http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
C18-PEG로 화학흡착된 실리콘 웨이퍼의 표면특성 및 선택적 알부민 흡착
배순언,박귀덕,한동근 한국생체재료학회 2008 생체재료학회지 Vol.12 No.4
Adsorption of albumin to biomaterial surfaces has been useful in both medical and pharmaceutical applications. It is known that the affinity of albumin increases by grafting C18 alkyl chain to the biomaterial surfaces. Brij® (alkyl PEGOH), which has both long poly(ethylene glycol) (PEG) side chain and stearyl (C18) alkyl end group, is specifically designed to get the functional surface to trigger the adsorption of albumin alone. In this study, thiol-derived Brij® (alkyl PEG-SH) macromer was synthesized from substituting terminal hydroxyl group of Brij® through tosylation, and the alkyl PEG-SH was assembled and chemisorbed on the gold-coated silicon wafer. The chemisorbed surface was characterized using ATR-FTIR, ESCA, SEM, and contact angles and albumin adsorption test. Since the Si surface modified with C18-PEG20 has a highly selective affinity to albumin, it can be useful as a nano-scale biosensor for protein chip, because it has mobile PEG groups for non-specific protein repulsion and C18 alkyl chains for selective adsorption of albumin.
표면개질에 의해 하이드록시아파타이트가 형성된 티타늄에 대한 특성 및 세포 점착
배순언 ( Soon Eon Bae ),박귀덕 ( Kwi Deok Park ),한동근 ( Dong Keun Han ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s
Titanium (Ti) and its alloys were frequently used in many surgical and dental implants because of its good biocompatibility and mechanical properties. However, they often lack a direct bonding with bone after implantation. In order to enhance a new bone formation, surface composition and roughness of metal implants need to be carefully controlled. In this study, Ti implant discs were modified by using two oxidative methods; chemical (NH4OH/H2O2/H2O) and physical (O2 plasma) treatments. Hydroxyapatite (HA) deposition on the surface of oxidative Ti samples was then induced in simulated body fluid (SBF) for 7 days in vitro. When the surface morphology of HA-formed Ti was determined using SEM, the surface layer was covered with nano-scaled HA particles. The chemically treated HA-Ti specimens provided preosteoblast with more favorable surface environment in up-regulating cell proliferation and alkaline phosphatase (ALP) activity. The present data indicated that the surface treatment of Ti could have a significant impact on HA formation, preosteoblast proliferation, and differentiation.