수종 Flavonoid의 항허피스바이러스효과

이지현,김영소,이종길,이혁구,한성순,Lee, Ji-Hyun,Kim, Young-So,Lee, Chong-Kil,Lee, Hyuk-Koo,Han, Seong-Sun 한국생약학회 1999 생약학회지 Vol.30 No.1

To search for less toxic antiherpetic agents, the inhibitory effects of twelve kinds of flavonoids including chrysin, quercetin, quercitrin, rutin, fisetin, gossypin, kaempferol, morin, naringenin, naringin, hesperetin and hesperidin on the plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Vero cells were examined by plaque reduction assay in vitro. Some flavonoids tested in this study showed potent antiherpetic activity, reducing intracellular replication of herpes simplex viruses when Vero cell monolayers were infected and subsequently cultured in medium containing flavonoids. Naringenin showed the most potent antiviral activity against HSV-1 with selectivity index (SI) of 19.1 and hesperetin showed the most potent antiviral activity against HSV-2 with SI of 9.8. These results suggest that some flavonoids may be a potential therapeutic agent for the treatment and prevention of herpes simplex virus infections.

90년대 말 한국영화의 환상성 경향 연구 - 김기덕의 <나쁜 남자>를 중심으로

이지현,LEE, Jihyun 성균관대학교 트랜스미디어연구소 2018 트랜스- Vol.4 No.-

90년대에 만들어진 환상적 한국영화 계열의 장르는 다양하다. 이들 작품의 환상성은 굳이 '귀신' 소재 영화들만 한정되어 발현되지 않는다. 예를 들어, 작가 이상(Lee sang)의 미스테리를 바탕으로 완성된 영화 <건축무한 육면각체의 비밀>이 구조주의적 환상의 이야기를 지녔다고 한다면, <텔미썸딩> 같은 작품은 심리주의적으로 관습적인 환상을 지니고 있다고 이야기할 수 있다. 본고는 당대 한국영화의 환상성을 '사실주의에 기반한 알레고리의 완성'을 통해 들여다본다. 그를 위해서 에티엔 수리오(Etienne Souriau)의 환상성 개념을 빌린다. 일부 영화에서 환상성은 현상하는 자연에서 직접 발견될 수 있으며, 이때 자연을 객관화시키는 주체로 자신들의 위치를 격상시키고, 자연에 대한 지배를 정당화한 인간 존재는 그 대가로 '소외'를 맞이하게 된다. 영화의 내러티브에서 이러한 소외의 개념은 알레고리를 통해 자주 드러나는데, 특히 에티엔 수리오가 이른 '개인의 경험'에 따른 환상성의 발현에서 이 점은 더욱 극명해진다. 그런 면에서 김기덕의 영화는 개인의 경험을 통해 사회의 요소들을 알레고리화 하는 대표적 예라 할 수 있다. 김기덕의 <나쁜 남자>를 중심으로, 본고는 90년대 한국의 환상적인 영화들이 사회의 모방을 통해 심미적인 환상성을 구축하는 과정을 분석한다. The genres of fantastic of Korean films created in the 90s are diverse. The fantastics of these works are not manifested only in 'Ghosts' movies. For example, If the film Mystery Of The Cube, which is based on the mystery of Lee Sang, has a story of structuralist fantasy, we can say that a movie like Tell Me Something has a psychologically conventional fantastic. This study examines the fantastic of contemporary Korean films through 'completion of allegory based on realism'. For this, we borrows the fantastic concept of Etienne Souriau. In some films, fantastics can be found directly in the developing nature. In this case, the human being who justifies their domination of nature by upgrading their position as the objectifying subject of nature becomes 'alienated' in return. The notion of this alienation in film narratives is often revealed through allegories, particularly in the manifestation of fantasy by Étienne Souriau in the early 'personal experience'. Kim kiduk's film is a representative example of allegorizing elements of society through individual experience. Focusing on Kim Giduk's Bad Guy, this essay analyzes the process in which fantastic films of Korea in the 90s build up aesthetic fantastic through imitation of society.

SaaS 플랫폼 기술 및 개발 동향

이지현,박경현,이상민,이원재,오병택,강성주,정문영,양경아,원희선,허성진,최완,Lee, J.H.,Park, K.H.,Lee, S.M.,Lee, W.J.,Oh, B.T.,Kang, S.J.,Chung, M.Y.,Yang, K.A.,Won, H.S.,Hur, S.J.,Choi, W. 한국전자통신연구원 2011 전자통신동향분석 Vol.26 No.5

본 고에서는 SaaS를 서비스로 제공하기 위한 기술인 SaaS(Software as a Service) 플랫폼 기술과 개발 동향을 소개한다. 이를 위해 국내외 SaaS 개발 시장의 동향을 살펴보고 국가 플랫폼 개발의 일환으로 2009년부터 ETRI에서 연구개발 중인 SaaS 플랫폼의 개발 및 기술 현황에 대해 살펴본다.

스트레스성 고혈압 환자에서 고혈압 약물 복용 없는 복합한의치료만의 강압 효과 - 증례보고

이지현,노민영,윤석영,전형선,한양희,임정태,Lee, Ji-hyun,Roh, Min-yeong,Yoon, Seok-yeong,Jun, Hyung-sun,Han, Yang-hee,Leem, Jung-tae 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study considered the effectiveness of integrative Korean medical treatment for stress-induced hypertensive patients without the use of conventional medication. Methods: A 62-year-old female with stress-induced hypertension (HTN) was hospitalized for 33 days. Her pattern identification was ascendant hyperactivity of liver yang (Ganyangsanghang)-type HTN. Herbal medicine and acupuncture were used for the treatment: Cheonggansoyo-san for 33 days and Chunwangbosim-dan for 15 days, together with acupuncture for 20 minutes twice a day. Blood pressure was checked daily during hospitalization with a digital sphygmomanometer in the brachial artery. Results: After 33 days of treatment, blood pressure decreased. The Handicap Inventory (DHI) scale and Pittsburg Sleep Quality Index (PSQI) scores both decreased. The patient also reported fewer complaints. A five-month follow-up after discharge, with no further treatment, confirmed stable blood pressure. Symptom improvements continued with no significant side effects. Conclusions: This study indicates that Korean medical treatment is effective for stress-induced hypertensive patients.

천연 Hesperetin의 항허피스바이러스작용과 Acyclovir 및 Vidarabine과의 병용효과

이지현,어성국,김영소,이종길,한성순,Lee, Ji-Hyun,Eo, Seong-Kug,Kim, Young-So,Lee, Chong-Kil,Han, Seong-Sun 한국생약학회 1999 생약학회지 Vol.30 No.1

To search for less toxic antiherpetic agents, the inhibitory effects of natural hesperetin on the plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in Vero cells were examined by the plaque reduction assay in vitro. Hesperetin inhibited plaque formations of HSV-1 and HSV-2 in a dose dependent manner. It also exhibited more potent antiherpetic activity on HSV-2 with selectivity index (SI) of 9.8 than on HSV-1 with SI of 8.4. The combined antiherpetic effects of hesperetin with nucleoside antiherpetic agents, acyclovir and vidarabine, were examined on the multiplication of these two strains of herpesviruses in Vero cells by the combination assay. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combinations of hesperetin with acyclovir on HSV-1 and HSV-2 showed synergistic effects with CI values of $0.29{\sim}0.73$ for 50%, 70%, 90% effective levels and those with vidarabine showed partially synergistic or additive effects with CI values of $0.83{\sim}1.33$.

초음파 분무 열분해 공정을 이용한 수계 SiO₂ Sol로부터의 구형 SiO₂ 분말 합성

이지현,황해진,한규성,황광택,김진호,Lee, Ji-Hyeon,Hwang, Hae-Jin,Han, Kyu-Sung,Hwang, Kwang-Taek,Kim, Jin-Ho 한국재료학회 2016 한국재료학회지 Vol.26 No.10

Using the ultrasonic pyrolysis method, spherical $SiO_2$ powders were synthesized from aqueous $SiO_2$ sol as a starting material. The effects of pyrolysis conditions such as reaction temperature, $SiO_2$ sol concentration, and physical properties of precursor were investigated for the morphologies of the resulting $SiO_2$ powders. The particle size, shape, and crystallite size of the synthesized $SiO_2$ powders were demonstrated according to the pyrolysis conditions. Generally, the synthesized $SiO_2$ particles were amorphous phase and showed spherical morphology with a smooth surface. It was revealed that increased crystallite size and decreased spherical $SiO_2$ particle size were obtained with increases of the pyrolysis reaction temperature. Also, quantity of spherical $SiO_2$ particles decreased with the decrease in the concentration and surface tension of the precursor.

Graft Polymer를 이용한 수계 세라믹 잉크의 합성 및 프린팅 특성평가

이지현,황해진,김진호,황광택,한규성,Lee, Ji-Hyeon,Hwang, Hae-Jin,Kim, Jin-Ho,Hwang, Kwang-Taek,Han, Kyu-Sung 한국재료학회 2019 한국재료학회지 Vol.29 No.10

Ink-jet printing is a manufacturing process technology that directly prints a digitalized design pattern onto a substrate using a fine ink jetting system. In this study, environmentally friendly yellow aqueous ceramic ink is synthesized by mixture of distilled water, yellow ceramic pigment and additives for ink-jet printing. The graft polymer, which combines electrostatic repulsion and steric hindrance mechanism, is used as a surfactant for dispersion stability of aqueous ceramic ink. Synthesized ceramic ink with graft polymer surfactant shows better dispersion stability than did ceramic ink with PAA surfactant; synthesized ink also shows desirable ink-jet printability with the formation of a single ink droplet during printability test. Finally, ceramic ink printed on glass substrate and ceramic ink with graft polymer surfactant shows a high contact angle without surface treatment on glass substrate. Consequently, it is confirmed that the ceramic ink with graft polymer surfactant can achieve high printing resolution without additional surface treatment process.

해외건축동향: 칠레·멕시코 - 건축사 Alejandro Aravena와 그의 사회적 건축

이지현,Lee, Jihyun 대한건축사협회 2016 建築士 Vol.2016 No.8

국내 시판 액상요구르트의 품질특성

이지현,박혜영,원주인,박혜인,최인덕,이석기,박지영,조동화,전용희,오세관,한상익,최혜선,Lee, Ji Hyun,Park, Hye Young,Won, Ju In,Park, Hye In,Choi, In Duck,Lee, Seuk Ki,Park, Ji Young,Joe, Dong Hwa,Jeon, Yong Hee,Oh, Sea Kwan,Han, Sang Ik,Ch 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.6

Yogurt is produced by fermentation of milk using bacteria known as "yogurt cultures". Most of these bacteria are probiotics such as Lactobacillus delbrueckii subsp. bulgaricus, Lb. rhamnosus, Streptococcus thermophilus, and Bifidobacterium. The domestic fermented milk market is increasing, and about 30 companies are producing yogurt. The purpose of this study was to analyze the quality characteristics of domestic commercial liquid yogurt. Total 30types of commercial yogurts were sampled and their physicochemicial properties, including pH, sugar content, acidity, viscosity, and microbial characteristics of lactic acid bacteria counts, were measured. Commercial liquid type yogurt showed a pH of 4.5, sugar content of 7.4-21.2%, total acid content of 0.4-0.9%, and viscosity of 0.1-250 cP. In terms of microbial populations, lactic acid bacteria counts were 7.2-11.3 log CFU/mL and anaerobic lactic acid bacteria counts were 8.0-11.5 log CFU/mL. The quality characteristics differed depending on the constituents of the sample and the microorganisms used. These results are related to the quality characteristics of yogurts and are useful for identifying new trends in the domestic fermented milk industry. 요구르트는 유산균을 이용하여 제조한 대표적인 유발효식품이다. 국내 유통되고 있는 요구르트는 약 30개의 업체에서 생산되고 있으며, 최근 당 저감화 정책 실시로 저당제품이 출시되고 있다. 본 연구는 국내 시판되고 있는 액상타입의 요구르트를 수집하여 제품의 일반적인 특성을 조사하였고, pH, 산도, 당도, 점도, 호기성 혐기성 유산균수를 측정하여 기초자료로 사용하고자 하였다. 탈지분유(97%) 및 원유(57%)가 주된 원료로 높은 빈도로 사용되고 있으며, 발효스타터는 요구르트에 100% 이용되고 있으며 주로 수입균주가 이용되고 있다. 당은 sucrose, oligosaccharide, xylitol이 첨가되었고, 그 외 구연산, vitamin C, gum류 등이 요구르트의 기능성과 물성 등을 개선하고자 하는 부원료로 사용되고 있는 것을 확인하였다. 30종의 요구르트의 품질특성을 분석한 결과 pH는 3.6-4.6, 당도는 7.4-21.2%, 총산도는 0.4-0.9%, 호기성 유산균수 7.2-11.3 log CFU/mL, 혐기성 유산균수는 8.0-11.5 log CFU/mL로 분석되었다. 본 연구에서 도출된 시판 액상타입 요구르트의 품질분석 결과는 다양한 소재를 접목한 요구르트 개발의 품질규격설정의 기초자료로 유용 할 것으로 사료된다.

한국도로교통협회와의 인연

이지현,Lee, Ji-Hyeon 한국도로교통협회 1997 도로교통 Vol.71 No.-