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성인의 구취의 인식과 치주상태 및 전신적인 요인들과의 관련성에 대한 후향적 연구
이정태,류은하,김근서,박신영,이인경,이효정 대한구강악안면병리학회 2016 대한구강악안면병리학회지 Vol.40 No.1
Halitosis is a bad odor in mouth. The etiology of halitosis is multifactorial including intra-oral and extra-oral causes. It affects social interactions in many people. The aim of this study is to investigate an association between recognition group and non-recognition group by evaluating halitosis level and systemic factors. Nineteen participants who visited Department of Periodontology of Seoul National University Bundang Hospital were enrolled. Volatile sulfur a compounds (VSCs) were measured by Oral ChromaⓇ, a questionnaire was requested and oral exam was carried out in all subjects. Female is more sensitive than male for oral malodor. VSCs level of hydrogen sulfide(H2S) and methyl mercaptan(CH3SH) in male is higher than that in female. Participants who gave appeal dry mouth seem to recognize halitosis.
구강편평세포암종에서의 Ki-67과 p53의 발현 ; 구강내 원발성 편평세포암종과 림프절로 전이된 편평세포암종의 비교
So-Young Choi,Jin-Wook Kim,Young-In Park,Sung-Min Kang,Su-Hyung Hong 대한구강악안면병리학회 2016 대한구강악안면병리학회지 Vol.40 No.3
This study was performed to investigate the correlation between the primary squamous cell carcinoma in oral cavity (POSCC) and paired metastatic oral squamous cell carcinoma in cervical lymph node (MOSCC) via immunohistochemical staining with Ki-67 and p53. The subjects included ten patients (20 specimens) who were diagnosed with OSCC with metastatic lymph nodes from 2010 to 2015 and surgically treated involving neck dissection in Kyungpook National University Hospital. Twenty specimens were stained immunohistochemically with Ki-67 and p53. The degrees of immunostaining by Ki-67 and p53 was evaluated as 0 (no positive cells), weak (1~25% positive cells), moderate (26-50% positive cells) and strong (>50% positive cells). Despite the strong tendency, there was no statistically significant result between expressions of Ki-67 and p53 in POSCC or MOSCC. We found that high expression of Ki-67 was significantly correlated with poor degree of differentiation. Our results suggest that expression of Ki-67 may be a predictable factor for degree of differentiation of POSCC and MOSCC.
이병황,유태민,이종헌,박경주 대한구강악안면병리학회 2014 대한구강악안면병리학회지 Vol.38 No.2
This study were to perform for verifying the activation areas in the human's brain during mastication by using functional-MRI (f-MRI)device on the basis of hypothesis regarding anatomical-physiological parts of brain processing the information of motor and sensoryfunction, and to perform further more for a providing basic provisional foundation about diagnosis, treatment and prognosis of abnormalocclusion as applying functional MRI. Generally healthy 10 volunteers who have a normal occlusion were selected. The half of membersof volunteers was female. Age distributions were approximately alike. Before taking a f-MRI, sufficient practice was carried out asstrict standards and made volunteers be not sensible to sweet taste of gum through chewing gum for 30 minutes before taking af-MRI. Functional images for all volunteers were firstly obtained, and then anatomical images were next. The functional images consistedof echo-planar image volumes which were sensitive to BOLD (blood oxygenation level-dependent) contrast in axial orientation. Thevolume covered the whole brain with a 64×64 matrix and 42 slices. Images with 64 volumes were acquired under periodic mastication. The orofacial sensorimotor cortex was primary responsible cerebral part during mastication and insula. And also supplementary motorarea and cerebellum in brain were intimately connected with mastication. Other numerous anatomical parts of brain were activatedin each volunteer during mastication, but there was no statistical significance in this experiment. Differences according to gender andage were no significance in this study. The f-MRI device showed the accurate and detailed image in activation area of brain throughvaluable device. It suggested that f-MRI might be helpful to establish the basis of funtional standard occlusion depend on activationarea of brain. This study were to perform for verifying the activation areas in the human's brain during mastication by using functional-MRI (f-MRI)device on the basis of hypothesis regarding anatomical-physiological parts of brain processing the information of motor and sensoryfunction, and to perform further more for a providing basic provisional foundation about diagnosis, treatment and prognosis of abnormal occlusion as applying functional MRI. Generally healthy 10 volunteers who have a normal occlusion were selected. The half of members of volunteers was female. Age distributions were approximately alike. Before taking a f-MRI, sufficient practice was carried out as strict standards and made volunteers be not sensible to sweet taste of gum through chewing gum for 30 minutes before taking a f-MRI. Functional images for all volunteers were firstly obtained, and then anatomical images were next. The functional images consisted of echo-planar image volumes which were sensitive to BOLD (blood oxygenation level-dependent) contrast in axial orientation. The volume covered the whole brain with a 64×64 matrix and 42 slices. Images with 64 volumes were acquired under periodic mastication. The orofacial sensorimotor cortex was primary responsible cerebral part during mastication and insula. And also supplementary motor area and cerebellum in brain were intimately connected with mastication. Other numerous anatomical parts of brain were activated in each volunteer during mastication, but there was no statistical significance in this experiment. Differences according to gender and age were no significance in this study. The f-MRI device showed the accurate and detailed image in activation area of brain through valuable device. It suggested that f-MRI might be helpful to establish the basis of funtional standard occlusion depend on activation area of brain.
박테리아 군집의 중심핵을 갖는 거대타석에서 제4형 트랜스굴르타미나제에 의한 타액의 뮤신-1과 프롤린 풍부 단백질들이 융합됨
김연숙,이석근 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.5
A patient complaining of severe pain in the right submandibular area showed a huge sialolith in radiogram. During the operation, the submandibular gland was much indurated, and large amount of pus was discharged out at an incision of the salivary gland. The removed salivary gland contained a huge sialolith in the major excretory duct of submandibular gland, which had an intact grayish-white surface in ovoid shape. In the histological examination its excretory ducts were extensively dilated without extravasation of saliva, and the involved salivary gland was almost destroyed by the granulomatous r eaction. Most of a cinar cells were d isappeared and r eplaced by ductal cells filled with exudative materials. The microsections of sialolith showed typical laminar structures of calcification containing amorphous basophilic material in the center, in which a lot of Gram positive and Gram negative microorganisms were found. In the center of sialolith numerous microorganisms were admixed with mucinous materials which were strongly positive for the antibody of mucin-1, and formed multiple colonies. In the periphery of the bacterial colonies proline rich proteins (PRPs) were condensely localized, and followed by the consistent positive reaction of transglutaminase 4 (TGase-4). These data suggest that the sialolith of this study is formed from the primary nidus of bacterial colony aggregated with salivary mucin-1 and PRPs by the crosslinking reaction of TGase-4.