Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

이석근,김연숙 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.3

Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke’s pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.

(1,3,6-3H)-Benzo(a) pyrene도포가 햄스터협낭의 발암효과에 관한 자기방사법적 연구

이석근,임창윤 서울大學校 齒科大學 1987 齒大 論文集 Vol.11 No.1

[인터뷰] “면민들 삶의 질 향상에 도움이 되도록 노력하겠다”

이석근 한국자치학회 2020 월간 주민자치 Vol.105 No.-

Ultrastructural Changes of Bone in Bisphosphonate-related Osteonecrosis of Jaws

이석근 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.5

The prolonged bisphosphonate (BP) uptakes are frequently resulted in BP-related osteonecrosis of jaws (BRONJ). The previous study reported that the BP-involved bones were stained blue by Masson trichrome and showed weak birefringence compared to the normal bone1). Using the representative twenty cases of BRONJ osteomyelitis the present study examined the ultrastructure of BP-involved bone by scanning electron microscope (SEM) using decalcified bone microsections. As the BP-involved bones showed different features from adjacent normal bone by blue staining in Masson trichrome method and by rare birefringence under polarizing microscope, the ultrastructure of BP-involved bone matrixes were distinguishable histologically in comparison with normal bone. The normal bone showed the tight attachment of interdigitating dendritic bone matrixes, producing many Haversian canaliculi, while the BP-involved bone showed the compact alignment of granular bone matrixes, resulted in the abortive Haversian canaliculi. The osteocytes in the lacunar spaces of BP-involved bone became shrunken and necrotic, and the BP-involved bone showed many tunnel-like spaces produced by direct chemical resorptions and proteolytic degradation of bone matrixes. Taken together, it was conspicuous that the BP-involved bones were abnormal in their stainability of Masson trichrome, birefringence under polarizing microscope, and ultrastructure under SEM. These findings of BP-involved bone may have an implication for the pathogenetic roles of BRONJ, and can be applicable for the differential diagnosis of BRONJ from other osseous lesions.

Cement 원료로서의 Shale(점토질) 사용 가치성 검토

이석근 한국시멘트협회 1975 시멘트 심포지움 Vol. No.

인사말

이석근 한국분석과학회 2009 분석과학 Vol.22 No.1

유한체적법과 유한요소법 기반의 상용 소프트웨어를 이용한 원심형 펌프의 전산유체해석

이석근,손일엽 한국CDE학회 2019 한국CDE학회 논문집 Vol.24 No.2

Computational fluid dynamic (CFD) simulations of a centrifugal pump have been performed using commercial CFD tools which are each based on finite volume (FVM) and finite element method (FEM). In this work, ANSYS FLUENT and midas NFX CFD were used for FVM and FEM CFD solver, respectively. A multiple reference frame was considered to model rotating and stationary parts for pseudo-transient simulations and a sliding mesh was used for a full time-transient calculations. Two different mesh systems were generated, which of each was appropriate for FVM and FEM to have converged solutions. The general characteristics of fluid flow within the centrifugal pump were compared between FLUENT and NFX and the difference of pressure change between inlet and outlet surface calculated by the two CFD tools were also investigated. The differences of pressure increases for the various flow rates between FVM and FEM pseudo-transient simulation were within 2%, which reflected that the flow behavior such as pressure and velocity within the pump was predicted similarly each other. It was also found that the results obtained from FLUENT were more sensitive to including time consideration than those from NFX.

복부 컴퓨터 단층촬영에서 간주위염을 보인 환자들의 임상적 특징

이석근,이현웅,홍윤석,이정민,이승현,장병국,정우진,박경식,조광범,황재석,안성훈,권중혁 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-

Correlation of the Peak Pressure Generated by an Underwater Spark Discharge with Energy Absorption in a Spark Channel

이석근,정경재,황용석 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.12

In this paper, we have explained the correlation between the amplitude of the underwater shock pressure generated by a spark discharge in water and the energy absorption in a spark channel. With the well-known theory of shock wave formation by an accelerating piston, the peak pressure is considered to be generated by the energy absorption in the spark channel until the expansion speed of the spark channel reaches its maximum value. To obtain the maximum channel speed, we solve the power balance equation with experimentally measured voltage and current waveforms as a transient heating source of the spark channel. It is found that the experimentally measured peak pressure is well correlated with the energy absorption until the maximum channel expansion speed, irrespective of the operating parameters such as the capacitance and the voltage. It is also found that the energy absorption in the spark channel is significantly influenced by the spark channel resistance, indicating that an appropriate resistance model for the spark channel is necessary for an improved analysis of an underwater spark discharge system. The physics-based estimation of the peak shock pressure presented in this paper is expected to be useful for optimizing underwater spark discharge systems utilized in various application fields.

내시경 점막 절제술 및 내시경 점막하 박리술 시행 중 발생한 위장천공의 비수술적 치료

이석근,조광범,홍윤석,이현웅,이정민,장병국,정우진,박경식,황재석,박은지 대한소화기내시경학회 2008 Clinical Endoscopy Vol.37 No.2

목적: 내시경 점막 절제술(endoscopic mucosal resection, EMR) 및 내시경 점막하 박리술(endoscopic submucosal dissection, ESD)은 점막에 국한된 조기 위암 및 전암성 병변에 대하여 비교적 비침습적인 치료법으로서 현재 시행되고 있으나 출혈, 천공 등의 합병증이 생길 수 있으며 이 중 천공은 사망률, 이환율을 높일 수 있다. 따라서 저자 들은 시술 중 천공이 발생했을 경우 내시경을 이용한 클립 봉합 등의 비수술적 방법을 통한 치료의 효과 및 안전성에 대해서 평가해 보고자 하였다. 대상 및 방법: 계명대학교 동산의료원 소화기 내과에서 2003년 2월부터 2007년 12월까지 점막을 침범한 조기 위암 및 위 선종을 가진 환자 중 EMR 또는 ESD를 시행한 482명, 507병소를 대상으로 하였고, 이 중 천공이 발생한 14예에 대해서 후향적으로 분석하였다. 결과: 총 14예에서 천공이 발생하였다(14/507, 2.8%). 천공이 발생한 환자들의 연령은 68세였으며, 병변의 크기는 평균 35.6 mm이었다. 천공이 발생한 위치는 분문부 1예, 전정부 4예였으며, 나머지 9예는 체부에서 발생하였다. 천공의 크기는 12예에서 5 mm 이하였으나, 2예에서는 크기가15 mm 이상이었다. 11예는 시술 중에 천공을 발견하여 클립 봉합을 하였으나, 3예에서는 시술 후 방사선 검사에서 천공이 발견되어 클립 봉합 없이 보존적 치료만 하였다. 보존적 치료로 금식, 정맥 내 수액 공급 및 항생제 치료(평균 5.8일)를 실시하였다. 14예 모두에서 수술적 치료 없이 증상이 호전되었고, 시술 후 평균 7.2일간 재원 후 특별한 증상 없이 퇴원하였다. 결론: 내시경 점막 절제술 및 내시경 점막하 박리술 시행 중 발생한 천공은 내시경을 이용한 즉각적인 클립 봉합 등의 비수술적 치료로 비교적 안전하게 치료될 수 있으므로 천공 발생 시 우선적으로 시행할 수 있다.