세상을 바꾸는 덕성인

신정하 덕성여자대학교 1996 근맥 Vol.32 No.-

색소 모낭배아종 - 1예 보고 -

신정하,이교영,정지한,유진영,강석진 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.3

Trichogerminoma is a rare cutaneous adnexal tumor that dysplays differentiation toward the hair germ epithelium. This tumor was first described by Sau et al. in 1992 and it is characterized by densely packed round nests or cell balls resembling hair bulbs. Herein, we report on a deeply pigmented and sharply circumscribed nodular tumor that was excised on the abdomen of a 48-year-old woman. Histologically the tumor involved both dermis and subcutis without any epidermal connection. The main nodule was subdivided into the smaller lobules by fibrous stroma. The lobules were composed of masses of basaloid cells that displayed peripheral palisading. Within the lobules, the basaloid cells formed numerous cell balls. The tumor presented the characteristic features of trichogerminoma. Interestingly, our case was the pigmented type, which was remarkable by virtue of the heavy melanin deposits found within and around the tumor nests. To the best of our knowledge, this is the first case of pigmented trichogerminoma that has been reported worldwide.

단일 시술자 담도내시경을 통한 담석 치료

신정하,오치혁,동석호 대한소화기학회 2022 대한소화기학회지 Vol.80 No.4

ERCP is the standard treatment for common bile duct stones (CBD stones). On the other hand, in approximately 10% of patients with CBD stones, the complete removal of the stones cannot be achieved by conventional ERCP, which performs endoscopic sphincterotomy followed by stone extraction. Additional advanced and complex procedures are often necessary to remove these “difficult bile duct stones”, including endoscopic papillary large balloon dilatation or mechanical lithotripsy. Advances in cholangioscopy have made electrohydraulic or laser lithotripsy under direct endoscopic visualization possible during ERCP. Cholangioscopy-guided lithotripsy using the SpyGlass DS system could be a better treatment tool for removing difficult stones. The focus of this review was to describe single-operator cholangioscopy in the management of difficult CBD stones.

식도에 발생한 이소성 피지샘 - 1예 보고 -

신정하,정지한,최현주,유진영,강석진,이교영 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.6

There are few reports of the endoscopic and histological features of ectopic sebaceous glands in the esophagus. Recently we observed a 2 mm whitish flat elevated nodule in the lower esophagus. A biopsy was taken under the clinical impression of a papilloma or ulcer scar. Histology revealed normal esophageal mucosa with mature ectopic sebaceous glands located in the lamina propria with no visible hair follicles. We report this case with a brief review of the literature related to the histological findings and histogenesis of esophageal ectopic sebaceous glands.

독립된 질환군으로서의 C1q 신병증

신정하,김태은,이교영,심상인,최영진 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.4

Background : C1q nephropathy (C1qN) is a controversial diagnostic entity defined by Jennette and Hipp in 1985. The prevalence is very low and a few large scale studies have been reported. Application of the criteria for clinical diagnostics of C1qN may cause confusion with other glomerulonephropathies, such as minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). In order to clarify the confusion with glomerulonephropathies, we did this study to identify the clinicopathological characteristics and the exact disease entity of C1qN. Methods : A total of 5,258 kidney biopsies at Kangnam St Mary’s Hospital were reviewed. Twenty three cases (0.44%) met the criteria of C1qN. Twenty eight cases showing dominant C1q deposits without electron dense depostis (EDD) grouped as C1q+EDD-, and previously diagnosed typical cases of MCD and FSGS were selected for this study. Four groups were compared to each other with regard to the clinical and pathological aspects of the disease. Results : C1qN patients had an average age of 30.4 years. Eighteen were males and 5 were females. Eighty seven percent had proteinuria and 18% had hematuria. By electron microscopy analysis, 100% had mesangial EDD and 47.8% showed foot process effacement. C1qN had some significant differences compared with C1q+EDD-, MCD and FSGS. Conclusions : C1qN is clinically and morphologically different from MCD and FSGS. However, additional long term studies are needed to fully define C1qN from other glomerulonephritis with C1q deposits. Background : C1q nephropathy (C1qN) is a controversial diagnostic entity defined by Jennette and Hipp in 1985. The prevalence is very low and a few large scale studies have been reported. Application of the criteria for clinical diagnostics of C1qN may cause confusion with other glomerulonephropathies, such as minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). In order to clarify the confusion with glomerulonephropathies, we did this study to identify the clinicopathological characteristics and the exact disease entity of C1qN. Methods : A total of 5,258 kidney biopsies at Kangnam St Mary’s Hospital were reviewed. Twenty three cases (0.44%) met the criteria of C1qN. Twenty eight cases showing dominant C1q deposits without electron dense depostis (EDD) grouped as C1q+EDD-, and previously diagnosed typical cases of MCD and FSGS were selected for this study. Four groups were compared to each other with regard to the clinical and pathological aspects of the disease. Results : C1qN patients had an average age of 30.4 years. Eighteen were males and 5 were females. Eighty seven percent had proteinuria and 18% had hematuria. By electron microscopy analysis, 100% had mesangial EDD and 47.8% showed foot process effacement. C1qN had some significant differences compared with C1q+EDD-, MCD and FSGS. Conclusions : C1qN is clinically and morphologically different from MCD and FSGS. However, additional long term studies are needed to fully define C1qN from other glomerulonephritis with C1q deposits.

Poor Outcome to Pembrolizumab in Lung Adenocarcinoma with High PD-L1 and STK11/KRAS co-mutations

신정하,이정미,손경희,곽원건,황재준,강성욱,장복순,최혜숙,김이형,최천웅,박명재,이승현 대한내과학회 2020 대한내과학회 추계학술대회 Vol.2020 No.1

英國王立新聞委員會

辛定夏 관훈클럽 1966 관훈저널 Vol.- No.11

정신장애인을 위한 동료지원가 직업 영역 개발 연구

신정하,신운재,이명수 서울시정신보건센터 2013 정신건강연구집 Vol.4 No.-

■ Objective:The purpose of this study is to explore the possibilities and effectiveness of Peer Support Program(PSP) for building up the evidence of new vocational rehabilitation territory for mentally disabled people. ■ Methods : From September to December in 2013, pre- and post-evaluation was conducted to the PSP providers, PSP users and mental health practitioners of project-participating mental health agencies. Wilcoxon Matched-Paris Signed-Ranks Test was performed for statistical analysis. ■ Results : There were no definite statistically significant results, however the subjective responses of PSP providers and users were promising. They reported positive emotional experiences while providing and receiving PSP which could make positive influences for their recovery. ■ Conclusion : PSP could be a promising strategy to expand vocational rehabilitation territory and also contribute to the recovery of people with mentally disabled. ■ 연구목적:동료지원가가 정신장애인의 직무로 가능할 것인지 탐색하고 동료지원서비스의 효과성을 분석하여 정신장애인 동료지 원가 직무영역 개발의 근거를 마련하고자 하였다. ■ 연구방법:동료지원가, 동료지원서비스 이용자, 동료지원가 고용 기관 실무자를 대상으로 2013년 9월 부터 12월까지 사전-사후 평가 및 설문조사를 실시하였다. 효과성 분석을 위해 윌콕슨의 순위검증(Wilcoxon Matched-Paris Signed-Ranks Test)을 수행하였다. ■ 연구결과:동료지원서비스의 효과성은 통계적으로 유의미하게 나타나지 않았지만 설문조사를 통해 동료지원가와 동료지원서비스 이용자들의 회복에 긍정적 영향을 미치는 것으로 나타났다. ■ 결 론:동료지원가는 동료지원서비스의 장점을 살린 정신장애인의 새로운 직무로 앞으로 확산 및 보급이 필요하며, 이를 위 해 다양한 노력과 지원이 요구된다.

호텔관리자의 리더십과 조직문화가 직무태도에 미치는 영향

신정하,김지은 한국호텔관광학회 2008 호텔관광연구 Vol.10 No.4

This study was conducted to examine the impact of leadership and organizational culture on employee attitude such as organizational commitment and job satisfaction. The studies on the holistic impact of leadership and organizational culture on employee attitude are not supported sufficiently although there are plenty of studies regarding leadership and organizational cultural tautologies. The actual results of this study as follows: Firstly transformational leadership and traditional leadership have a significant impact on employee attitude. Secondly, transformational leadership has more impact on employee attitude than traditional leadership. Finally, organizational culture in hotel has a significant impact on employee attitude. Especially developmental culture has a strongest impact on employee attitude. This study suggests that organizational and leader traits work as important factors to constitute hotel employees' job satisfaction and organizational commitment. Therefore, hotel organizations need to develop positive organizational culture and effective leadership style depending on the employees' needs and situational backgrounds.

호텔-고객 상호관계적 브랜드 자산에 따른 호텔 브랜드 태도 및 이용 충성도에 관한 연구

신정하 한국호텔관광학회 2010 호텔관광연구 Vol.12 No.3

This study investigated any relationships among hotel-customer brand equity, hotel satisfaction, hotel brand loyalty, and hotel loyalty. It was interesting that Customers' perception of hotel brand equity, particularly regarding the hotel-customer relationships, could influence hotel and brand evaluation and then in turn customer's intention-to-behavior toward hotel. Based on the literature review and experiences from the hotel industry, the theoretical background of study model was discussed and provided detailed information in literature section. Then, the study model was developed and research hypotheses were proposed. A total of 222 useful sample were collected from hotels in Seoul by using while face-to-face method. In order to test the proposed research hypotheses, frequence, factor analysis, multiple regression were performed. From the factor analysis, five dimensions of hotel-customer brand equity were identify and these are personnel brand equity, hotel-customer relationship brand, hotel employee attitude and appearance, hotel employee-customer relationship brand, differentiated superior hotel brand. Series multiple regression analysis showed that these hotel-customer relationship brand equity affect hotel satisfaction, hotel perceived brand loyalty, and loyalty. In particular, hotel-customer relationship brand and differentiated superior hotel brand mostly affect customer brand evaluation. More detailed discussion and implication were provided in the conclusion section.