채팅 취소 기능을 갖는 메신저 채팅 시스템 설계

이준성(Joon Sung Lee),임영민(Young Min Yim),이민규(Min Gyu Lee),오득환(Deuk Hwan Oh),이해연(Hae-Yeoun Lee) 한국정보기술학회 2016 Proceedings of KIIT Conference Vol.2016 No.6

오늘날 많은 사람들이 메신저를 사용하지만 잘못된 메시지를 전송하여 불편한 상황이 발생하는 경우가 많이 있다. 이에 따라 전송한 메시지를 취소하는 기법으로 단순 삭제, 메시지 변경, 백업 및 메시지 변경 방식을 사용 할 수 있다. 본 논문에서는 메신저를 사용하는 사용자의 실수를 보완하기 위한 다양한 메시지 취소 기법에 관해 설명하고, 메시지를 취소 기법으로서 백업 및 메시지 변경 방식을 이용한 채팅 시스템의 설계와 개발에 대하여 설명하겠다. 실험에서는 개발한 시스템에 대하여 메시지 취소 작업에 필요한 처리시간에 대해 측정해 보았다. In these days, many people use messengers for communication. However, embarrassing situations happen by sending wrong messages. In order to solve these situations, messages can be canceled by a simple removal method, a message change method, or a backup and message change method. To compensate user’s mistakes, this paper explains various methods for message cancellation and presents the design and implementation of a message chatting system with a backup and message change method. In the experiments, the execution time of message cancellation is measured.

간내담관담석의 경피경간 담도내시경적 치료성적

봉형근(Hyung Keun Bong),이영흥(Young Heung Lee),조영덕(Young Doek Cho),김진오(Jin Oh KIm),조주영(Joo Young Cho),김연수(Yun Soo Kim),이준성(Jun Seong Lee),이문성(Moon Sung Lee),황성규(Seong Gyu Hwang),심찬섭(Chan Sup Shim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objective: Intrahepatic stones provide a quite different spectrum of problems f by surgeons in the tem hemisphere. Although unilateral left intrahepatic stones have been treated by left hepatic lobectomy, bilateral or right intrahepatic stones can be even more troublesome because they frequently cannot be completely removed by conventional surgical stone extraction procedure. Recently, the use of a flexible fiberoptic choledochoscope, electrohydraulic lithotriptor (EHL) and dilators make it possible to completely remove intrahepatic stones by nonsurgi- cal procedures in the majority of c Methods: During the last 5 years, we treated intrahepatic stones in 114 patients with a fiberoptic choledochoscope, EHL and dilators via percutaneous transhepatic route. For construction of percutaneous transhepatic routes, we punctured intrahepatic ducts by ultrasonographic guidance and then dilated the tracts by PTBD set (Nipro Co., Japan) under fluoroscopic guidance. Choledochoscopy were performed at 4-6 weeks later, and Dormina basket, EHL, balloon or bougie dilators were used for removal of stones. Results: Success rates according to the locations of stones were 87.5% (14/16) in unilateral right intrahepatic stones, 92.9% (39/42) in unilateral left intrahepatic stones, and 89.3% (50/56) bilateral intrahepatic stones. Overall success rate was 90.4% (103/114). Causes of incomplete removal of the stones in our patients included the failure of construction or maintenance of percutaneous transhepatic routes in 4 cases, intrahepatic bile duct stricbm proximal to impacted stones in 3, acute ductal angulation in 2, and stones located at the very distal branches of intrahepatic ducts in 2 cases. Complications associated with the procedure were transient fever in 8 cases, severe hemobila in 2 cases and bihary perforation in 3 cases. Conclusion: These results suggest that gemutaneaus transhepatic choledochoscopic approach is a relatively safe and effective method for treatment of intrahepatic stones.

급성 담낭염의 비수술적 담낭배액술 - 내시경적 경비 담낭배액술 및 경피경간 담낭배액술을 중심으로

봉형근(Hyung Keun Bong),문종호(Jong Ho Moon),이영홍(Young Hong Lee),조영덕(Young Deok Cho),김진오(Jin Oh Kim),조주영(Joo Young Cho),김연수(Yun Soo Kim),이준성(Joon Seong Lee),이문성(Moon Sung Lee),황성규(Seong Gyu Hwang),심찬섭(Chan 대한소화기학회 1998 대한소화기학회지 Vol.30 No.1

N/A Background/Aims: Acute cholecystitis is the most common biliary emergency and until now, the choice of the treatment of this disease is surgical operation. But, the. Mortality and morbidity associated with surgical cholecystostomy in those patients are relatively high. Recently, PTCCD and ENGBD were developed as a useful method of nonsurgical cholecystic drainage in high surgical risk group of acute cholecystitis. The purpose of this study was tn assess the usefulness of nonsurgical cholecystic drainage such as PTCCD and ENCrBD in the patients with acute cholecystitis. Methods: Of 59 patients with acute cholecystitis treated with nonsurgical cholecystic drainage, 47 were calculous cholecystitis and 12 were acalculous cholecystitis. Nonsurgical chole- cystic drainages were successful in all 59 cases: PTCCD in 45 patients, ENGBD in rernaining 14 patients. 39 patients were treated with nonsurgical cholecystic drainages due to high surgical risk. In remaining 20 patients there were cholangiocarcinoma in 5 patients, netastatic heptna in 2, gallstone pancreatitis in 1, advanced gastric cancer in 2, refusal of surgery in 10. Results: The prompt clinical recovery were achieved in 42 patients(93.3%) with PTCCD and cornpletely in all 2 cases with ENGBD. In the group with 35 calculous cholecystitis performed PTCCD, 28 under- went PTCCS-L, 4 elective surgery and 3 died because of the underlying condition, In the group with 10 acalculous cholecystitis performed PTC(D, 8 patients need nr further treatment except drainage and remaining 2 patients underwent elective surgery. Jn the group with 12 calculous cholecystitis treated by ENGBD, 10 underwent elective surgery, l F.SWI. And I gallstone dissolu- tion with MTBE. In 2 acalculous cholecystitis treated by ENGBD, the one patient took no further treatment and the other underwent elective surgery. Complications related to PT( CD occurred in 10 of 45 patients, but there was no mortality re]ated to this procedure. No complications were noted related to ENGBD. Conclusions: We conclude that nonsurgical cholecystic drainage witli ENGBD and PTCCD were safe, effective and useful procedures for the management of acute cholecystitis, especially in high surgical risk group, (Korean J Gastroenterol 1997; 30:81 - 89)

직접 분사식 가솔린 인젝터의 내구 평가 시스템 개발

이준순 ( Jun Sun Lee ),김태영 ( Tae Young Kim ),김창업 ( Chang Up Kim ),오승묵 ( Seung Mook Oh ),최교남 ( Kyo Nam Choi ),이용규 ( Yong Gyu Lee ) 한국액체미립화학회 2014 한국액체미립화학회 학술강연회 논문집 Vol.2014 No.-

The performance and efficiency in gasoline engines have been improved by adopting direct fuel injection system, and the fuel injection pressure is demanded to keep increasing in order to improve the atomization of fuel and in-cylinder mixing characteristics. Recently, the fuel injection pressure increased up to 200 bar and more. Therefore, various evaluation systems are needed for development of high pressure fuel injector. One of them is durability evaluation system. In this study, a new system has been developed. This system can evaluate injectors at the similar engine operating conditions. This system is able to control fuel temperature from 35 to 80.... injection pressure up to 250 bar, and operate injector at the engine speed of 40,000rpm maximum. Moreover, this durability evaluation system is equipped with an emergency function, which can detect the unexpected increase in temperature and pressure and stop the system. High pressure injectors of GDI engine were evaluated with this system. Static flow rate, dynamic flow rate, and leakage of the injector were analyzed at the before and after of durability evaluation. As a result, it is possible to evaluate a high pressure injector of a direct injection engine with this system.

Ginsenoside Rg1 및 Rb1을 처리한 신경세포주(SH-SY5Y세포)의 유전자 발현양상

이준노,양병환,최승학,김석현,채영규,정경화,이준석,최강주,김영숙,Lee, Joon-Noh,Yang, Byung-Hwan,Choi, Seung-Hak,Kim, Seok-Hyun,Chai, Young-Gyu,Jung, Kyoung-Hwa,Lee, Jun-Seok,Choi, Kang-Ju,Kim, Young-Suk 대한생물정신의학회 2005 생물정신의학 Vol.12 No.1

Objectives:The ginsenoside Rg1 and Rb1, the major components of ginseng saponin, have neurotrophic and neuroprotective effects including promotion of neuronal survival and proliferation, facilitation of learning and memory, and protection from ischemic injury and apoptosis. In this study, to investigate the molecular basis of the effects of ginsenoside on neuron, we analyzed gene expression profiling of SH-SY5Y human neuroblastoma cells treated with ginsenoside Rg1 or Rb1. Methods:SH-SY5Y cells were cultured and treated in triplicate with ginsenoside Rg1 or Rb1($80{\mu}M$, $40{\mu}M$, $20{\mu}M$). The proliferation rates of SH-SY5Y cells were determined by MTT assay and microscopic examination. We used a high density cDNA microarray chip that contained 8K human genes to analyze the gene expression profiles in SH-SY5Y cells. We analyzed using the Significance Analysis of Microarray(SAM) method for identifying genes on a microarray with statistically significant changes in expression. Results:Treatment of SH-SY5Y cells with $80{\mu}M$ ginsenoside Rg1 or Rb1 for 36h showed maximal proliferation compared with other concentrations or control. The results of the microarray experiment yielded 96 genes were upregulated(${\geq}$3 fold) in Rg1 treated cells and 40 genes were up-regulated(${\geq}$2 fold) in Rb1 treated cells. Treatment with ginsenoside Rg1 for 36h induced the expression of some genes associated with protein biosynthesis, regulation of transcription or translation, cell proliferation and growth, neurogenesis and differentiation, regulation of cell cycle, energy transport and others. Genes associated with neurogenesis and neuronal differentiation such as SCG10 and MLP increased in ginsenoside Rg1 treated cells, but such changes did not occur in Rb1-group. Conclusion:Our data provide novel insights into the gene mechanisms involved in possible role for ginsenoside Rg1 or Rb1 in mediating neuronal proliferation or cell viability, which can elicit distinct patterns of gene expression in neuronal cell line. Ginsenoside Rg1 have more broad and strong effects than ginsenoside Rb1 in gene expression and related cellular physiology. In addition, we suggest that SCG10 gene, which is known to be expressed in neuronal differentiation during development and neuronal regeneration during adulthood, may have a role in enhancement of activity dependent synaptic plasticity or cytoskeletal regulation following treatment of ginsenoside Rg1. Further, ginsenoside Rg1 may have a possible role in regeneration of injured neuron, promotion of memory, and prevention from aging or neuronal degeneration.

우리나라 실리콘카바이드 취급사업장의 공기 중 분진 노출평가

이준정 ( Jun Jung Lee ),피영규 ( Young Gyu Phee ) 한국산업위생학회 2011 한국산업보건학회지 Vol.21 No.3

Occupational exposure to silicon carbide dust of manufacturing industries has seldom been evaluated in Korea. Accordingly, we evaluated various silicon carbide dust concentrations in the breathing zone of workers between May 2010 and July 2010. To compare silicon carbide dust concentrations, three dust samplers including the Institute of Occupational Medicine (IOM) sampler, 37mm cassette sampler, and Aluminum cyclone sampler were used. A total of 5 manufacturing industries producing abrasive and refractory materials using silicon carbide were investigated. The geometric mean concentrations were 2.04, 0.97, and 0.48 mg/m3 in inhalable, total and respirable silicon carbide dust, respectively. The geometric mean concentrations of silicon carbide in abrasive material manufacturing industries were slightly higher than that of refractory manufacturing industries, and finishing operations were higher than that of other operations. It was found that the results of exposure assessment in airborne dust at manufacturing industries using silicon carbide in Korea showed exceeding rate to American Conference of Governmental Industrial Hygienists Threshold Limit Value (3 mg/m3) was 10% in respirable dust samples. Therefore, with the consideration of the close relationship between smaller dust size and the occurrence of occupational respiratory diseases, it is suggested to promulgate the new occupational exposure limit for respirable silicon carbide dust.

내시경적 유두괄약근 절개술후 발생한 기종격증 및 피하기종

조영덕(Young Deok Cho),봉형근(Hyung Keun Bong),김진오(Jin Oh Kim),조주영(Joo Young Cho),김연수(Yun Soo Kim),이준성(Joon Seong Lee),이문성(Moon Sung Lee),황성규(Seong Gyu Hwang),심찬섭(Chan Sup Shim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

Perforation, bleeding, cholangitis, and pancreatitis are common complications of endoscopic sphincterorny(EST) that is considered a common effective method for treatment of distal bile duct obstruction and removal of bile duct stones. Perforation of duodenutn complicates endoscopic sphincterotomy in approximately 1% of cases. But, retroperitoneal, mediastinal and subcutaneous emphysema are very rare complications of endoscopic sphincterotomy. A 50-year-old woman was admitted to our hospital due to right upper quadrant abdominal pain for 1 week. An ERCP revealed markdly dilated commom bile duct and rnultiple ductal filling defects. For removal of' stones, EST was performed with pull type papillotome. About 1 hour later after procedure, she complained of chest pressure, shortness of breath and abdominal distension. The chest X-ray film revealed a pneumomediastinum, segmental atelectasis of left lower lung fields and subcutaneous emphysema. The simple abdominal X-ray showed mottled air densities in the right midabdomen and crescentic air densities in the right perirenal space. We report on a rare case of retroperitoneal duodenal perforation, pneumomediastinum and subcutaneous emphyserna following endoscopic sphinctero- tomy, in a patient with common bile duct stones. (Korean J Gastroenterol 1997; 29:399-403)

소화기 ; 만성 간질환에서 펜넬의®무작위, 이중맹검, 다기관 제4상 임상시험

김형준 ( Hyung Joon Kim ),이준성 ( June Sung Lee ),이현웅 ( Hyun Woong Lee ),김문영 ( Mun Young Kim ),남순우 ( Soon Woo Nam ),손주현 ( Ju Hyun Sohn ),조세현 ( Se Hyun Cho ),윤승규 ( Seung Gyu Yoon ),양진모 ( Jin Mo Yang ),박충기 ( 대한내과학회 2014 대한내과학회지 Vol.86 No.2

목적: 펜넬(Pennel(R))은 DDB에 마늘유(garlic oil)를 복합시킨 제제로 혈청 트랜스아미나제(AST와/또는 ALT)가 상승된 만성 간 질환자에서 펜넬의 치료 효과에 대한 유효성을 검증하기 위해 활성대조약인 레가론, 위약군과 비교 평가한 다 기관 제 4상 임상연구를 실시하였다. 방법: 총 11개 병원, 237명의 피험자가 연구에 참여하였다. 이 중 시험약군은 100명, 활성대조군은 102명, 위약군은 35명이었다. 12주간의 치료기간 동안 순응도는 좋았으며 중도 탈락은 없었다. 환자의 연령은 평균 46세, 남성의 비율이 높았다. 치료 전 ALT 값은 91 U/L였으며 66%가 비알코올성 지방간염, 15%가 알코올성 간염, 12%가 만성 C형간염 그리고 7%가 만성 B형간염 환자였다. 결과: 약물 투약 12주째 ALT 정상화 분율은 시험약군이 89명으로 89%, 활성대조군이 19명으로 18.6%, 위약군이 8명으로 22.9%로 나타났다(p < 0.001). 간염의 원인에 따른 분류에서도 시험군에서 통계적으로 의미 있게 ALT 정상화 분율의 비율이 높았다. 치료 전 대비 치료 12주의 ALT는 시험약군에서 평균 85 U/L 감소하였으나 활성대조군은 20 U/L, 위약군은 25 U/L 감소하였다. 항산화 효과 지표인 malondialdehyde(MDA)는 시험약군에서만 1.4 pmol/mg의 호전을 보였다. 하위그룹분석에서 비알코올성 지방간염과, 바이러스성 간염 환자에서 의미 있게 MDA 수치의 호전을 보였다(p < 0.001). 시험약물의 안전성 평가에서도 이상반응의 발생빈도가 위약군에 비해 차이가 없었다. 이상반응의 대부분은 감기, 피로, 설사 및 소화불량 등 grade 1의 경증이었으며 중대한 이상반응은 없었다. 삶의 질 평가 총점수도 시험약군이 치료 12주에 10점 이상 통계적으로 의미 있게 증가하였다(p < 0.001). 결론: 결론적으로 ALT가 상승한 만성 간 질환자를 대상으로 한 12주간의 펜넬 4상 임상 시험의 유효성과 안전성 평가에서 펜넬은 원인 질환과 무관하게 치료 4주 만에 급격한 ALT 수치의 정상화를 유도하였으며 항산화 효과를 보였다. 치료기간 동안 부작용이 거의 없는 안전한 약제로서 순응도가 뛰어났으며, 치료 후 삶의 질이 의미 있게 개선되는 효과를 보였다. Background/Aims: Biphenyl dimethyl dicarboxylate (DDB) combined with garlic oil (pennel) has been used to treat chronic liver disease. A randomized, double-blind, active- and placebo-controlled clinical trial was conducted to investigate the efficacy, safety and quality of life in chronic liver disease patients. Methods: A total of 237 patients with chronic liver disease were randomized into three groups; 100 patients were administered pennel, 102 patients Legalon as an active-control and 35 patients placebo for 12 weeks. The primary endpoint was the rate of alanine aminotransferase (ALT) normalization. We assessed differences in ALT levels and malondialdehyde (MDA) as an oxidative biomarker between 0 and 12 weeks, the improvement in quality of life using a chronic liver disease questionnaire (CLDQ) and the incidence of adverse events. Results: Among 237 patients, there were 157 patients with non-alcoholic fatty liver disease, 36 patients with alcoholic liver disease, and 28 patients with chronic hepatitis B and C. The incidence of ALT normalization at 12 weeks was 89% for the pennel group, 18.6% for the active-control group, and 22.9% for the placebo-control group (p < 0.001). The difference in serum ALT level between 0 and 12 weeks was significantly higher in the pennel group (p < 0.001) and the level of MDA was decreased in the pennel group, statistically (p < 0.001). There was no difference in incidence of adverse events among groups. The pennel group showed significant improvement based on the CLDQ (p < 0.001). Conclusions: Pennel can effectively improve the rate of ALT normalization and the quality of life with a safety profile in chronic liver disease. (Korean J Med 2014;86:179-189)

벤라팍신이 PC12 세포의 신경돌기 성장에 미치는 영향

오홍석,최준호,이준석,이준노,최미란,채영규,김석현,양병환,Oh, Hong-Seok,Choi, Joon-Ho,Lee, Jun-Seok,Lee, Joon-Noh,Choi, Mi-Ran,Chai, Young-Gyu,Kim, Seok-Hyeon,Yang, Byung-Hwan 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2

Objectives:The purpose of this study is to examine the effects of venlafaxine, one of novel antidepressant drugs, on neurite growth in PC12 cells. Methods:PC12 cells were cultured with NGF for eight days. Then different concentrations($0{\mu}M$, $1{\mu}M$, $5{\mu}M$) of venlafaxine were mixed with cultured PC12 cells. After 24 hours and 48 hours of culture, we compared the effects of venlafaxine on the total length of neurites of cultured PC12 cells between no venlafaxine treated group($0{\mu}M$) and venlafaxine treated groups($1{\mu}M$ and $5{\mu}M$). Additionally, we studied the concentration-dependent effect of venlafaxine on differentiation in PC12 cells. Results:Experimental results showed that 1) the mean length of neurites in $1{\mu}M$ and $5{\mu}M$ venlafaxine treated group was more increased than no venlafaxine treated group(p=0.002). 2) the length of neurite in $5{\mu}M$ venlafaxine treated group was more elongated than $1{\mu}M$ venlafaxine treated group(p=0.046). 3) the length of neurite in $6{\mu}M$ venlafaxine treated group was more elongated than all the other concentrations in our experiment. Above $6{\mu}M$, the length of neurite was shortened in inverse proportion to the concentration of venlafaxine. Conclusions:This results suggest that venlafaxine, one of novel antidepressant drugs, promotes the differentiation of neuron. This study is believed to be a first step toward understanding the molecular and cellular mechanisms of antidepressant treatment.

위내시경으로 진단된 양성위궤양 160 예에 대한 임상적 관찰 (pp.273-281)

강종식 ( Jong Sik Kang ),이준상 ( Joon Sang Lee ),김영규 ( Young Kyu Kim ),양웅석 ( Oong Sheuck Yang ),김한규 ( Han Gyu Kim ) 대한내과학회 1979 대한내과학회지 Vol.22 No.4