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김윤아(Yun Ah Kim),정명호(Myung Ho Jeong),주신배(Shin Bae Joo),최명자(Myung Ja Choi),김인수(In Soo Kim),김남호(Nam Ho Kim),김건형(Kun Hyung Kim),이승욱(Seung Uk Lee),조장현(Jang Hyun Cho),안영근(Young Keun Ahn),조상기(Sang Ki Cho),조정 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Background : Previous reports have mentioned the increased mortality of percutaneous coronary intervention (PCI) in elderly female patients compared with elderly male. The purpose of this study was to evaluate the clinical characteristics, coronary lesion, characteristics and differences of success rate of PCI between male and female elderly patients. Methods : Three hundred sixty six elderly patients (454 lesions), including 210 male (255 cases, 73.4±2.45 year-old) and 156 female (199 cases, 73.5±2.55 year-old) who underwent PCI at Chonnam National University Hospital between Jan '96 and Dec '98 (out of 3,030 patients during same period). We compared clinical characteristic, coronary artery lesion morphology, success and complication rates of PCI in elderly male and female patients. Result : Clinical diagnosis and risk factors for atherosclerosis were not different between two groups. Right coronary lesions were more common in female and left circumflex artery lesion less common in female patients. The success rate of balloon angioplasty was 93.2% (110/118) in male and 93.3% in (98/105) in female patients, and the success rates of stenting were 99.2% (136/137) in male and 100% (94/94) in female. Success rates of PCI were not different between two groups. Procedure-related mortality was one cardiac death (1/255, 0.39%) in male group only. Complications of elderly male were two occlusive dissection (OD: 2/255, 0.8%), three thrombotic occlusion (TO: 3/255, 1.2%) and two ventricular arrhythmia (VA) with shock (2/255, 0.8%). In 199 female patients, three OD (3/199, 1.5%), three TO (3/199, 1.5%) and two VA (2/199, 1.0%) developed. The complications rates were not different two groups. Conclusion : PCI in female patients older than 70 years can be performed with comparable success and complication rates to those of elderly male patients.(Korean J Med 60:456-462, 2001)
이홍순,이학중,박원,한창순,유수웅,주신배,선우인철 대한내과학회 1991 대한내과학회지 Vol.41 No.6
Acute myocardial infarction (AMI) rarely occurs in systemic lupus erythematosus (SLE), but mortality is as high as 50%. Also, AMI is a possible cause of inexplained heart failure in SLE patients. We experienced a case of AMI resulting from coronary vasculitis which was manifested by diffuse sclerotic narrowing of the coronary arteries in coronary angio-graphy in a 36-year-old male lupus patient. Management by prednisolone and post-centrifugal plasma-pheresis decreased systemic symptoms, chest pain, and cardiac enzymes. Follow up coronary angiography also revealed improved sclerotic lesions in the coronary arteries, The patient iss cunently under follow-up tsectment as an out-patient for 20 months with only skin manifestation without heart symtoms.
Terfenadine 과 Ketoconazole 을 복용한 후 발생한 Torsades de Pointes 2 례
박상준,이상훈,김기현,홍경표,김덕경,박승우,권현철,김준수,이원로,류재춘,박정의,주신배 대한내과학회 1998 대한내과학회지 Vol.54 No.1
Terfenadine is widely used because of nonsedating effect. But it could rarely provoke a potentially lethal ventricular tachyarrhythmia. Recently, we experienced two cases of torsades de pointes(TDP) occurred after combined use of terfenadine and ketoconazole in usual dose. In one case, 31-yr-old female presented palpitation and recurrent syncope of sudden onset after ingestion of terfenadine 60mg and ketoconzole 200mg 5 times. On attack, ECG showed a polymorphic ventricular tachycardia, and after attack, showed prolongation of QT interval and TU wave changes. Her laboratory findings were not contributory. TDP was controlled with MgSO₄ and isoproterenol infusion. Then, QT interval was normalized and no further episode occurred. In the other case, 32-yr-old female presented palpitation and recurrent syncope of sudden onset after ingestion of terfenadine 60mg and ketoconzole 200mg 5 times, ECG showed prolongation of QT interval and TU wave changes. Her laboratory findings were not contributory. TDP was controlled with MgSO₄ and isoproterenol infusion. Then, QT interval was normalized and no further episode occurred.