Alteration of Bile Acid Transporter Expression in Patients with Early Cholestasis Following Living Donor Liver Transplantation

정은선,정은선,김병기,이연수,배시현,윤승규,최종영,박영민,김동구,김소윤 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.1

Background : Intrahepatic cholestasis can occur early after living donor liver transplantation (LDLT). We investigated the changes in the expressions of the bile acid transporters and the liver histology in the patients who suffered with early cholestasis (EC) following LDLT. Methods : The histological differences between 15 graft livers with EC after LDLT and 5 graft livers with biliary stricture following LDLT were evaluated. The hepatic mRNA levels of the bile canaliculi transporters (BSEP, MRP2, MRP3, MDR1, MDR3, NTCP) in 40 (20 graft livers, 20 matched donor livers) liver biopsy tissues were analyzed by performing real-time reverse-transcription polymerase chain reaction (RT-PCR). Results : Microscopic examination revealed hepatocellular and/or bile canalicular cholestasis around acinar zone 3 in the livers of the patients with EC. In the livers with biliary stricture, the cholestasis was dominantly observed in the hepatocytic cytoplasm and in the bile ductules around the portal area rather than around acinar zone 3. The BSEP and MRP2 mRNA levels in the EC livers were significantly reduced by 44% and 23%, respectively (p=0.000), compared to the matched donor livers. The levels of MDR3 and NTCP mRNA in the EC livers increased by 738% (p=0.000) and 281% (p<0.01), respectively. The change of the expressions of the bile acid transporters in the patients with biliary stricture was less significant than that in the EC group. Conclusions : These results suggest that the altered expressions of the bile acid transporters may play a role in the pathogenesis of EC following LDLT. Background : Intrahepatic cholestasis can occur early after living donor liver transplantation (LDLT). We investigated the changes in the expressions of the bile acid transporters and the liver histology in the patients who suffered with early cholestasis (EC) following LDLT. Methods : The histological differences between 15 graft livers with EC after LDLT and 5 graft livers with biliary stricture following LDLT were evaluated. The hepatic mRNA levels of the bile canaliculi transporters (BSEP, MRP2, MRP3, MDR1, MDR3, NTCP) in 40 (20 graft livers, 20 matched donor livers) liver biopsy tissues were analyzed by performing real-time reverse-transcription polymerase chain reaction (RT-PCR). Results : Microscopic examination revealed hepatocellular and/or bile canalicular cholestasis around acinar zone 3 in the livers of the patients with EC. In the livers with biliary stricture, the cholestasis was dominantly observed in the hepatocytic cytoplasm and in the bile ductules around the portal area rather than around acinar zone 3. The BSEP and MRP2 mRNA levels in the EC livers were significantly reduced by 44% and 23%, respectively (p=0.000), compared to the matched donor livers. The levels of MDR3 and NTCP mRNA in the EC livers increased by 738% (p=0.000) and 281% (p<0.01), respectively. The change of the expressions of the bile acid transporters in the patients with biliary stricture was less significant than that in the EC group. Conclusions : These results suggest that the altered expressions of the bile acid transporters may play a role in the pathogenesis of EC following LDLT.

청혈플러스로 호전된 이상지질혈증 환자 4례 보고

정은선,김현태,최고은,오정민,조현경,유호룡,김윤식,설인찬,Jung, Eun Sun,Kim, Hyun Tae,Choi, Koh Eun,Oh, Jeong Min,Cho, Hyun Kyoung,Yoo, Ho Ryong,Kim, Yoon Sik,Seol, In Chan 대한중풍순환신경학회 2016 대한중풍.순환신경학회지 Vol.17 No.1

Dyslipidemia is a major risk factor for cardiovascular accidents (CVA) and heart disease, especially the ischemic type. Lowering of serum low-density lipoprotein cholesterol (LDL-C) levels is a primary measure for preventing atherosclerosis. Many medications are available for the treatment of dyslipidemia; however, these drugs have some side effects. Therefore, we treated dyslipidemia patients with Chunghyul-plus. Before treatment, patients' levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), and LDL-C were measured on an empty stomach. Thereafter, patients were administered 1000 mg (2 capsules) of Chunghyul-plus two or three times a day for 2 weeks. After treatment with Chunghyul-plus, patients' serum triglyceride, LDL-C, and total cholesterol levels decreased. The results of this study suggest that Chunghyul-plus might be useful in the treatment of dyslipidemia.

잘못된 정답자와 합격의 기쁨

정은선 사회발전연구소 1996 한국인 Vol.15 No.2

대학생의 인지적 유연성과 대학생활 적응 및 우울의 관계: 진로미결정의 매개 효과 검증

정은선,하정희 한국청소년학회 2019 청소년학연구 Vol.26 No.6

The purpose of the study was to investigate the relations between cognitive flexibility, college students's adjustment, depression and the mediating role of career indecision in these relations. For this study, 460 college students were recruited. Results were as follows. First, cognitive flexibility was positively associated with college student's adjustment and negatively associated with depression. Second, career indecision was negatively associated with college adjustment and positively associated with depression. Third, career indecision was mediated the relation of cognitive flexibility_alternative with college students' adjustment and depression. But career indecision was not mediated the relation of cognitive flexibility_control with college students' adjustment and depression Finally, meaning and limitation of this research and implication to counseling strategies and intervention were discussed in detail. 본 연구는 대학생의 인지적 유연성이 대학생활적응과 우울에 어떠한 영향을 미치는가를 확인하고 이 과정에서 진로미결정이 매개역할을 하는지 살펴보고자 하였다. 이를 위하여 대학생 479명을 대상으로 설문을 실시하였고, 불성실한 응답을 한 19명을 제외하여 총460명의 자료를 분석하였다. 먼저 SPSS 21.0과 AMOS 18.0 프로그램을 이용하여 상관분석 및 구조모형 검증을 실시하였고, 매개효과 분석을 위해 부트스트랩(Bootstrap)을 실시하였다. 연구결과 첫째, 대안적 인지유연성과 통제적 인지유연성 모두 대학생활적응과 유의한 정적 상관을 보였고 우울과는 부적으로 관련됨을 확인하였다. 또한 통제적 인지유연성은 대학생활적응 및 우울과 모두 높은 상관을 보이는 것으로 나타났다. 둘째, 대안적 인지유연성은 대학생활적응에 직접적으로 영향을 미치는 동시에 진로미결정을 매개로 대학생활적응에 영향을 미치는 것으로 나타났다. 셋째, 통제적 인지유연성은 대학생활적응과 우울에 직접적인 영향을 미치기는 하지만 이 과정에서 진로미결정의 매개효과는 발견할 수 없었다. 본 연구 결과를 바탕으로 하여 인지적 유연성과 진로미결정이 대학생활적응 및 우울에 영향을 미치는 과정을 이해하고, 학교와 상담기관 같은 실무현장에서 대학생활부적응과 우울을 호소하는 내담자들을 도울 수 있는 방안에 대해 논의하였다.

장기간~Furosemide를 복용한 환자에서 신석회화를 동반한 급성 간질성 신염 1예

정은선,김용수,김영옥,천경아,윤선애,임국희,방병기,홍순화,박재명 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.6

Drug-induced acute interstitial nephritis is characterized by renal interstitial inflammatory cell infiltration and commonly presents as acute renal failure. This is caused mainly by methicillin, non-steroidal antiinflammatory drugs, sulfonamide diuretics such as thiazide, but cases induced by furosemide are rare. We report a patient with acute interstitial nephritis causing reversible acute renal failure and dermatitis while she was taking furosemide. A 37-year old woman was referred to our hospital because of generalized skin rash and non-oliguric acute renal failure. She had peripheral eosinophilia (1,577/mm3) and serum creatinine level of 6.8mg/dL. Skin biopsy showed leukoclastic vasculitis and percutaneous renal biopsy showed severe interstitial infiltration of lymph ocyte and mild interstitial fibrosis with focal tubular atrophy. After withdrawal of furosemide, renal function and skin lesions were completely recovered.

Chitosan-shelled glucose-responsive polymer vesicles for oral delivery of insulin

정은선,김경택,박치영,임영준 한국고분자학회 2013 한국고분자학회 학술대회 연구논문 초록집 Vol.2013 No.10

A colorimetric glucose sensors based on a hydrogel inverse opal containing benzoboroxole

정은선,김경택 한국고분자학회 2012 한국고분자학회 학술대회 연구논문 초록집 Vol.2012 No.10

Doubly-Responsive Polymersomes for Smart Insulin Delivery Vehicles under Physiological Conditions

정은선,임소령,김경택 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.10

공무원으로 의제되는 한국방송공사 ‘임원’의 의미와 범위 : 대법원 2009. 10. 29. 선고 2009도7569 판결을 중심으로

정은선 이화여자대학교 법학전문대학원 2011 Ewha Law Review Vol.1 No.1

The accused, former KBS vice-president and director, was indicted with the suspicion of bribery. The prosecutor regarded those positions as public officers. However, there is no substantive enactment on the scope of KBS executives in the Broadcasting Law. The accused was convicted guilty because the Supreme Court stretched the meaning of KBS executives when applying The Law on Aggravated Punishment of Specific Crimes enforcement ordinance Article 2 and 3. In addition, the Court said that this interpretation was not against the principle of “Nulla Poena Sine Lege.” The Court valued the request of justice above everything else. However, it is an invariable principle that the judge should reach a verdict in accordance with the law itself. In case that such statutory interpretation is impossible, making use of a systemic interpretation would be recommendable. Meaning and scope of KBS executives, regarded as public officials, are as follows: KBS executives should be registered according to The Act on the Special Cases concerning the Matters to be Filed in the Register of Corporation, etc. Article 1 and 2. However, KBS vice-presidents and directors are not subject to register. Therefore, it would be desirable to interpret that those positions are not included in the scope of executives. Hence, the jury should acquit the accused, because it is hard to admit the accused to the suspicion of bribery. 연예기획사 P사 대표 박모씨는 드라마 외주제작사 선정 및 제작비 결정과 관련하여 유리한 결정을 내려달라는 취지로 피고인에게 4천만원을 건네주었고, 이에 피고인은 수뢰죄로 기소되었다. 피고인이 역임한 한국방송공사의 부사장 및 본부장 직책이 수뢰죄의 구성요건인 공무원으로 의제되는 임원에 해당된다고 보았기 때문이다. 그런데 「방송법」에는 한국방송공사의 임원의 범위에 대한 명문의 규정이 없는 상태이다. 이에 대하여 대법원은 「특정범죄가중 처벌등에관한법률」 시행령 제2조 제45호, 제3조 제2호에서의 임원의 범위를 부사장 및 본부장으로 넓혀 해석하여 피고인에 대하여 유죄 취지로 판단하였다. 그리고 이와 같은 해석이 죄형법정주의에 위배되는 것은 아니라고 보았다. 아마도 대법원은 법 적용의 구체적 타당성이라는 정의의 요청을 보다 중시하였던 것으로 판단된다. 그렇지만 법관은 법률에 구속되어 판단을 내려야 함이 원칙이다. 그리고 명문의 규정이 없는 경우에는 관련규정에 대한 입법자의 의도를 고려하는 한편 관계법령에 대하여 문언의 통상적인 의미에 충실하게 해석하여야 하고, 문언해석이 어려울 경우에는 보충적으로 체계해석을 활용하여야 한다. 이러한 원칙에 따라 공무원으로 의제되는 한국방송공사 임원의 의미와 범위에 대하여 검토한 결과는 다음과 같다 : 한국방송공사의 임원이라면 「법인 등의 등기사항에 관한 특례법」 제1조 및 제2조의 규정에 의하여 등기를 하여야 한다. 그러나 부사장 및 본부장은 등기대상이 아니므로 「특정범죄가중처벌등에관한법률」 시행령 제2조 제45호, 제3조 제2호에서의 임원의 범위에 포함되지 않는다고 해석하는 것이 바람직하다. 게다가 부사장 및 본부장은 직원과 마 찬가지로 사장이 임명하므로 ‘직원’의 성격이 강하다고 볼 여지도 있다. 따라서 피고인에 대하 여는 수뢰죄를 인정하기 어려우므로, 무죄를 선고함이 상당하다.

Study on enhanced broadband light absorption in inverted organic photo voltaic devices by using plasmonic gold nanorods

정은선,진원용,고금진,장미,강재욱 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.10