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춘계학술대회 : 포스터발표 ; 만성 B형 간염 환자의 치료에서 페그인터페론과 인터페론의 효과 비교
임대관,노지훈,한병훈,이상욱,윤병철 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
배경: 현재 만성 B형 간염 치료를 위한 약제는 여러 가지가 나와 있으며 계속 개발되어 임상에 적용중에 있다. 그중에서 인터페론에 branched-chain polyethyene glycol (PEG) molecule을 붙임으로 반감기를 길게 하여 주1회 투여가능해진 페그인터페론이 현재 만성C형 간염 환자에서는 효과적으로 사용되고 있다. 그에 반해 만성 B형 간염에서의 치료 효과에 대한 연구는 미미한 실정이다. 이에 연자등은 만성B형 간염치료에 있어서
Pb(Zr_(0.53)Ti_(0.47))O_(3)+x[wt%]Cr_(2)O_(3)세라믹스의 공진주파수 온도안정성 및 열에이징 효과
임대관,이개명 濟州大學校 産業技術硏究所 1998 산업기술연구소논문집 Vol.9 No.2
In this paper, Pb(Zr_(0.53)Ti_(0.47))0_(3)+ x[wt%]Cr_(2)O_(3) ceramics were fabricated. and thermal aging effects on the specimens were investigated. Thermal shock changed the temperature coefficients of resonant frequency of the specimens but, after thermal aging, the changing rate of their temperature coefficients due to thermal shock became very low. Thermal aging increased relative dielectirc constants of the specimen with no and a small Cr_(2)O_(3) additives. After thermal aging, Electro-mechanical coupling factor of all specimens decreased but the specimens with Cr_(2)O_(3) additives had the smaller temperature coefficients for resonant and antiresonant frequencies.
인체 췌장암세포주(Capan-1)의 증식에 미치는 amiloride의 억제효과
임대관,김신,김유리,노지훈,이지현,김지연,박무인,정근옥,박건영,구자영 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1
Background/Aims Cytoplasmic alkalinization induced by activation of the Na+/H+anti porter which is stimulated upon the addition of growth-promoting agents, such as insulin, epidermal growth factor, phorbol ester, plays an essential role in the initiation on cell proliferation. In the present study the effects of amiloride, a specific and reversible inhibitor of Na+/H+antiporter, on the growth of human pancreatic carcinoma cell line, Capan-1 cells was examined and the effects of 5-fluorouracil (5-FU) were also studied. Cell cycle analysis was done to examine the mechanisms for the inhibitory effects of amiloride. Materials/Methods The growth of Capan-1 cells were examined by counting cell number on two and four days treatment with 1 μM, 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 160 μM amiloride, and 0.1 ㎍/㎖, 0.3 ㎍/㎖ 5-FU, after plating Capan-1 cells into 35-mm2 plastic dishes at d density of 10x104 cells/dish. The reversibility of the effects of amiloride was examined on two day to eight days treatment with 20 μM amiloride after seeding 2×104 cells/dish. Cell cycle analysis was done on the sells after four days treatment with 20 μM amiloride. Results Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion (p<0.05). The inhibitary effect of amiloride on the growth of Capan -1 cells was firstly shown at the concentration of 5 μM, which is not so higher than the concentration of 0.1-0.2 μM attainable by administration of usual dose of amiloride (5-10㎎). Forty-eight percent inhibition of growth was found at an amiloride concentration of 20μM after 4 days treatment, and ninety-three percent inhibition of growth was found at an amiloride concentration of 160μM after 4 days treatment. The inhibitory effect of amiloride on growth of Capan-1 cells was reversible since removal of amiloride by a media change after 48 hours treatment lead to significantly more growth than amiloride treated group (p<0.05). The reversibility of growth inhibition suggests that amiloride in not a non-specific cytotoxin for Capan-1 cells. Amiloride combined with 5-FU significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion compared to an amiloride or a 5-FU alone (p<0.05). After four days treatment with 20 μM amiloride, the faction of cells in G0-G1 phase, S phase and G2-M phase was 47.3%, 35.8%, 16.9% respectively in the amiloride group (20 μM), and 44.3%, 37.1%, 18.6% in the control group. showing no significant differences between the two groups. Conclusions Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion, which was reversible. The reversibility of growth inhibition suggests that amiloride is not a non-specific cytotoxin for Capan-1 cells. The concentration of 5 μM, which is not so higher than the concentration of 0.1-0.2 μM attainable by administration of usual dose of amiloride (5-10㎎), which suggests amiloride or its analogues may be used alone or in conjunction with 5-FU for the treatment of pancreatic carcinoma. Further study is needed to clarify the effects of more potent analogues of amiloride on the growth of human pancreatic carcinoma cells.
Zr/Ti 비에 따른 PZT계 압전세라믹스의 온도안정성
임대관,현원석,이개명 濟州大學校 情報通信硏究所 1998 情報通信硏究所論文集 Vol.1 No.-
In this paper, temperature stabilities of Pb( Zr_xTi_(1-x))O₃ piezoelectric ceramic system according to Zr/Ti ratios were investigated. PZT ceramics with Zr/Ti =58/42, 56/44, 53/47, 50/50, 48/52 which are adjacent compositions to Mophotyophic phase were fabricated, and thermal aging effects on the specimen were measured. After thermal aging. the specimens with Zr/Ti=58/42, 56/44, 48/52 in them could have lower temperature coefficient for antiresonant frequency and the specimen with Zr/Ti = 58/42 which is a composition of Rhombohedral phase have had the lowest temperature coefficient for antiresonant frequency.
인체 췌장암세포주 (Capan-1)의 증식에 미치는 amiloride의 억제효과
임대관,김신,김유리,노지훈,이지현,박무인,정근옥,박건영,구자영 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1
Backgrounds/Aims : Cytoplasmic alkalinization induced by activation of the Na+/H+ anti porter which is stimulated upon the addition of growth-promoting agents, such as insulin, epidermal growth factor, phorbol ester, plays and essential role in the initiation on cell proliferation. In the present study the effects of amiloride, a specific and reversible inhibitor of Na+/H+ antiporter, on the growth of human pancreatic carcinoma cell line, Capan-1 cells was examined and the effects of 5-fluorouracil (5-FU) were also studied. Cell cyle analysis was done to examine the mechanisms for the inhibitory effects of amiloride. Materials/Methods : The growth of Capan-1 cells were examined by counting cell number on two and four days treatment with 1 uM, 5 uM, 10 uM, 20 uM, 40 uM, 80 uM, 160 uM amiloride, and 0.1 ug/ml, 03 ug/ml 5-FU, after plating Capan-1 cells into 35-mm2 plastic dishes at a density of 10x104 cells/dish. The reversibility of the effects of amiloride was examined on two day to eight days treatment with 20 uM amiloride after seeding 2x104 cells/dish. Cell cycle analysis was done on the cells after four days treatment with 20 uM amiloride. Results : Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion (p<0.05). The inhibitary efect of amiloride on the growth of Capan-1 cells was firstly shown at the concentration of 5 uM, which is not so higher than the concentration of 0.1-0.2 uM attainable by administration of usual dose of amiloride (5-10mg). Forty-eight percent inhibition of growth was found at an amiloride concentration of 20 uM after 4 days treatment, and ninety-three percent inhibition of growth was found at an amiloride concentration of 160 uM after 4 days treatment. The inhibitory effect of amiloride on growth of Capan-1 cells was reversible since removal of amiloride by a media change after 48 hours treatment lead to significantly more growth than amiloride treated group (p<0.05). The reversibility of growth inhibition suggests that amiloride is not a non-specific cytotoxin for Capan-1 cells. Amiloride combined with 5-FU significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion compared to an amiloride or a 5-FU alone (p<0.05). After four days treatment with 20 uM amiloride, the fraction of cells in G0-G1 phase, S phase and G2-M phase was 47.3%, 35.8%, 16.9% respectively in the amiloride groups (20 uM), and 44.3%, 37.1%, 18.6% in the control group, showing no significant differences between the two groups. Conclusions : Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion, which was reversible. The reversibility of growth inhibition suggests that amiloride is not a non-specific attainable by administration of usual dose of amiloride (5-10mg), which suggests amiloride or its analogues may be used alone or in conjuction with 5-FU for the treatment of pancreatic carcinoma. Further study is needed to clarify the effects of more potent analogues of amiloride on the growth of human pancreatic carcinoma cells.
Pb(Zr0.53)O₃+ x[wt%]Cr₂O₃세라믹스의 공진주파수 온도안정성 및 열에이징 효과
이개명,임대관 濟州大學校工科大學産業技術硏究所 1998 尖端技術硏究所論文集 Vol.9 No.2
In this paper, Pb(??)O₃ + x[wt%]Cr₂O₃ceramics were fabricated. and thermal aging effects on the specimens were investigated. Thermal shock changed the temperature coefficients of resonant frequency of the specimens but, after thermal aging, the changing rate of their temperature coefficients due to thermal shock became very low. Thermal aging increased relative dielectirc constants of the specimen with no and a small Cr₂O₃ additives. After thermal aging, Electro-mechanical coopting factor of all specimens decreased but the specimens with Cr₂O₃ additives had the smaller temperature coefficients for resonant and antiresonant frequencies.
포스터 전시 : 하부위장관 ; 원발성 항문 주위 림프종에 병발한 위 인환 세포암
임대관 ( Im Dae Gwan ),이시원 ( Lee Si Won ),박정필 ( Park Jeong Pil ),김신 ( Kim Sin ),김유리 ( Kim Yu Li ),김지연 ( Kim Ji Yeon ),박무인 ( Park Mu In ),박선자 ( Park Seon Ja ),이상호 ( Lee Sang Ho ),구자영 ( Gu Ja Yeong ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<증례>42세 여자 환자가 갑작스런 혈변을 주소로 LMC에서 결장내시경을 시행하여 치질로 생각하고 치질 절제술을 시행하였는데 조직검사결과 악성 림프종, large B cell type으로 나와 본원으로 전원되었다. 본원에서 검사한 결장내시경 소견상 항문 주위 궤양이 있는 부위에 조직 검사를 시행하였으나 림프종의 소견은 없었고, 병기결정을 위해 시행한 흉부 및 복부 CT, 골수 검사등에서는 정상소견을 보였다. 상부위장관 내시경 소견상 위 체부의 대만부위에