일치한 예(3명)에서는 함께 시행한경우 CT 단독보다 상위 진단을 하였다. 결론 : MPM의 병기판정에 있어서 MR을 함께 시행한 경우 CT 단독에 비해 보다 높은 정확도의 병기판정을 제공하여 수술대상이 되는 환자에서 수술 전 검사로서 중요한 역할을 수행할 것으로 기대된다.