만성간염환자의 삶의 질에 관한 연구

이명화,이지현,손수경 고신대학교(의대) 고신대학교 의과대학 학술지 1997 고신대학교 의과대학 학술지 Vol.12 No.1

-Abstract- This descriptive study was under taken to explore relationships between the quality of life and perceived state of health persons with chronic hepatitis to contribute theoretical understanding about these phenomenon of interest to the quality of nursing care. The subjects of this study were 100 persons with chronic hepatitis, both male and female, between 30 and 59 years of age. Data was obtained using a convenience sample technique from K Medical Center, B hospital and G hospital in Pusan from August, 1996, to November, 1996. The instruments used for this study were the quality of life scale developed by Ro, You-ja. Data was analyzed using a SPSS/PC program for ANOVA, t-test, Pearson Correlation Coefficients and Stepwise Multiple Regression. The results were as follows : 1. The mean score of the quality of life scale was 152.21. The mean scores on different dimensions were family relationships 3.44, relationships with neighbours 3.42, self-esteem 3.31, emotional life 3.14, physical state and function 3.06, economic life 3.06. 2. Higher scores on quality of life were correlated with educational level (F=2.945, p=0.05). 3. There was a significant positive correlation between the subjects perceptions of their current state of health and the quality of life score (r=0.3849, p<0.001). 4. Stepwise Multiple Regression analysis showed that 1) the perception of current health status was the main predictor and accounted for 14.99% of the total variance. 2) educational level accounted for an additional 23.6% of total variance. 5. The quality of life and the perception of their current health status of these patients with chronic hepatitis were generally lower than those of healthy adults and higher than those of cancer patients as noted in previous studies. In conclusion, the quality of life for these chronic hepatitis patients was lower than those of healthy adults and higher than those of cancer patients. The educational level was significant variable relating to quality of life of chronic hepatitis patients.

Comparative observational study of aminophylline with prophylactic and therapeutic uses for clinical outcomes in preterm infants

박경희,배미혜,이나래,한영미,변신연 고신대학교(의대) 고신대학교 의과대학 학술지 2018 고신대학교 의과대학 학술지 Vol.33 No.3

Objectives: Aminophylline has been used for prevention or treatment of apnea in preterm infants with idiopathic apnea of prematurity. The aim of this study was to assess the clinical usefulness of prophylactic in comparison with therapeutic aminophylline therapy. Methods: This retrospective observational study included infants born with a birth weight of < 2,500 g or at < 36 weeks of gestation. Infants born between August 2013 and July 2014 who received aminophylline therapy within 24 hr after birth were assigned to the prophylactic group, while infants born between August 2014 and July 2015 who received aminophylline therapy after obvious apnea were assigned to the therapeutic group. We compared clinical characteristics, including days of ventilator and oxygen therapy and bronchopulmonary dysplasia (BPD) between both groups. Results: Sixty—four patients and 25 infants were identified in the prophylactic and therapeutic groups, respectively. The mean gestational age and birth weight were 32.57 ± 1.96 weeks and 1765 ± 205 g, respectively, in the prophylactic group and 32.46 ± 1.82 weeks and 1770 ± 250 g, respectively, in the therapeutic group. No significant differences in clinical characteristics were found between the two groups. Similar clinical outcomes, including days of ventilator and oxygen therapy, intraventricular hemorrhage (IVH), periventricular leukomalacia, and BPD, were observed between the two groups. Conclusions: The present study showed that the prophylactic use of aminophylline does not improve the clinical outcomes, including BPD, IVH, and ventilator dependency as compared with therapeutic use. In other words, routine prophylactic use of aminophylline is unnecessary.

보온장갑 착용이 잠수복 착용 잠수사의 열 평형에 미치는 영향

최장규,연동수,박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1985 고신대학교 의과대학 학술지 Vol.1 No.1

The effect of wearing protective gloves on the thermal exchanges in cold water was studied in 4 Korean women wet suit divers. The subject was immersed in the water of critical temperature(average temperature was 16.5℃) and rested for 3 hours. The steady-state rectal temperature was lower with gloves(37.01±0.10(SE)℃) than without gloves(37.31±0.1℃), the different being statistically significant(P<0.05). On the other hand, the metabolic heat production was 17% higher with gloves(52.63±4.90(SE) kcal/hr·m²) than without gloves(44.93±2.49). Consequently, the total peripheral insulation was reduced(19%) by wearing gloves. At a given average skin temperature the threshold rectal temperature for shivering was approximately 0.5℃ higher without gloves than with gloves. These results suggest that 1)the total insulation of the wet suited subject is effectively increased by selective cooling of the hand, and 2) the metabolic rersponse to body cooling is sensitively affected by the skin temperature of the distal extremities. The practical implications of these findings are discussed.

Overcoming high pre-transplant isoagglutinin titers using high-dose intravenous immunoglobulin, salvage plasmapheresis, and booster rituximab without splenectomy in ABO-incompatible living donor liver transplantation: a case report

문형환 고신대학교(의대) 고신대학교 의과대학 학술지 2022 고신대학교 의과대학 학술지 Vol.37 No.2

High pre-transplant isoagglutinin is a risk factor for antibody-mediated rejection in ABO-incompatible living donor liver transplantation. A 55-year-old man with alcoholic liver cirrhosis underwent ABO-incompatible living donor liver transplantation. The initial isoagglutinin immunoglobulin G titer was 1:1,024. Despite five sessions of plasmapheresis, the isoagglutinin titer was not significantly reduced (from 1:1,024 to 1:512). We decided to perform 11 plasmaphereses and proceed with liver transplantation regardless of the isoagglutinin titer (1:128 at transplantation day). Instead, we planned to administer 0.5 g/kg intravenous immunoglobulin and booster rituximab (200 mg) after transplant. On postoperative day 6, the isoagglutinin titer increased from 1:32 to 1:64, and the patient received plasmapheresis twice. The patient maintained stable liver function without evidence of further complications or rejection. The high-dose intravenous immunoglobulin, salvage plasmapheresis, and booster rituximab protocol might be able to overcome a pre-transplant high isoagglutinin titer in ABO-incompatible living donor liver transplantation without splenectomy.

잠수복 착용 피검자에서 침수시 잠수장갑 및 버선 착용에 따른 체온조절기능의 변화

최장규,김정숙,박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

In 5 wet-suited subjects, changes in body temperature, heat exchanges and thermal insulations were studied at rest and during exercise in water of 13℃. The subjects wore neoprene gloves and boots in one series and exposed their hands and feet to water in the other series of experiments. In the subjects resting in water, the gloves and boots did not affect the level of rectal temperature but increased the mean skin temperature slightly, reducing the core-to-skin temperature gradient. However, the total thermal insulation of the subject was reduced significantly and consequently the rate of skin heat loss was increased by wearing gloves and boots. The metabolic response of the subject appeared to be significantly augmented by wearing gloves and boots. In exercising subjects the level of body temperature and the thermo-regulatory variables were not apparently changed by wearing gloves and bootss. These results indicated that in wet-suited subjects resting in cold water, exposure of hands and feet increases peripheral insulation and consequently effectively reduces heat loss to water. Such an effect of peripheral cooling is lost during exercise by hypermia to skeletal muscles in the limbs.

RENAL CORTICAL Na-K-ATPase IN CADMIUM-INTOXICATED RATS

김영규,박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

Changes in sodium, potassium-activated adenosinetriphosphatase(Na-K-ATPase) activity was studied in renal cortical microsomes of cadmium-intoxicated rats. Cadmium-intoxication was induced by subcutaneous injections of CdCl₂ dissolved in salinie at a dose of 2mg Cd/kg·day for 16 days. The Na-K-ATPase activity was determined at the end of 4th and 16th day of treatment and 20 days after treatment ceased, and the values were compared with those observed in matched control (saline-treated) animals. The enzyme activity was not significantly altered after 4 days of Cd-treatment, but it was markedly reduced after 16 days of the treatment(35.4±3.2(SE) m moles Pi/g protein per hr as opposed to 56.7±3.0 in the control). During 20 days of recovery period the enzyme activity was considerably reverted. These results are discussed in relation to changes in renal transport of Na⁺, glucose, and p-aminohippurate in cadmium-intoxicated animals.

발생중인 흰 쥐 뇌하수체의 Acetylcholinesterase에 대한 연구

김순옥,우재형 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

Experiments were made to determine the presence of cholinergic biomarker, acetylcholinesterase (AChE) in the rat hypophysis of development. A histochemical procedure for AChE was used to provide visualization of structure containg this enzyme. AChE activity of developing rat hypophysis first demonstrated in 16 days and then the more increased activity was found in 19 and 20 days. Cells staining for AChE were found in the pars distalis and pars intermedia of the developing rat hypophysis. Nerve fibers staining for AchE activity were observed in the pars nervosa. The presence of AChE and choling acetyltransferase(ChAT) (Sarah and Donald, 1983) in the pars intermedia and the pars nervosa is evidence for a cholinergic innervation to these regions. In te pars distalis, where other investigators have found muscarinic receptors, intense staining for AChE and absence of ChAT activity (Sarah and Donald, 1983) may indicate non-innervated, acetylcholine-sensitive sites.

CHANGES IN THERMAL INSULATION DURING UNDERWATER EXERCISE

박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

1. Steady-state thermal insulation was measured in protected and unprotected subjects during rest and exercise in water of critical temperature. 2. In unprotected subjects, maximal body insulation at rest increased as a linear function of mean subcutaneous fat thickness. In all subjects, howeer, body insulation declined as an exponential function of the exercise intensity, reaching approximately 25% of the resting value at work loads above 4 Met. These suggest that over 75% of maximal body insulation in resting subjects is achieved by use of skeletal muscle as an insulative barrier. 3. In wet-suited subjects, the overall insulation decreased to 1/2 with 2 Met and to 1/3 of the resting value with 3 Met exercise. This decrease in total insulation was due in part to the decrease ini insulation afforded by wet-suits. The reduction in apparent suit insulation during exercise may be attributed primarily to an increase in the effective heat exchange surface area as a result of exercise hyperemia of the limbs which are poorly insulated as compared with the trunk. 4. As a practical consequence, both in protected and unprotected individual, heat generated by muscular exercise in water colder than critical temperature cannot offset cooling unless the exercise intensity is great.

RENAL FUNCTION IN EXPERIMENTAL CADMIUM INTOXICATION

Y. K. Kim,J. K. Choi,J. S. Kim,Y. S. Park 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

Changes in renal functions were studied in rats treated with cadmium. Subcutaneous injections of CdCl₂(2mgCd/kg·day) for 16 days induced a marked polyuria and a reduction inn urine osmolality. These changes were accompanied by increase in urinary excretions of various solutes, such as proteins, glucose, urea, calcium, phosphate, chloride, and potassium. The change in urine flow was proportional to the change in total osmotic solute excretion. Creatinine excretion and TcH₂O remained unchanged. From these results we suggest that the mechanism of Cd-induced polyuria is an osmotic diuresis initiated by inhibition of proximal tubular reabsorption of various substances.

Human Leukemia 세포에 부착된 Ureaplasma urealyticum의 소장에 관한 전자현미경적 연구

장명웅,김광혁,박인달,배광성 고신대학교(의대) 고신대학교 의과대학 학술지 1988 고신대학교 의과대학 학술지 Vol.4 No.1

The rise and fall of adhered Ureaplasma urealyticum to human leukemia cell was investigated with the cultural method and electron microscopic method. The results obtained in this study are summerized as follows. U. urealyticum maximally adgered to human leukemia cell 8 hours after inoculation. The adhered U. Urealyticum to the cell surface phagocytized by human leukemia cell within 24 hours after inoculation. Many U. urealyticum was killed and digested by the cell. U. urealyticum couldn't replicated in human leukemia cell. On the other hand, U. urealyticum was able to multiplicate temporarily in the culture supernatant of human leukemia cell.