남자(男子) 치흔설(齒痕舌) 변증에 관한 임상적 고찰

이수정,백상인,이병권,이아람,김광록,윤현민,김원일,Lee, Soo-Jung,Baek, Sang-In,Lee, Byung-Gwon,Lee, Ah-Ram,Kim, Koang-Lok,Yoon, Hyun-Min,Kim, Won-Il 대한약침학회 2010 Journal of pharmacopuncture Vol.13 No.4

Objectives : The purpose of this study was to analyze the propensity and find out the Syndrome Differentiation of teeth-mark tongue by taking survey and body examinations with 178 male patients. 164 patients out of 178 were checked up on Heart Rate Variability (HRV), Accelerated Photoplethysmograpy (APG), Body Composition. This study was also planned to find out the distinctive characteristics of teeth-mark tongue diagnosis and compare differences between Qi-Deficiency and Accumulation of Dampness and Phlegm patients group. Methods : The questionnaire was carried out targeting 178 male with teeth-mark tongue respondents among who had Oriental Health Examination and patients from the 3rd oriental-internal medicine department in Dongeui Hospital from $1^{st}$, March 2005 to $30^{th}$, April 2010. Only 164 patients were checked on HRV, APG and Body composition examinations. Results : It showed that 86 patients had Qi-Deficiency and 78 had Dampness and Phlegm but 14 couldn't be categorized. The major symptoms of Qi-Deficiency compared to Dampness and Phlegm were 'Frequent running nose', 'Soft stool', 'Chronic fatigue', and 'Eyestrain'. On the contrary, Dampness and Phlegm's dominant symptoms were 'Chest discomfort', 'Feeling bloated', 'Back pain', 'Feeling sluggish', and 'Itchy skin'. However, all symptoms were not matched with the Syndrome Differentiation of Qi-Deficiency or Dampness and Phlegm. It also showed that teeth-mark tongue patients' frequent symptoms were 'Stuffy nose', 'Feeling bloated', 'Oliguria', 'Shoulder pain', 'Chronic fatigue' 'Eyestrain' and these symptoms were matched with the Syndrome Differentiation of Qi-Deficiency and Dampness and Phlegm. In the results from this study, there were no significant differences between Qi-Deficiency and Dampness and Phlegm. Conclusions : It is hard to conclude that teeth-mark tongue could be only one to diagnose Qi-Deficiency or Dampness and Phlegm with 3 examinations.

망막색소상피박리와 망막하출혈을 동반한 베게너씨 육아종증 1예

이수정,김상수,김완수,Soo Jung Lee,Sang Soo Kim,Wan Soo Kim,Ph,D 대한안과학회 2005 대한안과학회지 Vol.46 No.1

Purpose: To report a case of very limited Wegener’s granulomatosis presenting with inflammation of the anterior segment, orbital pseudotumor, retinal pigment epithelial detachment, and subretinal hemorrhage. Methods: A 54-year-old man who was treated for pachymeningitis was seen in consultation for painful swelling of the left eye and periorbit, and visual loss of the right eye developed 2 days after admission. He was diagnosed with peripheral keratitis, scleritis, anterior uveitis, and pseudotumor of the left eye, and RPE detachment in the macula of the right eye. He was started on treatment with antibiotics, NSAIDs, and steroids. Twelve days later, he had no response to the treatment and developed otitis media and skin ulcer. A skin biopsy was performed. Results: Histological analysis showed a necrotizing inflammation of the small vessels in the skin lesion. The clinical and radiologic findings and the positive antineutrophil cytoplasmic antibody (ANCA) test were consistent with a diagnosis of Wegener’s granulomatosis. Treatment with oral steroids and cyclophosphamide improved the systemic and ocular symptoms dramatically. One year later, he developed choroidal neovascularization and subretinal hemorrhage in the right eye. He was started on oral steroids and cyclophosphamide, with a dramatic improvement in his general health and ocular state.

숙성 조건에 따른 흑생강의 이화학적 특성 및 항산화 활성

이수정,류지현,남수진,구옥경,Lee, Soo Jung,Ryu, Ji Hyeon,Nam, Soo Jin,Koo, Ok Kyung 한국식품과학회 2020 한국식품과학회지 Vol.52 No.6

흑생강의 생리활성 규명을 위한 연구의 일환으로 흑생강의 제조공정을 숙성 조건에 따라 5단계로 구분하여 각 제조 단계에서 얻은 흑생강의 이화학적 특성 및 항산화 활성을 원료 생강과 비교하였다. 흑생강의 갈색도와 적색도(a값)는 숙성 기간이 경과됨에 따라 원료 생강에 비해 유의적으로 증가되는 경향이었으나, 명도(L값)와 황색도(b값)는 유의적으로 감소된 경향이었다. 총당은 숙성 2단계에서 가장 높은 함량이었으나, 숙성 3단계 이후부터는 유의적으로 감소되는 경향이었다. 흑생강에서 숙성 기간이 경과됨에 따라 gingerol 함량은 감소되었으나, 6-shogaol 함량은 17.7-34.1배 증가되었다. 총 페놀 및 플라보노이드 함량은 숙성 2단계에서 가장 높은 함량이었으며, 그 이후에는 감소되는 경향이었다. 흑생강의 라디칼 소거활성과 환원력은 각각 숙성 2단계 및 3단계에서 가장 높았으며 그 이후에는 점차 감소되는 경향이었다. 숙성단계별 흑생강의 항산화 활성은 갈색도, 6-shogaol, 총당 및 총 페놀의 함량과 높은 양(+)의 상관관계를 보여 2-3단계 숙성이 항산화 활성 증대에 효과적일 것으로 생각된다. The physicochemical properties and antioxidant activities of aged ginger (Zingiber officinale Roscoe) were investigated every four days during the twenty days of aging process and compared with fresh ginger. Browning intensity and redness value were significantly increased compared to fresh ginger; however, lightness and yellow values were significantly decreased. Total sugar content was the highest during the second step and decreased significantly after the third step. The content of gingerol decreased with aging whereas 6-shogaol increased from 17.7 to 34.1 times the baseline. Total phenolic and flavonoid contents were the highest during the second step and decreased in the subsequent steps. The radical scavenging activities and reducing power were the highest during the second and third steps, respectively, and then they gradually decreased. The antioxidant activities of aged ginger during the aging process showed a high correlation with browning intensity, 6-shogaol, total sugar, and total phenolic content. Therefore, our study suggested that aging during the second and third steps were effective in optimizing antioxidant activity.

Rhodotorula glutinis의 epoxide hydrolase 고효율 발현 유전자 재조합 Escherichia coli 생촉매 개발

이수정,김희숙,Lee Soo-Jung,Kim Hee-Sook 한국생명과학회 2006 생명과학회지 Vol.16 No.3

방향족 에폭사이드 기질에 대한 입체선택적 가수분해능이 우수한 Rhodotorula glutinis의 epoxide hydrolase (EH)를 codon usage를 고려한 Escherichia coli 균주에서 고효율로 발현할 수 있었다. 효모인 R. glutinis와 박테리아인 E. coli에서의 codon usage 선호도를 분석하고 그 차이를 고려하여 E. coli 에서 잘 사용되지 않는 rare codon에 대한 tRNA유전자정보가 들어 있는 pRARE plasmid를 함유한 E. coli 균주인 Rosetta(DE3)pLysS를 숙주세포로 사용하였다. R. glutinis EH를 발현시킨 재조합 E. coli를 생촉매로 사용하여 라세믹 styrene oxide 혼합물과 반응시켰을 때, (R)-styrene oxide에 대한 입체선택적 가수분해활성이 wild type R. glutinis 대비 매우 향상됨을 관찰할 수 있었다. 또한 라세믹 기질로부터 입체적으로 고순도인 99% ee 값을 갖는 광학적으로 순수한 (S)-styrene oxide를 얻을 수 있었다. The epoxide hydrolase (EH) of Rhodotorula glutinis which has a high enantioselectivity against aromatic epoxide substrates was expressed to high levels in Escherichia coli based on codon usage. We analysed the Preference of codon usage between the yeast, R. glutinis, and bacteria, E. coli. E. coli, Rosetta(DE3)pLysS, harbors pRARE plasmid with tRNA genes for rare-codons was employed as a host strain. The recombinant E. coli expressing R. glutinis EH showed an enhanced enantioselective hydrolysis activity toward racemic styrene oxide. Enantiopure (S)-styrene oxide with a high enantiopurity of 99% ee (enantiomeric excess) was obtained from racemic substrates.

설문을 통한 여성 기능성 위장장애 환자의 경향과 한방치료 효과에 대한 연구

이수정,김효진,한현영,이수영,김종환,김원일,Lee, Soo-Jung,Kim, Hyo-Jin,Han, Hyun-Young,Lee, Su-Young,Kim, Jong-Hwan,Kim, Won-Il 대한한의정보학회 2009 大韓韓醫情報學會誌 Vol.15 No.2

Objectives: Nowadays, the number of patients having the Functional Gastrointestinal Disturbance has been on the rise and this tendency is clear in the female group. This study is aimed to investigate their cause of disease, dietary lifestyle, digestion functions, general symptoms and any disadvantages in daily lives etc. Also, it would suggest any effective results from oriental medical treatments. Methods: The total number of 20 female patients, who have been participated in this study, have been treated at Oriental Internal Medicine, Dong-eui Hospital. We have performed the survey with 50 questionnaires. Results: Most patients were having dyspepsia and had been treated more than once before the survey. The major cause of their disease includes irregular eating habits(p<0.05) and stressful mental conditions. The patients had suffered much disadvantages in daily lives and different symptoms. Specially, pain in the below of stomach pit and early satiation were common.(p<0.05) However, the Discomfort index of patients has been decreased from 9.22 point to 2.85 point after oriental medical treatment. It means this treatment has meaningful effectiveness to the Functional Gastrointestinal Disturbance patients. Conclusion: We have investigated the features of female patients with Functional Gastrointestinal Disturbance and conclude that the Oriental Medical Treatment is effective to them.

가미사칠탕(加味四七湯)으로 호전된 우울증으로 인한 식욕부진 환자 치험 1례

이수정,하정빈,양지수,유재환,Lee, Su-jung,Ha, Jeong-been,Yang, Ji-soo,Lew, Jae-hwan 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study examined the effects of Gamisachil-tang on an anorexic patient with depression. Methods: A patient suffering from anorexia and depression was treated with Korean herbal medicine (Gamisachil-tang) for 14 days. To evaluate the therapeutic effect, we measured the daily food intake of the patient and used the Visual Analogue Scale (VAS) for anorexia. Results: Following treatment, both the patient's daily food intake of the patient and VAS score for anorexia had improved. Conclusion: These results suggest that Gamisachil-tang has a beneficial effect on both anorexia and depression.

시판 표고의 식품성분 특성 및 항산화 활성

이수정,류지현,김인수,Lee, Soo-Jung,Ryu, Ji-Hyeon,Kim, In-Soo 한국버섯학회 2021 한국버섯학회지 Vol.19 No.3

국내산 표고의 식품성분 특성 및 항산화 활성을 알아보기 위해 시판되고 있는 표고 5종을 경남 진주, 전남 광양 및 순천 지역의 농산물 시장 또는 대형 마트에서 구입하여 분석하였다. 수분 함량은 79.17~82.90 g/100 g으로 시료 간의 차이가 적었으나, 조단백질 함량에서 유의적인 차이를 보였다. 무기질 총량은 시료 간의 유의적인 차이를 보였으며, 특히 칼륨(K)의 함량이 가장 많았다. 총 아미노산 및 필수아미노산의 함량은 표고 "A"에서 월등히 높았으나, 총 아미노산에서 필수아미노산 및 aspartic acid와 glutamic acid의 함량 비율은 시료 간에 비슷한 수준이었다. β-Glucan 함량은 10.28~15.68 g/100 g으로 시료 간의 유의적인 차이를 보였다. 시판 표고의 색도와 전반적인 조직감에서는 시료 간의 두드러진 차이가 없었다. 총 페놀 함량은 19.92~30.77 mg/100 g, 플라보노이드 함량은 6.95~10.39 mg/100 g이었으며, 총 페놀 함량에 대한 플라보노이드 함량의 비율은 31.53~38.21%였다. DPPH 라디칼 소거활성은 74.92~79.04%, ABTS 라디칼 소거활성은 80.47~84.97%로 시료 간의 큰 차이를 보이지 않았으나, 환원력은 195.23~317.85 μM로 시료 간의 유의차를 보였다. 본 연구 결과, 공시한 표고 5종의 식품성분이나 항산화 활성에서 두드러진 차이는 보이지 않았다. This study analyzed food component characteristics and antioxidant activities in five kinds of domestic commercial shiitake mushrooms (Lentinula edodes). Moisture content (79.17-82.90 g/100 g) showed little difference, but there was a significant difference in crude protein content. Total mineral content showed a significant difference, and potassium (K) content was the highest. Total and essential amino acid contents were higher in mushroom A than in the other samples. Nonetheless, the ratios of essential amino acids, aspartic acid, and glutamic acid to total amino acids were similar in all samples. 𝛽-Glucan content was in the range of 10.28-5.68 g/100 g, exhibiting a significant difference. The color intensity and overall texture of the mushrooms showed no remarkable difference. Total phenol and flavonoid contents were in the range of 19.92-30.77 mg/100 g and 6.95-10.39 mg/100 g, respectively; the ratio of flavonoids to total phenols ranged from 31.53% to 38.21%. DPPH and ABTS radical scavenging activities were 74.92-79.04% and 80.47-84.97%, respectively, and showed little difference. However, the reducing power varied between 195.23 𝜇M and 317.85 𝜇M, displaying a significant difference in all samples. Therefore, this study observed similar trends in the food component characteristics and antioxidant activities of domestic commercial shiitake mushrooms.

3개월 이하 영아에서 가와사끼병의 임상 특징

이수정,김수정,김혜순,손세정,Lee, Soo Jeong,Kim, So Jung,Kim, Hae Soon,Sohn, Sejung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.6

목 적 : 3개월 이하 영아에서의 가와사끼병은 매우 드물고, 그 임상 양상이 비정형적이어서 조기 진단과 치료가 어렵고 심혈관계 합병증의 발생률이 높다. 이에 저자들은 이들의 임상적 특징을 알아봄으로써 이 환아군에서 가와사끼병의 조기 진단과 치료의 중요성을 강조하고자 하였다. 방 법 : 1998년 1월부터 2002년 7월까지 치료했던 전체 가와사끼병 환자 중에서 3개월 이하의 영아 11명을 대상으로 후향적 조사를 하였다. 결 과 : 전체 환자 291명 중 3개월 이하의 영아는 11명(3.8%)이었다. 이들 중 10명이 비정형 가와사끼병 환아로서, 주증상의 발현은 기존의 보고보다 적게 나타났고, 발열을 제외한 주증상 중 가장 흔한 증상은 구강점막의 변화(72.7%)였다. BCG 접종부 위의 발적은 6명의 환아에서 관찰되었는데(나머지 5명은 기록 미비로 알 수 없었음) 그중 2명에서는 아급성기에 심혈관계 합병증이 발생됨으로써 이러한 소견이 명백한 진단의 단서가 될 수 있음이 증명되었다. 면역글로불린(IVIG)의 발병 4.4일 이내의 조기 치료로 10명에서 즉각적인 임상적 호전을 보였으며, 1명에서는 IVIG 재치료를 하였다. 6명(54.5%)에서 심혈관계 합병증이 발생하였으나 추적검사에서 대부분 정상화되었다. 결 론 : 3개월 이하의 영아 가와사끼병 환아는 대부분 비정형적인 양상을 보이고 심혈관계 합병증의 발생률이 높은 고위험군으로 조기 진단과 치료가 중요하다. 이때 BCG 접종부위의 발적은 임상 증상이 거의 없는 나이 어린 영아 환아에서 매우 중요한 진단의 단서가 될 수 있으리라 생각한다. Purpose : Kawasaki disease(KD) is rare in infants <3 months of age. In this younger group, the diagnosis may be delayed due to lack of most of the clinical criteria, resulting in a high risk of cardiac complications. We examined clinical characteristics in these patients for early recognition and treatment. Methods : We conducted a retrospective study on the infants with KD aged three months or younger treated at our hospital from January 1998 to July 2002. Results : Of a total of 291 patients treated during the study period, 11(3.8%) were three months old or younger. Of the 11 patients, 10 had atypical presentations. Infants had fewer of the accepted criteria, and the most common findings were fever(100%) and oral mucosal changes(72.7%). Erythema at the site of BCG inoculation was observed in six of the 11 patients(unknown in the remaining five). This feature proved a definite diagnostic clue in two patients in whom cardiac complications developed in the subacute phase. Cardiac complications were found in six patients(54.5%) : three had coronary dilatation, two had coronary wall irregularity, and one had mitral valve prolapse with regurgitation. Defervescence occurred within $1.1{\pm}0.3day$ in 10 of the 11 patients treated with intravenous immunoglobulin(IVIG) and one was given a second course of IVIG. Echocardiographic abnormality persisted in only one patient with mitral regurgitation at the 6-month follow-up. Conclusion : Most patients with KD younger than three months of age have atypical presentations and a high complication rate. For early diagnosis, erythema at the BCG inoculation site, if present, could be used as a valid diagnostic clue to atypical KD in this age group.

성인 여성의 하반신 체형분석과 염상처리를 이용한 플레어 스커트의 외관분석

이수정,홍정민,Lee, Soo-Jung,Hong, Jeong-Min 한국의류산업학회 1999 한국의류산업학회지 Vol.1 No.3

미혼여성과 기혼여성을 대상으로 인체계측을 실시하여 직접 계측치와 지수치를 이용하여 주축요인분석을 한 결과 도출된 인자를 독립변수로 군집분석을 한 하반신 체형변인과 직물에 의한 플레어 스커트의 외관형상을 분석하기 위하여 영상처리를 이용하여 착용실험을 한 결괴는 다음과 같다. 1. 플레어 스커트의 헴라인 단면형상 분석 결과 체형변인에 의한 플레어 스커트의 드레이프 면적과 드레이프 계수는 드레이프의 면적이 크면 드레이프 계수도 큰 값을 나타내었다. 직물의 노드수는 드레이프성이 좋을수록 많이 형성되고 노드수가 많으면 노드지수 값은 작은 값을 가진다. 노드지수 값이 크면 노드의 고저가 균일하게 나타나고 작으면 노드의 고저가 불균일하게 나타난다. 또한 인체 측정치수의 허리둘레와 엉덩이둘레의 차이, 허리너비와 엉덩이너비의 차이 값이 큰 마름모형 체형변인에서 노드수는 많이 나타나고 노드지수 값은 작게 나타났다. 통형에 가까운 체형변인은 노드지수가 큰 값을 나타내므로 노드의 고저가 균일하게 나타났다. 직물의 노드수가 많으면 노드산 평균은 낮고, 노드지수 값이 큰 반면 노드수가 작으면 노드산펑균이 높으므로 노드산과 곡의 고저가 심하게 나타났다. 그러므로 직물의 드레이프성이 우수하다 할지라도 적정의 중량을 가지지 않으면 노드가 불균일하게 형성되어 의복 외관의 좋은 외관형상을 형성하지 못하는 결점이 나타나는 것으로 해석되었다. 2. 플레어 스커트의 헴라인 단면의 최대횡경은 인체측정값의 너비항목과 최대종경은 두께항목과 관련성이 높은 것으로 나타났다. 단면비의 값이 크면 최대횡경의 값이 크고 최대종경의 값이 작은 타원형에 가까운 단면형상이 나타나고, 단면비의 값이 작으면 최대횡경 값이 작고 최대총경 값이 큰 원형에 가까운 단변형상으로 나타났다. 3. 플레어 스커트의 외관형상 분석 결과 정면처짐분은 둘레항목, 너비항목 시아항목의 차이 값이 작을수록, 직물의 드레이프성이 좋을수록 크게 나타났다. 미혼여성과 기혼여성을 비교해 보면 기혼여성의 체형이 너비, 둘레항목사이의 치어 값이 적기 때문에 처짐분이 크게 나타났다. 측면처짐분은 인체측정값의 두께항목과 상관이 깊어 앞부분은 배두께가 클수록, 뒷부분은 엉덩이두께가 클수록 처짐분량이 크게 나타났다. 후면처짐분은 정면과 같이 S시료에서 드레이프성이 좋을수록 처짐분이 크고, 엉덩이너비는 크고, 엉덩이두께가 작올수록 처짐분이 크게 나타났다. 4. 플레어 스커트의 3차원 입체형상은 외관형상의 굴곡이 낮아 평평할 수록 이미지의 평균값은 높고 편차는 낮게 나타났다. 체형변인에 의한 플레어 스커트의 주름 형상을 정면, 측면, 후면에서 이미지 값 분포로 비교해 보면 정면, 후면보다 측면의 외관이 평활하여 이미지 분포폭이 좁게 나타나고 최빈값을 중심으로 회색에 가까운 쪽으로 치우쳐 있는 것을 불 수 있다. 5. 체형변인에 따른 플레어 스커트의 주름특성을 평가하기 위하여 영상처리법으로 얻은 결과를 3차원 업체형상으로 분석하기 위하여 6개의 영역을 측정한 결과 플레어 스커트는 체형유형에 따라 곡면을 형성하는 주름의 수와 주름강도가 다르게 나타나 위 아랫부분의 주름폭은 차이가 있었다. 위부분에서 아랫부분으로 내려올수록 주름높이 폭은 커졌다. 그러므로 주름의 높이와 플레어 스커트의 헴라인 단연형상의 노드각도와 밀접한 The aims of this study is to classify the lower somatotype of adult women and appearance analysis on the shape of flare skirts by using the image processing. Also We have made skirts in order to analyze the various types of appearance of flare skirts by using the image processing. The subjects for our wear test lower somatotype, who were controlled in their waist, abdomen and hip shapes. The flare skirts used for wear test were 112 types(combinated 14 fabric type and 8 lower somatotype). The effect of lower somatotype on the shape of flare skirts was determined by the horizontally hem line section shape and the silhouette of flare skirts with image processing. The data were analyzed by using analysis of variance and Turkey, Duncan multiple range test. The results obtained are summarized as follows: It is shown that the fabric weight elongation differs in fabrics properties, in direction of textures. The shape horizontal section of flare skirt hem line has differed with the number of nodes, wave-height of nodes and breadth of silhouette by fabrics properties and lower somatotype. It is noticed that the breadth of flare skirts by the silhouette has high correlation with the drape ability of fabrics and lower somatotype. Results for our flare skirts show changes in amplitude and mean with fabrics, somatotype. Therefore we can say that gray-level histograms are correlated with changes in appearance, differences in drape spacing and related fabric properties and their somatotype.

비만의 한방치료 효과 및 집단 간 효과차이에 관한 연구

이수정,김원일,Lee, Soo-Jung,Kim, Won-Il 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.3

Objectives : The purpose of this study were to evaluate the effects of oriental medical therapy on obesity and different effects according to Body Mass Index(BMI), menopause, obesity treatment experience, age, treatment period in patients. Methods : 46 patients were treated from November 2011 to April 2012 in Oriental Obesity Center, Dong-eui Medical Center. They were measured change of body compositions by bioelectrical impedance analysis every 2~3 weeks and 27 patients out of 46 were checked body compositions every 2 weeks. 46 and 27 patients were divided into two or three groups according to BMI, menopause, obesity treatment experience, age, treatment period. We compared before and after treatment body compositions. Results : Body compositions, except edema index were significantly reduced. Abdominal Visceral Fat(AVF) was significantly reduced in Obese group. Body Weight(BW), BMI, Body Fat(BF), Body Fat Percetage(BFP), Abdominal Visceral Fat Level(AVFL), Abdominal Visceral Fat(AVF), Abdominal Subcutaneous Fat(ASF) were significantly reduced in non-menopause group(43 female patients). But in 26 female patients out of 27, there were no significantly differences between groups in menopause. There were no significantly differences between groups in obesity treatment experience. But in 27 patients, BMI and AVF were significantly reduced in non-experience group and AVFL was significantly reduced in experience group. BW, BMI, BF, BFP, VAF, ASF were significantly reduced in younger age group. But in 27 patients, BW and Muscle were significantly reduced in younger age group. BMI, BF, BFP, Edema, AFVL, Abdominal Visceral Fat Area(AVFA), AVF, ASF were significantly reduced in longer treatment period group. Conclusion : The BF, BMI, BF, BFP, Muscle, AVFL, AVFA, AVF, ASF were almost decreased significantly. It resulted that the effects of oriental medical therapy in obesity was positive. And it was meaningful study to know about different effects between groups.