천식 환아와 보호자의 삶의 질에 영향을 주는 요인 조사를 위한 다 기관 공동 연구

조아름,이소연,김영호,유영,양현종,이주석,송태원,김우경,홍수종,강임주,이혜란 대한 소아알레르기 호흡기학회 2012 Allergy Asthma & Respiratory Disease Vol.22 No.1

Purpose:Pediatric asthma is the most common chronic disease in children. It negatively affects the health-related quality of life (QoL) in children with this disease and of their caregivers. This study evaluated the relationship between clinical disease severity and the QoL of patients with asthma and their caregivers. Methods:The study included 247 patients with asthma and their caregivers. The patients and caregivers completed the Korean Pediatric Asthma Quality of Life Questionnaire and the Korean Pediatric Asthma Caregivers Quality of Life Questionnaire, respectively, during clinic visits. The results were expressed as the mean score for each domain. All items were rated from 1 to 5: 1, low QoL; and 5, satisfactory QoL. Results:The emotion and activity QoL scores of boys were significantly higher than those of girls (P=0.001). The QoL of both patients and their caregivers was correlated more with the patients’ subjective symptom scores than with the clinical severity of asthma or with lung function. Conclusion:The QoL of patients with asthma and their caregivers decreased as asthmatic symptoms became worse. Controlling asthma symptoms is important for improving the QoL of both patients and their caregivers. Patients and their caregivers need to be evaluated and counseled during asthma treatment to improve their QoL. 목 적:소아 천식은 환아와 보호자 모두에게 활동 제한과 정신적, 경제적 영향을 줄 수 있으므로 이들의 삶의 질을 비교, 조사하고 각각에 영향을 줄 수 있는 요인들을 찾아보았다. 방 법:2009년 1월부터 2010년 6월까지 전국 9개 병원 소아청소년과 외래에 내원하는 천식 환아 247명과 그 보호자를 대상으로 KPAQLQ (Korean Pediatric Asthma Quality of Life Questionnaire), KPACQLQ (Korean Pediatric Asthma Caregivers Quality of Life Questionnaire)를 통한 설문 조사를 바탕으로 삶의 질을 평가하였으며 여기에 영향을 주는 관련 요인을 알아보고자 내원 당시 forced expiratory volume in 1 second (%), 천식 유병기간, 입원, 응급실 및 외래 방문 횟수, 사용하는 약제 등을 조사하였다. 결 과:여아보다 남아에서 삶의 질 점수가 높았으며 폐기능과 천식 중증도 분류에 따른 비교에서 환아와 보호자 모두 삶의 질에 유의한 차이가 없었지만, 환아의 주관적인 천식 증상 점수를 기준으로 비교하였을 때 증상 점수가 높은 환아와 보호자 군이 낮은 군에 비해 삶의 질 점수가 더 높았다. 결 론:천식 환아와 보호자의 삶의 질을 향상시키기 위해서는 천식 증상 조절을 통한 주관적인 천식 증상 개선이 중요하며 이와 함께 천식 환아와 보호자 모두의 삶의 질을 평가하고 조절하는 것이 이들의 삶의 질 향상을 위하여 반드시 필요하다.

「산불」과 「웰컴 투 동막골」의 전쟁 기억 비교・연구

조아름 한국비교문학회 2019 比較文學 Vol.0 No.77

The purpose of this paper is to compare and research Mountain Fire(1962) by Beomseok Cha and Welcome to Dongmakgol(2002) by Jangjin from the viewpoint of ‘cultural memory’ suggested by Yan Asman. Mountain Fire and Welcome to Dongmakgol are plays against the backdrop of Korean War. Both works remember the war based on the cover called ‘village(community)’. However, the method of memory appears totally differently. From where does that difference come? What provides a clue to the answer to this question is the ‘cultural memory’. The gist of ‘memory study’ which started from Morris Albox is that the memory is made up of social situations. That is, the memory does not recall the past fact as it is but reconstruct from the present viewpoint called ‘now, here’. Yan Asman shares this point of view on the memory and focuses on that the ‘cultural practice’ of the material and symbolic form facilitates this reconstruction of memory. He calls it a ‘cultural memory’. In the end, comparing and researching Mountain Fire and Welcome to Dongmakgol from the viewpoint of cultural memory is to examine the point of view on that-time war, second, to figure out how to organize the memory based on such point of view, third, to ultimately determine that the play functions as a social environment. 본고는 차범석의 「산불」(1962)과 장진의 「웰컴 투 동막골」(2002)을 작품이 창작될 당시의 전쟁에 대한 기억을 담아낸 문화적 산물로 분석하고자 한다. 「산불」과 「웰컴 투 동막골」은 한국전쟁을 소재로 한 희곡이다. 두 작품은 ‘부락(공동체)’이라는 배경을 바탕으로 전쟁을 기억한다. 그러나 기억의 방식은 전혀 다르게 나타난다. 그 차이는 어디에서 비롯되는가. 이러한 질문에 대한 대답의 단초를 제공해 주는 것이 ‘문화적 기억’이다. 모리스 알박스로부터 시작된 ‘기억 연구’의 요지는 기억이 사회적 상황에 의해 구성된다는 것이다. 즉, 기억은 과거사실을 있는 그대로 소환하는 것이 아니라 ‘지금, 여기’라는 현재적 관점에서 재구성하는 것이다. 아스만부부는 기억에 대한 알박스의 관점을 공유하며, 더 나아가 물질적이고 상징적인 형식의 ‘문화적 실천’이 이러한 기억의 재구성을 가능하게 한다는 점에 주목한다. 그리고 이를 ‘문화적 기억’이라고 말한다. 결국 「산불」과 「웰컴투 동막골」 ‘문화적 기억’의 관점에서 비교‧연구하는 일은 첫째, 작품이 창작될 당시의 전쟁에 대한 담론을 살펴보는 일이며, 둘째, 사회와 기억의 관계, 즉 사회가 기억을 구성하는데 어떻게 역할 하는가를 밝히는 일이며, 셋째, 궁극적으로 연극이 기억을 구성하는 문화적 실천으로 기능함을 밝히는 일일 것이다.

Bulky Side Group을 갖는 안트라센 유도체 기반의 고효율 청색 발광 재료의 합성과 전기 광학적 특성

조아름,박종욱 한국막학회 2018 한국막학회 총회 및 학술발표회 Vol.2018 No.11

Three new asymmetric light emitting organic compounds were synthesized with diphenylamine or triphenylamine side groups; 10-(3,5-diphenylphenyl)-N,N-diphenylanthracen-9-amine (MADa), 4-(10-(3,5-diphenylphenyl)anthracen-9-yl)-N,N-diphenylaniline (MATa), and 4-(10-(30,50-diphenylbiphenyl-4-yl) anthracen-9-yl)-N,N-diphenylaniline (TATa). MATa and TATa had a PLmax at 463 nm in the blue region, and MADa had a PLmax at 498 nm. The EL efficiency and color coordinate values (respectively) were 10.3 cd/A and (0.199, 0.152; bluish-green) for the MADa device, 4.67 cd/A and (0.151, 0.177) for the MATa device, and 6.07 cd/A and (0.149, 0.177) for the TATa device. The TATa device had a high external quantum efficiency (EQE) of 6.19%, and its luminance and power efficiencies and life-time were more than twice those of the MADN device.

급성 복통을 주소로 진단된 자발성 양측 부신 출혈에 의한 부신피질부전

조아름,홍주영,김동호,박민지,권미혜,박근용,원희관,임동미 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.S

Thomas Addison은 1855년 발표된 그의 논문에 일차성 부신피질부전에 의하여 발생한 근력 약화, 피로, 식욕부진, 복통, 체중감소, 색소침착 등에 대하여 처음으로 기술하였다[1,2]. 부신피질부전은 부신피질의 파괴에 의해 발생하는 당질 코르티코이드 결핍과 관련된 일차성과 뇌하수체에서 혈청 부신피질자극 호르몬(adrenocorticotropic hormone, ACTH)의 분비장애에 의해 발생하는 이차성으로 구분할 수 있다. 일차성과 이차성의 중요한 차이는 무기질 코르티코이드의 결핍이 일차성에는 있고 이차성에 는 없다는 점이다. 일차성 부신피질부전의 원인으로 이전에는 결핵에 의한 양측 부신 파괴가 가장 흔한 원인이었으나, 결핵 진단율 및 치료약제 보급률이 좋아진 20세기 후반부터는 감소 추세를 보이고 있으며, 선진국에서는 자가면역성 부신염에 의한 일차성 부신피질 부전이 80~90%로 가장 흔한 것으로 보고되었다[3]. 이외에 다른 감염성 질환, 전이성 암, 림프종, 부신출혈 또는 경색, 약물 등의 원인을 들 수 있다. 일차성 부신피질부전의 임상 증상과 징후로는 전신무력감, 식욕부진, 피로감, 체중감소, 과다한 색소침착, 오심, 복통, 기립성 저혈압, 저혈당, 전해질 장애 등이 올 수 있고, 심하면 탈수, 저혈압, 의식장애 및 쇼크가 동반될 수 있다. 일차성 부신피질부전은 본 증례와 같이 드물게 양측 부신 출혈성 경색으로 인해 발생되는 경우가 보고되었는데, 위험인자로는 항응고제 또는 헤파린 투여, 혈전성 질환, 항인지질 증후군과 같은 과응고 상태, 물리적 외상, 감염, 심한 스트레스와 관련되어 발생할 수 있으며 드물게 임신, 부신 종양, 쇼크 등이 원인이 되고 있다[4,5]. 그러나 본 증례와 같이 원인 없이 발생한 자발성 출혈에 의한 부신피질부전의 보고는 매우 드물다. 양측 부신 출혈의 임상 증상과 징후로는 저혈압, 쇼크, 복부, 등, 옆구리, 흉부의 통증, 발열, 의식저하, 복부 강직, 반발 압통 등이 있다[6]. 적절한 치료를 시행하지 않으면 쇼크가 진행하여 혼수와 사망에 이를 수 있어 정확하고 빠른 진단과 치료가 필요하다. 환자가 생존한다면 부신 기능은 드물게 수개월 후 정상으로 회복될 수 있다[7]. 저자들은 상복부 통증을 주소로 내원한 환자에서 매우 드물게 원인 없이 발생한 자발성 양측 부신 출혈에 의한 급성 부신피질부전 1예를 경험하였기에 보고하는 바이다.

수술 후 회복 향상 프로그램의 시행: 마취 관련 요소

조아름 대한의사협회 2021 대한의사협회지 Vol.64 No.12

Background: Enhanced recovery after surgery (ERAS) is a multidisciplinary and multimodal evidence-based approach aimed at improving the recovery of surgical patients. Successful implementation of ERAS protocols requires proper perioperative communication and collaboration among surgeons, anesthesiologists, nurses, and other medical personnel. Current Concepts: The anesthesiologist is the clinical leader responsible for the ERAS program. Preoperative patient evaluation, optimization, and patient education are essential components of the ERAS program. The program also involves preoperative fasting and carbohydrate loading to minimize catabolic effects. Selection of an appropriate anesthetic regimen, fluid and temperature management, avoidance of intra/postoperative nausea and vomiting, and multimodal pain management are the key components of ERAS for which the anesthesiologist is responsible. Discussion and Conclusion: Factors that enable the successful implementation of ERAS include the willingness to change to ERAS, formation of multidisciplinary teams to improve cooperation, and support from the hospital management, as well as standardization of order sets and care processes and the appropriate use of audits. As the leader of the ERAS team, the anesthesiologist should be actively involved in comprehensive management of the patient during the perioperative period.

Emitting and electron transport properties of Be complex derivative in OLED

조아름,박종욱,정효철,강석우,양가람,이수지 한국고분자학회 2018 한국고분자학회 학술대회 연구논문 초록집 Vol.43 No.1

Effects of aronia extract on lifespan and age-related oxidative stress in Drosophila melanogaster

조아름,임지영 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.5

The effects of aronia extract (AE) supplementation on the lifespan and age-associated oxidative stress was investigated in the fruit fly Drosophila melanogaster. Supplementation with 2.5 mg/mL of AE (AE 2.5) extended the mean lifespan in D. melanogaster by 18%. AE supplementation significantly improved locomotor activity at both 10 and 40 days. In 40-days-old flies, reactive oxygen species production was significantly lower and accumulation of the lipid oxidation product malondialdehyde had markedly decreased by 49.3% in the AE 2.5 group. The extended longevity and improved locomotion in the AE 2.5 group were probably because of increases in the level of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and expression of stress resistance genes (Hsp68, l(2)efl, and Jafrac1). Present study provides the evidence that dietary supplementation with AE extended lifespan and ameliorated age-related oxidative damages in D. melanogaster.

2P-105 Electroluminescent Properties of New Blue Emitters Based on Dibenzo-diazocine Moiety

조아름,정효철,이하윤,강석우,계광열,박종욱 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

In this study, 1-NADD and 2-NADD were designed and synthesized based on dual anthracene and DBDA moiety. Optical and electrical properties were examined by UV-visible absorption spectra and PL spectra. In the film state, 1-NADD and 2-NADD showed PLmax of 433 nm and 435 nm, respectively. 1-NADD and 2-NADD were used as non-doped emitting layer (EML) in OLEDs with the following structure : ITO/2-TNATA (60nm)/(NPB (15nm)/compounds (35nm)/Alq3 (20nm)/LiF (1nm)/Al (200nm). 2-NADD showed higher EL efficiencies than 1-NADD because hole and electron injection are easier in 2-NADD with a relatively narrow band gap and charge recombination occurs more effectively. In non-doped OLED devices, 1-NADD showed C.E. of 1.47 cd A-1 and E.Q.E of 0.91%, respectively. 2-NADD showed C.E. of 2.38 cd A-1 and E.Q.E of 1.26%, respectively.

Microvascular reactivity as a predictor of major adverse events in patients with on-pump cardiac surgery

조아름,이현정,홍정민,Kang Christine,김혜진,김은정,Kim Min Su,Jeon Soeun,Hwang Hyewon 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.4

Background: Microcirculatory disturbances are typically most severe during cardiopulmonary bypass (CPB), which occurs during cardiac surgeries. If microvascular reactivity compensates for microcirculatory disturbances during CPB, tissue hypoxemia can be minimized. The primary aim of this study was to assess whether microvascular reactivity during CPB could predict major adverse events (MAE) after cardiac surgery.Methods: This prospective observational study included 115 patients who underwent elective on-pump cardiac surgeries. A vascular occlusion test (VOT) with near-infrared spectroscopy was performed five times for each patient: before the induction of general anesthesia, 30 min after the induction of general anesthesia, 30 min after applying CPB, 10 min after protamine injection, and post-sternal closure. The postoperative MAE was recorded. The area under the receiver operating characteristic (AUROC) curve analysis was performed for the prediction of MAE using the recovery slope.Results: Of the 109 patients, MAE occurred in 32 (29.4%). The AUROC curve for the recovery slope during CPB was 0.701 (P < 0.001; 95% CI [0.606, 0.785]). If the recovery slope during CPB was < 1.08%/s, MAE were predicted with a sensitivity of 62.5% and specificity of 72.7%.Conclusions: Our study demonstrated that the recovery slope of the VOT during CPB could predict MAE after cardiac surgery. These results support the idea that disturbances in microcirculation induced by CPB can predict the development of poor clinical outcomes, thereby demonstrating the potential role of microvascular reactivity as an early predictor of MAE after cardiac surgery.

위해성평가의 불확실도 분석과 활용방안 고찰

조아름,김탁수,서정관,윤효정,김필제,최경희,Jo, Areum,Kim, Taksoo,Seo, JungKwan,Yoon, Hyojung,Kim, Pilje,Choi, Kyunghee 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.6

Objectives: Risk assessment is a tool for predicting and reducing uncertainty related to the effects of future activities. Probability approaches are the main elements in risk assessment, but confusion about the interpretation and use of assessment factors often undermines the message of the analyses. The aim of this study is to provide a guideline for systematic reduction plans regarding uncertainty in risk assessment. Methods: Articles and reports were collected online using the key words "uncertainty analysis" on risk assessment. Uncertainty analysis was conducted based on reports focusing on procedures for analysis methods by the World Health Organization (WHO) and U.S. Environmental Protection Agency (USEPA). In addition, case studies were performed in order to verify suggested methods qualitatively and quantitatively with exposure data, including measured data on toluene and styrene in residential spaces and multi-use facilities. Results: Based on an analysis of the data on uncertainty, three major factors including scenario, model, and parameters were identified as the main sources of uncertainty, and tiered approaches were determined. In the case study, the risk of toluene and styrene was evaluated and the most influential factors were also determined. Five reduction plans were presented: providing standard guidelines, using reliable exposure factors, possessing quality controls for analysis and scientific expertise, and introducing a peer review system. Conclusion: In this study, we established a method for reducing uncertainty by taking into account the major factors. Also, we showed a method for uncertainty analysis with tiered approaches. However, uncertainties are difficult to define because they are generated by many factors. Therefore, further studies are needed for the development of technical guidelines based on the representative scenario, model, and parameters developed in this study.