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안지오텐신 II의 적출심근 및 대동맥 평활근에 대한 작용기전
김규찬,김기환,엄융의,Kim, Kyu-Chan,Kim, Ki-Whan,Earm, Yung-E 대한생리학회 1983 대한생리학회지 Vol.17 No.1
Contractile responses of myocardium and vascular smooth muscle to angiotensin II were studied in isolated rabbit papillary muscles and aortic helical strips, with respect to the sensitivity and the mechanism of action. All experiments were performed in $HCO-_3\;-buffered Tyrode solution which was aerated with $3%\;CO_2-97%\;O_2$ and kept pH 7.35 at $35^{\circ}C$. Action potentials were measured by conventional microelectrode technique in the papillary muscles. Helical strips of vascular smooth muscle were prepared from the descending thoracic aorta of the rabbit. Angiotensin II elicited a positive inotropic effect in doses from $10^{-8}$ to $10^{-6}\;M$, and this effect was dose-dependent and characterized by a symmetrical increase of maximum dP/dt during contraction and relaxation phase. Slow responses (or slow action potentials) were induced by A. II $(10^{-6}\;M)$ in the papillary muscle hypopolarized by 27 mM $K^+$. These A. II-induced slow action potentials were eliminated by verapamil (2 mg/l), but not affected by propranolol $(10^{-5}\;M)$. In aortic helical strips, contractile force was increased dose-dependently in the range of $10^{-10}{\sim}10^{-7}\;M$ A. II. $ED_{50}$ in aorta was $3{\times}10^{-9}\;M$ A. II, whereas that in paillary muscle was $2.5{\times}10^{-7}\;M$ A. II. A. II contracted vascular smooth muscle in depolarizing concentration of $K^+$ (100 mM $K^+$), and also produced a sustained contraction even in the presence of verapamil and regitine. The results of this experiment suggest that the primarily important physiological role of A. II is the action on the blood vessel, and the positive inotropic effect of A. II in papillary muscle results from the increase of slow inward $Ca^{++}$ current, and that A. II-induced contraction of aorta is independent of transmembrane potential and associated with promoting bet transmembrane $Ca^{++}\;-influx$ and the mobilization of cellular $Ca^{++}$.
The Study of the SOA Enabled ERP Systems Implementation in Service Industry: Case Study
김규찬 한국산업정보학회 2012 한국산업정보학회논문지 Vol.17 No.1
The primary objective of this research is to explain how to implement the Service Oriented Architecture (hereafter SOA) enabled Enterprise Resource Planning (hereafter ERP) system successfully for service industries. An implementation of the ERP system help many organizations to alleviate the difficult job of supporting inflexible or legacy systems that in most cases result in cost increases, data redundancy and inaccuracy, and various inefficiencies. However, the ERP system is losing its market share rapidly to the cloud computing system which utilizes the Software-as-a-service (hereafter SaaS) and SOA. The SOA is an approach to integrate various types of IT resources to leverage existing ERP system, while at the same time building an infrastructure that can readily respond to new business environment and offer new dynamic applications. The companies that implement this system have less of a need for the kinds of all-in-one ERP system that have dominated the back office for decades and can move freely to best-of-breed applications. This research will identify the benefits and costs of the SOA enabled ERP system through case studies and its impact on competitive priorities such as cost, quality, delivery, and flexibility.