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안선현,박준성,정성현,이현우,박준은,김미향,김양수,이호섭,박태성,유은경,임인수,박주원,허지영,강명서,조성란 대한혈액학회 2013 Blood Research Vol.48 No.1
Background Acute promyelocytic leukemia (APL) can be life threatening, necessitating emergency therapy with prompt diagnosis by morphologic findings, immunophenotyping, cytogenetic analysis, or molecular studies. This study aimed to assess the current routine practices in APL and the clinico-pathologic features of APL. Methods We reviewed the medical records of 48 Korean patients (25 men, 23 women; median age, 51 (20‒80) years) diagnosed with APL in 5 university hospitals between March 2007 and February 2012. Results The WBC count at diagnosis and platelet count varied from 0.4 to 81.0 (median 2.0)×109/L and 2.7 to 124.0 (median 54.5)×109/L, respectively. The median values for prothrombin time and activated partial thromboplastin time were 14.7 (11.3‒44.1) s and 29 (24‒62) s, respectively. All but 2 patients (96%) showed a fibrin/fibrinogen degradation product value of >20 mg/mL. The D-dimer median value was 5,000 (686‒55,630) ng/mL. The t(15;17)(q22;q12 and PML-RARA fusion was found in all patients by chromosome analysis and/or multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), with turnaround times of 8 (2‒19) d and 7 (2‒13) d, respectively. All patients received induction chemotherapy: all-trans retinoic acid (ATRA) alone (N=11, 26%), ATRA+idarubicin (N=25, 58%), ATRA+cytarabine (N=3, 7%), ATRA+idarubicin+cytarabine (N=4, 9%). Conclusion Since APL is a medical emergency and an accurate diagnosis is a prerequisite for prompt treatment, laboratory support to implement faster diagnostic tools to confirm the presence of PML-RARA is required.
사람면역결핍바이러스감염 환자에서 2색 및 4색 유세포분석법을 이용한 T 림프구아형 분석
안선현,강선주,임영애,이위교,조성란 대한진단검사의학회 2013 Laboratory Medicine Online Vol.3 No.4
Background: Blood CD4+ T-lymphocyte (T4) count is a major clinical marker for the diagnosis and management of AIDS, and flow cytometry is considered the gold standard for T4 enumeration. Our aim was to compare the 2-color and 4-color flow cytometric methods for T-cell subset analysis in HIV-infected patients. Methods: T-cell subsets such as T3, T4, T8, and CD3+CD4-CD8- double negative T cells (DN T) were analyzed from the whole blood of 40 HIV-infected patients by using both 2-color and 4-color methods on a Cytomics FC500 analyzer. Statistical analyses using simple linear regression, paired t-tests, and Bland-Altman plots were performed. Results: The measured T3 (%), T4 (%), T4 (/μL), T8 (%), T8 (/μL), and DN T (%) differed significantly between the 2 methods (P<0.05), whereas the T4/T8 ratio did not. T3 (%), T4 (%), T4 (/μL), T8 (%), T8 (/μL), and T4/T8 measured by the 2 methods showed good correlation, with correlation coefficients above 0.96, whereas DN T (%) did not. The mean differences in T4 (%) and T8 (%) were 0.39% (limit of agreement (LoA), -1.64~2.43) and 1.26% (LoA, -3.37~5.89), respectively. Conclusions: Although there were statistically significant differences in the T cell subsets measured between the 2 methods, the differences were minor, and the 2 methods showed good correlation. As confirmed in this study, DN T (%) estimated by the 2-color method is lower than the actual value. We suggest that although the 2 methods can be used interchangeably, the 4-color method is recommended for the analysis of some specific subpopulations such as DN T (%).
안선현,박준성,정성현,이현우,박준은,김미향,김양수,이호섭,박태성,유은경,임인수,박주원,허지영,강명서,조성란 대한혈액학회 2013 Blood Research Vol.48 No.1
Background Acute promyelocytic leukemia (APL) can be life threatening, necessitating emergency therapy with prompt diagnosis by morphologic findings, immunophenotyping, cytogenetic analysis, or molecular studies. This study aimed to assess the current routine practices in APL and the clinico-pathologic features of APL. Methods We reviewed the medical records of 48 Korean patients (25 men, 23 women; median age, 51 (20‒80) years) diagnosed with APL in 5 university hospitals between March 2007 and February 2012. Results The WBC count at diagnosis and platelet count varied from 0.4 to 81.0 (median 2.0)×109/L and 2.7 to 124.0 (median 54.5)×109/L, respectively. The median values for prothrombin time and activated partial thromboplastin time were 14.7 (11.3‒44.1) s and 29 (24‒62) s, respectively. All but 2 patients (96%) showed a fibrin/fibrinogen degradation product value of >20 mg/mL. The D-dimer median value was 5,000 (686‒55,630) ng/mL. The t(15;17)(q22;q12 and PML-RARA fusion was found in all patients by chromosome analysis and/or multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), with turnaround times of 8 (2‒19) d and 7 (2‒13) d, respectively. All patients received induction chemotherapy: all-trans retinoic acid (ATRA) alone (N=11, 26%), ATRA+idarubicin (N=25, 58%), ATRA+cytarabine (N=3, 7%), ATRA+idarubicin+cytarabine (N=4, 9%). Conclusion Since APL is a medical emergency and an accurate diagnosis is a prerequisite for prompt treatment, laboratory support to implement faster diagnostic tools to confirm the presence of PML-RARA is required.
안선현 한국음악학학회 2008 음악학 Vol.16 No.-
How to approach to the study of the rhythmic structure for twentieth -century music is not always straightforward. According to David Lewin, there are two common ways to perceive rhythmic structure. The first is a traditional one that our traditional explications would assert an innate two-ness or even four-ness to our reactions to musical rhythm. The second is that acculturation is strongly conditioned upon our perception of rhythmic structure. It means that we still adopt the traditional way of four-ness to the rhythm of the twentieth-century music, though that is quite different from the perspective of the transitional music. Since the music still uses the quarter-, the eighth-note for expressing the complicated rhythm, the process of acculturation should happen for better understanding that the piece expresses the rhythmic pattern. This analysis applies the theory of weighting function to show how one can perceive the rhythmic pattern in Schoenberg's <Op. 19 no. 2.> The frequency of rhythmic duration within the rhythmic figure evokes some sense of metric accent and measures the rhythmic peak. It shows how certain durational values are established and are changed in each of the three sections. The durational value is changed based on a different sonority such as major third chord and minor third chord in each section. It means that the changed durational value related to the sonority makes the different rhythmic pattern. This study provides an example of acculturation which helps to understand the rhythm and its pattern of the twentieth-century music. Also, this analysis suggests another possibility to appreciate the twentieth-century music.