당뇨병 환자에서 소화성 궤양에 속발된 중복유문 1예

노지훈,임대관,문원,박선자,박무인,김규종,김윤정 대한소화기내시경학회 2008 Clinical Endoscopy Vol.36 No.6

중목유문은 유문 이외에 위전정부와 십이지장 구부 사이에 또 하나의 통로가 형성된 매우 드문 위장관 기형이다. 중복유문은 선천적으로도 발생하지만 대부분은 소화성 궤양과 같은 원인에 의한 후천적인 경우가 많다. 기저질환으로는 만성 폐쇄성 폐질환, 만성 신부전, 만성 류마티스질환, 전신성 홍반성 루푸스, 당뇨병 등을 볼 수 있다. 특히 당뇨병은 위십이지장 점막의 방어기능을 감소시켜 소화성 궤양의 치유지연에 영향을 주는 것으로 알려져 있다. 국내에서는 중복유문에 동반된 질환으로 폐결핵, 만성 기관지염, 류마티스성 관절염, 통풍이 보고되었으나 당뇨병 환자에서 발생한 중복유문은 그 보고가 없다. 저자들은 40년간의 합병증을 동반한 당뇨병력이 있는 74세 남자 환자에서 소화성 궤양에 합병된 중복유문을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

레이저를 이용한 금속 격자 (metal mesh) 투명전극 제조 기술동향

노지훈,김동식 한국레이저가공학회 2019 Laser Solutions Vol.22 No.10

파킨슨병 고열 증후군에 병발한 도파민 조절장애 증후군 1예

노지훈,이승환,박건우,이대희,고성범 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2

A few patients with Parkinson’s disease (PD) crave large amounts of levodopa therapy far beyond those needed to alleviate their symptoms, even in the state of overdose complication. Such harmful pattern of compulsive dopaminergic drug use is called as dopamine dysregulation syndrome (DDS). We report a chronic stage PD patient presenting with high fever and altered mentality, who had the DDS as well as the Parkinsonism hyperpyrexia syndrome (PHS).

완전 전도로 절제 결과 평가를 위해 동율동시 투여한 Adenosine

노지훈,이지현,임대관,박찬복,김성만,차태준,주승재,이재우 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common form of supraventricular tachycardia. Radiofrequency cather ablation (RFCA) of the slow pathway can treat AVNRT. Slow pathway ablation is associated with a risk of complete AV block in rare cases. In difficult cases, electrophysiologist should check degrees of artrioventriculr node(AVN) damage during and after ablation. There are several methods of identifying high risk of slow pathway ablation and identifying degree of AVN damage, but sometimes there are not perfect. Adenosine is effective in AVNRT termination by influencing AVN conduction. Use of adenosine can identify change of AVN conduction properties Methods : Adenosine tests were studied in 24 patients (10 men, 14 woman:43.5± 16.6 years) with inducible sustained AVNRT. Adenosine 6㎎ and 12㎎ were injected before and after successful ablation of slow pathway during sinus rhythm. Results : With adenosine 6㎎ injection, AVNRT occurred in 13patients and A-H jump in 15 patients before ablation, whereas AVNRT occurred in no patient and A-H jump in 5 atients after ablation. Adenosine 6㎎ induced AV block beats were significantly increased from 0.4±1.5 to 4.0±4.0 beats by ablation (p<0.05). Adenosine 6㎎ induced longest RR interval was also significantly increased from 876±319 to 1575±852 msec by ablation (p<0.05). And then adenosine 12 ㎎ were injected before and after ablation of slow pathway in 21 patients. AVNTR occurred in 13 versus 0 patient, A-H jump occurred in 16 versus 9 patients. the longest RR interval was 1590±714 versus 4245±3492 msec(p<0.05). Conclusion : After successful RFCA of AVNRT, adenosine increases the number of AV block beats and the longest RR interval significantly. Administration of adenosine during and after ablation can identify severe AV nodal damage which was induced by ablation. Administration of adenosine during and after RFCA enables us to estimate amount of AV nodal damage and it give us information about when to stop the cather ablation. Adenosine can be useful to identify patients with impending heart block during and after ablation of slow pathway.

Recent Updates on Subcortical Ischemic Vascular Dementia

노지훈,이재홍 대한뇌졸중학회 2014 Journal of stroke Vol.16 No.1

Vascular dementia (VaD) is a history-laden disease entity that dates back to the 19th century when arteriosclerotic brain atrophy due to hardening of the arteries was perceived as the major cause of senile dementia. Its existence had been overshadowed by the emergence of Alzheimer’s disease (AD) in the past century and research on AD dominated the field of dementia. Interest in VaD has been revived in recent years as vascular lesions have been shown to make great contributions to the development of dementia, particularly in the elderly. VaD has now evolved into the concept of vascular cognitive impairment (VCI), which encompasses not only VaD but also AD with cerebrovascular disorder and VCI with no dementia. The concept of VCI is intended to maximize the therapeutic potential in dementia management because the vascular component may be amenable to therapeutic intervention particularly in the early stages of cognitive impairment. Subcortical ischemic vascular dementia (SIVD) is pathologically driven by severe stenosis and the occlusion of small vessels that culminate into white matter ischemia and multiple lacunar infarctions in the subcortical structures. The relatively slow progression of symptoms and clinical manifestations associated with cholinergic deficits often make the differentiation of SIVD from AD difficult. The recent development of in vivo amyloid imaging enabled further pathological breakdown of SIVD into pure SIVD and mixed dementia with subcortical ischemia based on the absence or existence of amyloid pathology in the brain. In this article, the authors reviewed the emerging concepts of VaD/VCI and the clinical manifestations, biomarkers, treatments, and preclinical models of SIVD based on the pathophysiologic mechanisms of the disease.

포스터전시 : 간경변증의 진단에 초음파로 측정된 여러 가지 객관적 지표의 유용성

노지훈,임대관,윤병철,한병훈,이상욱 대한간학회 2005 춘계 학술대회 Vol.11 No.-

완속 전도로 절제 결과 평가를 위해 동율동시 투여한 Adenosine

노지훈,이지현,임대관,박찬복,김성만,차태준,주승재,이재우 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1

Background : Atrioventricular nodal recentrant tachycardia (AVNRT) is the most common form of supraventriicular tachycardia. Radiofrequency catheter ablation (RFCA) of the slow pathway can treat AVNRT. Slow pathway ablation is associated with a risk of complete AV block in rare cases. In difficult cases, electrophysiologist should check degrees of atrioventricular node (AVN) damage during and after ablation. There are several methods of identifying high risk of slow pathway ablation and identifying degree of AVN damage, but sometimes there are not perfect. Adenosine is effective in AVNRT termination by influencing AVN conduction. Use of adenosine can identify change of AVN conduction properties. Methods : Adenosine tests were studied in 24 patients (10 men, 14 women: 43.5±16.6 years) with inducible sustained AVNRT. Adenosine 6mg and 12mg were injected before and after successful ablation of slow pathway during sinus rhythm. Results : With adenosine 6mg injection, AVNRT occurred in 13 patients and A-H jump in 15 patients before ablation, whereas AVNRT occurred in no patient and A-H jump in 5 patients after ablation. Adenosine 6mg induced AV block beats were significantly increased from 0.4±1.5 to 4.0±4.0 beats by ablation (p<0.05). And then adenosine 12mg were injected before and after ablation of slow pathway in 21 patients. AVNRT occurred in 13 versus 0 patient, A-H jump occurred in 16 versus 9 patients. The longest RR interval was 1590±714 versus 4245±3492 msec (p<0.05). Conclusion : After successful RFCA of AVNRT, adenosine increases the number of AV block beats and the longest RR interval significantly. Administration of adenosine during and after ablation can identify severe AV nodal damage which was induced by ablation. Administration of adenosine during and after RFCA enables us to estimate amount of AV nodal damage and it give us information about when to stop the catheter ablation. Adenosine can be useful to identify patients with impending heart block during and after ablation of slow pathway.

춘계학술대회 : 포스터전시 ; 간경변증의 진단에 초음파로 측정된 여러 가지 객관적 지표의 유용성

노지훈,임대관,윤병철,한병훈,이상욱 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)

목적: 초음파 검사는 만성 간질환의 선별검사 및 경과관찰에 있어서 널리 사용되고 있으나, 간경변증으로 진행여부에 대한 판단은 비장의 크기 외에 간실질의 에코상, 간표면의 결절상 등 시술자의 숙련도나 경험 등 여러 인자에 의해서 진단의 정확도가 영향을 받는다. 이에 본 연구에서는 복부 초음파로 간경화증을 진단하기 위해 여러가지 객관적 지표를 검사하고자 하였다. 대상 및 방법: 2004년 3월부터 2005년 3월까지 만성간염군(만성 B형 또는 C형 간염 4

포스터 전시 : 소화기 ; S상결장에 발생한 거대 지방종의 내시경적 절제 1예

노지훈,임대관,김윤정,문원,김규종,박무인,박선자 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

Autonomic Service Composition of Localized Ubiquitous Services for Open Service Gateways

노지훈,윤원식,No, Ji-Hoon,Yoon, Won-Sik The Institute of Electronics and Information Engin 2011 電子工學會論文誌-TC (Telecommunications) Vol.41 No.4

무선 네트워크 기술 및 모바일 컴퓨팅 기기의 발전과 함께 웹 서비스 기술이 발전하여 유비쿼터스 환경에서 새로운 서비스가 출현하게 되었다. 이러한 서비스들은 홈, 사무실, 공항, 전시장 등과 같은 위치 환경과 깊은 관계가 있으며, 위치환경에 따라 차별화된다. 사용자의 환경정보에 따라 다양한 지역서비스를 사용하는데 필요한 프로그램들이 사용자의 기기에 동적으로 전달되어지고, 지역에 따라 분산된 다양한 서비스들을 효과적으로 관리해 주는 시스템이 요구된다. 본 논문에서는 편리하게 서비스 선택을 할 수 있으며 유용한 서비스를 사용자에게 제공해 줄 수 있는 자동 서비스 구성 시스템을 제안한다. 제안한 시스템은 사용자가 지역 서비스 존에 들어가게 되면 모바일 기기에 자동으로 지역서비스 프로그램을 설치하고 지역서비스를 제공하여 준다. 또한 본 시스템은 분산된 지역서비스를 원격에서 효율적으로 관리할 수 있으며, 원격 관리자, 서비스 게이트웨이, 모바일 기기로 구성되어 있다. 본 시스템을 802.11b 무선 네트워크와 OSGi 프레임워크 기반으로 구현하였다. Many types of services appear in a ubiquitous environment promulgated by the evolution of web service technology with the advances in wireless network technologies and mobile computing devices. These services differ according to their location environments, such as home, office, airport, and exhibition. It is required that a different set of services dynamically drops into the mobile user's device depending on their context and the distributed localized services are efficiently managed to seamlessly provide these localized services to the user. This paper proposes an Autonomic Service Composition System (ASCS) to provide useful services to the user with minimal or no effort for service selection. ASCS seamlessly installs the programs of localized services in the user's mobile device. It automatically provides localized services to users that are in the local service zone. Also ASCS can manage distributed localized services remotely and efficiently. ASCS is composed of a Remote Manager, Service Gateway, and Mobile Device. The prototype implementation uses 802.11b Wireless Network and Bundles using the OSGi Framework.