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심영복,최보규,정홍희,장주웅,양희석,배호재,박종철,이수홍 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
Hollow porous poly(D,L-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using thewater-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount ofCol1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MScould be fabricated successfully using sucrose and showed great potential as a controlled dual drugdelivery system.
인간 및 동물 유래 탈회골기질에 의한 골재생 특성 연구
김일환,이광일,이근수,정홍희,남상철,최원임,강경탁,심영복,장주웅 한국생체재료학회 2011 생체재료학회지 Vol.15 No.3
Since demineralized bone matrix (DBM) reveals powerful biological function of osteoinduction, it has wide potential application in bone repair and engineering. Due to the fact that almost tissue banks do not generally evaluate the degree of bone forming potential of their DBM before distribution, no studies have been reported uniformly favorable results so far. Allogeneic DBM has shortcomings related to procuring, processing and characterizing bone from a human donor pool. On the other hand, xenografting is increasingly being developed as a response to the shortage of human tissue. Hence, xenogeneic bone will be an unlimited supply of available material as long as it is safe for clinical transplantation and it can be processed to render. The characteristic studies on the bone tissue regeneration by allograft and xenograft were not much reported. For this study, 0.5-1.0 mm particle sized DBM was made from Human, Bovine and Porcine origin. Each grafting material was assayed for quantitative analysis of ingredient and then it was grafted into the dorsal subcutaneous area of nude mouse (age of 2 weeks). After 1, 2, 4, 8 weeks’ implantation, each implanted area was observed for radiobiology and histology. The result of this study was verified that osteoinductivity of allogeneic and xenogeneic DBM was similar. Therefore, xenogeneic DBM has the potential of good grafting material for clinical bone tissue regeneration.