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국소진행성 비소세포폐암 환자에서 weekly paclitaxel을 이용한 화학 방사선 동시요법의 효과
배성화 ( Sung Hwa Bae ),김경찬 ( Kyung Chan Kim ),이선아 ( Sun Ah Lee ),김소연 ( So Yeon Kim ),류헌모 ( Hun Mo Ryoo ),현대성 ( Dae Sung Hyun ),이상채 ( Sang Chae Lee ),예지원 ( Ji Won Yei ),배종엽 ( Jong Yup Bae ),정경재 ( Kyung J 대한내과학회 2005 대한내과학회지 Vol.69 No.4
목적 : 절제 불가능한 국소진행성 비소세포폐암 환자에서 paclitaxel을 이용한 화학 방사선 동시요법의 효과를 조사하기 위해 본 연구를 시행하였다. 방법 : 화학 방사선 동시요법 기간동안 paclitaxel을 매주 60㎎/㎡의 용량으로 1시간 동안 정맥으로 투여하였다. 방사선치료는 일일 1회 1.8Gy 분할량으로 주 5회 조사하였으며, 총 63Gy까지 조사하였다. 동시치료 이후 4주기의 paclitaxel/carboplatin 복합화학요법을 시행하였다. 결과 : 28명의 환자가 등록되었고, 남자가 25명, 여자가 3명이었고, 나이의 중앙값은 60세(범위: 41~73세)였다. 19명의 환자에서 계획된 화학 방사선 동시치료를 마쳤다. 완전관해는 5명, 부분관해는 15명으로 전체 관해율은 71.4%이었고, 7명의 환자에서 3도 이상의 폐렴이 발생하였는데 이 중 3명이 치료 관련 사망하였다. 중앙 생존기간은 17.5개월(95% 신뢰구간 12.5~22.5개월)이었고 무진행 생존기간의 중앙값은 8.0개월(95% 신뢰구간 4.1~11.9개월)이었다. 결론 : 국소진행성 비소세포폐암에서 paclitaxel을 포함한 화학 방사선 동시치료는 효과적이지만 폐의 부작용이 문제가 되며 환자 대상 선택과 추적에 주의를 요한다. Background : Combined modality therapy is standard treatment of unresectable, locally advanced stage III non-small cell lung cancer (NSCLC). However, the optimal chemotherapy regimen and duration of chemotherapy remain a matter of debate. We evaluated the efficacy and feasibility of concurrent chemoradiation therapy (CCRT) in patients with locally advanced NSCLC. Methods : PS 0-2 patients with histologically proven inoperable stage III NSCLC were eligible for this trial. The patients received paclitaxel (60㎎/㎡) on days 1, 8, 15, 22, 29, 36 with a concurrent radiotherapy (5days/week, 1.8Gy/day) starting day 1 with a total dose of 63 Gy. After CCRT, four cycles of consolidation chemotherapy with paclitaxel (140㎎/㎡) and carboplatin (AUC 5) was administered to patients with a partial, complete remission or stable disease. Results : Twenty eight patients with locally advanced NSCLC enrolled in this study. The median age of the patients was 60 years. Of the 28 patients, 19 received scheduled CCRT. Overall response rate was 71.4% including 5 complete responses and 15 partial responses. Grade 3 or 4 pulmonary complication was observed in 7 patients and 3 patients died of pneumonitis. The median overall survival was 17.5 months (95% CI, 12.5-22.5). The median progression free survival was 8.0 months (95% CI, 4.1-11.9). Conclusions : CCRT including paclitaxel in patients with locally advanced NSCLC led to an encouraging response rate and survival, but resulted in high incidence of severe pulmonary complication.(Korean J Med 69:379-386, 2005)
B형 간염 바이러스 감염과 동반된 비장의 원발성 악성 림프종 2예
배성화 ( Sung Hwa Bae ),박성훈 ( Sung Hoon Park ),류헌모 ( Hun Mo Ryoo ),김호각 ( Ho Gak Kim ),조창호 ( Chang Ho Cho ),이재련 ( Jae Lyun Lee ),이경희 ( Kyung Hee Lee ),현명수 ( Myung Soo Hyun ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.6
The incidence of primary splenic lymphoma is less than 1% of all non-Hodgkin`s lymphoma. Lymphotrophism of hepatitis C virus may play a important role in the development of primary splenic lymphoma. However, there is no report about primary splenic lymphoma associated with hepatitis B virus infection. We present two cases of primary splenic lymphoma associated with hepatitis B virus infection. They suffered from left upper quadrant abdominal pain and underwent diagnostic splenectomy. In case 1, the spleenhada10×10×9 cm lobulated tumor mass that replaced the splenic parenchyma. In case 2, the spleen contained two lobulated macronodular white tumors, measuring 3×2 cm and 2×2 cm. Splenic tumors were confirmed pathologically to be intermediate and high grade of B cell lymphoma. The patients received combination chemotherapy with CHOP. They are still alive without recurrence 23 months and 15 months after splenectomy. (Korean J Gastroenterol 2003;41:519-522)
항공사 서비스 인카운터 종사자의자기오락화 능력과 커뮤니케이션 상호작용 능력, 서비스수행간의 구조적 관계 연구
배성화 ( Seong Hwa Bae ),문상정 ( Sang Jeong Moon ) 한국관광산업학회 2014 Tourism Research Vol.39 No.1
The purpose of this study was to examine the relationships among the SAE(self-as-entertainment) capacity, communication interaction competence, and service performance. Additionally, it was intended to identify the applicability and effectiveness of the SAE construct for the field of service organizational behavior. A total of 320 questionnaires were distributed to the service encounter employees who work at the airport in five metropolitan areas nationwide S. KOREA for the subjects and the samples for this study. Out of 320 questionnaires, 282 questionnaires were collected in this study. All three hypotheses and a structural research model were set. The result of the analysis from utilizing SPSS Ver 21.0 and AMOS Ver 18.0 programs are as follow: Firstly, the mind-play and environment-modes of one``s self-as entertainment capacity had a positive influence on their communication interaction capabilities. Second, the environment-mode of one``s self-as entertainment capacity has a positive influence on one``s service performance. Third, the communication interaction competence had a positive influence on the service performance. This research has academic significance in point of analysis theoretical structure based on communication interaction competence and service performance as result variable of elf-as entertainment capacity recognized by Airline Service Encounter Employees.
Al-Mg합금의 컬러에 미치는 양극산화 및 착색처리의 영향
배성화,이현우,손인준,Bae, Sung Hwa,Lee, Hyun Woo,Son, Injoon 한국표면공학회 2019 한국표면공학회지 Vol.52 No.1
In this study, we investigated the effects of anodizing time, dyeing treatment time, and variations in coloring concentration on the color of an AA5052 alloy processed by dye-treated anodizing. The outward color of the anodized film changed to deep red according to increases in anodizing time, dyeing treatment time, and coloring concentration; accordingly, lightness $L^*$ decreased and saturation $a^*$ and $b^*$ increased. The concentration of the dye and the UV-visible absorbance showed a nearly perfect linear relationship, allowing a quantitative analysis of the absorbed dye. Because the quantity of absorbed dye increased as anodizing time, dyeing treatment time, and coloring concentration increased, the outward color of the anodized film deepened. In addition, from the GD-OES depth profile, we found that the dye was preferentially absorbed on the surface of the porous anodized film.
백상아 ( Sang Ah Baek ),류헌모 ( Hun Mo Ryoo ),배성화 ( Sung Hwa Bae ),조윤영 ( Yoon Young Cho ),김성규 ( Seong Gyu Kim ),김가영 ( Ga Young Kim ),김민근 ( Min Keun Kim ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.2
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a monoclonal plasma cell disorder. Patients with POEMS syndrome also have various clinical manifestations including generalized edema, pleural effusion, ascites, papilledema, and sclerotic bone lesions. These manifestations can lead to a misdiagnosis or delayed diagnosis. We recently experienced a 51-year-old male patient with POEMS syndrome whose sclerotic bone lesion was misdiagnosed as malignant bone metastasis of papillary thyroid carcinoma. We reassessed the patient and found polyneuropathy, hepatosplenomegaly, hypothyroidism, partial hypopituitarism, immunoglobulin G lambda-type monoclonal gammopathy, hypertrichosis, ascites, and multiple sclerotic bone lesions, all of which led us to a diagnosis of POEMS syndrome. Treatment with thalidomide and dexamethasone resulted in clinical and radiological improvement. The patient has remained in remission after peripheral blood stem cell transplantation.
혈액종양 : 미만성 거대 B세포 림프종의 중추신경계 재발 후 장기 생존한 2예
김성규 ( Seong Gyu Kim ),배성화 ( Sung Hwa Bae ),류헌모 ( Hun Mo Ryoo ) 대한내과학회 2015 대한내과학회지 Vol.88 No.2
A central nervous system (CNS) relapse is a rare but mostly fatal complication in patients with diffuse large B cell lymphoma (DLBCL). CNS involvement can occur as an isolated event or can be combined with progression of systemic disease. There are limited data on treatment outcomes of patients with DLBCL and secondary CNS involvement. We report the clinical data, treatments, and outcomes of two DLBCL patients with isolated CNS relapses involving the brain parenchyma. Isolated CNS disease involving the brain parenchyma may be potentially treatable as the initial relapse site after complete remission from systemic treatment. (Korean J Med 2015;88:218-223)
증례 : 혈액종양 ; 필라델피아 양성 급성골수성 백혈병에서 imatinib mesylate 투여로 완전관해 유도된 1예
장샛별 ( Saet Byul Jang ),배성화 ( Sung Hwa Bae ),정혜련 ( Hye Ryun Jung ),윤소연 ( So Yeon Yoon ),전언주 ( Eon Ju Jun ),강건우 ( Gun Woo Kang ),류헌모 ( Hun Mo Ryoo ) 대한내과학회 2010 대한내과학회지 Vol.78 No.1
Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) is a rare disease characterized by a poor prognosis with resistance to standard chemotherapy. We report a patient with Ph+AML with a minor BCR-ABL-positive mRNA transcript who achieved a hematologic, cytogenetic, and major molecular complete response after cytarabine-based chemotherapy followed by imatinib. After more than 6 months of continuous imatinib therapy, the patient is in continuous complete remission. Our results show that imatinib mesylate is effective in treating Ph+AML. (Korean J Med 78:132-137, 2010)
성공적 경피적 관상동맥 확장성형술후 나타나는 재협착과 영향 인자
석준호(Jun Ho Seok),김성목(Sung Mok Kim),배성화(Sung Hwa Bae),김봉준(Bong Jun Kim),윤지성(Ji Sung Yoon),이학준(Hak Jun Lee),신동구(Dong Gu Shin),김영조(Yeong Jo Kim),심봉섭(Bong Sup Shim) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
N/A Objective: Restenosis after successful PTCA remains the main limitation of this technique. Restenosis is a response to injury of the vessel wall, platelet aggregation, thrombus formation, liberation of growth factors, cellular hyperplasia involving predominantly smooth muscle proliferation and migration, and intercellular matrix formation. The identification of risk factors for restenosis could help to prevent and reduce the impact of this phenomenon. We undertook this study to evaluate retrospectively the association between risk factors and restenosis after PTCA Methods: We studied 123 patients and 174 lesions that underwent successful P1YA and the follow-up period (from PTCA to follow-up angiography) was 8.2±5.8 months in all patients. They were divided into two groups according to the restenosis. Clinical feature, lesional feature, PTCA procedural feature, and other risk factors were compared. Restenosis was defined as the cutoff paint of >50% in diameter stenosis at angiographic follow-up. Results: 1) Restenosis was found in 68 lesions after successful PTCA (39.1%), 2) Clinical features of restenosis group are similar to no restenosis group 3) Thrombus (p=0,002), total occlusion (p=0.001), severity of stenosis in the initial lesion (p=0.013) and residual stenosis (p=0.001) were found to be independently associated with restenosis, whereas other lesional characteristics were not. 4) Balloon inflation duration (p=0.017) and dissection (p=0.002) were found to be independently associated with restenosis, whereas other procedural characteristics were not. Conclusion: Thrombus, total occlusioo, dissection, severity of stenosis in the initial lesion, balloon inflation time, residual stenosis were found to be associated with restenosis after PTCA in our study.
증례 : 혈액종양 ; 16번 염색체 역위를 가진 급성 골수성 백혈병의 복막 골수성 육종 1예
김지윤 ( Ji Yoon Kim ),박병규 ( Byeong Kyu Park ),배성화 ( Sung Hwa Bae ),류헌모 ( Hun Mo Ryoo ),성우정 ( Woo Jung Sung ),이아진 ( A Jin Lee ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5
골수성 육종(Myeloid sarcoma)은 골수 외를 침범하는 질환으로 급성 골수성 백혈병에서 발생하는 드문 종양이다. inv (16) 염색체 이상을 가진 골수성 육종은 대부분 복강 내에서, 특히 소화관을 침범하는 종괴의 형태로 나타나지만 본 증례에서는 복막의 침윤 및 복수의 형태로 나타나 1예가 있어 보고하는 바이다. Myeloid sarcoma is an extramedullary myeloid neoplasm that usually involves the skin, soft tissues, and lymph nodes. Myeloid sarcoma is found in 2.5-9.1% of acute myeloid leukemia patients, usually those with t (8,21), while inv (16) is rarely associated with myeloid sarcoma. Consequently, little is known of the characteristics and incidence of inv (16) in myeloid sarcoma. Myeloid sarcoma in acute myeloid leukemia patients with inv (16) is most often found in the abdominal lesions, the intestinal tract is involved most commonly, in the form of a mass. Here, we report an unusual myeloid sarcoma presenting as peritoneal carcinomatosis in acute myeloid leukemia with inv (16) that appeared to be ascites. (Korean J Med 2015,89:581-584)
Azithromycin 투여로 폐기능이 호전된 폐쇄성 세기관지염
오지혜 ( Ji Hye Oh ),김경찬 ( Kyung Chan Kim ),김성우 ( Sung Woo Kim ),현대성 ( Dae Sung Hyun ),이상채 ( Sang Chae Lee ),배성화 ( Sung Hwa Bae ),정경재 ( Kyung Jae Jung ),권건영 ( Kun Young Kwon ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.5
Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient`s pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT. (Tuberc Respir Dis 2008;65:410-415)