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저등급 직장 카르시노이드 종양에서 Ki-67 발현이 예후를 예측할 수 있는가?
박선자 ( Seun Ja Park ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2
Prognostic Significance of Ki-67 Expression in Rectal Carcinoid Tumors
박선자(Seun Ja Park),박무인(Moo In Park),구선회(Sun Hoe Koo),구자영(Ja Young Koo) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4
Background/Aims: Comparative genomic hybridization (CGH) is a new powerful technique for the molecular cytogenetic analysis of cancer. Methods: Twenty-five colorectal carcinomas were screened for chromosomal aberrations using CGH. Results: All carcinomas had chromosomal aberrations, and the mean number of chromosomal aberrations per tumor was 5.3. The cases of chromosomal gains were more common than the cases of chromosomal losses. The cases of amplification of 7q region, which contains locus of c-met, was significantly higher in stage III and IV than in stage I and II (p 0.05). In three cases of stage IV (67%), two showed amplification of 7q and 20q, in which c-met oncogene and c-src oncogene are located, respectively. The chromosomal gains of tumor were mostly detected at 20q, 7q, and 13q. The chromosomal losses of tumor were frequently detected at 17p and 18q. Conclusions: The CGH may be useful in predicting the prognosis or therapeutic decision of colorectal carcinoma. Especially, the chromosomal changes at 7q, 20q and 13q as well as c-met and c-src may be useful markers for colorectal carcinoma. (Korean J Gastroenterol 2002;39:275-283)
박선자 ( Seun Ja Park ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.3
There are many reasons why doctors would not to be able to communicate with patients. First, medicine is science or humanity? Although object of medicine is human, modern medicine tends to regard human as broken machine. Second, gastroenterologists are overloaded by treatment of patients, providing education, attending academic conference, and writing papers. Above all things, it is much worse for gastroenterologists because of endoscopic procedures. The other problem is attitude of modern society about human suffering. Sufferings come from not only body but also mind or spirit. Although there are may difficult problems, if doctors listen to patients` history by their side, it will help to restore their faith. In addition, we need humanity education and improvement plans for medical service system. (Korean J Gastroenterol 2012;60:162-165)
박선자 ( Seun Ja Park ) 대한장연구학회 2007 Intestinal Research Vol.5 No.2
Polyps that contain carcinomatous changes that are confined to the mucosa (carcinoma-in-situ or severe dysplasia) do not have metastatic potential and are adequately treated with complete polypectomy or endoscopic mucosal resection. If deep invasion into the stalk has occurred or if adverse features (such as lymphatic invasion, or positive margins) are present, then en bloc colectomy is indicated. For lesions in the mid to upper rectum, a low anterior resection is the treatment of choice. To decrease the risk of local recurrence, patients should undergo optimal pelvic dissection with sharp mesorectal excision. Patients with pathologic lymph node-negative T3 or T4 lesions or any lymph node-positive cancer should receive preoperative or postoperative combined modality therapy. A major goal of preoperative therapy is to decrease the volume of the primary tumor and thus enhance sphincter preservation. For resectable colon cancer, the surgical procedure of choice is colectomy with en bloc removal of the regional lymph nodes. Laparoscopic colectomy has been advanced as an approach to the surgical management of colon cancer. Recently, the outcomes of cancer from a randomized trial comparing laparoscopically assisted and open surgery for curable colon cancer was reported. After a median of 4.4 years follow-up, similar cancer recurrence rates were observed in the two groups. The current management of disseminated metastatic colon cancer uses various active drugs, both in combination and as single agents: 5-FU/leucovorin, irinotecan, oxaliplatin, capecitabine, bevacizumab, and cetuximab. The choice of therapy is based on consideration of the type and timing of the prior therapy that has been administered and the differing toxicity profiles of the constituent drugs. As primary therapy for metastatic disease in a patient with good tolerance to intensive therapy, combination therapy consisting of fluoropyrimidines: FOLFOX (oxaliplatin, infusional fluorouracil, and leucovorin) or FOLFIRI (irinotecan, infusional fluorouracil, and leucovorin), with or without bevacizumab; bolus 5-FU/leucovorin/irinotecan with bevacizumab; 5-FU/leucovorin with bevacizumab were recommened. (Intest Res 2007;5:122-130)
인체 소화기암세포(AGS, HT-29)의 증식에 미치는 curcumin의 억제 효과
김기환 ( Ki Whan Kim ),박현용 ( Hyun Lyoung Park ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ),정근옥 ( Kun Oak Jung ),박건영 ( Kun Young Park ),구자영 ( Ja Young Koo ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 음식첨가제에 포함되어 있는 성분인 curcumin이 인체 소화기암세포(AGS, HT-29)의 중식에 미치는 효과를 좀더 자세히 알기 위해, 세포배양실험을 통하여 curcumin의 증식효과를 조사하고, 5-fluorouracil(5-FU)와의 병용효과를 조사하였으며, 증식억제에 따르는 각 세포주기별 변화를 조사하였다. <재료 및 방법> 증식기의 인체 소화기암세포(AGS, HT-29)를 6 well plate에 각 well당 1×10(5)개의 세포
임성경,박선자,박무인,문원,김성은,백승언,Seong Kyeong Lim,Seun Ja Park,Moo In Park,Won Moon,Sung Eun Kim,Sung-Uhn Baek 대한소화기암연구학회 2014 Journal of digestive cancer reports Vol.2 No.2
A 57-year-old male visited our hospital due to a growing abdominal mass for 1 month. The patient was diagnosed as transverse colon cancer with duodenal fistula, and then was treated with neoadjuvant concurrent chemoradiation therapy (2 cycles of FOLFOX-4, 3-dimensional conformal radiation therapy: 3,000 cGy in 10 fractions). Despite the improvement of colon cancer and associated inflammation, the symptom of colonic obstruction was aggravated. Thus transverse colon segmentectomy was done. After surgery, he have received adjuvant 12 cycles of FOLFOX-4 chemotherapy. Now, he is currently being followed up in cure state.
김재현,박선자,Jae Hyun Kim,Seun Ja Park 대한소화기암연구학회 2018 Journal of digestive cancer reports Vol.6 No.2
Colorectal cancer (CRC) is the third most common cause of cancer-related death in the world. Although the long-term outcome of patients with metastatic CRC is still poor, target therapy including anti EGFR agents and anti VEGF agents and immunotherapy including anti PD-1 antibody and anti CTLA-4 antibody have shown clinical benefits in the treatment of patient with metastatic CRC. In the future, the personalized treatment strategy based on the clinical characteristics and biologic features of patients with metastatic CRC will be necessary. In this review, we summarized the mechanisms and clinical evidences of target therapy and immunotherapy, and the guideline of clinical practice in patients with metastatic CRC.
내시경 점막 절제술로 진단 및 치료했던 위바닥샘형 선암
김성은,박선자,박무인,문원,김재현,정경원,김방주,장희경,Sung Eun Kim,Seun Ja Park,Moo In Park,Won Moon,Jae Hyun Kim,Kyoungwon Jung,Bang Ju Kim,Hee Kyung Chang 대한소화기암연구학회 2023 Journal of digestive cancer reports Vol.11 No.3
Gastric cancer is histologically classified into two types. One is the intestinal and diffuse type according to Lauren's classification, and the other is the differentiated and undifferentiated type based on Nakamura's classification. In 2007, Japanese groups proposed a new type of well-differentiated gastric adenocarcinoma in the gastric fundic glands with distinct endoscopic and clinicopathologic features. This is gastric adenocarcinoma of the fundic-gland type (GA-FG), a rare variant of gastric cancer. In a 2012 Korean study, of 6,000 cases of gastric cancer tissues, only three cases of GA-FG were identified. GA-FG is usually located in the upper third of the stomach and not known to be associated with the Helicobacter pylori infection. We herein report a case of GA-FG diagnosed in a 63-year-old man. A gastric polyp was incidentally detected during an upper endoscopy screening while conducting a health check-up, and he was diagnosed with GA-FG after an endoscopic mucosal resection (EMR) was conducted for diagnostic and therapeutic purposes. Our case suggests that for both diagnostic and therapeutic purposes, EMR may be beneficial in case of gastric polyps with suspected GA-FG.
5-fluorouracil 사용 중인 식도암 환자에서 발생한 관상동맥연축
이진욱,박무인,박선자,문원,김성은,김재현,정경원,Jin Wook Lee,Moo In Park,Seun Ja Park,Won Moon,Sung Eun Kim,Jae Hyun Kim,Kyoungwon Jung 대한소화기암연구학회 2017 Journal of digestive cancer reports Vol.5 No.1
5-Fluorouracil (5-FU) has been widely used in the treatment of various solid tumors. However, 5-FU cardiotoxicity is being reported with increasing frequency. The main symptom of cardiotoxicity is chest pain at rest with ischemic electrocardiographic changes. Up until now, the underlying mechanism has been suspected to be coronary artery spasm. However, this chest pain associated with 5-FU has several characteristics that are incompatible with coronary artery spasm; eg, inefficacy of calcium-channel blocker and a slow increase in cardiac enzyme levels. We experienced a case of 5-FU-induced cardiotoxicity which showed clinical findings consistent with acute myocardial infarction. Based on the clinical findings, coronary angiography, and no stenosis was noted. However, we concluded that the cardiotoxicity in this case was due to ischemia caused by coronary artery spasm. Because vasodilatator was effective and secondary attack was followed.
증례 : 소화기 ; 위험인자가 없는 환자에게 발생한 대장 내시경에 의한 우측 허혈성 대장염 1예
이은미 ( Eun Mi Lee ),박선자 ( Seun Ja Park ),송성은 ( Sung Eun Song ),김재현 ( Jae Hyun Kim ),김규종 ( Kyu Jong Kim ),박무인 ( Moo In Park ),박동양 ( Dong Yang Park ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3
저자 등은 평소 특별한 위험인자가 없었던 41세 여자 환자로 대장 내시경 시행 후 갑자기 발생한 혈변 및 우하복부 통증을 주소로 응급실에 내원하여 대장 내시경 및 복부 CT를 통해 대장 내시경에 의해 발생한 우측 대장의 허혈성 대장염으로 진단하고 금식 및 수액 공급 등의 보존적 치료로 회복된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Ischemic colitis is the most common form of intestinal ischemia. Although there are a variety of causes, the most common mechanism is acute, self-limited compromise in intestinal blood flow. Most cases of ischemic colitis are transient and resolve spontaneously, but right colon involvement is associated with poor outcome. Colonoscopy is the gold standard for the identification of colonic ischemia; however, very rarely, colonoscopy itself may induce ischemic colitis in patients with underlying predisposing factors, such as connective tissue disorders. We experienced a case of ischemic colitis of the right colon, following colonoscopy in a patient without risk factors. (Korean J Med 79:285-288, 2010)