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Dapsone으로 치료한 안면 파종상 속립성 루프스 2예
은철 ( Chul Eun ),이창우 ( Chang Woo Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6
Lupus miliaris disseminatus faciei (LMDF) is an asymptomatic papular eruption affecting the central area of the face. It runs a chronic course and can involute spontaneously with scarring. The treatment of LM~BF has not been satisfactory despite the use of many different kinds of topical and systemic agents. In the early 1980s, Kumano et al. reported their experiences with this disease using dapsone : the efficacy of dapsone was described as excellent. With this report in mind, we have used dapsone(50-100mg/d) in 2 patients with LMDF, and a marked irnprovement or almost cure of the skin disease were recognized. (Kor J Dermatol 1998;34(6): 1016-1020)
은철 ( Chul Eun ),노영석 ( Young Suck Ro ),이창우 ( Chang Woo Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4
Isotopic response is the occurrence of a new unrelated disease that appears at the same location as a previously already healed disease. In 1995, Wolf et al defined a this new phenomenon and reported eight new cases with fiftyeight cases corresponding to the definition for this phenomenon in literiture. We report two cases considered as isotopic response, urticarial vasculitis and erythema multiforme developed on striae distensae, respectively. (Kor J Dermatol 1996;34(4): 664-667)
유희준 ( Hee Joon Yu ),양홍윤 ( Hong Yoon Yang ),김윤석 ( Yun Suck Kim ),은철 ( Chul Eun ),장세진 ( Se Jin Jang ),박용욱 ( Yong Wook Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Trichoadenoma is a rare cutaneous tumor that was first described by Nikolowski in 1958. It usually occurs as a single tumor on the face and its size varies from 3 to 50mm in diameter. It may arise any time during adult life. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma, and it is considered as a benign tumor with differentiation toward the infundibular portion of the pilosebaceous canal. In this report, we describe a 61-year-old women who developed trichoadenoma on the left shoulder of 3 years duration. The lesion was asymptomatic and had grown slowly. Histopathological findings showed numurous horn cysts with central keratinous material and solid tumor islands reaching to the deep dermis. Immunohistochemical studies showed negative findings for eccrine differentiation. (Korean J Dermatol 1998;36(2) . 372-375)
피부 T세포 림프종에서의 p53 및 mdm-2단백 발현에 관한 연구
노영석,은철,박찬금 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2
P53 gene mutation appears to play an important role in the development of systemic lymphoma, and may be associated with tumor progression. However, its role in cutaneous lymphoma is currently unknown and only very limited series have focused on the role of p53 in cutaneous T-cell lymphoma. As dysfunction of p53 has also been suggested to occur after interaction with mdm-2 cellular oncogene, we have performed immunohistochemical analysis to investigate the patterns of p53 and mdm-2 expression in 12 cases of cutaneous T-cell lymphoma. Six cases were positive for p53, of which five were found to be high grade lymphomas, and eight cases were positive for mdm-2, of which six were found to be high grade lymphomas. All cases showing positive staining of p53 were of stage Ⅲ or Ⅳ. In six cases of primary cutaneous T-cell lymphomas, only one case was positive for p53. There was no consistent relationship between the expression of p53 and mdm-2, and the abnormal nuclear expression of p53 and mdm-2 did not seem to correlate with the presence of Epstein-Barr virus infection.