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양홍윤(Hong Yoon Yang),이창우(Chang Woo Lee),김영태(Young Tae Kim),김재홍(Jae Hong Kim),강형재(Hyung Jai Kang),김원석(Won Suk Kim),유태연(Tae Yun Yoo),김중환(Joong Hwang Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3
Among 13 patients with pemphigus : 8 of pemphigus vulgaris(PV), 4 of pemphigus foliaceus(PF), l of pemphigus erythematosus(PE), we have examined the sites of early lesions and the clinical appearances of the skin lesions. The most common site of the early lesions in PV was the oral mucosa, however, in PF and PE the face was affected first. The clinical appearances of the early lesions were flaccid bullae, erythematous papules and eczematoid patches. Clinicians should be aware of these clinical features of pemphigus for a more precise diagnosis and better management.
한국인 천포창 환자에서의 HLA - DRB1 대립유전자의 빈도에 관한 연구
양홍윤 ( Hong Yoon Yang ),이창우 ( Chang Woo Lee ),김수찬 ( Soo Chan Kim ),정진호 ( Jin Ho Chung ),유희준 ( Hee Joon Yu ),황적준 ( Juck Joon Hwang ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Background & Objectives : Pemphigus is an autoimmune bullous disease of the skin and mucous membranes. There are two major types of pemphigus, namely pemphigus vulgaris(PV) and pemphigus foliaceus(PF) which can be classified by the specificity of the autoantibodies against the epidermal desmosomal antigens in this disease. Like many other autoimmune diseases, pemphigus is also considered to be strongly associated with certain HLA alleles; some alleles can be detected with higher frequencies as compared with those found in ethnically matched populations. At this time, we tried to find out if there were certain HLA class II allele(s) associated significantly with Korean patients of pemphigus. Patients & Methods : Thirty patients with pemphigus (fifteen of PV and fifteen of PF), and one hundred healthy Korean controls were enrolled in this study. For the genotyping of HLA class II alleles in DRB1 loci, genomic DNAs prepared from buccal epithelia were amplified by polymerase chain reactions with nucleotide sequence-specific primers. Each allele of thirteen different generic types belonging to the DRB1 loci were used to identify the existence of each allele in both patient and control groups on gel electrophoreses. Results : In PV, there was a significantly increased frequency of HLA-DRB1*01 alleles than from the findings observed in the controls(pc=0.0013, RR:5). In patients with PF, there was a significant degree of association with HLA-DRB1*01(pc=0.00013, RR:5.5) when compared with that in normal controls. However, no allele of negative association with a significantly low frequency in the patient group was detected in both types of the disease. Conclusion : It can be suggested that DRB1*01 alleles may be susceptibility genes in Korean patients with PV, and DRB1*01 alleles could contribute to the autoimmune reactivity in patients with PF. This data shows different patterns in the frequency of each DRB1 allele in patient groups compared with those found in patients of other ethnic backgrounds. (Korean J Dermatol 1998;36(2): 252-260)
김중환,양홍윤,소순남,백혜승,황유정,김지현,김영태,김재홍 ( Joong Hwan Kim,Hong Yoon Yang,Soon Nam Soh,Hae Seung Paik,Yoo Jung Hwang,Ji Hyun Kim,Young Tae Kim,Jae Hong Kim ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A In view of high prevalence of penicillinase producing Neisseria gonorrhoeae(PPNG) and chromosomally mediated resistant Neisseria gonorrhoaea(CMRNG) among circulating N. gonorrhoeae and emergence of spectinomycin resistant strains in Korea, more effort is needed to seek new effective treatment regimens for gonorrhea. The objective of this trial was to establish the efficacy of enoxacin, one of new fluoroquinolones, in the treatment of uncomplicated male gonorrhea. A total of 112 male uncomplicated gonorrheal patients were treated with one of the two dose regimens at the VD Clinic, Choong-Ku Public Health Center, in Seoul, between January and August, 1990. The patients were divided randomly into two groups and assigned to one of the two different dose regimens of enoxacin: 300㎎, PO(group A) and 600㎎, PO(group B). One of 47 patients treated with enoxacin, 300㎎, PO, failed(2.1%) and two of 46 patients treated with enoxacin, 600㎎, PO, failed (4.3%) to recover. A single dose regimen of enoxacin, 300㎎, PO is exellent, sa?e and relatively inexpensive in the treatment of male uncomplicated gonococcal urethritis in Korea.
유희준 ( Hee Joon Yu ),양홍윤 ( Hong Yoon Yang ),김윤석 ( Yun Suck Kim ),은철 ( Chul Eun ),장세진 ( Se Jin Jang ),박용욱 ( Yong Wook Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Trichoadenoma is a rare cutaneous tumor that was first described by Nikolowski in 1958. It usually occurs as a single tumor on the face and its size varies from 3 to 50mm in diameter. It may arise any time during adult life. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma, and it is considered as a benign tumor with differentiation toward the infundibular portion of the pilosebaceous canal. In this report, we describe a 61-year-old women who developed trichoadenoma on the left shoulder of 3 years duration. The lesion was asymptomatic and had grown slowly. Histopathological findings showed numurous horn cysts with central keratinous material and solid tumor islands reaching to the deep dermis. Immunohistochemical studies showed negative findings for eccrine differentiation. (Korean J Dermatol 1998;36(2) . 372-375)
당뇨병 환자의 피부병변 및 조갑변화에 관한 임상적 고찰
백혜승(Hae Seung Paik),양홍윤(Hong Yoon Yang),김중환(Joong Hwan Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Background : Desmosomes are adhesive intercellular junctions that. for mean important component of the junction complexes of epithelial cells. They provide intercellular links between the intermediate filament cytoskeletons of adjacent cells and are has involved in maintaining the stritctural integrity of tissues. Objective : Calcium and retinioids ar:e major regulators of epidermal d fferentiation and their role on keratin proteins are well known. However, their effects on desmosom moleucles are unknown. To address this question we initiated a stdy of the effects of these epidermal differentiation regulators on desmosomal components, i.e., demoplikin, desmoglein, and pemphigus a atigens. Methods : We used monoclorial antibodies against desmoplakin(DF) and desmoglein(DG), and sera from patients with pemphigus vulgaris (PV), pemphigus foliaceus (DF) and paraneoplastic pemphigus (PNP) t,o study the effects of calcium and retinoic acids, which are major regulators of epidermal different,ation, on desmosomat protein formation in human cultured keratinoeytes. We performed immunofluorescence, immunoglotting and immunoprecipitation study using human keratinocytes cultured in high calcium media with or without retinoic acid and in low alcium media with or without retinoic acid. Results : 1. In low calcium (0.15mM) rnedia, PV antigen and DG were produced in a small amount and it appeared that these desmosomal proteins were located in cytosol. Thereas in high calcium (1,8mM) media production of these desmcsomal proteins was increased and they were assembled at, the desmosomal structures located in cell-cell contact margins. 2. PF antigen, which was idntical to the DG, were not producecio expressed in cultured kerati-nocytes even when cultured in high calcium media, 3. PNF antigen and DP were produced in cultured keratinocytes grow in both high and low calcium media but, their production was increased in high calcium media and only in high ealcium media they were assembled at the desninsomai structures. 4. Retinoic acids induced looiening of cell-cell contacts of culture keratinocytes and decreased t,he production of desmosomal grotein Conclusion : Our results suggests calcium is a major regulat,or of the production and assembly of desmosomal proteins including pemphigusantigens, but PF sera and minoclonal antibodies against DG show different, antigen binding characteristics. It appears that rtinvic acids inhibit production of desmosomal proteins. (Kor J Dermatol 1994;32(5):820 831)
유희준,권상진,조지형,양홍윤,박용욱,장세진 ( Hee Joon Yu,Sang Jin Kwon,Ji Hyeung Cho,Hong Yoon Yang,Yong Wook Park,Se Jin Jang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1
We experienced a case of arteriovenous hemangioma showing Dariers sign on the forehead of a 43-year-old man. He presented with a single, 1 * 1.5cm sized, violaceous, asymptomatic nodule with a history of an intermittent wheal at the lesional site. This skin lesion showed Dariers sign clinically and proliferation of mast cells histopathologically with the punch biopsy specirnen suggesting urticaria pig- mentosa. Howerer, we could diagnose it as a arteriovenous hemangioma on complete excision, as the specimen showed arteriovenous proliferation with increased mast cells in a perivascular pattern. This case showed confusing clinical signs and showed the importance of complete excision for the diagnosis of a small skin tumor especially when a vascular proliferating tumor is suspected. (Kor J Dermatol 1997;35(1): 209-213)
김중환 ( Joong Hwan Kim ),양홍윤 ( Hong Yoon Yang ),남채식 ( Tchae Sik Nam ),윤정용 ( Jeong Yong Yoon ),김영태 ( Young Tae Kim ),김재홍 ( Jae Hong Kim ),박현철 ( Hyun Chul Park ),임기섭 ( Ghi Seob Lim ),민태형 ( Tae Hyung Min ) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.3
The prevalence of PPNG among pretreatment isolates at a VD Clinic in Seoul has been studied and reported annually since 1981. In 1987, 649 strains of N. gonorrhoeae were isolated, among which 339(52.2%) were PPNGs. The prevalence of PPNG in Seoul is still increasing.
황유정(Yoo Jung Hwang),양홍윤(Hong Yoon Yang),김중환(Joong Hwan Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.5
Background : Vitiligo is riot quite a rare diseasep; it has about 1% prevalence. The cause of vitiligo is not clear, however, in recent studies an autoimmune origin is freqluei itily mentioned. Object : We tried to an lyze some clinical features of vitiligo and relate them with the presence of autoantibodies. Methods : A total of 381 vitiligo patients was included for the analysis of clinical features. A laboratory study included rhumatoid factor, antinuclear antibocoly, antithyroglobulin antibody and antimicrosome antibody. Some 62 patients were examined for opl thmologic changes. Results : One hundred and one(26.5%) of 381 patients exam ned showed at least one of the autoantibodies tested. Twenty nine pateints showed 2 different aitintibodies. The age at aonset of vitiligo in the autoantibody positive group was 6.6 years later than that of the autoantibody negative group. Autoimmune and/or endocrine diseases were more frequinty found among aut.oantibody positive patients. These diseas s included hyperthyroidism, diabetes me litus and alopecia areata. One patient revealed retinal hypoigmentation and showed no autoantibcidics. Conclusion : About 9% of vitiligo patients who were autoantiocyte positive had clinical evidence of diseases associated with the autoantibody. However, it is prudent. to xpect that more patients with t.he autoantibody may develop later systemic autoimmune diseases or endocrinopathies. A long term follow-up of these patients seem:, to be very important. (Kor J Dermatol 1993;31(5):657-663)