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소포성 갑상샘 유두암종의 세침흡인 세포검사의 정확도와 Galectin-3 면역염색의 유용성
정찬권,신정하,이현승,이아원,정은선,최영진,이교영,Jung, Chan-Kwon,Shin, Jung-Ha,Lee, Hyun-Seung,Lee, Ah-Won,Jung, Eun-Sun,Choi, Yeong-Jin,Lee, Kyo-Young 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
The cytologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) has become one of the common causes of false negative diagnoses when performing fine needle aspiration cytology (FNAC) of the thyroid gland. We retrospectively reviewed all the aspirates for which a diagnosis of FVPTC had been made based on the surgically excised specimens, regardless of the cytologic diagnosis. 145 FNACs was performed in 135 patients. The cytologic diagnoses were categorized as 2 unsatisfactory specimens (1.4%), 16 benign (11.0%), 49 atypical (33.8%) and 78 malignant lesions (53.8%). The tumor cells consistently showed significant nuclear overlapping, irregular nuclei and fine chromatin in all cases; however, nuclear grooves and inclusions were scarce. Galectin-3 immunostaining was performed on the cell blocks of 65 cases and this was positive for 45 cases (69.2%). The results of our study demonstrate that the determination of minimal cytologic criteria is needed to raise the sensitivity of detecting FVPTC by FNAC, and galectin-3 immunostaining is useful to make decisions on the surgical treatment of cytologically atypical thyroid nodules.
최현주,정지한,신정하,민기옥,강석진,이교영,유진영,Choi, Hyun-Joo,Jung, Ji-Han,Shin, Jung-Ha,Min, Ki-Ouk,Kang, Seok-Jin,Lee, Kyo-Young,Yoo, Jin-Young 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1
Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.
호텔기업 종사원 참여경영과 조직몰입의 관계에서 심리적 주인의식의 매개효과
강상묵(Sang-Muk Kang),신정하(Jung-Ha Shin),유양호(Yang-Ho Yoo) 한국콘텐츠학회 2010 한국콘텐츠학회논문지 Vol.10 No.10
본 연구는 호텔기업의 종사원 참여경영이 심리적 주인의식 및 조직몰입에 미치는 영향과 심리적 주인의식이 종사원 참여경영과 조직몰입의 관계에 미치는 매개효과를 밝혀내고자 서울지역에 소재한 특등호텔 종사원을 대상으로 실증분석을 시행하였다. 그 결과 종사원 참여경영이 심리적 주인의식과 조직몰입에 영향력이 있고, 심리적 주인의식이 조직몰입에 유의한 영향력이 있음을 밝혀냈다. 또한 심리적 주인의식이 종사원 참여경영과 정서적 몰입의 관계에 부분적인 매개효과를 나타냄을 밝혀냈다. 이 결과는 호텔기업 인적자원 관리의 중요성 및 종사원의 참여경영과 심리적 주인의식이 경쟁환경에서 우위를 점하기 위한 중요한 역할을 한다는 새로운 방향을 시사하는 결과라고 할 수 있다. The purpose of this study is reveal how employee participation management of deluxe hotels located in Seoul affects corporate employees' psychological ownership and organizational commitment. In addition, it tries to find out the mediating effect that the employees' psychological ownership has contributed to the relationship between employee participation management and organizational commitment. The results of this study are as follows; Firstly, employee participation management has a great effect on the employees' psychological ownership and organizational commitment. Secondly, employees' psychological ownership has a mediating effect between employee participation management and organizational commitments.
자궁경부 상피내병변에서 사람유두종바이러스 제자리부합법 및 L1 피각단백 면역조직화학염색의 임상적 유용성
정은선 ( Eun Sun Jung ),신정하 ( Jung Ha Shin ),이경지 ( Kyung Ji Lee ),김동철 ( Dong Chul Kim ),이아원 ( Ah Won Lee ),최영진 ( Yeong Jin Choi ),박종섭 ( Jong Sup Park ),이원철 ( Won Chul Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12
목적: 자궁경부 상피내 병변 (CIN)에서 사람유두종바이러스 (Human papillomavirus, HPV) DNA의 숙주 유전체로의 통합은 중요한 자궁경부암화 단계이다. 사람유두종바이러스 제자리부합법 (HPV In Situ Hybridization)은 HPV 감염 여부와 더불어 HPV통합여부 (핵내 미만성 염색 양상, 부체성 (episomal); 반점상, 통합 (integrated))를 확인할 수 있다. 또한 HPV 통합이 일어나면 L1 피각단백은 발현이 중지되므로 L1 피각단백 면역염색은 HPV 통합의 간접적 증거로 간주된다. 이에 자궁경부 상피내병변에서 HPV ISH 및 L1 피각단백 면역조직화학염색을 시행하여 각각의 유용성을 살펴보고자 하였다. 연구 방법: 자궁경부 세포진검사와 조직검사를 통하여 CIN이 진단된 26명의 환자 및 평활근종 환자 19명에서 HPV ISH 및 L1 피각단백 면역조직화학염색을 시행하였다. 결과: HPV ISH는 80.8% (21/26)에서 양성이었으며 (미만성 34.6%, 미만성+반점상 46.2%) L1 피각단백은 세포검체에서 65.4%(17/26) 조직에서 15.4% (4/26)에서 양성이었다. CIN 등급이 높아질수록 HPV ISH 염색상 반점상 염색양상이 흔하게 관찰되었고 이는 통계적으로 유의하였으며 (P=0.007) L1 피각단백 발현 상태와 CIN 등급간 연관성은 확인 할 수 없었다. 결론: HPV ISH는 조직에서 HPV 감염 여부와 HPV 통합여부를 확인할 수 있는 좋은 검사법으로, CIN이 진행할수록 HPV 통합이 더 흔하게 관찰되었다. L1 capsid protein 염색법은 조직에서보다 세포 검체에 적합한 검사법이다. Objective: HPV in situ hybridization (ISH) is able to detect HPV DNA and identify integrated HPV DNA by punctuate staining and episomal HPV by diffuse staining in the nuclei. Because the expression of L1 capsid protein disappears after integration of HPV DNA, immunohistochemistry (IHC) of L1 capsid protein can be used as a indirect evidence of integration. Therefore, we tried to evaluate the usefulness of HPV ISH and IHC of L1 capsid protein in Cervical intraepithelial neoplasia (CIN). Methods: Twenty six cervical lesions from patients with CIN and 19 normal cervical epithelium from patients with leiomyoma were evaluated with HPV ISH and IHC of L1 capsid protein. Results: HPV ISH was positive in 80.8% (21/26) in CIN. Among 21 positive cases, diffuse staining was observed in 42.9% and punctuated and diffuse staining in 57.1%. L1 capsid protein was positive in 65.4% (17/26) of cervical tissue sections and 15.4% (4/26) of cervical smears. The punctuated staining of HPV ISH was correlated with high grade CIN (P=0.007) but expression of L1 capsid protein was not associated with grade of CIN (P>0.05). Conclusion: HPV ISH is a useful tool to identify integrated HPV DNA in paraffin-embedded, formalin-fixed cervical tissue. HPV integration confirmed by HPV ISH was associated with high-grade CIN. IHC of L1 capsid protein showed better result using cytology smears than tissue sections.
패혈증 마우스 모델에서 가와사키병의 관상동맥 병변 관찰: 예비연구와 문헌고찰
김주현 ( Joo-hyun Kim ),김효진 ( Hyo-jin Kim ),신정하 ( Jung-ha Shin ),최의윤 ( Ui-yoon Choi ),이수영 ( Soo-young Lee ),한지환 ( Ji-whan Han ) 대한소아감염학회 2017 Pediatric Infection and Vaccine Vol.24 No.2
목적: 가와사키병의 환아뿐만 아니라, 다른 전신 염증 질병의 환아들에 관상동맥 병변(coronary arterial lesion [CAL])의 발생이 보고되었다. 본 연구에서는 전형적인 전신염증반응증후군(systemic inflammatory response syndrome [SIRS])의 소견을 보이는 패혈증 마우스 모델에서 가와사키병 환아에게 관찰되는 CAL이 발생하는지 확인하고자 하였다. 방법: 생후 6주 C57BL/6 마우스에 내독소를 복강내주사하여 SIRS를 보이는 패혈증 모델을 유도하였다. 대조군과 패혈증군의 주요 장기의 조직학적 소견을 비교하였고 패혈증 마우스에서 CAL을 찾기 위한 시도를 하였다. 결과: 대조군과 비교하여, 염증세포의 침윤이 패혈증 마우스의 심장, 간, 신장에 상대적으로 증가하였다. 패혈증 마우스의 심장에서 심근(심근염)과 심장 주위 연조직에 림프구 침윤을 확인하였다. 또한, 패혈증 마우스의 관상동맥을 관찰하였지만, CAL을 확인할 수는 없었다. 결론: 본 연구에서 패혈증 마우스 모델에서 CAL의 존재를 확인하는 것은 실패하였다. 하지만, SIRS를 유발하는 많은 종류의 원인 질병에서 CAL이 발생한다는 것은 잘 알려져 있다. 가와사키병을 포함한 다양한 전신 염증 질병에 나타나는 CAL의 임상적 의미에 대한 연구가 필요할 것이다. Purpose: Coronary arterial lesions (CALs) were reported to have developed in children with systemic inflammatory diseases, as well as those with Kawasaki disease (KD). The purpose of this study was to confirm that the CAL development in children with KD occurs in a mouse model of sepsis presenting typical systemic inflammatory response syndrome (SIRS). Methods: To induce the sepsis mouse model with SIRS, 6-week-old C57BL/6 mice were intraperitoneally injected with endotoxin. We compared histological findings of the major organs between the control and the sepsis groups and examined CAL in the heart of the septic mice. Results: Infiltrating inflammatory cells were relatively increased in the heart, liver, and kidneys of the sepsis group, compared with those of the control group. We confirmed lymphocytic infiltration in the myocardium (myocarditis) and the pericardial soft tissue of the heart. Furthermore, coronary artery of the septic mouse was identified, but CAL was not observed. Conclusions: In this study, we failed to confirm the existence of CAL in a mouse model of sepsis. However, it is well-known that CALs are seen in many kinds of diseases that cause SIRS. Our findings suggest further investigation into the clinical significance of CAL in various systemic inflammatory diseases, including KD.
부신생물 증후군으로 인한 성인형 스틸병의 임상상을 보인 기관지폐포암
김현진 ( Hyun Jin Kim ),곽승기 ( Seung Ki Kwok ),신정하 ( Jung Ha Shin ),조철수 ( Chul Soo Cho ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.1
Adult-onset Still`s disease (AOSD) is a systemic inflammatory disorder with the characteristics of high spiking fever, evanescent salmon-colored skin rash, arthralgia or arthritis, lymphadenopathy, hepato-splenomegaly, sore throat, leukocytosis, negative autoantibody and hyperferritinemia. There are reports that rheumatic diseases such as dermatomyositis, polymyositis, hypertrophic osteoarthropathy, and polymyalgia rheumatica are associated with neoplasms. And small cell lung cancer, thymoma, lymphoma, leukemia, and breast cancer are known to be more associated with paraneoplastic syndromes mimicking rheumatic diseases. We experienced a case with bronchioloalveolar carcinoma who developed clinical manifestations of AOSD. Although there are several reports that AOSD is associated with paraneoplastic syndrome, to our knowledge, this is the first case of bronchioloalveolar carcinoma mimicking AOSD reported in the world.