Collective “We” and the Communal Consciousness of Diaspora Identity in Chang-rae Lee`s On Such a Full Sea

이지은 ( Ji Eun Lee ) 서울대학교 미국학연구소 2014 미국학 Vol.37 No.2

This paper examines how Change-rae Lee`s On Such a Full Sea imagines a communal consciousness of diaspora identity through the use of a collective narrative voice that creates a narrative sense of split identity in readers` minds. The novel`s use of heroine figure, Fan, as a locus of communal consciousness very much corresponds to the conventional framework of the Bildungsroman narrative, which builds a communal consciousness incorporated into a progressive history through a depiction of the individual hero`s or heroine`s reconciliation with social norms. The narrative consciousness grounded in this individual hero/heroine invites readers to experience the sense of community congruent with the linear development of history. Lee`s novel, however, complicates the narrative consciousness through a collective narrative voice “we,” by shifting the referent from “we” inside the narrative frame to “we” outside the narrative frame and by dislocating the main figure Fan from society. The sense of disjointedness manifested by the narrative sense of split identity and the heroine`s displacement in society conceptualizes diaspora identity. Diaspora identity configured in this way propounds a more liberating version of communal consciousness as it allows deviations from norms and exploration of new possibilities not bound by nation or ethnicity. The communal consciousness of diaspora identity depicted in Lee`s novel challenges the homogeneous sense of community merged with history and gestures toward heterogeneous deviations from history.

청간해주탕(淸肝解酒湯)이 CYP2E1-transfected HepG2 cell에서 알코올유발 세포독성에 미치는 영향

이지은,김영철,우홍정,이장훈,Lee, Ji-Eun,Kim, Young-Chul,Woo, Hong-Jung,Lee, Jang-Hoon 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1

Objectives : Induction of CYP2E1 by ethanol is believed to be one of the major mechanism by which ethanol generate a state of oxidative stress. Previous studies showed that treatment with Chungganhaeju-tang prevents hepatic inflammation and apoptosis in alcoholic liver disease. The purpose of our study is to determine if Chungganhaeju-tang can also protect against alcohol-induced cytotoxicity in CYP2E1-transfected HepG2 cells. Materials and Methods : CYP2E1-transfected HepG2 cells and control vector-transfected HepG2 cells were exposed for isx hours to Chungganhaeju-tang, and then 50 mM of ethanol was added and left for two days. Results : Ethanol significantly decreased cell viability in CYP2E1-transfected HepG2 cells and increased apoptosis. These alterations were attenuated by Chungganhaeju-tang. This was accompanied by an improvement of NF-${\kappa}B$ and Akt activation. Conclusion : These results suggest that Chungganhaeju-tang exerts inhibitory effect against the cytotoxicity induced by alcohol in CYP2E1-transfected HepG2 cells, and that this is a protective action due, at least in part, to an activation of NF-${\kappa}B$ that plays a key role in the protection mechanism, and in reducing hepatotoxic cytokine gene expression.

산업재해에 의한 안외상에 대한 역학적 고찰

이지은,김수영,이승욱,이상준,Ji Eun Lee,MD,Soo Young Kim,MD,Seung Uk Lee,MD,Sang Joon Lee,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To investigate the epidemiological and clinical characteristics of industrial ocular trauma for treatment application and prevention. Methods: A retrospective survey of 207 eyes from 206 patients who visited Gosin University Gospel Hospital from January 1, 1998 to December 31, 2007 was performed. The age, sex, diagnosis, causes, injury site, primary ocular surgery, duration of hospitalization and treatment, and initial and final visual acuities were reviewed using the United States Eye Injury Registry (USEIR) form based on the Birmingham Eye Trauma Terminology (BETT). Results: The trauma incidence was higher in males (95.65%) in their forties (50.24%). The mean patient age was 41.5 years. Separately counted lesions were presented as a proportion to total injured eyes. The most common diagnosis of industrial ocular traumas was global injuries (124.1%), orbital wall fractures (6.3%), adnexal trauma (5.3%) and optic nerve injuries (3.4%). The most common cause of ocular injuries was flying iron piece (28.67%), and the cornea was the most frequent injured site (69.1%). In 43% of the patients, surgical treatments were performed and the most common surgery was primary closure of the cornea or sclera (82.02%), followed by vitrectomy (30.33%). The average of initial and final visual acuity (log MAR) was 1.2 and 0.93, respectively. In 69.7% of all patients, the final visual acuity was improved or stabilized compared to the initial status. Conclusions: Flying objects are still the most frequent cause of industrial ocular trauma and in approximately 70% of all patients, the final visual outcome improved or stabilized compared to the initial status. These types of ocular traumas can be significantly reduced by wearing protector shields along with educational safety programs.

농촌과 중소도시지역 40세 이상 성인의 영양소 섭취 질의 평가

이지은,안윤진,이주영,차정호,박찬,김규찬,Lee, Ji-Eun,Ahn, Youn-Jhin,Lee, Ju-Young,Cha, Jung-Ho,Park, Chan,Kimm, Ku-Chan 대한지역사회영양학회 2004 대한지역사회영양학회지 Vol.9 No.4

To assess the quality of nutrient intake by area of Korean adults, a dietary survey with the 3-day record method was obtained from 324 subjects aged 40 years and older but younger than 70 (52.4 $\pm$ 8.7) living in a rural area (Ansung) and suburban area of a middle-sized city (Ansan). The quality of nutrient intake was assessed by analyzing Nutrient Adequacy Ratio (NAR), Mean Adequacy Ratio (MAR) and Index of Nutritional Quality (INQ). The average daily mean energy intakes were 1,832 ㎉ for Ansung and 1,842 ㎉ for Ansan, respectively. Daily intakes of fat for Ansung and Ansan subjects were 40.9 and 40.3 g, and those for protein were 75.1 and 73.1 g, respectively. The overall calorie: protein: fat ratio (CPF) of energy intake was 63 : 17 : 20. Daily mean intakes of protein, fat, calcium, phosphorus, iron, potassium, carotene, sodium, thiamin, and niacin were significantly higher in Ansung residents than in Ansan subjects (p < .05). The average intakes of energy, calcium, vitamin A were lower than Recommend Dietary Allowance (RDA) in both areas. Note, over 30% of the study subjects had less than 75% of RDA of calcium, vitamin A and riboflavin. The MAR was higher in Ansung than Ansan residents (0.86 and 0.85, respectively; p < .05). INQs were over 1 for most nutrients except calcium (0.87), and that of calcium and phosphorus was each significantly higher in Ansung than Ansan subjects. Based on these results, nutrient intake quality of subjects aged 40 to 69 years living in the surveyed rural area is comparable to that of semi-industrialized suburban area in Korea. Dietary deficiency in all of calcium, vitamin A, and riboflavin, however, was a common problem for both rural and suburban residents.

미세변화형 신증후군(MCNS)으로부터 국소성 분절성 사구체 경화증(FSGS)으로 이행된 환아의 임상양상

이지은,육진원,이의성,김지홍,김병길,정현주,Lee Ji Eun,Yook Jinwon,Lee Eui Seong,Kim Ji Hong,Kim Pyung-Kil,Chung Hyun Joo 대한소아신장학회 2000 Childhood kidney diseases Vol.4 No.1

목 적 :소아의 원발성 신증후군 중 $85\%$이상을 차지하는 미세변화형 신증후군(MCNS)은 스테로이드 치료로 완전 관해가 잘 오는 예후가 양호한 질환이다. 반면 국소성 분절성 사구체 경화증(FSGS)은 치료에 잘 반응하지 않고 신부전으로의 진행 및 신이식 후의 재발률이 높아 장기 예후가 나쁜 것으로 알려져 있다. 신생검상 MCNS로 진단된 환아 중 여러 약물 요법에 반응이 불량하거나 증세의 악화가 있어 추적 관찰하며 시행한 2차 신생검상 FSGS로 조직 소견의 변화를 보이는 경우가 드물게 있어 본 저자들은 이들의 임상 양상의 특징을 비교 고찰하여 MCNS로부터 FSGS로 이행될 수 있는 위험 요인을 알아보고자 본 연구를 시행하였다. 대상 및 방법 : 1988년 1월부터 1999년 5월까지 세브란스 병원 소아과에서 신장생검 상 미세변화형 신증후군 및 국소성 분절성 사구체 경화증으로 진단받고 치료 중인 환아 296명을 대상으로 하였다. 조직 병리 소견상 미세변화형 신증후군을 보인 군(MCNS군), 국소성 분절성 사구체 경화증을 보인 군(FSGS군)및 MCNS로부터 FSGS로 이행된 군(이행군)등 3개 군으로 나누어 이들 각 군의 임상 양상 차이를 비교하였다. 결 과 : 대상 환아는 MCNS군 241명($81.4\%$), FSGS군 47명($15.9\%$), 이행군 8명($2.7\%$)으로 총 296명 이었으며, 평균 발병 연령은 MCNS군 $6.0{\pm}2.6$세, FSGS군 $7.2{\pm}4.3$세, 이행군 $8.3{\pm}2.6$세였고, 남녀비는 MCNS군 3.7:1, FSCS군 1.8:1, 이행군 3:1이었다. 내원 당시의 혈뇨, 고혈압, 24시간 뇨단백량, 혈청 알부민, 혈청 콜레스테롤, 혈청 크레아티닌 등을 비교하였으며, 이중 이행군:FSGS군 간의 비교에서 24시간 뇨단백량 $686:342mg/m^2/hr$(P<0.05), 혈청 알부민 1.92:2.47g/dL(P<0.05), 혈청 콜레스테를 494:343 mg/dL(P<0.05)으로 의미있는 차이를 보였고, 이외에는 이행군과 FSGS군 또는 MCNS군과의 사이에 의미있는 차이를 보이지는 않았다. 스테로이드 치료에 전혀 반응을 보이지 않는 경우는 MCNS군 $13.3\%$,이행군 $12.5\%$,FSGS군 $59.6\%$로 FSGS군이 의미있게 많았으며(P<0.05), 스테로이드 이외의 면역억제제 치료가 필요했던 경우는 MCNS군 $58.5\%$, 이행군 $100\%$, FSGS군 $80.8\%$로 MCNS군에 비해 이행군과 FSGS군이 의미있게 높았다(P<0.05). 평균재발횟수는 MCNS군 $0.84{\pm}0.21$회/6개월, 이행군 $1.07\pm}0.53$회/6개월로 의미있는 차이는 없었으며, 관해에서 첫 재발까지의 기간 역시 MCNS군 6.94${\pm}$1.92개월, 이행군 $6.71{\pm}4.89$개월, FSGS군 $5.27{\pm}12.48$개월로 각 군간의 의미있는 차이는 없었다. 결 론 : 미세변화형 신증후군에서 치료 경과중 국소성 분절성 사구체 경화증으로 이행된 예는 전체 MCNS의 249명중 8명으로 $3.2\%$였다. 이들의 임상양상의 특징을 비교 고찰한 결과 이행여부를 예측할 수 있는 위험요인은 없었다. 미세변화형 신증후군으로 진단된 환아 중에서 스테로이드 치료에 반응이 없거나 자주 재발하는 경우, 또는 강력한 면역치료에도 관해가 오지 않는 경우 등에는 신장 조직 생검을 재시행하여 국소성 분절성 사구체 경화증으로의 이행 여부를 확인해야 하겠다. Purpose: MCNS is found in approximately $85\%$ of the idiopathic nephrotic syndrome in children and shows good prognosis with initial steroid therapy. However in FSGS, there is poor prognosis with initial therapy and shows higher rate of progression to chronic renal failure and relapse after kindney transplantation. We have experienced 8 patients who were diagnosed as MCNS on initial renal biopsy and then progressed to FSGS on follow-up biopsy. So we have investigated their clinical course and risk factors for transition of MCNS to FSGS. Methods: We conducted a retrospective study with a review of histopathologic findings and clinical manifestations of 296 cases of MCNS and FSGS that were diagnosed from January 1988 to May 1999. We classified them into 3 groups according to the histopathologic finding; MCNS, FSGS, MCNS progressed to FSGS in follow-up biopsy. Results: The number of children was 296 cases comprising 241 cases($81.4\%$) showing MCNS, 8 cases($2.7\%$) transition group, 47 cases($15.9\%$) FSGS. The mean onset age was $6.0{\pm}2.6$years in MCNS, transition group $8.3{\pm}2.3$years, FSGS $7.2{\pm4.3$years, and the gender (M:F) ratio was 3.7:1 in MCNS, 3:1 in transition group, 1.8:1 in FSGS. Comparing the presence of initial hematuria, hypertension,24 hour urine protein, serum albumin, serum creatinine, there were significant difference between the transition group and the FSGS group in the following points; 24hour urine protein $684:342mg/m^2/hr$(P<0.05), serum albumin 1.92: 2.47g/dL(P<0.05), serum cholesterol 494:343mg/dL(P<0.05). Refractoriness to steroid therapy was 13.3$\%$ in MCNS. $12.5\%$ in transition group, $29.6\%$ in FSGS; significantly higher in FSGS(P<0.05). Immunosuppressant therapy was performed in $58.5\%$ of MCNS, $100\%$ in transition group, $80.8\%$ in FSGS; transition group showed significantly higher .ate(P<0.05) comparing with MCNS. Mean number of relapse and duration from onset to first relapse showed no significance difference between these groups. Conclusion: 249 patients with MCNS have been followed and $3.2\%$ (8 patients) of them has shown change in pathologic diagnosis from MCNS to FSCS. The risk factor for transition could not be found. Our results point to the need for a follow-up biopsy to certify the possibility of transition to FSCS in some MCNS cases with refractory cases to steroid therepy, frequent relapsing cases, or in case of no remission in spite of vigorous immunosuppressant therapy.

(R)-(-)-Linalool 유도체의 합성과 향취에 관한 고찰

이지은,김지은,안철진,Lee, Ji-Eun,Kim, Ji-Eun,Ahn, Chuljin 대한화학회 2021 대한화학회지 Vol.65 No.6

낙동강 하류 물금과 을숙도 수환경의 진핵 플랑크톤 종조성에 대한 분자모니터링

이지은,이상래,윤석현,정상옥,이진애,정익교,Lee, Jee Eun,Lee, Sang-Rae,Youn, Seok-Hyun,Chung, Sang Ok,Lee, Jin Ae,Chung, Ik Kyo 한국해양학회 2012 바다 Vol.17 No.3

본 연구는 메타게놈 분석법을 기초로 낙동강 하류 담수 환경의 물금과 기수 환경의 을숙도대교 정점에서 채수된 환경 시료내의 진핵 플랑크톤 종다양성 및 군집 구조를 비교 분석하고자 하였다. 수환경 시료에서 추출된 DNA에 대한 environmental Polymerase Chain Reaction(PCR)을 수행하여 18S rDNA 클론라이브러리를 구축하였고, colony PCR, PCR-Restriction Fragment Length Polymorphism(RFLP), 염기서열 결정 및 유사도 분석을 통하여 종다양성을 분석하였다. 물금 및 을숙도대교 정점에서 338개의 클론들을 분석하였고(170 clones, 물금; 168 clones, 을숙도대교), 그 결과 총 74개의 phylotype을 발굴하였다(49개, 물금; 25개, 을숙도대교). 발굴된 phylotype에 대한 계통 분석 결과, Stramenopiles, Cryptophyta, Viridiplantae, Alveolata, Rhizaria, Metazoa 및 Fungi 등의 분류군에 속하는 다양한 생물종이 발굴되었으며, 국내 미기록종 및 신종 후보 가능 생물종과 속(genus)이상의 새로운 분류학적 처리가 필요한 생물종의 존재를 확인하였다. 특히 Stramenopiles의 Pirsonia 및 Alveolata의 Perkinsea에 속하는 phylotypes 등 국내 미기록 생물종을 포함한 숨은 종다양성(cryptic species diversity)의 발굴은 분자모니터링 기법이 낙동강 하구역 수생태계 변화 모니터링을 위한 새로운 유용한 생물학적 정보를 제공할 수 있음을 제시하고 있다. We have studied the eukaryotic plankton species diversity to compare the community structure of fresh and brackish waters in the lower reaches of the Nakdong River using metagenomic methods. We constructed 18S rDNA clone libraries of total DNAs extracted from environmental water samples collected at Mulgeum (MG100929, fresh) and Eulsukdo bridge (ES, brackish). Through the steps of colony PCR, PCR-RFLP, sequencing and similarity analysis, we discovered the diverse species composition of eukaryotic plankton. Total 338 clones (170 at MG100929 and 168 at ES) were analyzed, and then we found 74 phylotypes (49 for MG100929 and 25 for ES). From the phylogenetic analysis, we confirmed various eukaryotic plankton of broad range of taxonomic groups, including Stramenopiles, Cryptophyta, Viridiplantae, Alveolata, Rhizaria, Metazoa, and Fungi. We also found several unreported species in Korea and candidates of new taxonomic entities at levels higher than genus. Especially, the cryptic species diversity including unreported phylotypes of Pirsonia (Stramenopiles) and Perkinsea (Alveolata) suggests that the molecular monitoring method can produce new informative biological data in monitoring the changes in the Nakdong River Mouth ecosystem.

소음인 곽향정기산으로 오치(誤治)한 소음인 망양증 환자 치험 1례

이지은,김민우,천세은,신용진,신선호,Lee, Ji-eun,Kim, Min-woo,Chun, Se-eun,Shin, Yong-jeen,Shin, Sun-ho 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.2

We report on a Soeumin patient with spontaneous sweating after a lung segmentectomy resulting from aspergillosis. During her inpatient stay, the patient received Soeumin Gwakhyangjunggi-san, Hwanggigyeji-tang, and Seungyangikgi-tang for herbal medication. She also received acupuncture, moxibustion, pharmacopuncture, and cupping therapy. A numeric rating scale (NRS) was used to assess the improvement of symptoms. Sweating was reduced, as reflected by an NRS change from 7 to 0, when the herbal medication changed from Soeumin Gwakhyangjunggi-san to Hwanggigyeji-tang. General weakness and chest discomfort were also relieved after using Hwanggigyeji-tang and Seungyangikgi-tang. These results suggest that Hwanggigyeji-tang and Seungyangikgi-tang are clinically effective for Soeumin patients who are appropriately diagnosed with yang collapse syndrome in the postoperative setting.

PET/co-PET 해도형 초극세사 트리코트의 알칼리 감량 가공에 따른 물성 및 특성 평가

이지은,김민석,김민구,고성익,정대호,고재왕,이승걸,Lee, Ji Eun,Kim, Min Seok,Kim, Min Gu,Ko, Seongik,Jung, Dae Ho,Ko, Jae Wang,Lee, Seung Geol 한국섬유공학회 2018 한국섬유공학회지 Vol.55 No.5

Artificial leather has been developed as a substitute for natural leather because of the high demand for high-quality products in automobile interiors and the living leather market. Artificial leather is generally manufactured using microfiber nonwoven fabric. In this study, we analyzed the weight loss behavior of PET/co-PET ultra-microfiber by alkali hydrolysis according to NaOH concentration (10-30% o.w.f.), treatment time (5-60 mins), and treatment temperature ($80-120^{\circ}C$) by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), and mechanical analysis. We found that the optimum condition for alkali hydrolysis is 25% NaOH o.w.f. aqueous solution with a treatment time of 30 min at $100^{\circ}C$.

괴화 추출물이 대식세포에서의 nitric oxide와 interleukin-6의 생성에 미치는 영향

이지은,이주연,최점일,김종관,김성조,Lee, Ji-Eun,Lee, Ju-Youn,Choi, Jeom-Il,Kim, Chong-Kwan,Kim, Sung-Jo 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.1

Both nitric oxide (NO) and interleukin-6 (IL-6) have been thought to have a role in the pathogenesis of inflammatory periodontal disease as it does in other inflammatory diseases, and the inhibitors of NO and IL-6 production have been considered as potential anti-inflammatory agents. In this study, we evaluated methanol extract of Sophorae Flos for inhibition of NO and IL-6 production in Prevotella intermedia LPS-induced mouse macrophages RAW264.7 cells. Dried Sopharae Flos was sliced, and extracted with 100% methanol. LPS from p. intermedia ATCC 25611 was prepared by the standard hot phenol-water method. NO production was assayed by measuring the accumulation of nitrite in culture supematants and IL-6 was measured using mouse IL-6 ELISA kit. Western blot analysis of iNOS and analysis of reverse transcription (RT)-PCR products were carried out. The methanol extract of Sophorae Flos concentration-dependently reduced the production of NO and the expression of iNOS protein and mRNA in RAw264.7 cells treated with P. intermedia LPS. Sophorae Flos also suppressed IL-6 production and the expression of IL-6 mRNA in RAw264.7 cells stimulated by P. intermedia LPS. The inhibition of NO and IL-6 production by Sophorae Flos may be useful in the therapy of inflammatory diseases such as periodontitis. This hypothesis, however, remains to be tested.