마음챙김에 기반한 인지치료(MBCT) 프로그램이 문제음주 대학생의 우울, 충동성 및 문제음주 행동에 미치는 효과

신정연,손정락 한국건강심리학회 2011 한국심리학회지 건강 Vol.16 No.2

The purpose of the this study was to explore the effects of the Mindfulness-Based Cognitive Therapy(MBCT) Program on depression, impulsivity, and problem drinking behavior of the college students with Problem Drinking. The Korean Version of Alcohol Use Disorders Identification Test(AUDIT-K), Problem Drinking Screening Test(PDST), Center for Epidemiologic Studies Depression Scale(CES-D), and Barratt Impulsiveness Scale(BIS) were used for screening in pre-test. 30 people who satisfies the problem drinking level(AUDIT-K over 12 point, PDST over 3 point) and experiences depression participated in this study. They got a relatively high score in CES-D and BIS. Then, 30 people were randomly assigned to a 10 weeks MBCT program group(n=15) or control group(n=15). The MBCT program for 9 people was administered for 10 sessions. Depression, impulsivity, and problem drinking were assessed at pre-test, post-test, 1-month follow-up, and 2-month follow-up periods. The results of this study were that scores of depression, impulsivity, and problem drinking in the MBCT program group were significantly decreased more than those in the control group. Finally, the implications and limitations of this study as well as suggestions for further research were discussed. 본 연구는 마음챙김에 기반한 인지치료(MBCT) 프로그램이 문제음주 대학생의 우울, 충동성 및 문제음주 행동에 미치는 효과를 알아보았다. 사전 조사에서 전북 지역 소재 대학에 재학 중인 학생 523명을 대상으로 알코올 사용 장애 척도-한국판, 문제음주 선별 검사, 한국판 역학연구센터 우울척도 및 Barratt 충동성 척도를 실시하였다. 그 중 문제음주 수준(알코올 사용 장애 척도-한국판 12점 이상, 문제음주 선별 검사 3점 이상)을 충족시키고, 우울감을 경험하는 30명이 본 연구에 참가하여 MBCT 프로그램 집단(15명)과 대기-통제집단(15명)으로 무선할당 되었다. MBCT 프로그램은 2개월 간 10회기 실시되었고, 각 회기는 80~100분의 시간이 소요되었다. MBCT 프로그램의 추적기간까지 총 10명(MBCT 프로그램 집단 6명, 대기-통제집단 4명)이 중도탈락 되었다. 우울, 충동성 및 문제음주 행동 정도는 사전, 사후, 1개월 추적 및 2개월 추적 기간 동안 검사를 통하여 총 20명의 참가자(MBCT 프로그램 집단 9명, 대기-통제집단 11명)에 대한 평가가 이루어졌다. 본 연구의 결과 MBCT 프로그램 집단이 대기-통제집단보다 우울, 충동성 수준이 유의하게 더 감소하였고, 문제음주 행동 수준은 유의하게 더 개선되었으며, 그 수준은 추적검사까지 유지되었다. 마지막으로 본 연구의 의의와 제한점 및 추후 연구를 위한 시사점이 논의되었다.

소집단 과제분석 훈련을 통한 수학과 학력향상 방안의 효과

신정연 충북대학교 과학교육연구소 1985 과학교육연구논총 Vol.4 No.1

섬애약쑥 추출물의 첨가 비율에 따른 식혜의 품질특성

신정연,우연우,조유림,서원택,최진상 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.2

This study was conducted to increase the functionality of Korean traditional beverage, Sikhye. The Sikhye were prepared by supplementation up to 20% of Seomaeyaksuk extract (SE) and saccharification for five hours (h). During the saccharification, turbidity of SE-added Sikhye (SES) was the highest at two hours of saccharification and then lowered gradually. L vlaue of SES did not show significant difference feduring saccharification, and both a and b value of Sikhye were increased as saccharification time passed and SE addition ratio was increased. The pH before saccharification was not significantly different by SE addition ratio but it was increased to 5.68-5.73 at 5 h saccharification. Soluble solid, total sugar and reducing sugar contents were enhanced as saccharification time and SE addition ratio were increased. The total phenolic compounds contents and DPPH radical scavenging activity showed a similar trend by saccharification time and SE addition. In sensory test, the evaluations of 5% SES and control were not significant different, but 20% SES group showed significant lower evaluation than other groups because strong color and mugwort flavor. From all of these results, physicochemical characteristics and antioxidant activity of SES was improved by SE addition but sensory characteristics was lower. Acceptable addition ratio of SE in Sikhye is determined to be within 15%.

MSG 첨가 비율을 달리한 섬애약쑥(Artemisia argyi H) 식혜의 유산균 발효에 따른 이화학적 특성

신정연,신정혜,강민정,최명효,박희린,최진상,배원열,서원택 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.2

For the production of γ-aminobutyric acid (GABA) contents increased Seomaeyaksuk fermentant, 0, 0.25, 0.5 and 1.0% of monosodium galutamate (MSG) was added in Seomaeyaksuk water extract 15% contained Sikhye and inoculated with Lactobacillus brevis (KI271266). Physicochemical properties were sampling and analyzed at each 1 day during 3 days fermentation. Goes on fermentation periods, the turbidity was gradually reduced, but lightness and the yellowness was increased, redness was decreased. Soluble solid was also decreased. The reducing sugars content were also decreased during fermentation. pH was 4.65-4.83 before fermentation but it was lower 3.15-3.68 after three days fermentation. The GABA contents increased by fermentation periods and it was the highest in MSG 1.0% added sample (354.38 mg/L). Fructose, glucose and sucrose contents were 50-67% decreased at three days fermentation than before fermentation. Among the organic acids, propionic acid, oxalic acid, citric acid and fumaric acid contents were decreased and lactic acid, acetic acid and succinic acid were increased during fermentation periods. Contents of total polyphenol and DPPH radical scavenging activity were the highest in MSG 0.5% added sample. From these results, we confirmed that increasing of GABA content when the manufacturing of Seomaeyaksuk lactic acid fermentation product, is possibile by addition of MSG without affecting physicochemical characteristics.

섬애약쑥 식초가 고지방-고콜레스테롤 급이 흰쥐의 체내 지질대사에 미치는 영향

신정연(Jeong Yeon Shin),강재란(Jae Ran Kang),신정혜(Jung Hye Shin),서원택(Weon Taek Seo),변희욱(Hee Uk Byun),최진상(Jin Sang Choi),강민정(Min Jung Kang) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.7

섬애약쑥 가공품 개발 및 그 활성 규명을 위한 연구의 일환으로 섬애약쑥 물 추출물을 이용하여 식혜를 제조해 당화시킨 후 알코올 발효와 초산발효를 차례로 거쳐 식초를 완성하였다. 고지방-고콜레스테롤 식이를 제공한 흰쥐에 섬애약쑥 식초를 경구 투여하여 체내 지질대사에 미치는 영향을 분석하였다. 실험군은 일반식이를 급이한 정상군(N), 고지방-고콜레스테롤 식이를 급이한 대조군(C), 대조군 식이 급이 후 콜레스테롤 치료 약물인 lovastatin을 20 ㎎/㎏ B.W. 투여한 양성대조군(PC), 섬애약쑥 추출물 대신에 물을 첨가하여 동일하게 제조한 맥아식초(TM)와 섬애약쑥 식초(TS)를 체중 ㎏당 2 mL씩 경구 투여한 군으로 나누었다. 4주간의 실험식이 급이 후 혈청 내 총 지질과 총 콜레스테롤 함량은 식초 급이군이 양성대조군보다 유의적으로 낮았으나 중성지질은 양성대조군과는 유의적인 차이가 없었고 대조군보다는 유의적으로 낮았다. HDL-콜레스테롤은 식초 급이군과 양성대조군 간에 유의적인 차이 없이 정상군보다 낮았으나 대조군보다는 유의적으로 높았다. LDL-콜레스테롤은 섬애약쑥 식초 급이군에서 190.68 ㎎/dL로 정상군을 제외한 실험군 중 가장 낮은 함량이었고 동맥경화지수와 심혈관계 질환 위험지수도 동일한 경향이었다. 혈청 총 단백질과 알부민 함량은 맥아식초와 섬애약쑥 식초 급이군이 대조군이나 양성대조군보다 유의적으로 낮았다. 간 손상 지표가 되는 AST는 정상군과 식초 급이군 간에 차이가 없었다. 섬애약쑥 식초의 급이는 간장 내 지질 농도 개선에도 효과가 있어 간장 내 총 지질, 총 콜레스테롤 및 중성지질의 농도를 대조군보다 유의하게 감소시켰다. 혈청 내 지질과산화물의 함량은 섬애약쑥 식초 급이군에서 정상군과 유사한 수준으로 감소하였으며, 간 조직에서는 대조군보다는 낮았으나 정상군보다는 유의적으로 높은 함량이었다. 이러한 결과는 DPPH를 이용한 항산화 활성 평가에서도 유사한 경향으로 섬애약쑥 식초 급이군 혈청의 항산화 활성이 55.69%로 정상군과 유의차가 없었으며, 간 조직의 활성은 52.39%로 대조군과 유의적인 차이가 없었다. 이상의 결과로부터 섬애약쑥 식초는 혈중 지질 농도를 개선하는 효과가 있음을 확인하였으며, 이는 식초 자체의 활성과 자체에 함유되어 있던 유효성분 및 발효과정에서 새로이 생성된 성분들이 복합적으로 작용한 결과로 판단된다. The effects of orally administered Seomaeyakssuk (Artemisia argyi H.) vinegar on lipid metabolism in Sprague-Dawley rats fed a high-fat and high-cholesterol (HFC) diet were analyzed. The experimental animals were divided into five groups: a normal diet group (normal, N), HFC diet group (control, C), HFC diet with lovastatin at 20 ㎎/㎏ body weight (B.W.) group (positive control, PC), HFC diet with malt vinegar group (TM), and HFC diet with Seomaeyaksuk vinegar group (TS) (2 mL/㎏ B.W.). After 4 weeks of feeding rats the experimental diet, contents of serum total lipids and total cholesterol levels of TM and TS groups were significantly lower than those of the PC group. Triglyceride contents of the TM and TS groups were not significantly different from those of the PC group but significantly lower than those of the C group. Content of serum high density lipoprotein-cholesterol was significantly lower than that of the N group but higher than that of the C group. Low density lipoprotein-cholesterol content of serum was 190.68 ㎎/dL in the TS group, which was the lowest except for the N group. Aspartate transaminase and albumin transaminase activities as a measurement of liver damage index were not significantly different between the TM, TS, and C groups. Serum thiobarbituric acid reactive substance content of the TS group was reduced to a similar level as the N group but was lower than that of the C group in the liver and significantly higher than that of the N group. Antioxidant activity of the TS group was 55.69% in serum, which was a similar to that of the N group, and was 52.39% in the liver, which was not significantly different than that of the C group. From these results, we conclude that Seomaeyakssuk vinegar improves serum lipid content as a result of the complex action of vinegar, an active ingredient of Seomaeyakssuk and a product of the fermentation process.

섬애약쑥 주정 추출물의 첨가 농도에 따른 발효식초의 품질 특성

신정연(Jeong Yeon Shin),강민정(Min Jung Kang),강재란(Jae Ran Kang),최진상(Jin Sang Choi),서원택(Weon Teak Seo),신정혜(Jung Hye Shin) 한국식품저장유통학회 2020 한국식품저장유통학회지 Vol.27 No.2

3단계 연속 발효법으로 제조한 섬애약쑥 식초의 품질 특성

신정연(Jeong Yeon Shin),신지현(Ji Hyeon Shin),강민정(Min Jung Kang),강재란(Jae Ran Kang),최진상(Jin Sang Choi),서원택(Weon Teak Seo),신정혜(Jung Hye Shin) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.1

섬애약쑥 추출물을 이용하여 식초를 제조함에 있어 γ-aminobutyric acid(GABA)의 함량을 증대시킬 수 있는 발효조건을 확립하고자 섬애약쑥 추출물을 첨가하여 제조한 식혜를 발효원으로 하고, MSG를 첨가하여 유산균 발효, 알코올 발효 및 초산 발효를 차례로 진행하여 식초를 제조하였다. 섬애약쑥 물 추출물이 15% 첨가된 쑥 식혜에 MSG를 0, 0.25, 0.5 및 1.0% 첨가하고, 김치로부터 분리 동정한 GABA 함량 증대 효과가 있는 유산균인 Lactobacillus brevis(KI271266)를 접종하여 3일간 발효하였다. MSG의 첨가 농도가 높을수록 GABA의 함량도 높았으며, 발효기간이 경과할수록 그 함량도 증가하여 3일간의 발효 완료 후 MSG 1.0% 첨가군에서는 354.38 mg/L로 가장 높은 함량이었다. 유산균 발효물에 종 배양한 Saccharomyces cerevisiae를 5% 접종하여 6일간 정치배양 하였으며, 알코올 발효 후 초산균을 접종하여 20일간 정치발효 시키면서 4일 간격으로 시료를 취하여 이화학적 특성 변화를 분석하였다. 초산 발효 동안 pH는 점차 감소하여 발효 20일 후에 2.61~3.26의 범위였고, 이와 상반되게 산도는 점차 증가하여 4.88~6.17%였다. 유기산은 총 7종이 검출되었는데 acetic acid의 함량이 가장 큰 폭으로 증가하였고, 다음으로 succinic acid가 함량도 높고 발효기간 동안 증가율도 높았다. 초산 발효 동안 GABA 함량은 점차 감소하는 경향이었는데, 발효 20일에 MSG 무첨가군보다 0.25% 첨가군에서는 약 6.5배, 1.0% 첨가군에서는 약 14배 더 높은 함량이었다. 발효 완료된 식초의 총 페놀화합물 함량은 MSG 0~0.5% 첨가군보다 1.0% 첨가군에서 더 높았으며, 이들 시료에서 DPPH 라디칼 소거활성도 더 높았다. 이상의 결과로 보아 3단계 연속발효를 거쳐 GABA 함량이 높은 섬애약쑥 식초를 제조할 수 있었으며, 이러한 과정을 거쳐 제조된 식초는 식초 자체의 활성, 쑥 자체에 함유되어 있던 유효성분 및 발효 과정에서 새로이 생성된 성분들이 복합적으로 작용하여 생리활성이 더 우수할 것으로 기대된다. This study was conducted to develop fermented foods using Artemisia argyi H. (seomaeyaksuk) and identify its activity. Vinegar was completed through a three-step fermentation process (lactic acid fermentation, alcoholic fermentation, and acetic acid fermentation). A sikhye added with 15% seomaeyaksuk water extract was used as the fermentation substance. Each sikhye was added with 0, 0.25, 0.5, and 1.0% monosodium glutamic acid (MSG) to enhance γ-aminobutyric acid (GABA) content and then fermented at 30°C for 3 days with Lactobacillus brevis (KI271266). GABA content increased with fermentation period and was the highest in the MSG 1.0%-added sample (354.38 mg/L). Saccharomyces cerevisiae starter was inoculated for alcohol fermentation and analyzed at 0, 2, 4, and 6 days. During alcohol fermentation, alcohol content was 1.75∼5.35% at 2 days, and was the highest in the 0.25% MSG-added group. After 6 days of alcohol fermentation, Acetobacter pasteurianus A8 was inoculated for acetic acid fermentation for 20 days. Samples were taken at 4-day intervals. pH level decreased while acid content gradually increased during fermentation. Seven kinds of organic acids were detected, and acetic acid content was most abundant. GABA contents were higher 6.5- and 14-fold higher in the MSG 0.25%- and 1.0%-added samples, respectively, compared to the non-MSG sample. After completion of acetic acid fermentation, the total polyphenol content of vinegar was higher in the MSG 1.0%-added sample compared to the 0∼0.5% MSG-added samples. 1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity was also higher in the 1.0% MSG-added sample than others. Based of these results, we confirmed that the addition of MSG enhanced GABA contents and antioxidant activity as a result of the complex action of vinegar itself, the active ingredient of seomaeyaksuk, and new products of the fermentation process.

[응용논문] IT 융합 환경에서의 모바일 장비를 이용한 생산관리 시스템

신정독(Jaden Shin),김희식(Hie-Sik Kim),원서연(Seo-Yeon Won),주재홍(Jae Hong Joo) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.IT융합 No.-

Results of Colorectal Cancer Screening of the National Cancer Screening Program in Korea, 2008

신정임,김연주,한미아,이후연,최귀선,전재관,박은철 대한암학회 2010 Cancer Research and Treatment Vol.42 No.4

Purpose This study aims to investigate the current situation of national colorectal cancer screening by analyzing participation rates, positive rates of screening methods and screening rate of secondary screening tests in colorectal screening of the national cancer screening program in 2008. Materials and Methods With database about target population and screened individuals of the national cancer screening program, the results of target population and participants of colorectal cancer screening in 2008 were analyzed. Among adults aged over 50 years of medical aid and beneficiaries of national health insurance paying lower 50% premiums in the total subscribers, 4,640,365 were target population of colorectal cancer screening and the data of 984,915undergoing fecal occult blood test (FOBT) as a primary screening were analyzed. Results The colorectal cancer screening rate was 21.2%and the rates of national health insurance subscribers, females and the elderly aged 60-64 years were higher than those of others. The recipients with a positive result in FOBT recorded approximately 7.5%. Medical aid beneficiaries (7.9%), males (8.8%) and seniors aged over 75 years (9.1%) showed higher positive rates than the average one. Out of the FOBT positive recipients, 43.0%took a secondary screening and the rate undergoing colonoscopy (31.4%) was higher than that of doing doublecontrast barium enema test (11.6%). Conclusion Colorectal cancer screening rate of medical aid beneficiaries and people paying lower 50% premiums among national health insurance subscribers, was different according to demographic characters (gender, age and types of health insurance). This finding meant that screening for the vulnerable needed to be encouraged by considering socio-demographic characters. Additionally, more efforts were necessary to increase the secondary screening rate of people with a positive result in primary one.

미숙아 동맥관 개존 치료에서 indomethacin과 ibuprofen의 효과

최욱선,신정연,최병민,은백린,유기환,홍영숙,이주원 대한소아청소년과학회 2006 Clinical and Experimental Pediatrics (CEP) Vol.49 No.12

Purpose : This study was conducted to compare the efficacy and safety of ibuprofen and indomethacin in the treatment of patent ductus arteriosus (PDA) in preterm infants and to determine whether ibuprofen can be an alternative drug. Methods : A total of 32 preterm infants with symptomatic PDA were enrolled in the study. Twelve infants received intravenous ibuprofen 10 mg/kg, followed by 5 mg/kg after 24 and 48 hours. As a comparative group, twenty premature infants received three doses of indomethacin 0.1-0.2 mg/kg every 12 hours. Results : PDA was closed in 11 of 12 infants of the ibuprofen group (92 percent) and in 18 of 20 infants of the indomethacin group (90 percent). Serum sodium concentration decreased along with time significantly (P<0.0001) and to its lowest level at 48 hours after administration of the third dose (P=0.0011) in both groups, but showed no significant difference between two groups. Serum BUN and creatinine concentrations were not changed significantly before or after treatment in each group and showed no difference between thetwo groups. The amount of urine output did not change along with time significantly in both groups (P=0.0725), and showed no significant difference between two groups. Conclusion : Ibuprofen has similar effects to indomethacin in the rate of PDA closure and complication when compared. It has similar changes in serum sodium level and complications when compared to indomethacin for the treatment of PDA in preterm infants. Therefore, intravenous ibuprofen may be used as an alternative agent in the treatment of symptomatic PDA in preterm infants. Purpose : This study was conducted to compare the efficacy and safety of ibuprofen and indomethacin in the treatment of patent ductus arteriosus (PDA) in preterm infants and to determine whether ibuprofen can be an alternative drug. Methods : A total of 32 preterm infants with symptomatic PDA were enrolled in the study. Twelve infants received intravenous ibuprofen 10 mg/kg, followed by 5 mg/kg after 24 and 48 hours. As a comparative group, twenty premature infants received three doses of indomethacin 0.1-0.2 mg/kg every 12 hours. Results : PDA was closed in 11 of 12 infants of the ibuprofen group (92 percent) and in 18 of 20 infants of the indomethacin group (90 percent). Serum sodium concentration decreased along with time significantly (P<0.0001) and to its lowest level at 48 hours after administration of the third dose (P=0.0011) in both groups, but showed no significant difference between two groups. Serum BUN and creatinine concentrations were not changed significantly before or after treatment in each group and showed no difference between thetwo groups. The amount of urine output did not change along with time significantly in both groups (P=0.0725), and showed no significant difference between two groups. Conclusion : Ibuprofen has similar effects to indomethacin in the rate of PDA closure and complication when compared. It has similar changes in serum sodium level and complications when compared to indomethacin for the treatment of PDA in preterm infants. Therefore, intravenous ibuprofen may be used as an alternative agent in the treatment of symptomatic PDA in preterm infants.